Cited by 65Psoriasis: Treatment and PathogenesisArtificial Intelligence in Healthcare and EducationArtificial Intelligence in Healthcare

Machine learning applications in the evaluation and management of psoriasis: a systematic review

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Yu, Kimberley, Syed, Maha N., Bernardis, Elena, Gelfand, Joel M.·2020·Journal of Psoriasis and Psoriatic Arthritis

Abstract

Background: Machine learning (ML), a subset of artificial intelligence (AI) that aims to teach machines to automatically learn tasks by inferring patterns from data, holds significant promise to aid psoriasis care. Applications include evaluation of skin images for screening and diagnosis as well as clinical management including treatment and complication prediction. Objective: To summarize literature on ML applications to psoriasis evaluation and management and to discuss challenges and opportunities for future advances. Methods: We searched MEDLINE, Google Scholar, ACM Digital Library, and IEEE Xplore for peer-reviewed publications published in English through December 1, 2019. Our search queries identified publications with any of the 10 computing-related keywords and “psoriasis” in the title and/or abstract. Results: Thirty-three studies were identified. Articles were organized by topic and synthesized as evaluation- or management-focused articles covering 5 content categories: (A) Evaluation using skin images: (1) identification and differential diagnosis of psoriasis lesions, (2) lesion segmentation, and (3) lesion severity and area scoring; (B) clinical management: (1) prediction of complications and (2) treatment. Conclusion: Machine learning has significant potential to aid psoriasis evaluation and management. Current topics popular in ML research on psoriasis are the evaluation of medical images, prediction of complications, and treatment discovery. For patients to derive the greatest benefit from ML advancements, it is helpful for dermatologists to have an understanding of ML and how it can effectively aid their assessments and decision-making.

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  • A meta-analysis evaluating the performance of image-based AI models for skin disease severity assessment has not been reported.

    “Notably, a meta-analysis evaluating the performance of image-based AI models for skin disease severity assessment has not been reported.15,16”

    From Assessing the performance of artificial intelligence models in evaluating inflammatory skin disease severity: a systematic review and meta-analysis (2025) · cites this paper as [15]

    The Results (page unavailable) say this review qualitatively synthesized 33 studies, including 12 on image-based lesion severity and area scoring; the Methods likewise describe a qualitative synthesis. That supports the narrower point that this review did not perform a performance meta-analysis, but the paper does not establish the broader claim that no such meta-analysis had been reported elsewhere. (LLM, conf=0.78)

