Cited by 71Oral microbiology and periodontitis researchAtherosclerosis and Cardiovascular DiseasesHeat shock proteins research

Anti- P. gingivalis Response Correlates with Atherosclerosis

Ford, P.J., Gemmell, E., Timms, P., Chan, A., Preston, F.M., Seymour, G.J.·2007·Journal of Dental Research

Abstract

Significant associations between atherosclerosis and both Porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, Chlamydia pneumoniae, have been shown. Many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. The aim of the present study was to examine the atherogenic effect of repeated immunizations with either or both of these agents, and to determine if molecular mimicry of bacterial heat-shock protein (HSP), termed GroEL, and host (h) HSP60 was involved. Atherogenesis was examined in apolipoprotein-E-deficient (-/-) mice following intraperitoneal immunizations with P. gingivalis, C. pneumoniae, P. gingivalis, and C. pneumoniae or vehicle. Lesion area in the proximal aorta and levels of serum antibodies to P. gingivalis, C. pneumoniae, and GroEL were measured. The increased pathogen burden of P. gingivalis, but not of C. pneumoniae, enhanced atherosclerosis. hHSP60 was detected in lesions, and in P. gingivalis-immunized mice, lesion development was correlated with anti-GroEL antibody levels, supporting the involvement of molecular mimicry between GroEL and hHSP60.

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Crossref · 10.1177/154405910708600105

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Authors
Ford, P. J., Gemmell, E., Timms, P., Chan, A., Preston, F. M., & Seymour, G. J.
Affiliations
Queensland University of Technology (AU)
Corresponding author
Ford, P.J.
Venue
Journal of Dental Research
Published
2007-01
Volume
86
Issue
1
Pages
35-40
ISSN
  • 0022-0345 (ISSN-L)
  • 1544-0591
OpenAlex
W1535724990
Cited by
71
References
24
Citations by year
2026: 4 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 13 · 2012: 4
FWCI
8.54
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Dental Research (publishedVersion)
  • PubMed (publishedVersion)
  • Faculty of Health; Institute of Health and Biomedical Innovation
Funders
  • American Association for Dental, Oral, and Craniofacial Research
  • International Association for Dental Research
  • Australian Dental Research Foundation
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords
Porphyromonas gingivalis, Chlamydia pneumoniae, atherosclerosis, molecular mimicry, heat shock protein 60, GroEL, periodontal pathogens, atherogenesis, ApoE-deficient mice, bacterial immunization, aortic atherosclerotic lesions
MeSH terms
Animals, Antibodies, Bacterial, Antigens, Bacterial, Antigens, Differentiation, Aortic Diseases, Apolipoproteins E, B-Lymphocytes, Immunoglobulin G, Immunization, Macrophages, Male, Mice, Inbred Strains, CD4-Positive T-Lymphocytes, Porphyromonas gingivalis, Chlamydophila pneumoniae, CD8-Positive T-Lymphocytes, Molecular Mimicry, Chaperonin 60, Antigens, CD19, Atherosclerosis, Mice

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