Iron Absorption from Supplements Is Greater with Alternate Day than with Consecutive Day Dosing in Iron-Deficient Anemic Women
Open accessAbstract
In iron-depleted women without anemia, oral iron supplements induce an increase in serum hepcidin (SHep) that persists for 24 hours, decreasing iron absorption from supplements given later on the same or next day. Consequently, iron absorption from supplements is highest if iron is given on alternate days. Whether this dosing schedule is also beneficial in women with iron-deficiency anemia (IDA) given high-dose iron supplements is uncertain. The primary objective of this study was to assess whether, in women with IDA, alternate-day administration of 100 and 200 mg iron increases iron absorption compared to consecutive-day iron administration. Secondary objectives were to correlate iron absorption with SHep and iron status parameters. We performed a cross-over iron absorption study in women with IDA (n=19; median hemoglobin 11.5 mg/dL; mean serum ferritin 10 mg/L) who received either 100 or 200 mg iron as ferrous sulfate given at 8 AM on days 2, 3 and 5 labeled with stable iron isotopes 57Fe, 58Fe and 54Fe; after a 16-day incorporation period, the other labeled dose was given at 8 AM on days 23, 24 and 26 (days 2, 3 and 5 of the second period). Iron absorption on days 2 and 3 (consecutive) and day 5 (alternate) was assessed by measuring erythrocyte isotope incorporation. For both doses, SHep was higher on day 3 than on day 2 (P
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dosing iron 48 h apart enhances iron absorption compared to three daily doses because it allows sufficient time for hepcidin levels to decrease and remove the mucosal block on absorption.
“They found that dosing 48 h apart enhanced iron absorption compared to three daily doses as it allows sufficient time for hepcidin levels to decrease and remove the mucosal block on absorption [34,35].”
From Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota (2021) · cites this paper as [34]
The Results report higher iron absorption with alternate-day than consecutive-day dosing, and the Figure 2 caption says hepcidin returned to baseline by 48 hours. But the Discussion explicitly says the absence of residual absorption inhibition at 48 hours is evidence against a lasting mucosal block, not that the interval removes one. The study compared doses on days 2, 3, and 5, not with a regimen of three daily doses; page numbers were not supplied. (LLM, conf=0.87)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredOther groups have confirmed enhanced iron absorption with single dosing once daily or alternate day dosing.
“Other groups have also confirmed enhanced iron absorption with single dosing once daily or alternate day dosing [33,34,36].”
From Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota (2021) · cites this paper as [34]
The dynamics of the increase in hepcidin levels after oral iron therapy have suggested that alternate-day administration of iron salts is an alternative to daily refracted doses, with the former being a protocol that increases both efficacy and tolerability, at least in women with iron deficiency without or with mild anemia.
“The dynamics of the increase in hepcidin levels after oral iron therapy have suggested that alternate-day administration of iron salts is an alternative to daily refracted doses, with the former being a protocol that increases both efficacy and tolerability, at least in women with iron deficiency without or with mild anemia.116,118,119”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [116]
By changing iron dosing schedules to reflect the negative feedback mechanisms intrinsic to mammalian iron homeostasis, fractional iron uptake can be maximized.
“By changing iron dosing schedules to reflect the negative feedback mechanisms intrinsic to mammalian iron homeostasis, fractional iron uptake can be maximized. 185 , 186”
From The battle for iron in enteric infections (2020) · cites this paper as [185]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A systematic analysis of global anemia burden from 1990 to 2010
Kassebaum, N. J., Jasrasaria, R., Naghavi, M., Wulf, S. K., Johns, N. E., Lozano, R., Regan, M. C., Weatherall, D. J., Chou, D. P., Eisele, T. P., et al. (2013) · Blood · doi:10.1182/blood-2013-06-508325 · Cited by 2,115 · see citing works
Tolkien, Z., Stecher, L., Mander, A. P., Pereira, D. I. A., & Powell, J. J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117383 · Cited by 833 · see citing works
Jaeggi, T., Kortman, G. A. M., Moretti, D., Chassard, C., Holding, P., Dostal, A., Boekhorst, J., Timmerman, H. M., Swinkels, D. W., Tjalsma, H., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307720 · Cited by 622 · see citing works
Self-citationUK guidelines on the management of iron deficiency in pregnancy
