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Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis
Open accessAbstract
Fracture healing and distraction osteogenesis have important applications in orthopedic, maxillofacial, and periodontal treatment. In this review, the cellular and molecular mechanisms that regulate fracture repair are contrasted with bone regeneration that occurs during distraction osteogenesis. While both processes have many common features, unique differences are observed in the temporal appearance and expression of specific molecular factors that regulate each. The relative importance of inflammatory cytokines in normal and diabetic healing, the transforming growth factor beta superfamily of bone morphogenetic mediators, and the process of angiogenesis are discussed as they relate to bone repair. A complete summary of biological activities and functions of various bioactive factors may be found at COPE (Cytokines & Cells Online Pathfinder Encyclopedia), http://www.copewithcytokines.de/cope.cgi .
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Cited by
The biology of fracture healing
Marsell, R., & Einhorn, T. A. (2011) · Injury · doi:10.1016/j.injury.2011.03.031 · Cited by 1,824
Self-citationThe roles of vascular endothelial growth factor in bone repair and regeneration
Hu, K., & Olsen, B. R. (2016) · Bone · doi:10.1016/j.bone.2016.06.013 · Cited by 678
Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534
Diabetes and Its Effect on Bone and Fracture Healing
Jiao, H., Xiao, E., & Graves, D. T. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0286-8 · Cited by 522
Self-citationCurrent Advances in Immunomodulatory Biomaterials for Bone Regeneration
Lee, J., Byun, H., Madhurakkat Perikamana, S. K., Lee, S., & Shin, H. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801106 · Cited by 452
Metadata
- Authors
- AI-Aql, Z. S., Alagl, A. S., Graves, D. T., Gerstenfeld, L. C., & Einhorn, T. A.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2008-02
- Volume
- 87
- Issue
- 2
- Pages
- 107-118
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2133819222
- Cited by
- 691
- References
- 0
- FWCI
- 19.05
- Type
- journal article
- Language
- en
- Open access
- green
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- AI-Aql, Z. S., Alagl, A. S., Graves, D. T., Gerstenfeld, L. C., & Einhorn, T. A. (2008). Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis. Journal of Dental Research. https://doi.org/10.1177/154405910808700215
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
