Density and Distribution of Hippocampal Neurotransmitter Receptors in Autism: An Autoradiographic Study
Abstract
Neuropathological studies in autistic brains have shown small neuronal size and increased cell packing density in a variety of limbic system structures including the hippocampus, a change consistent with curtailment of normal development. Based on these observations in the hippocampus, a series of quantitative receptor autoradiographic studies were undertaken to determine the density and distribution of eight types of neurotransmitter receptors from four neurotransmitter systems (GABAergic, serotoninergic [5-HT], cholinergic, and glutamatergic). Data from these single concentration ligand binding studies indicate that the GABAergic receptor system (3[H]-flunitrazepam labeled benzodiazepine binding sites and 3[H]-muscimol labeled GABA(A) receptors) is significantly reduced in high binding regions, marking for the first time an abnormality in the GABA system in autism. In contrast, the density and distribution of the other six receptors studied (3[H]-80H-DPAT labeled 5-HT1A receptors, 3[H]-ketanserin labeled 5-HT2 receptors, 3[H]-pirenzepine labled M1 receptors, 3[H]-hemicholinium labeled high affinity choline uptake sites, 3[H]-MK801 labeled NMDA receptors, and 3[H]-kainate labeled kainate receptors) in the hippocampus did not demonstrate any statistically significant differences in binding.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reduced GABAA and GABAB receptor density and system activity have been reported in the brains of autistic patients.
“Additionally, other studies have reported reduced GABAA [129, 130] and GABAB [124, 130] receptor density and system activity in the brains of autistic patients.”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [129]
Cites
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855 · see citing works
Iversen, G. R., & Norpoth, H. (1987) · Springer eBooks · doi:10.1007/978-3-642-04898-2_117 · Cited by 1,515 · see citing works
Pirenzepine distinguishes between different subclasses of muscarinic receptors
Hammer, R., Berrie, C. P., Birdsall, N. J. M., Burgen, A. S. V., & Hulme, E. C. (1980) · Nature · doi:10.1038/283090a0 · Cited by 1,273 · see citing works
GABA: an excitatory transmitter in early postnatal life
Cherubini, E., Gaïarsa, J., & Ben‐Ari, Y. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90003-d · Cited by 1,108 · see citing works
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083 · see citing works
Histoanatomic observations of the brain in early infantile autism
Bauman, M., & Kemper, T. L. (1985) · Neurology · doi:10.1212/wnl.35.6.866 · Cited by 964 · see citing works
Self-citationMolecular biology of GABA A receptors
Olsen, R. W., & Tobin, A. J. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.5.2155149 · Cited by 960 · see citing works
GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'
Ben‐Ari, Y. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01147-8 · Cited by 795 · see citing works
(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.7.862 · Cited by 590 · see citing works
Neuropathology of Infantile Autism
Kemper, T. L., & Bauman, M. (1998) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199807000-00001 · Cited by 585 · see citing works
Self-citationFrom ion currents to genomic analysis: Recent advances in GABAA receptor research
Rabow, L. E., Russek, S. J., & Farb, D. H. (1995) · Synapse · doi:10.1002/syn.890210302 · Cited by 469 · see citing works
Hippocampus in autism: a Golgi analysis
Raymond, G. V., Bauman, M. L., & Kemper, T. L. (1995) · Acta Neuropathologica · doi:10.1007/s004010050401 · Cited by 387 · see citing works
Self-citationAutism and maternally derived aberrations of chromosome 15q
Schroer, R. J., Phelan, M. C., Michaelis, R. C., Crawford, E. C., Skinner, S. A., Cuccaro, M. L., Simensen, R. J., Bishop, J., Skinner, C. D., Fender, D., et al. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980401)76:4 · Cited by 375 · see citing works
Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers
Cook, E. H., Courchesne, R. Y., Cox, N. J., Lord, C., Gonen, D., Guter, S. J., Lincoln, A., Nix, K., Haas, R., Leventhal, B. L., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301832 · Cited by 369 · see citing works
High affinity GABA receptors — Autoradiographic localization
PALACIOS, J. M., Wamsley, J. K., & Kuhar, M. J. (1981) · Brain Research · doi:10.1016/0006-8993(81)91034-9 · Cited by 309 · see citing works
Autoradiographic localisation of benzodiazepine receptors in the brains of humans and animals
Young, W. S., & Kuhar, M. J. (1979) · Nature · doi:10.1038/280393a0 · Cited by 257 · see citing works
Benzodiazepine binding in human brain: Characterization using [3H] flunitrazepam
Speth, R. C., Wastek, G. J., Johnson, P. C., & Yamamura, H. I. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90610-0 · Cited by 213 · see citing works
TiPS receptor and ion channel nomenclature supplement 1994
Watson, S. P., & Girdlestone, D. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90180-5 · Cited by 200 · see citing works
GABAergic cells and signals in CNS development.