Pavord, S. R., Myers, B., Robinson, S. E., Allard, S., Strong, J., & Oppenheimer, C. A. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.09012.x · Cited by 606 · see citing works
Moretti, D., Goede, J. S., Zeder, C., Jiskra, M., Chatzinakou, V., Tjalsma, H., Melse-Boonstra, A., Brittenham, G., Swinkels, D. W., & Zimmermann, M. B. (2015) · Blood · doi:10.1182/blood-2015-05-642223 · Cited by 547 · see citing works
Self-citationDiagnosis and Management of Iron-Deficiency Anaemia
COOK, J. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.08.022 · Cited by 452 · see citing works
Regulation of the Iron Homeostatic Hormone Hepcidin
Sangkhae, V., & Nemeth, E. (2017) · Advances in Nutrition · doi:10.3945/an.116.013961 · Cited by 446 · see citing works
Stoffel, N. U., Cercamondi, C. I., Brittenham, G., Zeder, C., Geurts-Moespot, A. J., Swinkels, D. W., Moretti, D., & Zimmermann, M. B. (2017) · The Lancet Haematology · doi:10.1016/s2352-3026(17)30182-5 · Cited by 435 · see citing works
Self-citationZoller, H., Weiss, G., Theurl, I., Koch, R. O., Vogel, W., Obrist, P., Pietrangelo, A., Montosi, G., & Haile, D. J. (2001) · Gastroenterology · doi:10.1053/gast.2001.24033 · Cited by 304 · see citing works
Nutritional iron turned inside out: intestinal stress from a gut microbial perspective
Kortman, G. A. M., Raffatellu, M., Swinkels, D. W., & Tjalsma, H. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12086 · Cited by 291 · see citing works
New insights into iron deficiency and iron deficiency anemia
Camaschella, C. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.02.004 · Cited by 278 · see citing works
Lund, E. K., Wharf, S. G., Fairweather‐Tait, S. J., & Johnson, I. T. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.2.250 · Cited by 241 · see citing works
Are we giving too much iron? Low-dose iron therapy is effective in octogenarians
Rimon, E., Kagansky, N., Kagansky, M., Mechnick, L., Mashiah, T., Namir, M., & Levy, S. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.01.065 · Cited by 221 · see citing works
Cogswell, M. E., Looker, A. C., Pfeiffer, C. M., Cook, J. D., Lacher, D. A., Beard, J. L., Lynch, S. R., & Grummer‐Strawn, L. M. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27151 · Cited by 214 · see citing works
Brown, E., Hopper, J., Hodges, J. L., Bradley, B., Wennesland, R., & Yamauchi, H. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104677 · Cited by 203 · see citing works
Iron deficiency: new insights into diagnosis and treatment
Camaschella, C. (2015) · Hematology · doi:10.1182/asheducation-2015.1.8 · Cited by 201 · see citing works
Paganini, D., Uyoga, M. A., Kortman, G. A. M., Cercamondi, C. I., Moretti, D., Barth-Jaeggi, T., Schwab, C., Boekhorst, J., Timmerman, H. M., Lacroix, C., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-314418 · Cited by 172 · see citing works
Self-citationTroutt, J. S., Rudling, M., Persson, L., Ståhle, L., Angelin, B., Butterfield, A. M., Schade, A. E., Cao, G., & Konrad, R. J. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.186866 · Cited by 100 · cited 1× · see citing works
“The increase after iron administration is distinct(18) from the natural circadian increase in SHep over the day.(19) We previously showed that twice daily administration of 60 mg oral iron sharply augments the circadian SHep increase and results in higher SHep on the next day compared to once daily dosing with 120 mg…”
BackgroundLund, E. K., Fairweather‐Tait, S. J., Wharf, S. G., & Johnson, I. T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.11.2928 · Cited by 90 · see citing works
Intermittent oral iron supplementation during pregnancy.
Peña-Rosas, J. P., De-Regil, L., Malave, H. G., Flores-Urrutia, M. C., & Dowswell, T. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009997.pub2 · Cited by 89 · see citing works
Diurnal Rhythm rather than Dietary Iron Mediates Daily Hepcidin Variations
Schaap, C., Hendriks, J. C., Kortman, G. A. M., Klaver, S. M., Kroot, J. J., Laarakkers, C. M., Wiegerinck, E. T. G., Tjalsma, H., Janssen, M. C. H., & Swinkels, D. W. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.194977 · Cited by 81 · see citing works
Mobilization of storage iron is reflected in the iron isotopic composition of blood in humans
Hotz, K., Krayenbuehl, P., & Walczyk, T. (2011) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-011-0851-2 · Cited by 69 · see citing works
Combating iron deficiency: daily administration of iron is far superior to weekly administration
Hallberg, L. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.213 · Cited by 59 · see citing works
Nesheim, M. C., Peña‐Rosas, J. P., Sanjur, D., Frongillo, E. A., Garcia‐Casal, M. N., Crompton, D. W. T., Viteri, F. E., & Lorenzana, P. (2004) · Journal of Nutrition · doi:10.1093/jn/134.5.1099 · Cited by 29 · see citing works
The effect of phlebotomy on serum erythropoietin levels in normal healthy subjects.
