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Cited by 13Stroke Rehabilitation and RecoveryDementia and Cognitive Impairment ResearchLong-Term Effects of COVID-19

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Long-term psychological consequences of stroke (OX-CHRONIC): A longitudinal study of cognition in relation to mood and fatigue after stroke: Protocol

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Demeyere, Nele, Williams, Owen A, Milosevich, Elise, Chiu, Evangeline G, Drozdowska, Bogna A, Dillon, Avril, Dawes, Helen, Thomas, Shirley, Kuppuswamy, Annapoorna, Pendlebury, Sarah T, J Quinn, Terence·2021·European Stroke Journal
DOI 10.1177/23969873211046120PMC PMC8948513

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Abstract

Background: The long-term psychological consequences of stroke and how cognitive problems change over time after the first-year following stroke remain unclear. Particularly, trajectories of domain-specific and domain-general cognitive functions and how cognition interacts with mood, fatigue and quality of life are not well described. Aims: To determine the prevalence, trajectories and wider impact of domain-specific cognitive impairment in long-term stroke survivors, in relation to mood, fatigue and quality of life. Methods: Participants who previously took part in the Oxford Cognitive Screening study, completed the 6-month follow-up with cognitive, mood, fatigue and quality of life assessments and agreed to be contacted for future research will be recruited into OX-CHRONIC. The eligible cohort is between 2- and 9-years post-stroke. Cognition will be assessed with a detailed neuropsychological battery, alongside questionnaire measures of mood, fatigue, activities of daily life and quality of life measures at two timepoints, 1 year apart. Additionally, medical records will be accessed to extract further clinical information about the stroke and patients may opt-in to wear an activity monitor for 1 week to provide fine-grained measures of sleep and activity. The study protocol and study materials were approved by the national ethics committee (REC Ref: 19/SC/0520). Planned outputs: OX-CHRONIC will provide detailed data on the evolving cognitive profiles of stroke survivors over several years post-stroke. Estimates of long-term prevalence as well as the effect of changes in cognitive profiles on mood, fatigue and quality of life will be examined. This study is funded by a Priority Programme Grant from the Stroke Association (SA PPA 18/100032).

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Metadata

Authors
Demeyere, N., Williams, O. A., Milosevich, E., Chiu, E. G., Drozdowska, B. A., Dillon, A., Dawes, H., Thomas, S., Kuppuswamy, A., Pendlebury, S. T., & J Quinn, T.
Affiliations
  • University of Oxford (GB)
  • University of Glasgow (GB)
  • Oxford Brookes University (GB)
  • University of Nottingham (GB)
  • UCL Queen Square Institute of Neurology (GB)
  • John Radcliffe Hospital (GB)
  • Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK 2
Corresponding author
Demeyere, Nele
ORCID
Venue
European Stroke Journal
Publisher
Oxford University Press (OUP)
Published
2021-12-01
Volume
6
Issue
4
Pages
428-437
ISSN
  • 2396-9873 (ISSN-L)
  • 2396-9881
DOI
10.1177/23969873211046120
PMC
PMC8948513
OpenAlex
W3211632948
Cited by
13
References
5
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 3
FWCI
1.44
Type
journal article
Language
en
Open access
Licence
Locations
  • European Stroke Journal (publishedVersion, cc-by)
  • medRxiv (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
Funders
Stroke Association UK (SA PPA 18/100032)
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Keywords
stroke, long-term cognitive impairment, cognitive trajectories, mood, fatigue, quality of life, activities of daily living, sleep, physical activity, stroke survivors, neuropsychological assessment

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