The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells
Open accessAbstract
During early embryogenesis, blood vessels and hematopoietic cells arise from a common precursor cell, the hemangioblast. Recent studies have identified endothelial progenitor cells in the peripheral blood, and there is accumulating evidence that a subset of these cells is derived from precursors in the bone marrow. Here we show that adult bone marrow–derived, phenotypically defined hematopoietic stem cells (c-kit+, Sca-1+, lineage–) give rise to functional endothelial cells. With the exception of the brain, donor-derived cells are rapidly integrated into blood vessels. Durably engrafted endothelial cells express CD31, produce von Willebrand factor, and take up low-density lipoprotein. Analysis of DNA content indicates that donor-derived endothelial cells are not the products of cell fusion. Self-renewal of stem cells with hematopoietic and endothelial cell potential was revealed by serial transplantation studies. The clonal origin of both hematopoietic and endothelial cell outcomes was established by the transfer of a single cell. These results suggest that adult bone marrow–derived hematopoietic stem cells may serve as a reservoir for endothelial cell progenitors.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., et al. (2001) · Nature Medicine · doi:10.1038/nm1101-1194 · Cited by 1,860
Changing potency by spontaneous fusion
Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G. (2002) · Nature · doi:10.1038/nature729 · Cited by 1,494
Cited by
Concise Review: Circulating Endothelial Progenitor Cells for Vascular Medicine
Asahara, T., Kawamoto, A., & Masuda, H. (2011) · Stem Cells · doi:10.1002/stem.745 · Cited by 411
Göthert, J. R., Gustin, S. E., van Eekelen, J. A. M., Schmidt, U., Hall, M. A., Jane, S. M., Green, A. R., Göttgens, B., Izon, D. J., & Begley, C. G. (2004) · Blood · doi:10.1182/blood-2003-11-3952 · Cited by 285
Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia–reperfusion injury in rats
Fadini, G. P., Sartore, S., Schiavon, M., Albiero, M., Baesso, I., Cabrelle, A., Agostini, C., & Avogaro, A. (2006) · Diabetologia · doi:10.1007/s00125-006-0401-6 · Cited by 255
Teratomas from pluripotent stem cells: A clinical hurdle
Fong, C., Gauthaman, K., & Bongso, A. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22775 · Cited by 222
Metadata
- Authors
- Bailey, A. S., Jiang, S., Afentoulis, M., Baumann, C. I., Schroeder, D. A., Olson, S. B., Wong, M. H., & Fleming, W. H.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-01-01
- Volume
- 103
- Issue
- 1
- Pages
- 13-19
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2069905905
- Cited by
- 270
- References
- 3
- FWCI
- 14.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bailey, A. S., Jiang, S., Afentoulis, M., Baumann, C. I., Schroeder, D. A., Olson, S. B., Wong, M. H., & Fleming, W. H. (2004). Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells. Blood. https://doi.org/10.1182/blood-2003-05-1684
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