Maeda, H., Hitomi, Y., Hirata, R. D. C., Tohyama, H., Suwata, J., Kamata, S., Fujino, Y., & Murata, N. (1992) · PubMed · Cited by 21 · see citing works
The nature of internal iron exchange in man.
HOSAIN, F., Marsaglia, G., Noyes, W. A., & Finch, C. A. (1962) · PubMed · Cited by 18 · see citing works
Schotten, N., Laarakkers, C. M., Roelofs, R., Origa, R., van Kraaij, M. G. J., & Swinkels, D. W. (2016) · American Journal of Hematology · doi:10.1002/ajh.24636 · Cited by 11 · see citing works
Prediction of human iron bioavailability using rapid c-ELISAs for human plasma hepcidin
Stoffel, N. U., Zeder, C., Fort, E., Swinkels, D. W., Zimmermann, M. B., & Moretti, D. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-0097 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Pasricha, S.-R., Tye-Din, J., Muckenthaler, M. U., & Swinkels, D. W. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32594-0 · Cited by 1,069 · see citing works
Iron metabolism and iron disorders revisited in the hepcidin era
Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734 · see citing works
Iron deficiency anaemia: pathophysiology, assessment, practical management
Kumar, A., Sharma, E., Marley, A., Samaan, M., & Brookes, M. (2022) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2021-000759 · Cited by 351 · see citing works
Snook, J. A., Bhala, N. B., Beales, I., Cannings, D., Kightley, C., Logan, R. P., Pritchard, D. M., Sidhu, R., Surgenor, S., Thomas, W., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-325210 · Cited by 312 · see citing works
AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia
Ko, C. W., Siddique, S. M., Patel, A. C., Harris, A. S., Sultan, S., Altayar, O., & Falck-Ytter, Y. T. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.06.046 · Cited by 219 · see citing works
Kontoghiorghes, G. J., & Kontoghiorghe, C. (2020) · Cells · doi:10.3390/cells9061456 · Cited by 197 · see citing works
Oral iron supplementation in iron-deficient women: How much and how often?
Stoffel, N. U., von Siebenthal, H. K., Moretti, D., & Zimmermann, M. B. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100865 · Cited by 205 · see citing works
Self-citationon behalf of the SPOG Pediatric Hematology Working Group, Mattiello, V., Schmugge, M., Hengartner, H., von der Weid, N., & Renella, R. (2020) · European Journal of Pediatrics · doi:10.1007/s00431-020-03597-5 · Cited by 168 · see citing works
Patient blood management during the COVID–19 pandemic: a narrative review
Baron, D. M., Franchini, M., Goobie, S. M., Javidroozi, M., Klein, A. A., Lasocki, S., Liumbruno, G. M., Múñoz, M., Shander, A., Spahn, D. R., et al. (2020) · Anaesthesia · doi:10.1111/anae.15095 · Cited by 120 · see citing works
Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota
Bloor, S. R., Schutte, R., & Hobson, A. R. (2021) · Microbiology Research · doi:10.3390/microbiolres12020033 · Cited by 117 · see citing works
“Other groups have also confirmed enhanced iron absorption with single dosing once daily or alternate day dosing [33,34,36].”
