Cited by 303Extracellular vesicles in diseaseCancer-related molecular mechanisms researchMicroRNA in disease regulation

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer

Open access

Kogure, T., Yan, I. K., Lin, W.-L., Patel, T.·2013·Genes & Cancer

DOI 10.1177/1947601913499020PMC PMC3807642

Open this paper in CoChat — free account Open PDF

Abstract

Although the expression of long noncoding RNA (lncRNA) is altered in hepatocellular cancer (HCC), their biological effects are poorly defined. We have identified lncRNA with highly conserved sequences, ultraconserved lncRNA (ucRNA) that are transcribed and altered in expression in HCC. Extracellular vesicles, such as exosomes and microvesicles, are released from tumor cells and can transfer biologically active proteins and RNA across cells. We sought to identify the role of vesicle-mediated transfer of ucRNA as a mechanism by which these novel lncRNA could influence intercellular signaling with potential for environmental modulation of tumor cell behavior. HCC-derived extracellular vesicles could be isolated from cells in culture and taken up by adjacent cells. The expression of several ucRNA was dramatically altered within extracellular vesicles compared to that in donor cells. The most highly significantly expressed ucRNA in HCC cell-derived extracellular vesicles was cloned and identified as a 1,198-bp ucRNA, termed TUC339. TUC339 was functionally implicated in modulating tumor cell growth and adhesion. Suppression of TUC339 by siRNA reduced HCC cell proliferation, clonogenic growth, and growth in soft agar. Thus, intercellular transfer of TUC339 represents a unique signaling mechanism by which tumor cells can promote HCC growth and spread. These findings expand the potential roles of ucRNA in HCC, support the existence of selective mechanisms for lncRNA export from cells,…

Integrity signals

Registry

Crossref · 10.1177/1947601913499020

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Prediction of complete gene structures in human genomic DNA
Burge, C., & Karlin, S. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.0951 · Cited by 4,211
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
Pan, Q., Shai, O., Lee, L. J., Frey, B. J., & Blencowe, B. J. (2008) · Nature Genetics · doi:10.1038/ng.259 · Cited by 3,951
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,039
Ultraconserved Elements in the Human Genome
Bejerano, G., Pheasant, M., Makunin, I., Stephen, S., Kent, W. J., Mattick, J. S., & Haussler, D. (2004) · Science · doi:10.1126/science.1098119 · Cited by 1,732
Genetic variation in microRNA networks: the implications for cancer research
Ryan, B. M., Robles, A. I., & Harris, C. C. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2867 · Cited by 1,269

