The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Iron deficiency: new insights into diagnosis and treatment
Abstract
Iron deficiency and iron deficiency anemia are common conditions worldwide affecting especially children and young women. In developing countries, iron deficiency is caused by poor iron intake and/or parasitic infection, whereas vegetarian dietary choices, poor iron absorption, and chronic blood loss are common causes in high-income countries. Erythropoiesis stimulating agents can result in functional iron deficiency for erythropoiesis even when stores are iron-replete. Diagnosis of iron deficiency is straightforward, except when it occurs in the context of inflammatory disorders. Oral iron salts correct absolute iron deficiency in most patients, because low hepcidin levels facilitate iron absorption. Unfortunately frequent side effects limit oral iron efficacy. Intravenous iron is increasingly utilized, because currently available preparations allow rapid normalization of total body iron even with a single infusion and are effective also in functional iron deficiency and in iron deficiency associated with inflammatory disorders. The evidence is accumulating that these preparations are safe and effective. However, long-term safety issues of high doses of iron need to be further explored.
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In the citing paper
“Although many laboratory indexes may be helpful for the ID differential diagnostic workup, such as the mean corpuscular volume (MCV), the reticulocyte count and reticulocyte Hb content, the soluble transferrin receptor and its correlation with SF, and hepcidin measurement, based on the real-life evidence, the determination of iron status by using SF and TSAT is the most commonly deployed strategy”
From Defining Global Thresholds for Serum Ferritin: A Challenging Mission in Establishing the Iron Deficiency Diagnosis in This Era of Striving for Health Equity (2025) · cites this paper as [19]
In the citing paper
“It is a usual practice in many specialties and guidelines to assume that, regardless of the lower normality value of the ferritin test used, SF <30 ng/mL (irrespective of the TSAT value) or SF <100 ng/mL and TSAT <20% are the hallmarks of absolute ID; while SF >100 ng/mL and TSAT <20% usually indicate AI in the context of infection or inflammation [1,2,15,16,17,18,19,20].”
From Defining Global Thresholds for Serum Ferritin: A Challenging Mission in Establishing the Iron Deficiency Diagnosis in This Era of Striving for Health Equity (2025) · cites this paper as [19]
In the citing paper
“Iron deficiency is the most common pathology of iron homeostasis, eventually resulting in iron deficiency anemia, the most frequent anemia worldwide (Camaschella, 2015).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Camaschella, 2015
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Cites
Weiss, G., & Goodnough, L. T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra041809 · Cited by 3,800
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Self-citationA systematic analysis of global anemia burden from 1990 to 2010
Kassebaum, N. J., Jasrasaria, R., Naghavi, M., Wulf, S. K., Johns, N. E., Lozano, R., Regan, M. C., Weatherall, D. J., Chou, D. P., Eisele, T. P., et al. (2013) · Blood · doi:10.1182/blood-2013-06-508325 · Cited by 2,115
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084
Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency
Anker, S. D., Comin Colet, J., Filippatos, G., Willenheimer, R., Dickstein, K., Drexler, H., Lüscher, T. F., Bart, B., Banasiak, W., Niegowska, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0908355 · Cited by 2,083
Camaschella, C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1401038 · Cited by 1,678
Self-citationIdentification of erythroferrone as an erythroid regulator of iron metabolism
Kautz, L., Jung, G., Valore, E. V., Rivella, S., Nemeth, E., & Ganz, T. (2014) · Nature Genetics · doi:10.1038/ng.2996 · Cited by 1,127
Sazawal, S., Black, R. E., Ramsan, M., Chwaya, H. M., Stoltzfus, R. J., Dutta, A., Dhingra, U., Kabole, I., Deb, S., Othman, M. K., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67962-2 · Cited by 981
Tolkien, Z., Stecher, L., Mander, A. P., Pereira, D. I. A., & Powell, J. J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117383 · Cited by 833
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
Finberg, K. E., Heeney, M. M., Campagna, D. R., Aydınok, Y., Pearson, H. A., Hartman, K. R., Mayo, M. M., Samuel, S. M., Strouse, J. J., Markianos, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.130 · Cited by 675
Research works printed but not linked: 1
- Camaschella, 2016, Iron Deficiency and Disorders of Haem Synthesis
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The Role of Iron Regulation in Immunometabolism and Immune-Related Disease
Cronin, S. J. F., Woolf, C. J., Weiss, G., & Penninger, J. M. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00116 · Cited by 299
Stoffel, N. U., Zeder, C., Brittenham, G. M., Moretti, D., & Zimmermann, M. B. (2020) · Haematologica · doi:10.3324/haematol.2019.220830 · Cited by 241
Mantadakis, E. (2020) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2020.041 · Cited by 197
Essential Role of Patient Blood Management in a Pandemic: A Call for Action
Shander, A., Goobie, S. M., Warner, M. A., Aapro, M., Bisbe, E., Pérez-Calatayud, Á. A., Callum, J. L., Cushing, M. M., Dyer, W. B., ERHARD, J., et al. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004844 · Cited by 195
The role of iron repletion in adult iron deficiency anemia and other diseases
Elstrott, B. K., Khan, L., Olson, S. R., Raghunathan, V. M., DeLoughery, T. G., & Shatzel, J. J. (2019) · European Journal Of Haematology · doi:10.1111/ejh.13345 · Cited by 182
Metadata
- Authors
- Camaschella, C.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Camaschella, Clara
- ORCID
- Camaschella, Clara
- Venue
- Hematology
- Publisher
- American Society of Hematology
- Published
- 2015-12-05
- Volume
- 2015
- Issue
- 1
- Pages
- 8-13
- ISSN
- 1520-4383 (ISSN-L)
- 1520-4391
- OpenAlex
- W2220231666
- Cited by
- 201
- References
- 42
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 22 · 2023: 19 · 2022: 32 · 2021: 18 · 2020: 24 · 2019: 23 · 2018: 21 · 2017: 7 · 2016: 2
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hematology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Keywords
- iron deficiency, iron deficiency anemia, diagnosis, treatment, oral iron supplementation, intravenous iron, hepcidin, functional iron deficiency, erythropoiesis-stimulating agents, inflammation, iron absorption, parasitic infection, vegetarian diet, chronic blood loss, iron toxicity
- MeSH terms
- Iron Deficiencies, Administration, Oral, Animals, Disease Models, Animal, Female, Ferritins, Hematologic Tests, Hematology, Humans, Inflammation, Infusions, Intravenous, Infusions, Parenteral, Iron, Male, Transferrin, Anemia, Iron-Deficiency, Dietary Supplements, Genetic Predisposition to Disease
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