Barker, J. L., Behar, T. N., Li, Y., Liu, Q., Ma, W., Maric, D., Maric, I., Schaffner, A. E., Serafini, R., Sv, S., et al. (1998) · PubMed · Cited by 166 · see citing works
Quantitative film autoradiography of opiate agonist and antagonist binding in rat brain.
Geary, W. A., & Wooten, G. F. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33577-9 · Cited by 131 · see citing works
Quantitative autoradiography of neurotransmitter receptors in Huntington disease
Penney, J. B., & Young, A. B. (1982) · Neurology · doi:10.1212/wnl.32.12.1391 · Cited by 115 · see citing works
Dennis, T., Dubois, A., Bénavidès, J., & Scatton, B. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20029-5 · Cited by 110 · see citing works
Sandberg, K. L., & Coyle, J. T. (1985) · Brain Research · doi:10.1016/0006-8993(85)90451-2 · Cited by 99 · see citing works
Paradoxical reactions elicited by diazepam in children with classic autism.
Marrosu, F., Marrosu, M. G., Rachel, M. G., & Biggio, G. (1987) · PubMed · Cited by 96 · see citing works
Differential stimulation of [3H]MK-801 binding to subpopulations of NMDA receptors
Monaghan, D. T. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90183-t · Cited by 78 · see citing works
Lidow, M. S., Goldman‐Rakic, P. S., Gallager, D. W., & Rakic, P. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902800104 · Cited by 77 · see citing works
Monaghan, D. T., Nguyen, L. V., & Cotman, C. W. (1986) · Neurochemical Research · doi:10.1007/bf00965595 · Cited by 30 · see citing works
Faull, R. L. M., Villiger, J. W., & Holford, N. H. G. (1987) · Brain Research · doi:10.1016/0006-8993(87)91091-2 · Cited by 25 · see citing works
Daval, J., Werck, M., Nehlig, A., & de Vasconcelos, A. P. (1991) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(91)90052-n · Cited by 23 · see citing works
Faull, R. L. M., & Villiger, J. W. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90098-x · Cited by 22 · see citing works