Flagged first, then by citations

Show all 23 references

Sorted by citations

Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926
Exosomes: biogenesis, biologic function and clinical potential
Zhang, Y., Liu, Y., Liu, H., & Tang, W. H. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0282-2 · Cited by 2,119
LNCcation: lncRNA localization and function
Bridges, M. C., Daulagala, A. C., & Kourtidis, A. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202009045 · Cited by 1,556
Exosome-based liquid biopsies in cancer: opportunities and challenges
Wang, Y., Hurley, J. D., Roberts, D., Chakrabortty, S. K., Enderle, D., Noerholm, M., Breakefield, X. O., & Skog, J. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.01.074 · Cited by 882
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
Okugawa, Y., Grady, W. M., & Goel, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.011 · Cited by 782
Exosomes in cancer: small particle, big player
Zhang, X., Yuan, X., Shi, H., Wu, L., Qian, H., & Xu, W. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0181-x · Cited by 799
Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders
Riazifar, M., Mohammadi, M. R., Pone, E. J., Yeri, A., Lässer, C., Segaliny, A. I., McIntyre, L. L., Shelke, G. V., Hutchins, E., Hamamoto, A., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01004 · Cited by 551
Exosomes: From Garbage Bins to Promising Therapeutic Targets
Rashed, M. H., Bayraktar, E., Helal, G. K., Abd‐Ellah, M. F., Amero, P., Chávez‐Reyes, A., & Rodriguez‐Aguayo, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030538 · Cited by 536
Clinical utility of circulating non-coding RNAs — an update
Anfossi, S., Babayan, A., Pantel, K., & Călin, G. A. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0035-x · Cited by 464
CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA
Conigliaro, A., Costa, V., Dico, A. L., Saieva, L., Buccheri, S., Dieli, F., Manno, M., Raccosta, S., Mancone, C., Tripodi, M., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0426-x · Cited by 435
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Yang, J., Xu, J., Wang, W. T., Zhang, B., Yu, X., & Shi, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01480-x · Cited by 412
Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4
Xiao, J., Pan, Y., Li, X. H., Yang, X. Y., Feng, Y. L., Tan, H. H., Jiang, L., Feng, J., & Yu, X. Y. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.181 · Cited by 373
Aortic Valve Stenosis
Goody, P. R., Hosen, M. R., Christmann, D., Niepmann, S. T., Zietzer, A., Adam, M., Bönner, F., Zimmer, S., Nickenig, G., & Jansen, F. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313067 · Cited by 358
Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment
Xu, Z., Chen, Y., Ma, L., Chen, Y., Liu, J., Guo, Y., Yu, T., Zhang, L., Zhu, L., & Shu, Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.046 · Cited by 337
Circular RNA: a novel biomarker and therapeutic target for human cancers
Lei, B., Tian, Z., Fan, W., & Ni, B. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.28047 · Cited by 315
Circulating long non-coding RNAs in cancer: current status and future perspectives
Qi, P., Zhou, X.-Y., & Du, X. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0524-4 · Cited by 313
Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles
Iraci, N., Leonardi, T., Gessler, F., Vega, B., & Pluchino, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020171 · Cited by 301
Involvement of Extracellular Vesicle Long Noncoding RNA (linc-VLDLR) in Tumor Cell Responses to Chemotherapy
Takahashi, K., Yan, I. K., Wood, J., Haga, H., & Patel, T. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0636 · Cited by 258
Self-citation
Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration
Fu, Y., Karbaat, L., Wu, L., Leijten, J., Both, S. K., & Karperien, M. (2017) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0365 · Cited by 277
Long noncoding RNAs: a potential novel class of cancer biomarkers
Yarmishyn, A. A., & Kurochkin, I. V. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00145 · Cited by 274
Regulation of Macrophage Activation and Polarization by HCC-Derived Exosomal lncRNA TUC339
Li, X., Lei, Y., Wu, M., & Li, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102958 · Cited by 273
Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes
Berrondo, C., Flax, J. D., Kucherov, V., Siebert, A. L., Osinski, T. L., Rosenberg, A. F., Fucile, C., Richheimer, S., & Beckham, C. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147236 · Cited by 272
