Altered amino acid excretion in children with autism
Abstract
Autism is a complex and life-long behavioural disorder of unknown aetiology. Recent reports have indicated the involvement of digestive tract dysfunction and possible complications from inadequate nutrition. In this study, 34 autistic children (12 untreated and 22 receiving therapeutic treatments related to digestive function and nutritional uptake) and 29 control subjects (all 5-15 years of age) were investigated to determine whether there were any anomalies in the urinary excretion of amino acids, glucose, sucrose, arabinose and tartaric acid using GC/FID and GC/MS analysis techniques. Significantly lower relative urinary levels of essential amino acids were revealed for both the untreated (mean +/- SEM, 32.53 +/- 3.09%) and treated (31.98 +/- 2.87%) autistic children compared with the controls (37.87 +/- 1.50%). There were no significant differences in measured excretions of sugars or tartaric acid. It was concluded that the untreated autistic children had evidence of altered metabolic homeostasis.
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Amino-acid transport and degradation differ between TD and ASD individuals.
“amino-acid transport and degradation differ between TD and ASD individuals (Aldred et al., 2003; Evans et al., 2008)”
From Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019) · cites this paper as Evans et al., 2008
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Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182 · see citing works
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Self-citation
- Authors
- Evans, C., Dunstan, H. R., Rothkirch, T., Roberts, T. K., Reichelt, K. L., Cosford, R., Deed, G., Ellis, L. B., & Sparkes, D. L.
- Affiliations
- University of Newcastle Australia (AU)
- Venue
- Nutritional Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2008-02
- Volume
- 11
- Issue
- 1
- Pages
- 9-17
- ISSN
- 1028-415X (ISSN-L)
- 1476-8305
- OpenAlex
- W2061570847
- Cited by
- 71
- References
- 18
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutritional Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- autism spectrum disorder, amino acid excretion, urinary amino acids, essential amino acids, metabolic homeostasis, gastrointestinal dysfunction, nutritional status, children, glucose, sucrose, arabinose, tartaric acid
- MeSH terms
- Adolescent, Amino Acids, Amino Acids, Essential, Arabinose, Autistic Disorder, Child, Child, Preschool, Female, Glycosuria, Homeostasis, Humans, Male, Sex Characteristics, Sucrose, Tartrates
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