The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions
Abstract
Proteins secreted by activated platelets can adhere to the vessel wall and promote the development of atherosclerosis and thrombosis. Despite this biologic significance, however, the complement of proteins comprising the platelet releasate is largely unknown. Using a proteomics approach, we have identified more than 300 proteins released by human platelets following thrombin activation. Many of the proteins identified were not previously attributed to platelets, including secretogranin III, a potential monocyte chemoattractant precursor; cyclophilin A, a vascular smooth muscle cell growth factor; calumenin, an inhibitor of the vitamin K epoxide reductase-warfarin interaction, as well as proteins of unknown function that map to expressed sequence tags. Secretogranin III, cyclophilin A, and calumenin were confirmed to localize in platelets and to be released upon activation. Furthermore, while absent in normal vasculature, they were identified in human atherosclerotic lesions. Therefore, these and other proteins released from platelets may contribute to atherosclerosis and to the thrombosis that complicates the disease. Moreover, as soluble extracellular proteins, they may prove suitable as novel therapeutic targets.
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Cites
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Platelet Activation and Atherothrombosis
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Platelets: The missing link between the blood and brain?
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Activated Platelets Induce Estrogen Receptor β Expression in Endometriotic Stromal Cells
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Metadata
- Authors
- Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J. P., Cahill, D. J., Emili, A., Fitzgerald, D. J., & Maguire, P. B.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-03-15
- Volume
- 103
- Issue
- 6
- Pages
- 2096-2104
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2041340494
- Cited by
- 814
- References
- 4
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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