Cited by 303Extracellular vesicles in diseaseCancer-related molecular mechanisms researchMicroRNA in disease regulation

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Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer

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Kogure, T., Yan, I. K., Lin, W.-L., Patel, T.·2013·Genes & Cancer

DOI 10.1177/1947601913499020PMC PMC3807642

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Abstract

Although the expression of long noncoding RNA (lncRNA) is altered in hepatocellular cancer (HCC), their biological effects are poorly defined. We have identified lncRNA with highly conserved sequences, ultraconserved lncRNA (ucRNA) that are transcribed and altered in expression in HCC. Extracellular vesicles, such as exosomes and microvesicles, are released from tumor cells and can transfer biologically active proteins and RNA across cells. We sought to identify the role of vesicle-mediated transfer of ucRNA as a mechanism by which these novel lncRNA could influence intercellular signaling with potential for environmental modulation of tumor cell behavior. HCC-derived extracellular vesicles could be isolated from cells in culture and taken up by adjacent cells. The expression of several ucRNA was dramatically altered within extracellular vesicles compared to that in donor cells. The most highly significantly expressed ucRNA in HCC cell-derived extracellular vesicles was cloned and identified as a 1,198-bp ucRNA, termed TUC339. TUC339 was functionally implicated in modulating tumor cell growth and adhesion. Suppression of TUC339 by siRNA reduced HCC cell proliferation, clonogenic growth, and growth in soft agar. Thus, intercellular transfer of TUC339 represents a unique signaling mechanism by which tumor cells can promote HCC growth and spread. These findings expand the potential roles of ucRNA in HCC, support the existence of selective mechanisms for lncRNA export from cells,…

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Additional file 3 of Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
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Additional file 5 of Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
Weber, D. G., Casjens, S., Brik, A., Raiko, I., Lehnert, M., Taeger, D., Gleichenhagen, J., Kollmeier, J., Bauer, T. T., Brüning, T., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12299402
Additional file 1 of Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
Weber, D. G., Casjens, S., Brik, A., Raiko, I., Lehnert, M., Taeger, D., Gleichenhagen, J., Kollmeier, J., Bauer, T. T., Brüning, T., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12299387
Additional file 4 of Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
Weber, D. G., Casjens, S., Brik, A., Raiko, I., Lehnert, M., Taeger, D., Gleichenhagen, J., Kollmeier, J., Bauer, T. T., Brüning, T., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12299399
Additional file 2 of Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
Weber, D. G., Casjens, S., Brik, A., Raiko, I., Lehnert, M., Taeger, D., Gleichenhagen, J., Kollmeier, J., Bauer, T. T., Brüning, T., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12299390
Additional file 1 of Upregulation of long non-coding RNA LOC284454 may serve as a new serum diagnostic biomarker for head and neck cancers
Fan, C., Wang, J., Tang, Y., Zhang, S., Xiong, F., Guo, C., Zhou, Y., Li, Z., Li, X., Li, Y., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13004267

Authors: Kogure, T., Yan, I. K., Lin, W.-L., & Patel, T.
Affiliations: Mayo Clinic (US)
Mayo Clinic in Florida (US)
Corresponding author: Patel, T.
ORCID: Kogure, T.
Yan, I. K.
Patel, T.
Venue: Genes & Cancer
Publisher: SAGE Publications
Published: 2013-07-01
Volume: 4
Issue: 7-8
Pages: 261-272
ISSN: 1947-6019 (ISSN-L)
1947-6027
DOI: 10.1177/1947601913499020
PMC: PMC3807642
OpenAlex: W2118018590
Cited by: 303
References: 23
Citations by year: 2026: 3 · 2025: 5 · 2024: 13 · 2023: 16 · 2022: 28 · 2021: 31 · 2020: 37 · 2019: 32 · 2018: 31 · 2017: 30 · 2016: 37 · 2015: 25 · 2014: 14 · 2013: 1
FWCI: 11.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Genes & Cancer (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK069370)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords: long non-coding RNA, extracellular vesicles, exosomes, microvesicles, hepatocellular carcinoma, intercellular RNA transfer, tumor cell proliferation, tumor cell adhesion, tumor microenvironment

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Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer

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