Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism
Open accessAbstract
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To advance our understanding of the biology contributing to VTE, we conducted a genome-wide association study (GWAS) of VTE and a transcriptome-wide association study (TWAS) based on imputed gene expression from whole blood and liver. We meta-analyzed GWAS data from 18 studies for 30 234 VTE cases and 172 122 controls and assessed the association between 12 923 718 genetic variants and VTE. We generated variant prediction scores of gene expression from whole blood and liver tissue and assessed them for association with VTE. Mendelian randomization analyses were conducted for traits genetically associated with novel VTE loci. We identified 34 independent genetic signals for VTE risk from GWAS meta-analysis, of which 14 are newly reported associations. This included 11 newly associated genetic loci (C1orf198, PLEK, OSMR-AS1, NUGGC/SCARA5, GRK5, MPHOSPH9, ARID4A, PLCG2, SMG6, EIF5A, and STX10) of which 6 replicated, and 3 new independent signals in 3 known genes. Further, TWAS identified 5 additional genetic loci with imputed gene expression levels differing between cases and controls in whole blood (SH2B3, SPSB1, RP11-747H7.3, RP4-737E23.2) and in liver (ERAP1). At some GWAS loci, we found suggestive evidence that the VTE association signal for novel and previously known regions colocalized with expression quantitative trait locus signals. Mendelian randomization analyses suggested that blood traits may contribute to the underlying risk of VTE. To conclude, we identified 16 novel susceptibility loci for VTE; for some loci, the association signals are likely mediated through gene expression of nearby genes.
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Common genetic variants in PLCG2 link the enzyme to type 1 diabetes and venous thromboembolism.
“Common genetic variants in PLCG2 also link the enzyme to type 1 diabetes (119) and venous thromboembolism (120), which could have a shared autoimmune etiology.”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [120]
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Bowden, J., Davey Smith, G., & Burgess, S. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv080 · Cited by 9,816 · see citing works
Bowden, J., Davey Smith, G., Haycock, P. C., & Burgess, S. (2016) · Genetic Epidemiology · doi:10.1002/gepi.21965 · Cited by 8,922 · see citing works
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279 · see citing works
Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
Burgess, S., Butterworth, A., & Thompson, S. G. (2013) · Genetic Epidemiology · doi:10.1002/gepi.21758 · Cited by 6,050 · see citing works
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, B. K., Loh, P.-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., & Neale, B. M. (2015) · Nature Genetics · doi:10.1038/ng.3211 · Cited by 5,559 · see citing works
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
Common SNPs explain a large proportion of the heritability for human height
Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446 · see citing works
Giambartolomei, C., Vukcevic, D., Schadt, E. E., Franke, L., Hingorani, A. D., Wallace, C., & Plagnol, V. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004383 · Cited by 4,261 · see citing works
Mutation in blood coagulation factor V associated with resistance to activated protein C
Bertina, R. M., Koeleman, B. P. C., Koster, T., Rosendaal, F. R., Dirven, R. J., de Ronde, H., van der Velden, P. A., & Reitsma, P. H. (1994) · Nature · doi:10.1038/369064a0 · Cited by 3,769 · see citing works
Self-citationTrends in the Incidence of Deep Vein Thrombosis and Pulmonary Embolism
Silverstein, M. D., Heit, J. A., Mohr, D. N., Petterson, T. M., O’Fallon, W. M., & Melton, L. J. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.6.585 · Cited by 2,653 · see citing works
Self-citationIntegrative approaches for large-scale transcriptome-wide association studies
Gusev, A., Ko, A., Shi, H., Bhatia, G., Chung, W., Penninx, B. W. J. H., Jansen, R., de Geus, E. J. C., Boomsma, D. I., Wright, F. A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3506 · Cited by 2,479 · see citing works
Ward, L. D., & Kellis, M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr917 · Cited by 2,229 · see citing works
EPIC- InterAct Consortium, Burgess, S., Scott, R. A., Timpson, N. J., Davey Smith, G., & Thompson, S. G. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0011-z · Cited by 1,803 · see citing works
Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Yang, J., DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Ferreira, T., Morris, A. P., Medland, S. E., Madden, P. A. F., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2012) · Nature Genetics · doi:10.1038/ng.2213 · Cited by 1,712 · see citing works
Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten‐Jacobs, L. C. A., Giese, A., van der Laan, S. W., Grétarsdóttir, S., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0058-3 · Cited by 1,566 · see citing works
Self-citationPower and predictive accuracy of polygenic risk scores
Dudbridge, F. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003348 · Cited by 1,509 · see citing works
Association analysis identifies 65 new breast cancer risk loci
Michailidou, K., Lindström, S., Dennis, J., Beesley, J., Hui, S., Kar, S., Lemaçon, A., Soucy, P., Glubb, D. M., Rostamianfar, A., et al. (2017) · Nature · doi:10.1038/nature24284 · Cited by 1,380 · see citing works
Self-citationPredictors of Recurrence After Deep Vein Thrombosis and Pulmonary Embolism
Heit, J. A., Mohr, D. N., Silverstein, M. D., Petterson, T. M., O’Fallon, W. M., & Melton, L. J. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.6.761 · Cited by 1,348 · see citing works
Self-citationThe Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle, W. J., Elding, H., Jiang, T., Allen, D., Ruklisa, D., Mann, A. L., Mead, D., Bouman, H., Riveros-Mckay, F., Kostadima, M. A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.042 · Cited by 1,224 · see citing works
van der Harst, P., & Verweij, N. (2018) · Circulation Research · doi:10.1161/circresaha.117.312086 · Cited by 1,141 · see citing works
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Collaborative Association Study of Psoriasis (CASP), Tsoi, L. C., Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium 2, Spain, S. L., Knight, J., Ellinghaus, E., Stuart, P. E., Capon, F., et al. (2012) · Nature Genetics · doi:10.1038/ng.2467 · Cited by 1,024 · see citing works
Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis
Koupenova, M., Clancy, L., Corkrey, H. A., & Freedman, J. E. (2018) · Circulation Research · doi:10.1161/circresaha.117.310795 · Cited by 998 · see citing works
Cortés, A., Hadler, J. S., Robinson, P. C., Leo, P., Cremin, K., Pryce, K., Harris, J., Bradbury, L. A., Kenna, T., Yang, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2667 · Cited by 855 · see citing works
Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J. P., Cahill, D. J., Emili, A., Fitzgerald, D. J., & Maguire, P. B. (2003) · Blood · doi:10.1182/blood-2003-08-2804 · Cited by 813 · see citing works
Pe'er, I., Yelensky, R., Altshuler, D., & Daly, M. J. (2008) · Genetic Epidemiology · doi:10.1002/gepi.20303 · Cited by 783 · see citing works
The International IBD Genetics Consortium (IIBDGC), Ellinghaus, D., International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Genetic Analysis of Psoriasis Consortium (GAPC), Psoriasis Association Genetics Extension (PAGE), Jostins, L., Spain, S. L., Cortes, A., Bethune, J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3528 · Cited by 751 · see citing works
Estimation of significance thresholds for genomewide association scans
Dudbridge, F., & Gusnanto, A. (2008) · Genetic Epidemiology · doi:10.1002/gepi.20297 · Cited by 703 · see citing works
Predictors of Survival After Deep Vein Thrombosis and Pulmonary Embolism
Heit, J. A., Silverstein, M. D., Mohr, D. N., Petterson, T. M., O’Fallon, W. M., & Melton, L. J. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.5.445 · Cited by 590 · see citing works
Self-citationKirino, Y., Bertsias, G. K., Ishigatsubo, Y., Mizuki, N., Tuğal-Tutkun, İ., Seyahi, E., Özyazgan, Y., Sacli, F. S., Erer, B., Inoko, H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2520 · Cited by 557 · see citing works
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531 · see citing works
Quality control and conduct of genome-wide association meta-analyses
Winkler, T. W., Day, F. R., Croteau‐Chonka, D. C., Wood, A. R., Locke, A. E., Mägi, R., Ferreira, T., Fall, T., Graff, M., Justice, A. E., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.071 · Cited by 502 · see citing works
New gene functions in megakaryopoiesis and platelet formation
Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic‐Canic, J., Elling, U., Goodall, A. H., Labrune, Y., et al. (2011) · Nature · doi:10.1038/nature10659 · Cited by 404 · see citing works