BackgroundIron Deficiency in Celiac Disease: Prevalence, Health Impact, and Clinical Management
Montoro, M. A., Santolaria, S., Cañamares‐Orbís, P., & García‐Erce, J. A. (2021) · Nutrients · doi:10.3390/nu13103437 · Cited by 102 · see citing works
Oral iron supplementation: new formulations, old questions
Pantopoulos, K. (2024) · Haematologica · doi:10.3324/haematol.2024.284967 · Cited by 95 · see citing works
The role of oral iron in the treatment of adults with iron deficiency
Lo, J. O.-T., Benson, A. E., Martens, K. L., Hedges, M. A., McMurry, H. S., DeLoughery, T. G., Aslan, J. E., & Shatzel, J. J. (2022) · European Journal Of Haematology · doi:10.1111/ejh.13892 · Cited by 77 · see citing works
Pasricha, S., Mwangi, M. N., Moya, E., Ataíde, R., Mzembe, G., Harding, R., Zinenani, T., Larson, L. M., Demir, A. Y., Nkhono, W., et al. (2023) · The Lancet · doi:10.1016/s0140-6736(23)00278-7 · Cited by 80 · see citing works
KDIGO 2026 Clinical Practice Guideline for the Management of Anemia in Chronic Kidney Disease (CKD)
Tonelli, M. A., Berns, J. B., Bozkurt, B., Cheung, R., Cuevas, Y., Effa, E. E., Eisenga, M. F., Fishbane, S., Ginzburg, Y. Z., Haase, V. H., et al. (2026) · Kidney International · doi:10.1016/j.kint.2025.06.006 · Cited by 96 · see citing works
Kaundal, R., Bhatia, P., Jain, A., Jain, A., Nampoothiri, R. V., Mishra, K., Jandial, A., Goni, D., Sandal, R., Jindal, N., et al. (2019) · Annals of Hematology · doi:10.1007/s00277-019-03871-z · Cited by 66 · see citing works
The battle for iron in enteric infections
Sousa Gerós, A., Simmons, A., Drakesmith, H., Aulicino, A., & Frost, J. N. (2020) · Immunology · doi:10.1111/imm.13236 · Cited by 58 · see citing works
Richards, T., Breymann, C., Brookes, M., Lindgren, S. C., Macdougall, I. C., McMahon, L. P., Munro, M. G., Nemeth, E., Rosano, G. M. C., Schiefke, I., et al. (2021) · Annals of Medicine · doi:10.1080/07853890.2020.1867323 · Cited by 62 · see citing works
Fertrin, K. Y. (2020) · Hematology · doi:10.1182/hematology.2020000132 · Cited by 59 · see citing works
Graham, F. J., Masini, G., Pellicori, P., Cleland, J. G. F., Greenlaw, N., Friday, J. M., Kazmi, S., & Clark, A. L. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2251 · Cited by 59 · see citing works
Refining Treatment Strategies for Iron Deficient Athletes
McCormick, R., Sim, M., DAWSON, B. T., & Peeling, P. (2020) · Sports Medicine · doi:10.1007/s40279-020-01360-2 · Cited by 58 · see citing works
Rogozińska, E., Daru, J., Nicolaides, M., Amezcua‐Prieto, C., Robinson, S. E., Wang, R., Godolphin, P. J., Saborido, C. M., Zamora, J., Khan, K. S., et al. (2021) · The Lancet Haematology · doi:10.1016/s2352-3026(21)00137-x · Cited by 61 · see citing works
Balendran, S., & Forsyth, C. J. (2021) · Australian Prescriber · doi:10.18773/austprescr.2021.052 · Cited by 51 · see citing works
Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes
Ebea, P. O., Vidyasagar, S., Connor, J. R., Frazer, D. M., Knutson, M. D., & Collins, J. F. (2024) · British Journal of Haematology · doi:10.1111/bjh.19268 · Cited by 64 · see citing works
O'Toole, F., Sheane, R., Reynaud, N., McAuliffe, F. M., & Walsh, J. M. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.15270 · Cited by 53 · see citing works
von Siebenthal, H. K., Gessler, S., Vallelian, F., Steinwendner, J., Kuenzi, U.-M., Moretti, D., Zimmermann, M. B., & Stoffel, N. U. (2023) · EClinicalMedicine · doi:10.1016/j.eclinm.2023.102286 · Cited by 43 · see citing works
Self-citationIron deficiency, supplementation, and sports performance in female athletes: A systematic review
Pengelly, M., Pumpa, K. L., Pyne, D. B., & Etxebarria, N. (2024) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2024.101009 · Cited by 43 · see citing works
Wine, E., Aloi, M., Biervliet, S. V., Bronský, J., de Carpi, J. M., Gasparetto, M., Gianolio, L., Gordon, H., Hojsak, I., Hudson, A. S., et al. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.70097 · Cited by 47 · see citing works
Iron Deficiency in Menstruating Adult Women: Much More than Anemia
Fernández‐Jiménez, M. C., Moreno, G., Wright, I., Shih, P., Vaquero, M. P., & Remacha, A. F. (2020) · Women s Health Reports · doi:10.1089/whr.2019.0011 · Cited by 39 · see citing works
