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Cited by 233Osteoarthritis Treatment and MechanismsMusculoskeletal pain and rehabilitationLower Extremity Biomechanics and Pathologies

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Muscle Impairments in Patients With Knee Osteoarthritis

Open access
Alnahdi, Ali H., Zeni, Joseph A., Snyder-Mackler, Lynn·2012·Sports Health A Multidisciplinary Approach
DOI 10.1177/1941738112445726PMC PMC3435919
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Abstract

CONTEXT: Muscle impairments associated with knee osteoarthritis (OA) are the primary underlying cause of functional limitations. Understanding the extent of muscle impairments, its relationship with physical function and disease progression, and the evidence behind exercise therapy that targets muscle impairments is crucial. EVIDENCE ACQUISITION: An electronic search for relevant articles using MEDLINE and CINHAL databases up to September 2011 was performed. In addition to the electronic search, retrieved articles were searched manually for relevant studies. RESULTS: Quadriceps, hamstrings, and hip muscles are significantly impaired in subjects with knee OA compared with age-matched controls. Muscle strength, especially quadriceps, is a major determinant of both performance-based and self-reported physical function. Whether stronger quadriceps is protective against knee OA onset and progression is not clear. Exercise therapy, including global and targeted resistance training, is effective in reducing pain and improving function in subjects with knee OA. CONCLUSIONS: Subjects with knee OA have significant muscle impairments. These muscle impairments affect physical function and should be targeted in therapy. Further research is needed to explore the relationship between quadriceps strength and knee OA initiation and progression and to determine the optimal exercise prescription that augments outcomes in this patient population.

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Research works printed but not linked: 7

  1. Baker KR, 2001, J Rheumatol, 28, 1655
  2. Centers for Disease Control and Prevention, 2009, MMWR Weekly, 58, 421
  3. Diracoglu D, 2009, Acta Reumatol Port, 34, 72
  4. Fransen M, 2008, Cochrane Database Syst Rev, 4, CD004376
  5. Jan MH, 1990, J Formos Med Assoc, 89, 873
  6. Messier SP, 1992, Arch Phys Med Rehabil, 73, 29
  7. Thorp LE, 2010, J Musculoskelet Neuronal Interact, 10, 166

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Metadata

Authors
Alnahdi, A. H., Zeni, J. A., & Snyder-Mackler, L.
Affiliations
  • King Saud University (SA)
  • University of Delaware (US)
  • Department of Physical Therapy, University of Delaware, Newark, Delaware
ORCID
Venue
Sports Health A Multidisciplinary Approach
Publisher
SAGE Publications
Published
2012-06-19
Volume
4
Issue
4
Pages
284-292
ISSN
  • 1941-0921 (ISSN-L)
  • 1941-7381
DOI
10.1177/1941738112445726
PMC
PMC3435919
OpenAlex
W2101943922
Cited by
233
References
75
Citations by year
2026: 19 · 2025: 25 · 2024: 29 · 2023: 29 · 2022: 26 · 2021: 13 · 2020: 18 · 2019: 13 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 8 · 2014: 9 · 2013: 2
FWCI
4.67
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Sports Health A Multidisciplinary Approach (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
Keywords
knee osteoarthritis, muscle impairment, quadriceps strength, hamstrings, hip muscle strength, physical function, resistance training, exercise therapy, disease progression, analgesia

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