Self-citationSmith, N. L., Chen, M., Dehghan, A., Strachan, D. P., Basu, S., Soranzo, N., Hayward, C., Rudan, I., Sabater‐Lleal, M., Bis, J. C., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.869156 · Cited by 369 · see citing works
Self-citationHeritability and genomics of gene expression in peripheral blood
Wright, F. A., Sullivan, P. F., Brooks, A. I., Zou, F., Sun, W., Xia, K., Madar, V., Jansen, R., Chung, W., Zhou, Y.-H., et al. (2014) · Nature Genetics · doi:10.1038/ng.2951 · Cited by 362 · see citing works
Byrnes, J. R., & Wolberg, A. S. (2017) · Blood · doi:10.1182/blood-2017-03-745349 · Cited by 346 · see citing works
Trégouët, D., Heath, S. C., Saut, N., Biron‐Andréani, C., Schved, J., Pernod, G., Galan, P., Drouet, L. O., Zélénika, D., Juhan-Vague, I., et al. (2009) · Blood · doi:10.1182/blood-2008-11-190389 · Cited by 318 · see citing works
Self-citationVENOUS THROMBOEMBOLIC DISEASE AND ABO BLOOD TYPE
Jick, H., Westerholm, B., Vessey, M., Lewis, G., Slone, D., Inman, W. W., Shapiro, S., & Worcester, J. (1969) · The Lancet · doi:10.1016/s0140-6736(69)91955-2 · Cited by 317 · see citing works
Gene Variants Associated With Deep Vein Thrombosis
Bezemer, I. D. (2008) · JAMA · doi:10.1001/jama.299.11.1306 · Cited by 303 · see citing works
Behçet's syndrome: disease manifestations, management, and advances in treatment
Yazıcı, H., Fresko, İ., & Yurdakul, S. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0436 · Cited by 286 · see citing works
Beavan, T. E. D. (1964) · The Lancet · doi:10.1016/s0140-6736(64)92923-x · Cited by 283 · see citing works
Germain, M., Chasman, D. I., de Haan, H. G., Tang, W., Lindström, S., Weng, L.-C. C., de Andrade, M., de Visser, M. C. H., Wiggins, K. L., Suchon, P., et al. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.01.019 · Cited by 263 · see citing works
Self-citationThe Genotype-Tissue Expression (GTEx) project
Lonsdale, J., Thomas, J., Salvatore, M., Phillips, R., Lo, E., Shad, S., Hasz, R., Walters, G., Garcia, F., Young, N., et al. (2013) · Nature Genetics · doi:10.1038/ng.2653 · Cited by 263 · see citing works
de Willige, S. U., de Visser, M. C. H., Houwing‐Duistermaat, J. J., Rosendaal, F. R., Vos, H. L., & Bertina, R. M. (2005) · Blood · doi:10.1182/blood-2005-05-2180 · Cited by 250 · see citing works
Self-citationGenome-Wide Complex Trait Analysis (GCTA): Methods, Data Analyses, and Interpretations
Yang, J., Lee, S., Goddard, M. E., & Visscher, P. M. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-447-0_9 · Cited by 236 · see citing works
Klarin, D. M., Program, V. A. M. V., Busenkell, E., Judy, R., Lynch, J. A., Levin, M. G., Haessler, J., Aragam, K. G., Chaffin, M. D., Haas, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0519-3 · Cited by 236 · see citing works
Self-citationAssociation of Genetic Variations With Nonfatal Venous Thrombosis in Postmenopausal Women
Smith, N. L., Hindorff, L. A., Heckbert, S. R., Lemaître, R. N., Marciante, K. D., Rice, K. M., Lumley, T., Bis, J. C., Wiggins, K. L., Rosendaal, F. R., et al. (2007) · JAMA · doi:10.1001/jama.297.5.489 · Cited by 206 · see citing works
Self-citationThe genetics of venous thromboembolism
Gohil, R., Peck, G., & Sharma, P. K. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-01-0013 · Cited by 193 · see citing works
Giese, A., Adams, H. H. H., Chen, W.-M., Bakker, P. I. W. D., Hsu, F., Lee, J.-M., Lin, W.-Y., O'Donnell, M. J., Salomaa, V. V., Sapkota, B. R., et al. (2018) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/27851 · Cited by 189 · see citing works
Self-citationSabater‐Lleal, M., Huffman, J. E., de Vries, P. S., Marten, J., Mastrangelo, M. A., Song, C., Pankratz, N., Ward-Caviness, C. K., Yanek, L. R., Trompet, S., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.034532 · Cited by 168 · see citing works
Self-citationHeritability in the genome-wide association era
Zaitlen, N., & Kraft, P. L. (2012) · Human Genetics · doi:10.1007/s00439-012-1199-6 · Cited by 156 · see citing works
Self-citationHeit, J. A., Armasu, S. M., Asmann, Y. W., Cunningham, J. M., Matsumoto, M., Petterson, T. M., & de Andrade, M. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04810.x · Cited by 156 · see citing works
Self-citationGenetics of Venous Thrombosis: Insights from a New Genome Wide Association Study
Germain, M., Saut, N., Greliche, N., Christian Dina, C., Lambert, J., Perret, C., Cohen, W., Oudot‐Mellakh, T., Antoni, G., Alessi, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025581 · Cited by 155 · see citing works
Self-citation[Genetics of venous thromboembolism].