Weyand, A. C., Sidonio, R. F., & Sholzberg, M. (2022) · Haemophilia · doi:10.1111/hae.14535 · Cited by 38 · see citing works
Yilma, H., Sedlander, E., Rimal, R. N., Pant, I., Munjral, A., & Mohanty, S. (2020) · BMC Public Health · doi:10.1186/s12889-020-8271-2 · Cited by 37 · see citing works
Update on the management of vitamins and minerals in cystic fibrosis
Sankararaman, S., Hendrix, S. J., & Schindler, T. (2022) · Nutrition in Clinical Practice · doi:10.1002/ncp.10899 · Cited by 37 · see citing works
Ubom, A. E., Begum, F., Ramašauskaitė, D., Nieto‐Calvache, A. J., Oguttu, M., Nunes, I., Malel, Z. J., Beyeza‐Kashesya, J., & Wright, A. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70529 · Cited by 54 · see citing works
Pasupathy, E., Kandasamy, R., Thomas, K., & Basheer, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-29034-9 · Cited by 33 · see citing works
Iron Deficiency Anaemia in Pregnancy: A Narrative Review from a Clinical Perspective
Obianeli, C., Afifi, K., Stanworth, S. J., & Churchill, D. (2024) · Diagnostics · doi:10.3390/diagnostics14202306 · Cited by 32 · see citing works
de Souza, L. V., Hoffmann, A., Fischer, C., Petzer, V., Aßhoff, M., Theurl, I., Tymoszuk, P., Seifert, M., Brigo, N., Hilbe, R., et al. (2022) · Haematologica · doi:10.3324/haematol.2022.281149 · Cited by 33 · see citing works
How I treat anemia in older adults
Oyedeji, C. I., Artz, A. S., & Cohen, H. J. (2023) · Blood · doi:10.1182/blood.2022017626 · Cited by 32 · see citing works
Lorinczova, H. T., Fitzsimons, O., Mursaleen, L., Renshaw, D. W., Begum, G., & Zariwala, M. G. (2020) · Antioxidants · doi:10.3390/antiox9080645 · Cited by 31 · see citing works
The definition, screening, and treatment of postpartum anemia: A systematic review of guidelines
de Viñaspre‐Hernández, R. R., Gea-Caballero, V., Juárez‐Vela, R., & Barragán, F. J. I. (2020) · Birth · doi:10.1111/birt.12519 · Cited by 31 · see citing works
Pai, R., Chong, Y. S., Clemente-Chua, L. R., Irwinda, R., Huynh, T. N. K., Wibowo, N., Gamilla, M. C. Z. N., & Mahdy, Z. A. (2023) · Nutrients · doi:10.3390/nu15143125 · Cited by 30 · see citing works
Giordano, G., Napolitano, M., Battista, V. D., & Lucchesi, A. (2020) · Annals of Hematology · doi:10.1007/s00277-020-04361-3 · Cited by 31 · see citing works
Review of intervention products for use in the prevention and control of anemia
de Romaña, D. L., Mildon, A., Golan, J. M., Jefferds, M. E., Rogers, L. M., & Arabi, M. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15062 · Cited by 40 · see citing works
Bumrungpert, A., Pavadhgul, P., Piromsawasdi, T., & Mozafari, M. R. (2022) · Nutrients · doi:10.3390/nu14030452 · Cited by 28 · see citing works
Loveikyte, R., Boer, M., van der Meulen, C. N., ter Steege, R. W. F., Tack, G. J., Kuyvenhoven, J. P., Jharap, B., Vu, M. K., Vogelaar, L., West, R. L., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226843 · Cited by 27 · see citing works
Empowering the Potential of CAR-T Cell Immunotherapies by Epigenetic Reprogramming
Alvanou, M., Lysandrou, M., Christofi, P., Psatha, N., Spyridonidis, A., Παπαδοπούλου, Α., & Yannaki, E. (2023) · Cancers · doi:10.3390/cancers15071935 · Cited by 27 · see citing works
Green strength: The role of micronutrients in plant-based diets for athletic performance enhancement
Ayaz, A., Zaman, W., Radak, Z. O., & Gu, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32803 · Cited by 26 · see citing works
Banerjee, A., Athalye, S., Shingade, P. P., Khargekar, V., Mahajan, N., Madkaikar, M. R., & Khargekar, N. C. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102742 · Cited by 36 · see citing works
Chaber, R., Helwich, E., Lauterbach, R., Mastalerz–Migas, A., Matysiak, M. J., Peregud-Pogorzelski, J. W., Styczyński, J., Szczepański, T., & Jackowska, T. (2024) · Nutrients · doi:10.3390/nu16213623 · Cited by 24 · see citing works
Screening, Treatment, and Monitoring of Iron Deficiency Anemia in Pregnancy and Postpartum
Elmore, C., & Ellis, J. A. (2022) · Journal of Midwifery & Women s Health · doi:10.1111/jmwh.13370 · Cited by 24 · see citing works
