The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mast cells produce interleukin-25 upon FcεRI-mediated activation
Abstract
Interleukin-25 (IL-25) is a recently described T helper 2 (TH2) cell–derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–producing cells. When bone marrow–derived mast cells were stimulated by immunoglobulin E cross-linking, IL-25 mRNA was induced within 30 minutes in a calcineurin-dependent manner, and the levels of IL-25 mRNA were comparable with those of activated TH2 cells. Production of IL-25 by mast cells was also detected at protein levels by immunoblotting. These results suggest that mast cells may enhance TH2-type immune response by producing IL-25.
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Hurst, S. D., Muchamuel, T., Gorman, D. M., Gilbert, J. M., Clifford, T., Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T. T., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.443 · Cited by 619
A Novel Cytokine Receptor-Ligand Pair
Shi, Y., Ullrich, S. J., Zhang, J., Connolly, K., Grzegorzewski, K. J., Barber, M. C., Wang, W., Wathen, K., Hodge, V., Fisher, C. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910228199 · Cited by 232 · cited 2×
“The expression of IL-25 results in the expansion of eosinophils through the production of IL-5 from an unidentified non-T cell population (2-4), whereas other IL-17 family cytokines induce the expansion of neutrophils (5-7).”
Background
Cited by
Targeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414
TH2 cell development and function
Walker, J. A., & McKenzie, A. N. J. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.118 · Cited by 632
Saenz, S. A., Taylor, B. C., & Artis, D. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00713.x · Cited by 484
Epithelial cell–derived cytokines: more than just signaling the alarm
Roan, F., Obata-Ninomiya, K., & Ziegler, S. F. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124606 · Cited by 484
IL-25 regulates Th17 function in autoimmune inflammation
Kleinschek, M. A., Owyang, A. M., Joyce-Shaikh, B., Langrish, C. L., Chen, Y., Gorman, D. M., Blumenschein, W. M., McClanahan, T., Brombacher, F., Hurst, S. D., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061738 · Cited by 396
Metadata
- Authors
- Ikeda, K., Nakajima, H., Suzuki, K., Kagami, S.-I., Hirose, K., Suto, A., Saito, Y., & Iwamoto, I.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-05-01
- Volume
- 101
- Issue
- 9
- Pages
- 3594-3596
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1982955578
- Cited by
- 240
- References
- 2
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ikeda, K., Nakajima, H., Suzuki, K., Kagami, S.-I., Hirose, K., Suto, A., Saito, Y., & Iwamoto, I. (2003). Mast cells produce interleukin-25 upon FcεRI-mediated activation. Blood. https://doi.org/10.1182/blood-2002-09-2817
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