Alhenc‐Gelas, M., & Aiach, M. (2003) · PubMed · Cited by 152 · see citing works
Lin, D. Y., & Zeng, D. (2009) · Genetic Epidemiology · doi:10.1002/gepi.20435 · Cited by 151 · see citing works
Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis
Arita, K., South, A. P., Filho, G. H., Sakuma, T. H., Lai‐Cheong, J. E., Clements, S. E., Odashiro, M., Odashiro, D. N., Hans-Neto, G., Hans, N. R., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.002 · Cited by 149 · see citing works
Genetic variants associated with deep vein thrombosis: the F11 locus
Li, Y., Bezemer, I. D., Rowland, C. M., Tong, C. H., Arellano, A. R., Catanese, J. J., Devlin, J. J., Reitsma, P. H., Bare, L. A., & Rosendaal, F. R. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03544.x · Cited by 128 · see citing works
Self-citationImputation and quality control steps for combining multiple genome-wide datasets
Verma, S. S., de Andrade, M., Tromp, G., Kuivaniemi, H., Pugh, E., Namjou‐Khales, B., Mukherjee, S., Jarvik, G. P., Kottyan, L. C., Burt, A., et al. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00370 · Cited by 127 · see citing works
Rezende, S. M., Lijfering, W. M., Rosendaal, F. R., & Cannegieter, S. C. (2013) · Haematologica · doi:10.3324/haematol.2013.083840 · Cited by 123 · see citing works
Self-citationHuang, J., Sabater‐Lleal, M., Asselbergs, F. W., Trégouët, D., Shin, S., Ding, J., Baumert, J. J., Oudot‐Mellakh, T., Folkersen, L., Johnson, A. D., et al. (2012) · Blood · doi:10.1182/blood-2012-06-436188 · Cited by 122 · see citing works
Self-citationHinds, D. A., Buil, A., Ziemek, D., Martínez-Pérez, Á., Malik, R., Folkersen, L., Germain, M., Mälarstig, A., Brown, A. A., Soria, J. M., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw037 · Cited by 122 · see citing works
Self-citationTang, W., Teichert, M., Chasman, D. I., Heit, J. A., Morange, P., Guo, L., Pankratz, N., Leebeek, F. W. G., Paré, G., de Andrade, M., et al. (2013) · Genetic Epidemiology · doi:10.1002/gepi.21731 · Cited by 120 · see citing works
Self-citationKlarin, D. M., Emdin, C. A., Natarajan, P., Conrad, M. F., & Kathiresan, S. (2017) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.116.001643 · Cited by 117 · see citing works
Self-citationMeta‐analysis of sex‐specific genome‐wide association studies
Mägi, R., Lindgren, C. M., & Morris, A. P. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20540 · Cited by 115 · see citing works
Eriksson, J. K., Jacobsson, L., Bengtsson, K., & Askling, J. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209315 · Cited by 113 · see citing works
Smith, N. L., Rice, K. M., Bovill, E. G., Cushman, M., Bis, J. C., McKnight, B., Lumley, T., Glazer, N. L., Vlieg, A. V. H., Tang, W., et al. (2010) · Blood · doi:10.1182/blood-2010-10-315473 · Cited by 110 · see citing works
Self-citationTang, W., Schwienbacher, C., Lopez, L. M., Ben‐Shlomo, Y., Oudot‐Mellakh, T., Johnson, A. D., Samani, N. J., Basu, S., Gögele, M., Davies, G., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.05.009 · Cited by 102 · see citing works
Self-citationWells, P. S., Anderson, J. L., Scarvelis, D., Doucette, S. P., & Gagnon, F. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj179 · Cited by 96 · see citing works
Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
Eicher, J. D., Chami, N., Kacprowski, T., Nomura, A., Chen, M., Yanek, L. R., Tajuddin, S. M., Schick, U. M., Slater, A. J., Pankratz, N., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.05.005 · Cited by 96 · see citing works
Self-citationA meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