Maas, L. A., Krishna, M., & Parian, A. M. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07599-1 · Cited by 28 · see citing works
The effect of iron dosing schedules on plasma hepcidin and iron absorption in Kenyan infants
Uyoga, M. A., Mikulic, N., Paganini, D., Mwasi, E., Stoffel, N. U., Zeder, C., Karanja, S. M., & Zimmermann, M. B. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa174 · Cited by 23 · see citing works
Self-citationPostoperative anemia in cardiac surgery patients: a narrative review
Li, M. M., Miles, S. J., Callum, J., Lin, Y., Karkouti, K., & Bartoszko, J. M. (2023) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-023-02650-9 · Cited by 22 · see citing works
The ASH-ASPHO Choosing Wisely Campaign: 5 hematologic tests and treatments to question
O’Brien, S. H., Badawy, S. M., Rotz, S. J., Shah, M. D., Makarski, J., Bercovitz, R. S., Hogan, M. S., Luchtman‐Jones, L., Panepinto, J. A., Priola, G. M., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2020003635 · Cited by 21 · see citing works
Loveikyte, R., Bourgonje, A. R., van der Reijden, J. J., Bulthuis, M. L. C., Hawinkels, L. J. A. C., Visschedijk, M. C., Festen, E. A. M., van Dullemen, H. M., Weersma, R. K., van Goor, H., et al. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad010 · Cited by 21 · see citing works
Consensus guidelines for diagnosis and management of anemia in epidermolysis bullosa
Liy‐Wong, C., Tarango, C., Pope, E., Coates, T. D., Bruckner, A. L., Feinstein, J. A., Schwieger‐Briel, A., Hubbard, L. D., Jane, C., Torres-Pradilla, M., et al. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-022-02448-w · Cited by 21 · see citing works
Han, L., Huang, Y., Li, B., Wang, W., Sun, Y., Zhang, X., Zhang, W., Liu, S., Zhou, W., Xia, W., et al. (2023) · Theranostics · doi:10.7150/thno.82553 · Cited by 21 · see citing works
Micronutrient bioavailability: concepts, influencing factors, and strategies for improvement
Richards, J. D., Cori, H., Rahn, M., Finn, K., Bárcena, J., Kanellopoulos, A. K., Péter, S., & Spooren, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1646750 · Cited by 27 · see citing works
AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia
Kaunitz, J. D., & Ganz, T. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.03.001 · Cited by 20 · see citing works
Giorgetti, A., Husmann, F. M. D., Zeder, C., Herter‐Aeberli, I., & Zimmermann, M. B. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac003 · Cited by 19 · see citing works
Self-citationPatient Blood Management, Anemia, and Transfusion Optimization Across Surgical Specialties
Kiyatkin, M. E., Mladinov, D., Jarzebowski, M., & Warner, M. A. (2023) · Anesthesiology Clinics · doi:10.1016/j.anclin.2022.10.003 · Cited by 21 · see citing works
The ASH‐ASPHO Choosing Wisely Campaign: 5 hematologic tests and treatments to question
O’Brien, S. H., Badawy, S. M., Rotz, S. J., Shah, M. D., Makarski, J., Bercovitz, R. S., Hogan, M. S., Luchtman‐Jones, L., Panepinto, J. A., Priola, G. M., et al. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.28967 · Cited by 18 · see citing works
Daily versus alternate day oral iron therapy in iron deficiency anemia: a systematic review
Kamath, S., Parveen, R. S., Hegde, S., Mathias, E. G., Nayak, V., & Boloor, A. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02817-7 · Cited by 18 · see citing works
Adaptive immunity and vaccination – iron in the spotlight
Preston, A. E., Drakesmith, H., & Frost, J. N. (2021) · Immunotherapy Advances · doi:10.1093/immadv/ltab007 · Cited by 20 · see citing works
Diagnosis and management of iron deficiency in females
Sholzberg, M., Hillis, C., Crowther, M. A., & Selby, R. (2025) · Canadian Medical Association Journal · doi:10.1503/cmaj.240570 · Cited by 20 · see citing works
Roberts, G. P., Benusiglio, P. R., Bisseling, T. M., Coit, D. G., Davis, J. L., Grimes, S., Guise, T. A., Hardwick, R. H., Harris, K. L., Mansfield, P. F., et al. (2022) · Gastric Cancer · doi:10.1007/s10120-022-01318-5 · Cited by 16 · see citing works
