The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer’s disease
Open accessAbstract
NAD(P)H:quinone oxidoreductase 1 (NQO1), a redox-regulated flavoenzyme, plays a central role in monitoring cellular redox state. NQO1 acts to protect against oxidative stress induced by a variety of metabolic situations, including metabolism of quinones and other xenobiotics, by: (i) functioning as a two electron donor to provide a shunt that competes with the formation of reactive oxygen species; (ii) maintaining reduced coenzyme Q; and (iii) regulating the stress activated kinase pathway. In Alzheimer's disease, while there is abundant evidence for the involvement of oxidative stress, the cause or the consequences are largely unresolved. We suspected that increased NQO1 could signal a major shift in redox balance in Alzheimer's disease and, in this study, found that NQO1 is localized not only to neurofibrillary tangles but also the cytoplasm of hippocampal neurons. By marked contrast, there is very little NQO1 in the same neuronal populations in young and age-matched controls. This novel association of NQO1 further buttresses the nexus of oxidative stress, via free radicals, with selective neuronal vulnerability and also supports a fundamental abnormality in redox balance in Alzheimer's disease.
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“Ho-1 and NQO1 are upregulated in AD patients [22,23]”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [23]
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Luo, J., Li, S., Qin, X. Y., Peng, Q., Liu, Y., Yang, S., Qin, X., Xiong, Y., & Zeng, Z. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1004573 · Cited by 11
Metadata
- Authors
- Raina, A. K., Templeton, D. J., deak, J. C., Perry, G., & Smith, M. A.
- Affiliations
- Case Western Reserve University (US)
- ORCID
- Venue
- Redox Report
- Publisher
- Informa UK Limited
- Published
- 1999-02
- Volume
- 4
- Issue
- 1-2
- Pages
- 23-27
- ISSN
- 1351-0002 (ISSN-L)
- 1743-2928
- OpenAlex
- W1972676451
- Cited by
- 120
- References
- 38
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Redox Report (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association
- American Health Assistance Foundation
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- NQO1, NAD(P)H:quinone oxidoreductase 1, Alzheimer's disease, oxidative stress, redox homeostasis, flavoenzyme, neurofibrillary tangles, hippocampal neurons, reactive oxygen species, neuronal vulnerability
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Humans, Quinone Reductases, Oxidative Stress
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