Transcriptome of Extracellular Vesicles: State-of-the-Art
Turchinovich, A. A., Drapkina, O. M., & Tonevitsky, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00202 · Cited by 260
Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges
Lane, R. E., Korbie, D. J., Hill, M. M. C., & Trau, M. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-018-0192-7 · Cited by 255
The fusion of two worlds: Non-coding RNAs and extracellular vesicles - diagnostic and therapeutic implications (Review)
Sato-Kuwabara, Y., Melo, S. A., Soares, F. A., & Călin, G. A. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2712 · Cited by 245
Clinical application of a microfluidic chip for immunocapture and quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification
Fang, S., Tian, H., Li, X., Jin, D., Li, X., Kong, J., Yang, C., Yang, X., Lu, Y., Luo, Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175050 · Cited by 237
Modulation of hypoxia-signaling pathways by extracellular long non-coding RNA regulator of reprogramming
Takahashi, K., Yan, I. K., Haga, H., & Patel, T. C. (2014) · Journal of Cell Science · doi:10.1242/jcs.141069 · Cited by 231
Self-citation
Emerging roles of exosomes during epithelial–mesenchymal transition and cancer progression
Greening, D. W., Gopal, S. K., Mathias, R. A., Liu, L., Sheng, J., Zhu, H., & Simpson, R. J. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.008 · Cited by 224
Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
Grammatikakis, I., Panda, A. C., Abdelmohsen, K., & Gorospe, M. (2014) · Aging · doi:10.18632/aging.100710 · Cited by 222
LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions
Barbagallo, C., Brex, D., Caponnetto, A., Cirnigliaro, M., Scalia, M., Magnano, A., Caltabiano, R., Barbagallo, D., Biondi, A., Cappellani, A., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.05.009 · Cited by 224
Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases
Sahoo, S., Adamiak, M., Mathiyalagan, P., Kenneweg, F., Kafert-Kasting, S., & Thum, T. (2021) · Circulation · doi:10.1161/circulationaha.120.049254 · Cited by 218
Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma
Parasramka, M. A., Maji, S., Matsuda, A., Yan, I. K., & Patel, T. C. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.03.004 · Cited by 212
Self-citation
Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease
Koeck, E. S., Iordanskaia, T., Sevilla, S., Ferrante, S. C., Hubal, M. J., Freishtat, R. J., & Nadler, E. P. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.06.050 · Cited by 210
Non-coding RNAs regulation of macrophage polarization in cancer
Mohapatra, S., Pioppini, C., Özpolat, B., & Călin, G. A. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01313-x · Cited by 209
LncRNAs regulate metabolism in cancer
Lin, W., Zhou, Q., Wang, C., Zhu, L., Bi, C., Zhang, S., Wang, X., & Jin, H. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.40769 · Cited by 208
Self-citation
Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2
Lang, H., Hu, G., Zhang, B., Kuang, W., Chen, Y., Wu, L., & Xu, G. (2017) · Oncology Reports · doi:10.3892/or.2017.5742 · Cited by 202
Circulating lncRNA H19 in plasma as a novel biomarker for breast cancer
Zhang, K., Luo, Z., Zhang, Y., Zhang, L., Wu, L., Liu, L., Yang, J., Song, X., & Liu, J. (2016) · Cancer Biomarkers · doi:10.3233/cbm-160630 · Cited by 199
Evaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer
Weber, D. G., Johnen, G., Casjens, S., Bryk, O., Pesch, B., Jöckel, K., Kollmeier, J., & Brüning, T. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-518 · Cited by 198
Exosomal lncRNAs as new players in cell-to-cell communication
Dragomir, M. P., Chen, B., & Călin, G. A. (2018) · Translational Cancer Research · doi:10.21037/tcr.2017.10.46 · Cited by 196
Genome-Wide lncRNA Microarray Profiling Identifies Novel Circulating lncRNAs for Detection of Gastric Cancer
Zhang, K., Shi, H., Xi, H., Wu, X., Cui, J., Gao, Y., Liang, W., Hu, C., Liu, Y., Li, J., et al. (2016) · Theranostics · doi:10.7150/thno.16044 · Cited by 192
Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression
Wu, L., Zhang, X., Zhang, B., Shi, H., Yuan, X., Sun, Y., Pan, Z., Qian, H., & Xu, W. (2016) · Tumor Biology · doi:10.1007/s13277-016-5071-5 · Cited by 189
Long noncoding RNA in liver diseases
Takahashi, K., Yan, I., Haga, H., & Patel, T. (2014) · Hepatology · doi:10.1002/hep.27043 · Cited by 184
Self-citation
Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice
Haga, H., Yan, I. K., Takahashi, K., Matsuda, A., & Patel, T. C. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0226 · Cited by 183
Self-citation
Progress and Prospects of Long Noncoding RNAs (lncRNAs) in Hepatocellular Carcinoma
Li, C., Chen, J., Zhang, K., Feng, B., Wang, R., & Chen, L. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430109 · Cited by 179
The therapeutic and diagnostic role of exosomes in cardiovascular diseases
Zamani, P., Fereydouni, N., Butler, A. E., Navashenaq, J. G., & Sahebkar, A. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.10.010 · Cited by 184
Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs
Lee, H., Zhang, D., Zhu, Z., Cruz, C. S. D., & Jin, Y. (2016) · Scientific Reports · doi:10.1038/srep35250 · Cited by 174
The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance
Xavier, C. P. R., Caires, H. R., Barbosa, M. A. G., Bergantim, R., Guimarães, J. E., & Vasconcelos, M. H. (2020) · Cells · doi:10.3390/cells9051141 · Cited by 182
Circulating CUDR , LSINCT ‐5 and PTENP 1 long noncoding RNA s in sera distinguish patients with gastric cancer from healthy controls
Dong, L., Qi, P., Xu, M., Ni, S., Huang, D., Xu, Q., Weng, W., Tan, C., Sheng, W., Zhou, X., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29484 · Cited by 167
RNA Biomarkers: Frontier of Precision Medicine for Cancer
Xi, X., Li, T., Huang, Y., Sun, J., Zhu, Y., Yang, Y., & Lu, Z. J. (2017) · Non-Coding RNA · doi:10.3390/ncrna3010009 · Cited by 163
Tumour cell–derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth
Haga, H., Yan, I. K., Takahashi, K., Wood, J. D., Zubair, A. C., & Patel, T. C. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.24900 · Cited by 159
Self-citation
Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications
Ahmadi, M., & Rezaie, J. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02426-5 · Cited by 165
Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats
Alzahrani, F. A., El‐Magd, M. A., Abdelfattah‐Hassan, A., Saleh, A. A., Saadeldin, I. M., El‐Shetry, E. S., Badawy, A. A., & Alkarim, S. (2018) · Stem Cells International · doi:10.1155/2018/8058979 · Cited by 157
Circulating RNAs as new biomarkers for detecting pancreatic cancer
Kishikawa, T. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i28.8527 · Cited by 157
MicroRNAs, Long Noncoding RNAs, and Their Functions in Human Disease
Xue, M., Zhuo, Y., & Shan, B. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7046-9_1 · Cited by 154
The Clinical Relevance of Long Non-Coding RNAs in Cancer
da Silva, A. M., Bullock, M. D., & Călin, G. A. (2015) · Cancers · doi:10.3390/cancers7040884 · Cited by 157
Endothelial- and Immune Cell-Derived Extracellular Vesicles in the Regulation of Cardiovascular Health and Disease
Jansen, F., Li, Q., Pfeifer, A., & Werner, N. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.08.004 · Cited by 149
Vesiculated Long Non-Coding RNAs: Offshore Packages Deciphering Trans-Regulation between Cells, Cancer Progression and Resistance to Therapies
Fatima, F., & Nawaz, M. (2017) · Non-Coding RNA · doi:10.3390/ncrna3010010 · Cited by 147
Identification of Cancer-Related Long Non-Coding RNAs Using XGBoost With High Accuracy
Zhang, X., Li, T., Wang, J., Li, J., Chen, L., & Liu, C. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00735 · Cited by 142
Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading
Sutaria, D. S., Badawi, M., Phelps, M. A., & Schmittgen, T. D. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2123-5 · Cited by 140
Circulating biomarkers to monitor cancer progression and treatment
Rapisuwon, S., Vietsch, E. E., & Wellstein, A. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2016.05.004 · Cited by 143
SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming
Li, Y., Zhao, Z., Liu, W., & Li, X. (2020) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-020-03244-7 · Cited by 135
Novel Genetic and Epigenetic Biomarkers of Prognostic and Predictive Significance in Stage II/III Colorectal Cancer
Luo, X.-J., Zhao, Q., Liu, J. S., Zheng, J., Qiu, M., Ju, H., & Xu, R. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.12.017 · Cited by 140
Unpacking extracellular vesicles: RNA cargo loading and function
Dellar, E. R., Hill, C., Melling, G. E., Carter, D. R. F., & Baena-López, L. A. (2022) · Journal of Extracellular Biology · doi:10.1002/jex2.40 · Cited by 145
Exosome: Function and Role in Cancer Metastasis and Drug Resistance