1998 Receptor and ion channel nomenclature.
(1998) · PubMed · Cited by 22 · see citing works
The autoradiographic perspective of central benzodiazepine receptors: A short review
Fernández‐López, A., Chinchetru, M. A., & Fernández, P. C. (1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)89717-0 · Cited by 17 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454 · see citing works
Robertson, C. E., & Baron-Cohen, S. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.112 · Cited by 1,157 · see citing works
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
Dawson, G. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000370 · Cited by 1,138 · see citing works
Neuroanatomic observations of the brain in autism: a review and future directions
Bauman, M. L., & Kemper, T. L. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.09.006 · Cited by 919 · see citing works
Self-citationAdvancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827 · see citing works
Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723 · see citing works
Self-citationChauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656 · see citing works
The genetics of autistic disorders and its clinical relevance: a review of the literature
Freitag, C. M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001896 · Cited by 638 · see citing works
Neuropathological findings in autism
Palmen, S. J. M. C. (2004) · Brain · doi:10.1093/brain/awh287 · Cited by 527 · see citing works
GABAergic interneuron origin of schizophrenia pathophysiology
Nakazawa, K., Zsiros, V., Jiang, Z., Nakao, K., Kolata, S., Zhang, S., & Belforte, J. E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.022 · Cited by 498 · see citing works
Pardo, C. A., & Eberhart, C. G. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00102.x · Cited by 514 · see citing works
Drug interactions at GABAA receptors
Korpi, E. R., Gründer, G., & Lüddens, H. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00013-8 · Cited by 474 · see citing works
GABAA Receptor Downregulation in Brains of Subjects with Autism
Fatemi, S. H., Reutiman, T. J., Folsom, T. D., & Thuras, P. D. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0646-7 · Cited by 439 · see citing works
GABA system dysfunction in autism and related disorders: From synapse to symptoms
Coghlan, S., Horder, J., Inkster, B., Méndez, M. A., Murphy, D., & Nutt, D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.005 · Cited by 437 · see citing works
Belmonte, M. K., Cook, E. H., Anderson, G. M., Rubenstein, J. L. R., Greenough, W. T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L. M., Powell, S. B., Levitt, P. R., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001499 · Cited by 442 · see citing works
The developmental neurobiology of autism spectrum disorder
DiCicco-Bloom, E., Lord, C., Zwaigenbaum, L., Courchesne, E., Dager, S. R., Schmitz, C., Schultz, R. T., Crawley, J., & Young, L. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1712-06.2006 · Cited by 434 · see citing works
Samaco, R. C., Hogart, A., & LaSalle, J. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi045 · Cited by 420 · see citing works
Neurochemistry in the pathophysiology of autism.
McDougle, C. J., Erickson, C. A., Stigler, K. A., & Posey, D. J. (2005) · PubMed · Cited by 408 · see citing works
Ma, D. Q., Whitehead, P. L., Menold, M. M., Martin, E. R., Ashley‐Koch, A. E., Mei, H., Ritchie, M. D., DeLong, G. R., Abramson, R. K., Wright, H. H., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/433195 · Cited by 355 · see citing works
Epigenetics of autism spectrum disorders
Schanen, N. C. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl213 · Cited by 341 · see citing works
Altered neural connectivity in excitatory and inhibitory cortical circuits in autism
Zikopoulos, B., & Barbas, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00609 · Cited by 313 · see citing works
AUTISM: A Window Onto the Development of the Social and the Analytic Brain
Baron‐Cohen, S., & Belmonte, M. K. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144137 · Cited by 342 · see citing works
Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications
Yip, J., Soghomonian, J.-J., & Blatt, G. J. (2007) · Acta Neuropathologica · doi:10.1007/s00401-006-0176-3 · Cited by 303 · see citing works
Self-citationGABAergic Signaling as Therapeutic Target for Autism Spectrum Disorders
Cellot, G., & Cherubini, E. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00070 · Cited by 301 · see citing works
The critical period of valproate exposure to induce autistic symptoms in Sprague–Dawley rats
Kim, K. C., Kim, P., Go, H. S., Choi, C. S., Yang, S., Cheong, J. H., Shin, C. Y., & Ko, K. H. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.12.018 · Cited by 285 · see citing works
Neurobiological bases of autism–epilepsy comorbidity: a focus on excitation/inhibition imbalance
Bozzi, Y., Provenzano, G., & Casarosa, S. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13595 · Cited by 250 · see citing works
Neurons in the fusiform gyrus are fewer and smaller in autism
van Kooten, I. A. J., Palmen, S. J. M. C., von Cappeln, P., Steinbusch, H. W. M., Korr, H., Heinsen, H., Hof, P. R., van Engeland, H., & Schmitz, C. (2008) · Brain · doi:10.1093/brain/awn033 · Cited by 263 · see citing works
Exploring the Validity of Valproic Acid Animal Model of Autism
Mabunga, D. F. N., Gonzales, E. L., Kim, J., Kim, K. C., & Shin, C. Y. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.285 · Cited by 247 · see citing works
Laurence, J. A., & Fatemi, S. H. (2005) · The Cerebellum · doi:10.1080/14734220500208846 · Cited by 246 · see citing works
Autism spectrum disorders and neuropathology of the cerebellum
Hampson, D. R., & Blatt, G. J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00420 · Cited by 247 · see citing works
Self-citationDeLorey, T. M., Sahbaie, P., Hashemi, E., Homanics, G. E., & Clark, J. D. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.09.009 · Cited by 224 · see citing works
Molecular genetics of autism spectrum disorder
Veenstra-VanderWeele, J. M., & Cook, E. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001505 · Cited by 220 · see citing works
Decreased GABA <sub>B</sub> receptors in the cingulate cortex and fusiform gyrus in Autism
Oblak, A. L., Gibbs, T. T., & Blatt, G. J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06858.x · Cited by 203 · see citing works
Self-citationKim, K. C., Kim, P., Go, H. S., Choi, C. S., Park, J. H., Kim, H. J., Jeon, S. J., dela Pena, I. C., Han, S., Cheong, J. H., et al. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12147 · Cited by 212 · see citing works
Bauman, M. L. (2006) · Johns Hopkins University Press eBooks · doi:10.1353/book.3225 · Cited by 215 · see citing works
Self-citationDeidda, G., Bozarth, I. F., & Cancedda, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00119 · Cited by 192 · see citing works
Rojas, D. C. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1216-0 · Cited by 191 · see citing works
Decreased left perisylvian GABA concentration in children with autism and unaffected siblings
Rojas, D. C., Singel, D., Steinmetz, S. E., Hepburn, S., & Brown, M. S. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.01.045 · Cited by 185 · see citing works
Cortical interneurons in autism
Contractor, A., Ethell, I. M., & Portera‐Cailliau, C. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00967-6 · Cited by 180 · see citing works
Oblak, A. L., Gibbs, T. T., & Blatt, G. J. (2009) · Autism Research · doi:10.1002/aur.88 · Cited by 187 · see citing works
Self-citationStephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180 · see citing works
Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Rooney, R. J., Patel, D. H., & Thuras, P. D. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0924-z · Cited by 182 · see citing works
Santangelo, S. L., & Tsatsanis, K. (2005) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200505020-00001 · Cited by 183 · see citing works
Alterations in GABAergic Biomarkers in the Autism Brain: Research Findings and Clinical Implications
Blatt, G. J., & Fatemi, S. H. (2011) · The Anatomical Record · doi:10.1002/ar.21252 · Cited by 180 · see citing works
