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NGF Up-regulates TRPA1: Implications for Orofacial Pain
Abstract
The transient receptor potential ankyrin repeat 1 (TRPA1) channel is believed to be involved in many forms of acute and chronic hyperalgesia. Nerve Growth Factor (NGF) regulates chronic inflammatory hyperalgesia by controlling gene expression in sensory neurons, including genes involved in inflammatory hyperalgesia in the dental pulp. We hypothesized that NGF increases functional activities of the TRPA1 channel in trigeminal ganglion neurons. Here, we show that NGF induced a concentration- and time-dependent up-regulation of TRPA1 mRNA in trigeminal ganglia neurons, as detected by real-time RT-PCR and in situ hybridization. In addition, NGF evoked a time-dependent increase of mustard oil (MO)-evoked TRPA1 activation in trigeminal ganglia neurons. Collectively, these findings demonstrate that NGF participates in the functional up-regulation of TRPA1 in trigeminal ganglia neurons. These enhanced activities of TRPA1 could play an important role in the development of hyperalgesia following nerve injury and inflammation in the orofacial region.
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Cited by
Eid, S. R., Crown, E. D., Moore, E. L., Liang, H. A., Choong, K.-C., Dima, S., Henze, D. A., Kane, S. A., & Urban, M. O. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-48 · Cited by 447
Gouin, O., L’Herondelle, K., Lebonvallet, N., Le Gall-Ianotto, C., Sakka, M., Buhé, V., Plée-Gautier, E., Carré, J.-L., Lefeuvre, L., Misery, L., et al. (2017) · Protein & Cell · doi:10.1007/s13238-017-0395-5 · Cited by 425
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Regeneration of Dental-Pulp-like Tissue by Chemotaxis-Induced Cell Homing
Kim, J. Y., Xin, X., Moioli, E. K., Chung, J., Lee, C. H., Chen, M., Fu, S. Y., Koch, P. D., & Mao, J. J. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0181 · Cited by 364
Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs
Nassenstein, C., Kwong, K., Taylor‐Clark, T., Kollarik, M., MacGlashan, D. M., Braun, A., & Undem, B. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.148379 · Cited by 349
Metadata
- Authors
- Diogenes, A., Akopian, A. N., & Hargreaves, K. M.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2007-06
- Volume
- 86
- Issue
- 6
- Pages
- 550-555
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2028688696
- Cited by
- 163
- References
- 0
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Diogenes, A., Akopian, A. N., & Hargreaves, K. M. (2007). NGF Up-regulates TRPA1: Implications for Orofacial Pain. Journal of Dental Research. https://doi.org/10.1177/154405910708600612
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