The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
Open accessAbstract
Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high morbidity and mortality rates. The development of novel therapies for sepsis is critically dependent on an understanding of the basic mechanisms of the disease. The pathophysiology of severe sepsis involves a highly complex, integrated response that includes the activation of a number of cell types, inflammatory mediators, and the hemostatic system. Central to this process is an alteration of endothelial cell function. The goals of this article are to (1) provide an overview of sepsis and its complications, (2) discuss the role of the endothelium in orchestrating the host response in sepsis, and (3) emphasize the potential value of the endothelium as a target for sepsis therapy.
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(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Inadequate Antimicrobial Treatment of Infections
Kollef, M. H., Sherman, G., Ward, S., & Fraser, V. J. (1999) · Chest · doi:10.1378/chest.115.2.462 · Cited by 1,805
Multiple organ dysfunction syndrome: exploring the paradigm of complex nonlinear systems
Seely, A. J. E., & Christou, N. V. (2000) · Critical Care Medicine · doi:10.1097/00003246-200007000-00003 · Cited by 287
Protective genes expressed in endothelial cells: a regulatory response to injury
Bach, F. H., Hancock, W. W., & Ferran, C. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01129-8 · Cited by 220
Cited by
Sepsis: a roadmap for future research
Cohen, J., Vincent, J.-L., Adhikari, N. K. J., Machado, F. R., Angus, D. C., Calandra, T., Jaton, K., Giulieri, S., Delaloye, J., Opal, S., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70112-x · Cited by 992
Jackson, S. P., Darbousset, R., & Schoenwaelder, S. M. (2019) · Blood · doi:10.1182/blood-2018-11-882993 · Cited by 616
Pyroptosis-Induced Inflammation and Tissue Damage
Vasudevan, S. O., Behl, B., & Rathinam, V. A. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101781 · Cited by 412
Endothelial barrier dysfunction in septic shock
Opal, S. M., & van der Poll, T. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12331 · Cited by 353
The two-event model of transfusion-related acute lung injury
Silliman, C. C. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000214292.62276.8e · Cited by 231
Metadata
- Authors
- Aird, W. C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-05-15
- Volume
- 101
- Issue
- 10
- Pages
- 3765-3777
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2141868068
- Cited by
- 1,131
- References
- 6
- FWCI
- 24.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
