Anti- P. gingivalis Response Correlates with Atherosclerosis
Abstract
Significant associations between atherosclerosis and both Porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, Chlamydia pneumoniae, have been shown. Many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. The aim of the present study was to examine the atherogenic effect of repeated immunizations with either or both of these agents, and to determine if molecular mimicry of bacterial heat-shock protein (HSP), termed GroEL, and host (h) HSP60 was involved. Atherogenesis was examined in apolipoprotein-E-deficient (-/-) mice following intraperitoneal immunizations with P. gingivalis, C. pneumoniae, P. gingivalis, and C. pneumoniae or vehicle. Lesion area in the proximal aorta and levels of serum antibodies to P. gingivalis, C. pneumoniae, and GroEL were measured. The increased pathogen burden of P. gingivalis, but not of C. pneumoniae, enhanced atherosclerosis. hHSP60 was detected in lesions, and in P. gingivalis-immunized mice, lesion development was correlated with anti-GroEL antibody levels, supporting the involvement of molecular mimicry between GroEL and hHSP60.
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More recent work has linked Porphyromonas gingivalis to atherosclerosis, smoking, and several cancers.
“while more recent work has linked Porphyromonas gingivalis to atherosclerosis[185], smoking[186], and several cancers[187].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [185]
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- Authors
- Ford, P. J., Gemmell, E., Timms, P., Chan, A., Preston, F. M., & Seymour, G. J.
- Affiliations
- Queensland University of Technology (AU)
- Corresponding author
- Ford, P.J.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2007-01
- Volume
- 86
- Issue
- 1
- Pages
- 35-40
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W1535724990
- Cited by
- 71
- References
- 24
- Citations by year
- 2026: 4 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 13 · 2012: 4
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Faculty of Health; Institute of Health and Biomedical Innovation
- Funders
- American Association for Dental, Oral, and Craniofacial Research
- International Association for Dental Research
- Australian Dental Research Foundation
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- Porphyromonas gingivalis, Chlamydia pneumoniae, atherosclerosis, molecular mimicry, heat shock protein 60, GroEL, periodontal pathogens, atherogenesis, ApoE-deficient mice, bacterial immunization, aortic atherosclerotic lesions
- MeSH terms
- Animals, Antibodies, Bacterial, Antigens, Bacterial, Antigens, Differentiation, Aortic Diseases, Apolipoproteins E, B-Lymphocytes, Immunoglobulin G, Immunization, Macrophages, Male, Mice, Inbred Strains, CD4-Positive T-Lymphocytes, Porphyromonas gingivalis, Chlamydophila pneumoniae, CD8-Positive T-Lymphocytes, Molecular Mimicry, Chaperonin 60, Antigens, CD19, Atherosclerosis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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