Self-citationOblak, A. L., Gibbs, T. T., & Blatt, G. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.021 · Cited by 175 · see citing works
Self-citationGenetics of glutamate and its receptors in autism spectrum disorder
Nisar, S., Bhat, A. A., Masoodi, T., Hashem, S., Akhtar, S., Ali, T. A., Amjad, S., Chawla, S., Bagga, P., Frenneaux, M. P., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01506-w · Cited by 173 · see citing works
Tipping the balance of autism risk: potential mechanisms linking pesticides and autism
Shelton, J. F., Hertz-Picciotto, I., & Pessah, I. N. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104553 · Cited by 164 · see citing works
GABAergic System Dysfunction in Autism Spectrum Disorders
Zhao, H., Mao, X., Zhu, C., Zou, X., Peng, F., Yang, W., Li, B., Li, G., Ge, T., & Cui, R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.781327 · Cited by 172 · see citing works
Parvalbumin-, calbindin-, and calretinin-immunoreactive hippocampal interneuron density in autism
Lawrence, Y. A., Kemper, T. L., Bauman, M. L., & Blatt, G. J. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2009.01234.x · Cited by 165 · see citing works
Self-citationInvestigation of autism and GABA receptor subunit genes in multiple ethnic groups
Collins, A. L., Ma, D., Whitehead, P. L., Martin, E. R., Wright, H. H., Abramson, R. K., Hussman, J. P., Haines, J. L., Cuccaro, M. L., Gilbert, J. R., et al. (2006) · Neurogenetics · doi:10.1007/s10048-006-0045-1 · Cited by 163 · see citing works
Rojas, D. C., Maharajh, K., Teale, P. D., & Rogers, S. J. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-66 · Cited by 158 · see citing works
McCauley, J. L., Olson, L. M., Delahanty, R., Amin, T., Nurmi, E. L., Organ, E. L., Jacobs, M. M., Folstein, S. E., Haines, J. L., & Sutcliffe, J. S. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30038 · Cited by 155 · see citing works
Slower Rate of Binocular Rivalry in Autism
Robertson, C. E., Kravitz, D., Freyberg, J., Baron-Cohen, S., & Baker, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0448-13.2013 · Cited by 153 · see citing works
Whitney, E. R., Kemper, T. L., Rosene, D. L., Bauman, M. L., & Blatt, G. J. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22056 · Cited by 142 · see citing works
Self-citationMolecular analysis of nicotinic receptor expression in autism
Martin-Ruiz, C. M., Lee, M., Perry, R. H., Baumann, M., Court, J. A., & Perry, E. K. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.01.003 · Cited by 141 · see citing works
Gould, G. G., Hensler, J. G., Burke, T. F., Benno, R. H., Onaivi, E. S., & Daws, L. C. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07104.x · Cited by 138 · see citing works
Fatemi, S. H., Folsom, T. D., Kneeland, R. E., & Liesch, S. B. (2011) · The Anatomical Record · doi:10.1002/ar.21299 · Cited by 137 · see citing works
Kim, K. C., Lee, D.-K., Go, H. S., Kim, P., Choi, C. S., Kim, J., Jeon, S. J., Song, M., & Shin, C. Y. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8535-2 · Cited by 135 · see citing works
Brown, M. S., Singel, D., Hepburn, S., & Rojas, D. C. (2012) · Autism Research · doi:10.1002/aur.1260 · Cited by 133 · see citing works
Dickinson, A. H., Jones, M., & Milne, E. (2016) · Brain Research · doi:10.1016/j.brainres.2016.07.011 · Cited by 128 · see citing works
Méndez, M. A., Horder, J., Myers, J., Coghlan, S., Stokes, P. R. A., Erritzøe, D., Howes, O. D., Lingford-Hughes, A. R., Murphy, D., & Nutt, D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.008 · Cited by 127 · see citing works
Functional regulation of GABAA receptors in nervous system pathologies
Hines, R. M., Davies, P. A., Moss, S. J., & Maguire, J. L. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.007 · Cited by 125 · see citing works
Saravi, S. S. S., & Dehpour, A. R. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.11.006 · Cited by 125 · see citing works
Sagiv, S. K., Harris, M. H., Gunier, R. B., Kogut, K. R., Harley, K. G., Deardorff, J., Bradman, A., Holland, N., & Eskenazi, B. (2018) · Environmental Health Perspectives · doi:10.1289/ehp2580 · Cited by 125 · see citing works