de Vries, P. S., Chasman, D. I., Sabater‐Lleal, M., Chen, M., Huffman, J. E., Steri, M., Tang, W., Teumer, A., Marioni, R. E., Grossmann, V., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv454 · Cited by 94 · see citing works
Self-citationTsantes, A. Ε., Nikolopoulos, G. K., Bagos, P. G., Rapti, E., Mantzios, G., Kapsimali, V., & Travlou, Α. (2007) · PubMed · Cited by 93 · see citing works
Rossi, E., & Stefano, V. D. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-01-0011 · Cited by 90 · see citing works
A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts
Lindström, S., Loomis, S. J., Turman, C., Huang, H., Huang, J., Aschard, H., Chan, A. T., Choi, H. K., Cornelis, M. C., Curhan, G. C., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173997 · Cited by 88 · see citing works
Self-citationAssociation between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis
Tsantes, A. Ε., Bagos, P. G., Rapti, E., Mantzios, G., Kapsimali, V., Travlou, Α., & Nikolopoulos, G. K. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-12-0745 · Cited by 82 · see citing works
Austin, H. D., Staercke, C. D., Lally, C. A., Bezemer, I. D., Rosendaal, F. R., & Hooper, W. C. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04185.x · Cited by 80 · see citing works
Self-citationDennis, J., Johnson, C. Y., Adediran, A. S., de Andrade, M., Heit, J. A., Morange, P.-E., Trégouët, D.-A., & Gagnon, F. (2012) · Blood · doi:10.1182/blood-2011-10-383448 · Cited by 78 · see citing works
Self-citationBuil, A., Trégouët, D., Souto, J. C., Saut, N., Germain, M., Rotival, M., Tiret, L., Cambien, F., Lathrop, M. G., Zeller, T., et al. (2010) · Blood · doi:10.1182/blood-2010-01-263038 · Cited by 76 · see citing works
Self-citationWhole-exome sequencing in evaluation of patients with venous thromboembolism
Lee, E., Dykas, D. J., Leavitt, A. D., Camire, R. M., Ebberink, E. H. T. M., de Frutos, P. G., Gnanasambandan, K., Gu, S. X., Huntington, J. A., Lentz, S. R., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017005249 · Cited by 74 · see citing works
Danjou, F., Żołędziewska, M., Sidore, C., Steri, M., Busonero, F., Maschio, A., Mulas, A., Perseu, L., Barella, S., Porcu, E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3307 · Cited by 71 · see citing works
Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults
Smith, N. L., Huffman, J. E., Strachan, D. P., Huang, J., Dehghan, A., Trompet, S., Lopez, L. M., Shin, S., Baumert, J. J., Vitart, V., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.009480 · Cited by 70 · see citing works
Self-citationKNG1 Ile581Thr and susceptibility to venous thrombosis
Morange, P., Oudot‐Mellakh, T., Cohen, W., Germain, M., Saut, N., Antoni, G., Alessi, M., Bertrand, M., Dupuy, A., Letenneur, L., et al. (2011) · Blood · doi:10.1182/blood-2010-11-319053 · Cited by 67 · see citing works
Self-citationMorange, P., Bezemer, I. D., Saut, N., Bare, L. A., Burgos, G., Brocheton, J., Durand, H., Biron‐Andréani, C., Schved, J., Pernod, G., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.02.011 · Cited by 63 · see citing works
Self-citationPsoriasis and risk of venous thromboembolism: a systematic review and meta-analysis
Ungprasert, P., Sanguankeo, A., Upala, S., & Suksaranjit, P. (2014) · QJM · doi:10.1093/qjmed/hcu073 · Cited by 61 · see citing works
Novel genetic predictors of venous thromboembolism risk in African Americans
Hernandez, W., Gamazon, E. R., Smithberger, E., O’Brien, T. J., Harralson, A. F., Tuck, M., Barbour, A., Kittles, R. A., Cavallari, L. H., & Perera, M. A. (2016) · Blood · doi:10.1182/blood-2015-09-668525 · Cited by 59 · see citing works
de Vries, P. S., Sabater‐Lleal, M., Huffman, J. E., Marten, J., Song, C., Pankratz, N., Bartz, T. M., de Haan, H. G., Delgado, G. E., Eicher, J. D., et al. (2019) · Blood · doi:10.1182/blood-2018-05-849240 · Cited by 55 · see citing works