Finlayson-Trick, E. C., Nearing, J. T., Fischer, J. A. J., Ma, Y., Wang, S., Kroeun, H., Goldfarb, D. A., & Karakochuk, C. D. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.05273-22 · Cited by 16 · see citing works
How I treat anemia in the perisurgical setting
Shander, A., Kaufman, M., & Goodnough, L. T. (2020) · Blood · doi:10.1182/blood.2019003945 · Cited by 16 · see citing works
Iron deficiency and pulmonary arterial hypertension
Lan, M., Wu, S., & Fernandes, T. M. (2022) · Nutrition in Clinical Practice · doi:10.1002/ncp.10884 · Cited by 15 · see citing works
van der Staaij, H., Donker, A. E., Bakkeren, D. L., Salemans, J. M. J. I., Mignot-Evers, L. A. A., Bongers, M. Y., Dieleman, J. P., Galesloot, T. E., Laarakkers, C. M., Klaver, S. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031917 · Cited by 16 · see citing works
Regression to the Mean: A Statistical Phenomenon of Worthy Consideration in Anemia Research
Cochrane, K. M., Williams, B. A., Fischer, J. A. J., Samson, K. L. I., Pei, L. X., & Karakochuk, C. D. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa152 · Cited by 14 · see citing works
Hemoglobin distributions and prevalence of anemia in a multiethnic United States pregnant population
Kang, W., Irvine, C., Wang, Y., Clark, A. G., Gu, Z., Pressman, E. K., & O'Brien, K. O. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.01.022 · Cited by 14 · see citing works
Alkhalid, Y., Darji, Z., Shenkar, R., Clancy, M. S., Dyamenahalli, U., & Awad, I. A. (2023) · Vascular Medicine · doi:10.1177/1358863x231151731 · Cited by 14 · see citing works
Heusschen, L., Berendsen, A. A. M., Deden, L. N., Hazebroek, E. J., & Aarts, E. O. (2022) · Obesity Surgery · doi:10.1007/s11695-022-06256-w · Cited by 13 · see citing works
Uçan, A., Kaya, Z. I., Yılmaz, E. Ö., Vasi, İ., & Özgeyik, M. O. (2023) · Medicine · doi:10.1097/md.0000000000034421 · Cited by 12 · see citing works
Blood management during the COVID-19 pandemic
Tolich, D. J., Aurón, M., McCoy, K., Dargis, M., & Quraishy, N. (2020) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.87a.ccc053 · Cited by 12 · see citing works
James, A., Li, G., List, R., Lonabaugh, K. P., Smith, A. D., Barros, A. J., Somerville, L., & Albon, D. P. (2023) · Pediatric Pulmonology · doi:10.1002/ppul.26805 · Cited by 12 · see citing works
Meliš, P., Lucijanić, M., Kranjčec, B., Berković, M. C., & Marušić, S. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16368 · Cited by 11 · see citing works
Caljé, E., Groom, K. M., Dixon, L., Marriott, J., Foon, R., Oyston, C., Bloomfield, F. H., & Jordan, V. (2024) · Systematic Reviews · doi:10.1186/s13643-023-02400-4 · Cited by 13 · see citing works
The EHA Research Roadmap: Anemias
Iolascon, A., Rivella, S., Anagnou, N. P., Camaschella, C., Swinkels, D. W., Muckenthaler, M. U., Porto, G., Barcellini, W., Andolfo, I., Risitano, A. M., et al. (2021) · HemaSphere · doi:10.1097/hs9.0000000000000607 · Cited by 11 · see citing works
Snoek, K. M., van de Woestijne, N., Willemsen, S. P., Klaassen, R. A., Galjaard, S., Laven, J. S. E., Steegers‐Theunissen, R. P. M., & Schoenmakers, S. (2022) · Nutrients · doi:10.3390/nu14040736 · Cited by 11 · see citing works
Preoperative Anemia Management: What’s New in 2020?
Rubinger, D. A., Cahill, C. M., Ngo, A., Gloff, M. S., & Refaai, M. A. (2020) · Current anesthesiology reports · doi:10.1007/s40140-020-00385-7 · Cited by 11 · see citing works
Tang, X., Reidlinger, D. P., Crichton, M., Craggs‐Dino, L., Fayet‐Moore, F., & Marshall, S. (2024) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2024.09.007 · Cited by 11 · see citing works
Assessing Human Iron Kinetics Using Stable Iron Isotopic Techniques
Stoffel, N. U., Zeder, C., & Zimmermann, M. B. (2024) · Clinical Pharmacokinetics · doi:10.1007/s40262-024-01421-z · Cited by 10 · see citing works
Self-citationHoving, V., Donker, A. E., Schols, S. E. M., & Swinkels, D. W. (2025) · British Journal of Haematology · doi:10.1111/bjh.20030 · Cited by 10 · see citing works
The use of iron after surgery: a systematic review and meta‐analysis
Lim, J., Joo, J., MacLean, B., & Richards, T. (2025) · Anaesthesia · doi:10.1111/anae.16605 · Cited by 10 · see citing works
