The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Rewiring the Brain: Potential Role of the Premotor Cortex in Motor Control, Learning, and Recovery of Function Following Brain Injury
Open accessAbstract
The brain is a plastic organ with a capability to reorganize in response to behavior and/or injury. Following injury to the motor cortex or emergent corticospinal pathways, recovery of function depends on the capacity of surviving anatomical resources to recover and repair in response to task-specific training. One such area implicated in poststroke reorganization to promote recovery of upper extremity recovery is the premotor cortex (PMC). This study reviews the role of distinct subdivisions of PMC: dorsal (PMd) and ventral (PMv) premotor cortices as critical anatomical and physiological nodes within the neural networks for the control and learning of goal-oriented reach and grasp actions in healthy individuals and individuals with stroke. Based on evidence emerging from studies of intrinsic and extrinsic connectivity, transcranial magnetic stimulation, functional neuroimaging, and experimental studies in animals and humans, the authors propose 2 distinct patterns of reorganization that differentially engage ipsilesional and contralesional PMC. Research directions that may offer further insights into the role of PMC in motor control, learning, and poststroke recovery are also proposed. This research may facilitate neuroplasticity for maximal recovery of function following brain injury.
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“In humans, good functional recovery after stroke is associated with remapping of sensorimotor function in motor, somatosensory and premotor circuits5,6 and is accompanied by increases in cortical thickness in these reorganizing areas7.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [6]
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Extensive Cortical Rewiring after Brain Injury
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Brain–computer interface boosts motor imagery practice during stroke recovery
Pichiorri, F., Morone, G., Petti, M., Toppi, J., Pisotta, I., Molinari, M., Paolucci, S., Inghilleri, M., Astolfi, L., Cincotti, F., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24390 · Cited by 695
CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury
Joy, M. T., Ben Assayag, E., Shabashov-Stone, D., Liraz-Zaltsman, S., Mazzitelli, J., Arenas, M., Abduljawad, N., Kliper, E., Korczyn, A. D., Thareja, N. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.044 · Cited by 389
Várkuti, B., Guan, C., Pan, Y., Phua, K. S., Ang, K. K., Kuah, C. W. K., Chua, K. S. G., Ang, B. T., Birbaumer, N., & Sitaram, R. (2012) · Neurorehabilitation and neural repair · doi:10.1177/1545968312445910 · Cited by 263
Connectivity measures are robust biomarkers of cortical function and plasticity after stroke
Wu, J., Quinlan, E. B., Dodakian, L., McKenzie, A. L., Kathuria, N., Zhou, R. J., Augsburger, R., See, J., Le, V., Srinivasan, R., et al. (2015) · Brain · doi:10.1093/brain/awv156 · Cited by 220
Molecular, cellular and functional events in axonal sprouting after stroke
Carmichael, S. T., Kathirvelu, B., Schweppe, C. A., & Nie, E. H. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.02.007 · Cited by 206
Metadata
- Authors
- Kantak, S. S., Stinear, J. W., Buch, E. R., & Cohen, L. G.
- Affiliations
- Shirley Ryan AbilityLab (US)
- Northwestern University (US)
- National Institute of Neurological Disorders and Stroke (US)
- Venue
- Neurorehabilitation and Neural Repair
- Publisher
- SAGE Publications
- Published
- 2011-09-16
- Volume
- 26
- Issue
- 3
- Pages
- 282-292
- ISSN
- 0888-4390 (ISSN-L)
- 1545-9683
- 1552-6844
- PMC
- PMC4886541
- OpenAlex
- W2050666996
- Cited by
- 245
- References
- 89
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 19 · 2023: 26 · 2022: 18 · 2021: 12 · 2020: 22 · 2019: 16 · 2018: 16 · 2017: 12 · 2016: 14 · 2015: 11 · 2014: 15 · 2013: 17 · 2012: 5
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurorehabilitation and neural repair (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (ZIANS002978)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- premotor cortex, dorsal premotor cortex, ventral premotor cortex, stroke recovery, upper extremity recovery, motor reorganization, neuroplasticity, corticospinal tract, motor learning, reach and grasp, brain injury
- MeSH terms
- Brain Injuries, Humans, Learning, Motor Activity, Motor Cortex, Recovery of Function
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