Rojas, D. C., Teale, P. D., Maharajh, K., Kronberg, E., Youngpeter, K., Wilson, L. B., Wallace, A., & Hepburn, S. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-11 · Cited by 118 · see citing works
Glutamate mediated signaling in the pathophysiology of autism spectrum disorders
Choudhury, P. R., Lahiri, S., & Rajamma, U. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.06.023 · Cited by 121 · see citing works
Global motion perception deficits in autism are reflected as early as primary visual cortex
Robertson, C. E., Thomas, C., Kravitz, D. J., Wallace, G. L., Baron-Cohen, S., Martin, A., & Baker, C. I. (2014) · Brain · doi:10.1093/brain/awu189 · Cited by 122 · see citing works
Levels of Bcl-2 and P53 Are Altered in Superior Frontal and Cerebellar Cortices of Autistic Subjects
Araghi‐Niknam, M., & Fatemi, S. H. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000005322.27203.73 · Cited by 123 · see citing works
Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism
Delahanty, R., Kang, J., Brune, C. W., Kistner, E. O., Courchesne, E., Cox, N. J., Cook, E. H., Macdonald, R. L., & Sutcliffe, J. S. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.118 · Cited by 122 · see citing works
The Neuropathology of Autism: A Review
Pickett, J., & London, E. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000186921.42592.6c · Cited by 122 · see citing works
Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism
Banerjee, A., García‐Oscos, F., Roychowdhury, S., Galindo, L. C., Hall, S., Kilgard, M. P., & Atzori, M. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001216 · Cited by 120 · see citing works
Cattane, N., Richetto, J., & Cattaneo, A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.001 · Cited by 118 · see citing works
Neurobiological Correlates of Autism: A Review of Recent Research
Penn, H. E. (2006) · Child Neuropsychology · doi:10.1080/09297040500253546 · Cited by 117 · see citing works
The Neurobiological Context of Autism
Keller, F., & Persico, A. M. (2003) · Molecular Neurobiology · doi:10.1385/mn:28:1:1 · Cited by 114 · see citing works
Yip, J., Soghomonian, J., & Blatt, G. J. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21520 · Cited by 112 · see citing works
Self-citationAutism and 15q11‐q13 disorders: Behavioral, genetic, and pathophysiological issues
Dykens, E. M., Sutcliffe, J. S., & Levitt, P. R. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20042 · Cited by 108 · see citing works
GABAergic interneurons in epilepsy: More than a simple change in inhibition
Marafiga, J. R., Pasquetti, M. V., & Calcagnotto, M. E. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.106935 · Cited by 107 · see citing works
Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission
Montanari, M., Martella, G., Bonsi, P., & Meringolo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073861 · Cited by 105 · see citing works
Evidence of parallels between mercury intoxication and the brain pathology in autism
Kern, J. K., Geier, D. A., AUDHYA, T. K., King, P. G., Sykes, L. K., & Geier, M. R. (2012) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2012-1887 · Cited by 100 · see citing works
Zürcher, N. R., Bhanot, A., McDougle, C. J., & Hooker, J. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.002 · Cited by 99 · see citing works
Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder
Frye, R. E., Casanova, M. F., Fatemi, S. H., Folsom, T. D., Reutiman, T. J., Brown, G. L., Edelson, S. M., Slattery, J. C., & Adams, J. B. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00192 · Cited by 94 · see citing works
Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Rustan, Ø. G., Rooney, R. J., & THURAS, P. D. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2078-x · Cited by 94 · see citing works
A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons
Lin, Y., Frei, J. A., Kilander, M. B. C., Shen, W., & Blatt, G. J. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00263 · Cited by 91 · see citing works
Self-citationAltered Balance of Proteolytic Isoforms of Pro-Brain-Derived Neurotrophic Factor in Autism
Garcia, K. L. P., Yu, G., Nicolini, C., Michalski, B., Garzon, D. J., Chiu, V. S., Tongiorgi, E., Szatmári, P., & Fahnestock, M. L. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31824b27e4 · Cited by 93 · see citing works