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  1. [1]Esteva A, Kuprel B, Novoa RA, Dermatologist-level classification of skin cancer with deep neural networks. Nature. 2017; 542(7639): 115. 28117445 PMC8382232
  2. [2]Fujisawa Y, Otomo Y, Ogata Y, Deep learning-based, computer-aided classifier developed with a small dataset of clinical images surpasses board-certified dermatologists in skin tumour diagnosis. British J Dermatol. 2019; 180(2): 373– 381. 29953582
  3. [3]Haenssle HA, Fink C, Schneiderbauer R, Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists. Ann Oncol. 2018; 29(8): 1836– 1842. 29846502
  4. [4]Han SS, Kim MS, Lim W, Park GH, Park I, Chang SE. Classification of the clinical images for benign and malignant cutaneous tumors using a deep learning algorithm. J Investigat Dermatol. 2018; 138(7): 1529– 1538. 29428356
  5. [6]Tschandl P, Rosendahl C, Akay BN, Expert-level diagnosis of nonpigmented skin cancer by combined convolutional neural networks. JAMA Dermatol. 2019; 155(1): 58– 65. 30484822 PMC6439580
  6. [8]Brinker TJ, Hekler A, Utikal JS, Skin cancer classification using convolutional neural networks: systematic review. J Med Int Res. 2018; 20(10): e11936. PMC6231861 30333097
  7. [9]Emre Celebi M, Alp Aslandogan Y, Stoecker WV, Iyatomi H, Oka H, Chen X. Unsupervised border detection in dermoscopy images. Skin Res Technol. 2007; 13(4): 454– 462. 17908199 PMC3191533
  8. [10]Maglogiannis I, Doukas CN. Overview of advanced computer vision systems for skin lesions characterization. IEEE Transact Inform Technol Biomed. 2009; 13(5): 721– 733. 19304487
  9. [11]Ferris LK, Harkes JA, Gilbert B, Computer-aided classification of melanocytic lesions using dermoscopic images. J Ame Acad Dermatol. 2015; 73(5): 769– 776. 26386631
  10. [12]Zortea M, Schopf TR, Thon K, Performance of a dermoscopy-based computer vision system for the diagnosis of pigmented skin lesions compared with visual evaluation by experienced dermatologists. Artif Intell Med. 2014; 60(1): 13– 26. 24382424
  11. [13]Okon E, Rachakonda V, Hong HJ, Callison-Burch C, Lipoff JB. Natural language processing of reddit data to evaluate dermatology patient experiences and therapeutics. J Am Acad Dermatol. 2019: S0190–9622(19)32371–0. 31306722
  12. [14]Moll J, Wright V. Psoriatic arthritis. Sem Arthrit Rheumat. 1973; 3(1): 55– 78. 4581554
  13. [16]Dubreuil M, Rho YH, Man A, Diabetes incidence in psoriatic arthritis, psoriasis and rheumatoid arthritis: a UK population-based cohort study. Rheumatology. 2013; 53(2): 346– 352. 24185762 PMC3894671
  14. [17]Gelfand JM, Dommasch ED, Shin DB, The risk of stroke in patients with psoriasis. J Investigat Dermatol. 2009; 129(10): 2411– 2418. PMC2864921 19458634
  15. [18]Kimball AB, Gladman D, Gelfand JM, National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening. J Ame Acad Dermatol. 2008; 58(6): 1031– 1042. PMC3716382 18313171
  16. [19]Rachakonda TD, Schupp CW, Armstrong AW. Psoriasis prevalence among adults in the United States. J Ame Acad Dermatol. 2014; 70(3): 512– 516. 24388724
  17. [21]Aggarwal SLP. Data augmentation in dermatology image recognition using machine learning. Skin Res Technol. 2019; 25(6): 815– 820. 31140653
  18. [22]Kim S, Kim J, Hwang M, Smartphone-based multispectral imaging and machine-learning based analysis for discrimination between seborrheic dermatitis and psoriasis on the scalp. Biomed Optic Exp. 2019; 10(2): 879– 891. PMC6377911 30800521
  19. [23]Zhao S, Xie B, Li Y, Smart identification of psoriasis by images using convolutional neural networks: a case study in China. J Eur Acad Dermatol Venereol. 2020; 34(3): 518– 524. 31541556
  20. [24]Shrivastava VK, Londhe ND, Sonawane RS, Suri JS. Computer-aided diagnosis of psoriasis skin images with HOS, texture and color features: a first comparative study of its kind. Comp Meth Program Biomed. 2016; 126: 98– 109. 26830378
  21. [25]Shrivastava VK, Londhe ND, Sonawane RS, Suri JS. Reliability analysis of psoriasis decision support system in principal component analysis framework. Data Knowledge Engine. 2016; 106: 1– 17.
  22. [26]Shrivastava VK, Londhe ND, Sonawane RS, Suri JS. Reliable and accurate psoriasis disease classification in dermatology images using comprehensive feature space in machine learning paradigm. Exp Syst Appli. 2015; 42(15–16): 6184– 6195.
  23. [27]Mashaly H, Masood N, Mohamed AS. Classification of papulosquamous skin diseases using image analysis. Skin Res Technol. 2012; 18(1): 36– 44. 21338407
  24. [28]Verma AK, Pal S, Kumar S. Classification of skin disease using ensemble data mining techniques. Asian Pacific J Can Prevent. 2019; 20(6): 1887– 1894. PMC7021628 31244314
  25. [29]Dash M, Londhe ND, Ghosh S, Semwal A, Sonawane RS. PsLSNet: automated psoriasis skin lesion segmentation using modified U-net-based fully convolutional network. Biomed Sign Process Control. 2019; 52: 226– 237.
  26. [30]George YM, Aldeen M, Garnavi R. Automatic psoriasis lesion segmentation in two-dimensional skin images using multiscale superpixel clustering. J Med Imag. 2017; 4(4): 044004. PMC5680527 29152533
  27. [31]Lu J, Kazmierczak E, Manton JH, Sinclair R. Automatic segmentation of scaling in 2-d psoriasis skin images. IEEE Transact Med Imag. 2012; 32(4): 719– 730. 23288330
  28. [32]Shrivastava VK, Londhe ND, Sonawane RS, Suri JS. A novel and robust Bayesian approach for segmentation of psoriasis lesions and its risk stratification. Comp Meth Program Biomed. 2017; 150: 9– 22. 28859832
  29. [33]Jarad TS, Dawood AJ. Accurate segmentation of psoriasis diseases images using k-means algorithm based on cielab (l* a* b) color space. J Theoret Appli Inform Technol. 2017; 95(17): 12.
  30. [35]Taur JS, Lee GH, Tao CW, Chen CC, Yang CW. Segmentation of psoriasis vulgaris images using multiresolution-based orthogonal subspace techniques. IEEE Transact Syst Man Cybernet Part B (Cybernetics). 2006; 36(2): 390– 402. 16602598
  31. [36]Taur JS. Neuro-fuzzy approach to the segmentation of psoriasis images. J VLSI Sign Process Syst Sign Image Video Technol. 2003; 35(1): 19– 27.
  32. [37]George Y, Aldeen M, Garnavi R. Psoriasis image representation using patch-based dictionary learning for erythema severity scoring. Comput Med Imaging Graph. 2018; 66: 44– 55. 29524784
  33. [38]Raina A, Hennessy R, Rains M, Objective measurement of erythema in psoriasis using digital color photography with color calibration. Skin Res Technol. 2016; 22(3): 375– 380. 26517973 PMC4851905
  34. [39]George YM, Aldeen M, Garnavi R. Automatic scale severity assessment method in psoriasis skin images using local descriptors. IEEE J Biomed Health Inform. 2020; 24(2): 577– 585. 30990451
  35. [40]Fadzil MHA, Prakasa E, Asirvadam VS, Nugroho H, Affandi AM, Hussein SH. 3D surface roughness measurement for scaliness scoring of psoriasis lesions. Comp Biol Med. 2013; 43(11): 1987– 2000. 24054912
  36. [41]Meienberger N, Anzengruber F, Amruthalingam L, Observer-independent assessment of psoriasis affected area using machine learning. J Euro Acad Dermatol Venereol. 2020; 34(6): 1362– 1368. 31594034
  37. [42]Fink C, Fuchs T, Enk A, Haenssle HA. Design of an algorithm for automated, computer-guided PASI measurements by digital image analysis. J Med Syst. 2018; 42(12): 248. 30390142
  38. [43]Shrivastava VK, Londhe ND, Sonawane RS, Suri JS. Exploring the color feature power for psoriasis risk stratification and classification: a data mining paradigm. Comp Biol Med. 2015; 65: 54– 68. 26298486
  39. [44]Shrivastava VK, Londhe ND, Sonawane RS, Suri JS. First review on psoriasis severity risk stratification: an engineering perspective. Comp Biol Med. 2015; 63: 52– 63. 26005793
  40. [45]Shrivastava VK, Londhe ND, Sonawane RS, Suri JS. A novel approach to multiclass psoriasis disease risk stratification: machine learning paradigm. Biomed Sign Process Control. 2016; 28: 27– 40.
  41. [46]Gomez DD, Butakoff C, Ersbøll B, Carstensen JM. Automatic change detection and quantification of dermatological diseases with an application to psoriasis images. Patt Recogn Lett 2007; 28(9): 1012– 1018.
  42. [47]Savolainen L, Kontinen J, Alatalo E, Röning J, Oikarinen A. Comparison of actual psoriasis surface area and the psoriasis area and severity index by the human eye and machine vision methods in following the treatment of psoriasis. Acta Dermato-Venereol. 1998; 78(6): 466– 467. 9833051
  43. [48]Savolainen L, Kontinen J, Röning J, Oikarinen A. Application of machine vision to assess involved surface in patients with psoriasis. Brit J Dermatol. 1997; 137(3): 395– 400. 9349336
  44. [49]Feldman SR, Krueger GG. Psoriasis assessment tools in clinical trials. Ann Rheum Dis. 2005; 64(Suppl 2): ii65– 68. 15708941 PMC1766877
  45. [50]Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and the risk of diabetes mellitus: a systematic review and meta-analysis. JAMA Dermatol. 2013; 149(1): 84– 91. 23407990
  46. [51]Patrick MT, Stuart PE, Raja K, Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients. Nat Comm. 2018; 9(1): 4178. PMC6177414 30301895
  47. [52]Munger E, Choi H, Dey AK, Application of machine learning to determine top predictors of non-calcified coronary burden in psoriasis: an observational cohort study [published online ahead of print October 31, 2019]. J Am Acad Dermatol. 2019: S0190-9622(19)32983-4. PMC7428853 31678339
  48. [53]Patrick MT, Raja K, Miller K, Drug repurposing prediction for immune-mediated cutaneous diseases using a word-embedding-based machine learning approach. J Investigat Dermatol. 2019; 139(3): 683– 691. PMC6387843 30342048
  49. [54]Zhang R, Cairelli MJ, Fiszman M, Using semantic predications to uncover drug–drug interactions in clinical data. J Biomed Inform. 2014; 49: 134– 147. 24448204 PMC4058371
  50. [55]Tomalin LE, Kim J, da Rosa JC, Early quantification of systemic inflammatory-proteins predicts long-term treatment response to Tofacitinib and Etanercept: Psoriasis response predictions using blood. J Investigat Dermatol. 2019; 140(5): 1026– 1034. 31705874
  51. [56]Abel EA, DiCicco LM, Orenberg EK, Fraki JE, Farber EM. Drugs in exacerbation of psoriasis. J Ame Acad Dermatol. 1986; 15(5): 1007– 1022. 2878015
  52. [57]Katragadda C, Finnane A, Soyer HP, Technique standards for skin lesion imaging: a Delphi consensus statement. JAMA Dermatol. 2017; 153(2): 207– 213. 27892996
  53. [59]Alexis AF, Paul B. Psoriasis in skin of color: epidemiology, genetics, clinical presentation, and treatment nuances. J Clin Aesth Dermatol. 2014; 7(11): 16. PMC4255694 25489378
  54. [60]Fadzil MA, Ihtatho D, Affandi AM, Hussein S. Area assessment of psoriasis lesions for PASI scoring. J Med Engine Technol. 2009; 33(6): 426– 436. 19557605
  55. [61]Vezhnevets V, Sazonov V, Andreeva A. A survey on pixel-based skin color detection techniques. In: Proc. Graphicon, Moscow, Russia; 2003 9 (Vol. 3, pp. 85– 92).
  56. [62]Yang J, Lu W, Waibel A. Skin-color modeling and adaptation. In: Asian Conference on Computer Vision; 1998 1 8 (pp. 687– 694). Springer, Berlin, Heidelberg.
  57. [63]Gläser R, Röwert J. Hyperpigmentation due to topical calcipotriol and photochemotherapy in two psoriatic patients. Brit J Dermatol. 1998; 139(1): 148– 151. 9764169
  58. [64]Komorowski M, Celi LA, Badawi O, Gordon AC, Aldo F. The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care. Nat Med. 2018; 24(11): 1716. 30349085

Cited by

Sorted by citations

Authors
Yu, K., Syed, M. N., Bernardis, E., & Gelfand, J. M.
Affiliations
University of Pennsylvania (US)
Corresponding author
Yu, Kimberley
Venue
Journal of Psoriasis and Psoriatic Arthritis
Published
2020-08-31
Volume
5
Issue
4
Pages
147-159
ISSN
  • 2475-5303 (ISSN-L)
  • 2475-5311
OpenAlex
W3082120157
Cited by
65
References
6
Citations by year
2026: 7 · 2025: 16 · 2024: 16 · 2023: 14 · 2022: 7 · 2021: 5
FWCI
0.63
Type
journal article
Language
en
Open access
Locations
  • Journal of Psoriasis and Psoriatic Arthritis (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
University of Pennsylvania (Center for Clinical Epidemiology and Biostatistics)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
Keywords
psoriasis, machine learning, artificial intelligence, skin lesion segmentation, psoriasis diagnosis, differential diagnosis, treatment prediction, complication prediction, dermatology

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