Self-citationMarik, P. E., & Cavallazzi, R. (2015) · PLOS ONE · doi:10.1371/journal.pone.0143252 · Cited by 53 · see citing works
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Egeberg, O. (1965) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516509077290 · Cited by 49 · see citing works
Huang, J., Huffman, J. E., Yamakuchi, M., Trompet, S., Asselbergs, F. W., Sabater‐Lleal, M., Trégouët, D., Chen, W., Smith, N. L., Kleber, M. E., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302088 · Cited by 48 · see citing works
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Bucciarelli, P., Maino, A., Felicetta, I., Abbattista, M., Passamonti, S. M., Artoni, A., & Martinelli, I. (2015) · Thrombosis Research · doi:10.1016/j.thromres.2015.07.020 · Cited by 47 · see citing works
Sennblad, B., Basu, S., Mazur, J., Suchon, P., Martínez-Pérez, Á., Vlieg, A. V. H., Trương, V., Li, Y., Gådin, J. R., Tang, W., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw401 · Cited by 46 · see citing works
Self-citationFröbel, J., Cadeddu, R., Hartwig, S., Bruns, I., Wilk, C. M., Kündgen, A., Fischer, J., Schroeder, T. A., Steidl, U. G., Germing, U., et al. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.023168 · Cited by 42 · see citing works
Identification of unique venous thromboembolism-susceptibility variants in African-Americans
Armasu, S. M., McCauley, B. M., Kullo, I., Sicotte, H., Pathak, J., Chute, C. G., Gottesman, O., Böttinger, E. P., Denny, J. C., Roden, D. M., et al. (2017) · Thrombosis and Haemostasis · doi:10.1160/th16-08-0652 · Cited by 34 · see citing works
Self-citationLappegård, J., Skjelbakken, T., Brækkan, S. K., Hansen, J., & Ellingsen, T. S. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-04-0335 · Cited by 34 · see citing works
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Bezemer, I. D., Arellano, A. R., Tong, C. H., Rowland, C. M., Ireland, H., Bauer, K. A., Catanese, J. J., Reitsma, P. H., Doggen, C. J. M., Devlin, J. J., et al. (2009) · Haematologica · doi:10.3324/haematol.2008.003020 · Cited by 32 · see citing works
Self-citationSchneppenheim, R., Hellermann, N., Brehm, M. A., Klemm, U., Obser, T., Huck, V., Schneider, S. W., Denis, C. V., Tischer, A., Auton, M. T., et al. (2018) · Blood · doi:10.1182/blood-2018-04-843425 · Cited by 29 · see citing works
Morange, P., Saut, N., Antoni, G., Emmerich, J., & Trégouët, D. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04082.x · Cited by 24 · see citing works
Self-citationYen, T., Lu, W., Lien, L.-M., Thomas, P. A., Lee, T.-Y., Chiu, H., Sheu, J., & Lin, K. (2014) · BioMed Research International · doi:10.1155/2014/728019 · Cited by 19 · see citing works
Hanson, E., Nilsson, S., Jood, K., Norrving, B. G., Engström, G., Blomstrand, C., Lindgren, A., Melander, O., & Jern, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075286 · Cited by 14 · see citing works
Venous Thromboembolism Prophylaxis after Hip or Knee Arthroplasty
Anderson, D. R., Doucette, S. P., & Kahn, S. R. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1803708 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Egeberg O. Thrombophilia caused by inheritable deficiency of blood anti- thrombin. Scand J Clin Lab Invest. 1965; 17(1):92.
- Klarin D, Busenkell E, Judy R, et al. Genetic analysis of venous thromboembolism high- lights the genetic overlap of thrombosis with lipids and arterial vascular disease. Nat Genet. In press.
- Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating platelets as medi- ators of immunity, inflammation, and throm- bosis. Circ Res. 2018;122(2):337-351.