Zhang, C., Ji, Q., Yang, Y., Li, Q., & Wang, Z. (2018) · Technology in Cancer Research & Treatment · doi:10.1177/1533033818763450 · Cited by 138
Exosomes in hepatocellular carcinoma: a new horizon
Chen, R., Xu, X., Tao, Y., Qian, Z., & Yu, Y. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-018-0315-1 · Cited by 139
Exosomes and Their Role in Cancer Progression
Osaki, M., & Okada, F. (2019) · Yonago acta medica · doi:10.33160/yam.2019.06.002 · Cited by 139
The functional roles of exosomal long non-coding RNAs in cancer
Wang, M., Zhou, L., Yu, F., Zhang, Y., Li, P., & Wang, K. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03018-3 · Cited by 131
Exosomes and Hepatocellular Carcinoma: From Bench to Bedside
Sasaki, R., Kanda, T., Yokosuka, O., Kato, N., Matsuoka, S., & Moriyama, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061406 · Cited by 128
Sources and Functions of Extracellular Small RNAs in Human Circulation
Fritz, J. V., Heintz-Buschart, A., Ghosal, A., Wampach, L., Etheridge, A., Galas, D., & Wilmes, P. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050711 · Cited by 121
CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression
Wang, Z., Zhao, K., Hackert, T., & Zöller, M. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00097 · Cited by 127
A serum-circulating long noncoding RNA signature can discriminate between patients with clear cell renal cell carcinoma and healthy controls
Wu, Y., Yq, W., Weng, W.-W., Zhang, Q.-Y., Xq, Y., Gan, H.-L., Yang, Y.-S., Zhang, P.-P., Sun, M., Xu, M.-D., et al. (2016) · Oncogenesis · doi:10.1038/oncsis.2015.48 · Cited by 118
HCC-Derived Exosomes: Critical Player and Target for Cancer Immune Escape
Han, Q., Zhao, H., Yu, J., Yin, C., & Zhang, J. (2019) · Cells · doi:10.3390/cells8060558 · Cited by 120
Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis
Devhare, P. B., & Ray, R. B. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.11.001 · Cited by 119
Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
Kosaka, N., Kogure, A., Yamamoto, T., Urabe, F., Usuba, W., Prieto‐Vila, M., & Ochiya, T. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0219-1 · Cited by 119
Exosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironment
Chen, H., Zhang, C., Wang, H., & Zhao, L. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1887552 · Cited by 112
Upregulation of the long noncoding RNA PCAT-1 correlates with advanced clinical stage and poor prognosis in esophageal squamous carcinoma
Shi, W., Wu, Q., Li, S., Yang, T., Liu, Z.-H., Tong, Y., Tuo, L., Wang, S., & Cao, X. (2015) · Tumor Biology · doi:10.1007/s13277-014-2863-3 · Cited by 108
Blockade of lncRNA‐ASLNCS5088–enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation
Chen, J., Zhou, R., Liang, Y., Fu, X., Wang, D., & Wang, C. (2019) · The FASEB Journal · doi:10.1096/fj.201901610 · Cited by 106
The Role of Extracellular Vesicles: An Epigenetic View of the Cancer Microenvironment
Qian, Z., Shen, Q., Yang, X., Qiu, Y., & Zhang, W. (2015) · BioMed Research International · doi:10.1155/2015/649161 · Cited by 107
Droplet digital PCR improves urinary exosomal miRNA detection compared to real-time PCR
Wang, C., Ding, Q., Plant, P. J., Basheer, M. F., Yang, C., Tawedrous, E., Krizova, A., Boulos, C., Farag, M. S., Cheng, Y., et al. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.03.008 · Cited by 111
Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery
Sutaria, D. S., Jiang, J., Elgamal, O. A., Pomeroy, S. M., Badawi, M. A., Zhu, X., Pavlovicz, R. E., Azevedo‐Pouly, A. C. P., Chalmers, J. J., Li, C., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1333882 · Cited by 106
Long non-coding RNAs as biomarkers and therapeutic targets: Recent insights into hepatocellular carcinoma
Qiu, L., Tang, Q., Li, G., & Chen, K. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.10.007 · Cited by 102
Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers
Carotenuto, P., Fassan, M., Pandolfo, R., Lampis, A., Vicentini, C., Cascione, L., Paulus-Hock, V., Boulter, L., Guest, R. V., Quagliata, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312278 · Cited by 101
Self-citation
Extracellular Vesicle: An Emerging Mediator of Intercellular Crosstalk in Lung Inflammation and Injury
Lee, H., Abston, E. D., Zhang, D., Rai, A., & Jin, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00924 · Cited by 100
The role of extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma
Yang, N., Li, S., Li, G., Zhang, S., Tang, X., Ni, S., Jian, X.-M., Xu, C., Zhu, J., & Lu, M. (2016) · Oncotarget · doi:10.18632/oncotarget.12465 · Cited by 102
Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer
Mohankumar, S., & Patel, T. C. (2015) · Briefings in Functional Genomics · doi:10.1093/bfgp/elv058 · Cited by 99
Self-citation
Herpesviruses hijack host exosomes for viral pathogenesis
Sadeghipour, S., & Mathias, R. A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.03.005 · Cited by 100
The combination of circulating long noncoding RNAs AK001058, INHBA-AS1, MIR4435-2HG, and CEBPA-AS1 fragments in plasma serve as diagnostic markers for gastric cancer
Ke, D., Li, H., Zhang, Y., An, Y., Fu, H., Fang, X., & Zheng, X. (2017) · Oncotarget · doi:10.18632/oncotarget.15628 · Cited by 94
Pancreatic cancer stem cell markers and exosomes - the incentive push
Heiler, S., Wang, Z., & Zöller, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i26.5971 · Cited by 91
Role of extracellular vesicles in liver diseases and their therapeutic potential
Kostallari, E., Valainathan, S. R., Biquard, L., Shah, V. H., & Rautou, P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.026 · Cited by 93
New Insights into the Epigenetics of Hepatocellular Carcinoma
Wahid, B., Ali, A., Rafique, S., & Idrees, M. (2017) · BioMed Research International · doi:10.1155/2017/1609575 · Cited by 95
Extracellular RNAs: A New Awareness of Old Perspectives
Sadik, N., Cruz, L., Gurtner, A., Rodosthenous, R. S., Dusoswa, S. A., Ziegler, O., van Solinge, T. S., Wei, Z., Salvador, A. M., György, B., et al. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7652-2_1 · Cited by 94
Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability
Hewson, C., Capraro, D., Burdach, J., Whitaker, N. J., & Morris, K. V. (2016) · Non-coding RNA Research · doi:10.1016/j.ncrna.2016.06.001 · Cited by 90
Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis
Xu, J.-S., Liao, K.-L., & Zhou, W.-M. (2018) · Stem Cells International · doi:10.1155/2018/4837370 · Cited by 87
Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry
Danielson, K., Estanislau, J., Tigges, J., Toxavidis, V., Camacho, V., Felton, E. J., Khoory, J. A., Kreimer, S. D., Ivanov, A. R., Mantel, P., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144678 · Cited by 84
Characters, functions and clinical perspectives of long non-coding RNAs
Wu, R., Su, Y., Wu, H., Dai, Y., Zhao, M., & Lu, Q. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1179-y · Cited by 87
LncRNAs as Chromatin Regulators in Cancer: From Molecular Function to Clinical Potential
Begolli, R., Sideris, N., & Giakountis, A. (2019) · Cancers · doi:10.3390/cancers11101524 · Cited by 90
The long noncoding RNAs PVT1 and uc002mbe.2 in sera provide a new supplementary method for hepatocellular carcinoma diagnosis
Yu, J., Han, J., Zhang, J., Li, G., Liu, H., Cui, X., Xu, Y., Li, T., Liu, J., & Wang, C. (2016) · Medicine · doi:10.1097/md.0000000000004436 · Cited by 79
The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma
Chen, X., Tang, F. R., Arfuso, F., Cai, W.-Q., Ma, Z., Yang, J., & Sethi, G. (2019) · Biomolecules · doi:10.3390/biom10010066 · Cited by 79
Exosome-Based Treatment for Atherosclerosis
Heo, J., & Kang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23021002 · Cited by 79
Papillary thyroid cancer–derived exosomes contain miRNA-146b and miRNA-222
Lee, J. C., Zhao, J., Gundara, J. S., Serpell, J. W., Bach, L. A., & Sidhu, S. B. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.02.027 · Cited by 79

Authors: Kogure, T., Yan, I. K., Lin, W.-L., & Patel, T.
Affiliations: Mayo Clinic (US)
Mayo Clinic in Florida (US)
Corresponding author: Patel, T.
ORCID: Kogure, T.
Yan, I. K.
Patel, T.
Venue: Genes & Cancer
Publisher: SAGE Publications
Published: 2013-07-01
Volume: 4
Issue: 7-8
Pages: 261-272
ISSN: 1947-6019 (ISSN-L)
1947-6027
DOI: 10.1177/1947601913499020
PMC: PMC3807642
OpenAlex: W2118018590
Cited by: 303
References: 23
Citations by year: 2026: 3 · 2025: 5 · 2024: 13 · 2023: 16 · 2022: 28 · 2021: 31 · 2020: 37 · 2019: 32 · 2018: 31 · 2017: 30 · 2016: 37 · 2015: 25 · 2014: 14 · 2013: 1
FWCI: 11.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Genes & Cancer (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK069370)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Keywords: long non-coding RNA, extracellular vesicles, exosomes, microvesicles, hepatocellular carcinoma, intercellular RNA transfer, tumor cell proliferation, tumor cell adhesion, tumor microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks