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Cited by 143Liver Disease Diagnosis and TreatmentLiver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis

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Ucar, Fatma, Sezer, Sevilay, Erdogan, Serpil, Akyol, Sumeyya, Armutcu, Ferah, Akyol, Omer·2013·Redox Report
DOI 10.1179/1351000213y.0000000050PMC PMC6837573
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Abstract

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the most common underlying causes of chronic liver injury. They are associated with a wide spectrum of hepatic disorders including basic steatosis, steatohepatitis, and cirrhosis. The molecular and cellular mechanisms underlying hepatic injury in NAFLD and NASH are still unknown. This review describes the roles of oxidative stress and inflammatory responses in the pathogenesis of NAFLD and its progression to NASH.

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References 59 · Cited by 143

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Metadata

Authors
Ucar, F., Sezer, S., Erdogan, S., Akyol, S., Armutcu, F., & Akyol, O.
Affiliations
Ankara Numune Eğitim ve Araştırma Hastanesi (TR)
ORCID
Sezer, Sevilay
Venue
Redox Report
Publisher
Informa UK Limited
Published
2013-07
Volume
18
Issue
4
Pages
127-133
ISSN
  • 1351-0002 (ISSN-L)
  • 1743-2928
DOI
10.1179/1351000213y.0000000050
PMC
PMC6837573
OpenAlex
W1976902613
Cited by
143
References
59
Citations by year
2026: 9 · 2025: 8 · 2024: 10 · 2023: 13 · 2022: 14 · 2021: 21 · 2020: 17 · 2019: 21 · 2018: 9 · 2017: 1 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 1
FWCI
0.75
Type
journal article
Language
en
Open access
Locations
  • Redox Report (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Malatya Turgut Özal University Institutional Repository (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
oxidative stress, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, liver inflammation, liver injury, pathogenesis, liver cirrhosis, steatosis
MeSH terms
Animals, Fatty Liver, Humans, Iron, Liver, Liver Cirrhosis, Mitochondria, Liver, Lipid Peroxidation, Biomarkers, Reactive Oxygen Species, Oxidative Stress, Disease Progression, Non-alcoholic Fatty Liver Disease

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CoChat. (2026). Citation check: The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis. https://app.cochat.ai/papers/10.1179/1351000213y.0000000050
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Ucar, F., Sezer, S., Erdogan, S., Akyol, S., Armutcu, F., & Akyol, O. (2013). The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis. Redox Report. https://doi.org/10.1179/1351000213y.0000000050