Cited by
Sorted by citations
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Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Alonso, A., Beaton, A. Z., Bittencourt, M. S., Boehme, A. K., Buxton, A. E., Carson, A. P., Commodore-Mensah, Y., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001052 · Cited by 5,987 · see citing works
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Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000950 · Cited by 5,784 · see citing works
Khan, F., Tritschler, T., Kahn, S. R., & Rodger, M. A. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32658-1 · Cited by 789 · see citing works
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Mishra, A., Malik, R., Hachiya, T., Jürgenson, T., Namba, S., Posner, D. C., Kamanu, F., Koido, M., Grand, Q. L., Shi, M., et al. (2022) · Nature · doi:10.1038/s41586-022-05165-3 · Cited by 593 · see citing works
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Zietz, M., Zucker, J. E., & Tatonetti, N. P. (2020) · Nature Communications · doi:10.1038/s41467-020-19623-x · Cited by 577 · see citing works
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O’Sullivan, J. W., Raghavan, S., Márquez‐Luna, C., Luzum, J. A., Damrauer, S. M., Ashley, E. A., O’Donnell, C. J., Willer, C. J., & Natarajan, P. (2022) · Circulation · doi:10.1161/cir.0000000000001077 · Cited by 424 · see citing works
Self-citationKlarin, D. M., Program, V. A. M. V., Busenkell, E., Judy, R., Lynch, J. A., Levin, M. G., Haessler, J., Aragam, K. G., Chaffin, M. D., Haas, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0519-3 · Cited by 236 · see citing works
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Desch, K. C., Ozel, A. B., Halvorsen, M., Jacobi, P. M., Golden, K. L., Underwood, M. I., Germain, M., Trégouët, D., Reitsma, P. H., Kearon, C., et al. (2020) · Blood · doi:10.1182/blood.2019004161 · Cited by 56 · see citing works
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Rodriguez, B. A. T., Bhan, A., Beswick, A. D., Elwood, P. C., Niiranen, T., Salomaa, V. V., Trégouët, D., Morange, P., Civelek, M., Ben‐Shlomo, Y., et al. (2020) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2020.06.008 · Cited by 46 · see citing works
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Romiti, G. F., Corica, B., Borgi, M., Visioli, G., Pacella, E., Cangemi, R., Proietti, M., Basili, S., & Raparelli, V. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15068 · Cited by 36 · see citing works
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Manderstedt, E., Lind‐Halldén, C., Halldén, C., Elf, J. L., Svensson, P. J., Dahlbäck, B., Engström, G., Melander, O., Baras, A., Lotta, L. A., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.023018 · Cited by 34 · see citing works
Nazarzadeh, M., Bidel, Z., Mohseni, H., Canoy, D., Pinho‐Gomes, A., Hassaïne, A., Dehghan, A., Trégouët, D., Smith, N. L., & Rahimi, K. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac135 · Cited by 34 · see citing works
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Gueuning, M., Thun, G. A., Wittig, M., Galati, A.-L., Meyer, S., Trost, N., Gourri, E., Fuß, J., Sigurdardottir, S., Merki, Y., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007133 · Cited by 33 · see citing works
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Li, J., Lu, A., Si, S., Zhang, K., Tang, F., Yang, F., & Xue, F. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157165 · Cited by 26 · see citing works
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Chen, Y., Li, H., Lai, L., Feng, Q., & Shen, J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.572194 · Cited by 22 · see citing works
Swystun, L. L., Michels, A., & Lillicrap, D. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.04.014 · Cited by 21 · see citing works
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Razzaq, M., Iglesias, M. J., Ibrahim‐Kosta, M., Goumidi, L., Soukarieh, O., Proust, C., Roux, M., Suchon, P., Boland, A., Daiain, D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93390-7 · Cited by 20 · see citing works
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Damoah, C. E., Snir, O., Hindberg, K., Garred, P., Ludviksen, J. K., Brækkan, S. K., Morelli, V. M., Mollnes, T. E., & Hansen, J. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.317746 · Cited by 16 · see citing works
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Self-citationTan, M. C. B., Isom, C. A., Liu, Y., Trégouët, D., Lindström, S., Wang, L., Smith, E. N., Gordon, W., Vlieg, A. V. H., de Andrade, M., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105233 · Cited by 16 · see citing works
Self-citationMeta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus.