Naquin, E. R., Garg, R., Chen, W. J., Karmakar, E., Prasad, A., Mandadi, S., Depala, K. S., Gopianand, J. S., & Gnana‐Prakasam, J. P. (2025) · Nutrients · doi:10.3390/nu17182964 · Cited by 10 · see citing works
Avances en el diagnóstico y tratamiento de deficiencia de hierro y anemia ferropenica
Alvarado, C. S., Yanac-Avila, R., Marron-Veria, E., Málaga-Zenteno, J., & Adamkiewicz, T. V. (2022) · Anales de la Facultad de Medicina · doi:10.15381/anales.v83i1.21721 · Cited by 10 · see citing works
Anemia after kidney transplantation
Guzzo, I., & Atkinson, M. A. (2022) · Pediatric Nephrology · doi:10.1007/s00467-022-05743-7 · Cited by 10 · see citing works
Expert consensus on improving iron deficiency anemia management in obstetrics and gynecology in Asia
Leung, T. W., Damodaran, P., Torres, R. P., Chuncharunee, S., Chu, M. Y., Gamilla, Z., Lim, N. R., Luna, J. T. P., Huang, J., Li, W. H., et al. (2023) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14804 · Cited by 9 · see citing works
Serum Ferritin Levels: A Clinical Guide in Patients With Hair Loss
Zhang, D. (2023) · Cutis · doi:10.12788/cutis.0837 · Cited by 10 · see citing works
A Systematic Review of Isotopically Measured Iron Absorption in Infants and Children Under 2 Years
Gallahan, S., Brower, S., Wapshott‐Stehli, H. L., dos Santos, J. B., & Ho, T. T. B. (2024) · Nutrients · doi:10.3390/nu16223834 · Cited by 9 · see citing works
Thalassemias and Sickle Cell Diseases in Pregnancy: SITE Good Practice
Pinto, V. M., Cima, R., Maggio, R. D., Alga, M. L., Gigante, A., Longo, F., Pasanisi, A., Venturelli, D., Cassinerio, E., Casale, M., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14030948 · Cited by 9 · see citing works
Clarke, L., Froessler, B., Tang, C., King, K., Ross, B., Kidson‐Gerber, G., Dugan, C., Townsend, L., Uppal, T., Baxter, L., et al. (2025) · Internal Medicine Journal · doi:10.1111/imj.16602 · Cited by 9 · see citing works
Kashinath, S. K., & Kouides, P. A. (2023) · Expert Review of Hematology · doi:10.1080/17474086.2023.2166925 · Cited by 9 · see citing works
Evaluating the Importance of Patient Blood Management During COVID-19 Pandemic
Chegini, A. (2022) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.112910 · Cited by 9 · see citing works
Csulak, E., Takács, T., Babis, B., Horváth, L., Márton, P., Lakatos, B. K., Kovács, A. D., Staub, L., Szabó, L. E., Dohy, Z., et al. (2023) · Clinical Cardiology · doi:10.1002/clc.24117 · Cited by 9 · see citing works
Kron, A., Giudice, M. E. D., Sholzberg, M., Callum, J. L., Cserti-Gazdewich, C. M., Swarup, V., Huang, M., Distefano, L., Anani, W. Q., Skeate, R. C., et al. (2022) · Pilot and Feasibility Studies · doi:10.1186/s40814-022-01042-y · Cited by 9 · see citing works
Anemia and Transfusion Medicine
Kalra, S. K., & Aurón, M. (2024) · Medical Clinics of North America · doi:10.1016/j.mcna.2024.04.002 · Cited by 8 · see citing works
Kaberi‐Otarod, J., Still, C. D., Wood, G. C., & Benotti, P. N. (2024) · Nutrients · doi:10.3390/nu16193350 · Cited by 8 · see citing works
Recent Advances in Research on Iron Metabolism, Ferritin, and Hepcidin
Polizzi, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020906 · Cited by 8 · see citing works
- Authors
- Stoffel, N. U., Zeder, C., Brittenham, G. M., Moretti, D., & Zimmermann, M. B.
- Affiliations
- ETH Zurich (CH)
- Columbia University (US)
- Corresponding author
- Stoffel, Nicole U.
- Venue
- Haematologica
- Published
- 2019-08-14
- Volume
- 105
- Issue
- 5
- Pages
- 1232-1239
- ISSN
- 0390-6078 (ISSN-L)
- 1592-8721
- PMC
- PMC7193469
- OpenAlex
- W2967031988
- Cited by
- 241
- References
- 30
- Citations by year
- 2026: 38 · 2025: 35 · 2024: 30 · 2023: 53 · 2022: 40 · 2021: 15 · 2020: 28 · 2019: 2
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Haematologica (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron absorption, iron deficiency anemia, alternate-day dosing, oral iron supplementation, ferrous sulfate, hepcidin, iron status, erythrocyte iron incorporation, iron stable isotopes, women
- MeSH terms
- Female, Humans, Iron, Switzerland, Cross-Over Studies, Anemia, Iron-Deficiency, Dietary Supplements, Hepcidins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