Kenet, T., Froemke, R. C., Schreiner, C. E., Pessah, I. N., & Merzenich, M. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701944104 · Cited by 97 · see citing works
Basal ganglia and autism – a translational perspective
Subramanian, K., Brandenburg, C., Orsati, F. T., Soghomonian, J., Hussman, J. P., & Blatt, G. J. (2017) · Autism Research · doi:10.1002/aur.1837 · Cited by 89 · see citing works
Self-citationBerbel, P. J., Navarro, D., & Román, G. C. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00146 · Cited by 85 · see citing works
Fatemi, S. H., & Folsom, T. D. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.10.010 · Cited by 85 · see citing works
Minshawi, N. F., Hurwitz, S., Morriss, D. H., & McDougle, C. J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2307-3 · Cited by 85 · see citing works
Neural Hyperexcitability in Autism Spectrum Disorders
Takarae, Y., & Sweeney, J. (2017) · Brain Sciences · doi:10.3390/brainsci7100129 · Cited by 82 · see citing works
Rossignol, D. A., & Frye, R. E. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00087 · Cited by 79 · see citing works
Beversdorf, D. Q., & MISSOURI AUTISM SUMMIT CONSORTIUM* (2016) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000351 · Cited by 74 · see citing works
Minshew, N. J., Sweeney, J. A., Bauman, M. L., & Webb, S. J. (2005) · doi:10.1002/9780470939345.ch18 · Cited by 78 · see citing works
Self-citationAshley‐Koch, A. E., Mei, H., Jaworski, J. M., Ma, D. Q., Ritchie, M. D., Menold, M. M., DeLong, G. R., Abramson, R. K., Wright, H. H., Hussman, J. P., et al. (2006) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2006.00253.x · Cited by 75 · see citing works
NMDARs in neurological diseases: a potential therapeutic target
González, J., Jurado-Coronel, J. C., Ávila, M. F., Sabogal, A., Capani, F., & Barreto, G. E. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2014.940941 · Cited by 74 · see citing works
Zhubi, A., Chen, Y., Guidotti, A., & Grayson, D. R. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.02.003 · Cited by 74 · see citing works
Optogenetic Insights into Social Behavior Function
Yizhar, O. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.029 · Cited by 72 · see citing works
Altered amino acid excretion in children with autism
Evans, C., Dunstan, H. R., Rothkirch, T., Roberts, T. K., Reichelt, K. L., Cosford, R., Deed, G., Ellis, L. B., & Sparkes, D. L. (2008) · Nutritional Neuroscience · doi:10.1179/147683008x301360 · Cited by 71 · see citing works
Fung, L. K., Flores, R. E., Gu, M., Sun, K., James, D. M., Schuck, R. K., Jo, B., Park, J. H., Lee, B. C., Jung, J. H., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0756-y · Cited by 71 · see citing works
Ray, M. A., Graham, A. J., Lee, M. H., Perry, R. H., COURT, J. A., & Perry, E. K. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.017 · Cited by 71 · see citing works
- Authors
- Blatt, G. J., Fitzgerald, C. M., Guptill, J. T., Booker, A. B., Kemper, T. L., & Bauman, M. L.
- Affiliations
- Boston University (US)
- Corresponding author
- Blatt, Gene J.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2001-12
- Volume
- 31
- Issue
- 6
- Pages
- 537-543
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W1488489801
- Cited by
- 322
- References
- 33
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 1 · 2023: 14 · 2022: 16 · 2021: 12 · 2020: 14 · 2019: 7 · 2018: 12 · 2017: 11 · 2016: 17 · 2015: 18 · 2014: 22 · 2013: 15 · 2012: 23
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, hippocampus, neurotransmitter receptors, receptor density, GABAergic system, benzodiazepine binding site, GABAA receptor, serotonin receptors, 5-HT1A receptor, 5-HT2 receptor, M1 muscarinic receptor, NMDA receptor, kainate receptors, limbic system
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Autoradiography, Binding Sites, Cell Count, Flunitrazepam, Hippocampus, Humans, Male, Muscimol, Receptors, Neurotransmitter, Receptors, GABA, GABA Modulators, Culture Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review