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Cited by 314

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production

Morelli, Adrian E., Larregina, Adriana T., Shufesky, William J., Zahorchak, Alan F., Logar, Alison J., Papworth, Glenn D., Wang, Zhiliang, Watkins, Simon C., Falo, Louis D., Thomson, Angus W.·2003·Blood
DOI 10.1182/blood-2002-06-1769
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Abstract

Under steady-state conditions, internalization of self-antigens embodied in apoptotic cells by dendritic cells (DCs) resident in peripheral tissue followed by DC migration and presentation of self-peptides to T cells in secondary lymphoid organs are key steps for induction and maintenance of peripheral T-cell tolerance. We show here that, besides this traffic of apoptotic cells mediated by peripheral tissue–resident DCs, splenic marginal zone DCs rapidly ingest circulating apoptotic leukocytes, process apoptotic cell–derived peptides into major histocompatibility complex class II (MHC-II) molecules, and acquire CD8α during their mobilization to T-cell areas of splenic follicles. Because apoptotic cells activate complement and some complement factors are opsonins for phagocytosis and play roles in the maintenance of peripheral tolerance, we investigated the role of complement receptors (CRs) in relation to phagocytosis of apoptotic cells by DCs. Apoptotic cell uptake by marginal zone DCs was mediated in part via CR3 (CD11b/CD18) and, to a lesser extent, CR4 (CD11c/CD18) and was reduced significantly in vivo in hypocomplementemic animals. Following phagocytosis of apoptotic cells, DCs exhibited decreased levels of mRNA and secretion of the proinflammatory cytokines interleukin 1α (IL-1α), IL-1β, IL-6, IL-12p70, and tumor necrosis factor α (TNF-α), without effect on the anti-inflammatory mediator transforming growth factor β1 (TGF-β1). This selective inhibitory effect was at least partially mediated through C3bi-CD11b/CD18 interaction. Characterization of apoptotic cell/DC interaction and its outcome provides insight into the mechanisms by which apoptotic cells affect DC function without disrupting peripheral tolerance.

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Metadata

Authors
Morelli, A. E., Larregina, A. T., Shufesky, W. J., Zahorchak, A. F., Logar, A. J., Papworth, G. D., Wang, Z., Watkins, S. C., Falo, L. D., & Thomson, A. W.
Venue
Blood
Publisher
American Society of Hematology
Published
2003-01-15
Volume
101
Issue
2
Pages
611-620
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2002-06-1769
OpenAlex
W1972489295
Cited by
314
References
53
FWCI
5.64
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. https://app.cochat.ai/papers/10.1182/blood-2002-06-1769
The paper
Morelli, A. E., Larregina, A. T., Shufesky, W. J., Zahorchak, A. F., Logar, A. J., Papworth, G. D., Wang, Z., Watkins, S. C., Falo, L. D., & Thomson, A. W. (2003). Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood. https://doi.org/10.1182/blood-2002-06-1769

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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