Mathey, C. M., Maj, C., Eriksson, N., Krebs, K., Westmeier, J., David, F. S., Koromina, M., Scheer, A. B., Szabo, N., Wedi, B., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.11.921 · Cited by 15 · see citing works
Guman, N. A. M., Mulder, F. I., Ferwerda, B., Zwinderman, A. H., Kamphuisen, P. W., Buller, H. R., & van Es, N. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.07.009 · Cited by 15 · see citing works
Drăgan, A., & Drăgan, A. Ş. (2024) · Cancers · doi:10.3390/cancers16020458 · Cited by 15 · see citing works
Proteomics in thrombosis research
Edfors, F., Iglesias, M. J., Butler, L. M., & Odeberg, J. (2022) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12706 · Cited by 14 · see citing works
The Importance of Glycosylation in COVID-19 Infection
Pribić, T., Lauc, G., & Trbojević‐Akmačić, I. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-70115-4_12 · Cited by 14 · see citing works
Genetic associations of protein-coding variants in venous thromboembolism
He, X., Wu, B., Liu, Y., Yu, C., Deng, Y., Li, Z.-Y., Fei, C.-J., Liu, W., Ge, Y., Kang, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47178-8 · Cited by 14 · see citing works
The X chromosome’s influences on the human brain
Jiang, Z., Sullivan, P. F., Li, T., Zhao, B., Wang, X., Luo, T., Huang, S.-C., Guan, P. Y., Chen, J., Yang, Y., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq5360 · Cited by 19 · see citing works
Morange, P., Peiretti, F., Gourhant, L., Proust, C., Soukarieh, O., Pulcrano-Nicolas, A.-S., Saripella, G. V., Stefanucci, L., Lacroix, R., Ibrahim‐Kosta, M., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009284 · Cited by 14 · see citing works
Self-citationGenes and proteins associated with the risk for cancer-associated thrombosis
Buijs, J. T., & Versteeg, H. H. (2020) · Thrombosis Research · doi:10.1016/s0049-3848(20)30396-0 · Cited by 14 · see citing works
Zöller, B., Pirouzifard, M., Svensson, P. J., Holmquist, B., Stenman, E., Elston, R. C., Song, Y. E., Sundquist, J., & Sundquist, K. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020323 · Cited by 13 · see citing works
Manderstedt, E., Halldén, C., Lind‐Halldén, C., Elf, J. L., Svensson, P. J., Engström, G., Melander, O., Baras, A., Lotta, L. A., Zöller, B., et al. (2022) · Thrombosis and Haemostasis · doi:10.1055/a-1738-1564 · Cited by 13 · see citing works
Li, N., An, P., Wang, J., Zhang, T., Qing, X., Wu, B., Sun, L., Ding, X. D., Niu, L., Xie, Z., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104091 · Cited by 13 · see citing works
A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity
Xu, H., Knauss, E. A., de la Fuente, M., Li, W., Conlon, R. A., LePage, D. F., Jiang, W., Renna, S. A., McKenzie, S. E., & Nieman, M. T. (2024) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2024.03.004 · Cited by 13 · see citing works
Limperger, V., Kenet, G., Kiesau, B., Köther, M., Schmeiser, M., Länger, F. P., Juhl, D., Shneyder, M., Franke, A., Klostermeier, U. C., et al. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02169-6 · Cited by 13 · see citing works
Immunological analysis and differential genes screening of venous thromboembolism
Gao, L.-N., Li, Q., Xie, J.-Q., Yang, W.-X., & You, C.-G. (2021) · Hereditas · doi:10.1186/s41065-020-00166-6 · Cited by 12 · see citing works
Sex chromosomes and cardiovascular disease
Spiering, A. E., Groenheide, P. J., Mokrý, M., Onland‐Moret, N. C., Civelek, M., Reue, K., Benavente, E. D., & den Ruijter, H. M. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf224 · Cited by 12 · see citing works
Sacchetti, S., Puricelli, C., Mennuni, M. G., Zanotti, V., Giacomini, L., Giordano, M., Dianzani, U., Patti, G., & Rolla, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052523 · Cited by 17 · see citing works
Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program
Seyerle, A. A., Laurie, C. A., Coombes, B. J., Jain, D., Conomos, M. P., Brody, J. A., Chen, M., Gogarten, S. M., Beutel, K. M., Gupta, N., et al. (2023) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.121.003532 · Cited by 12 · see citing works
Self-citationThe Risk of Venous Thromboembolism Attributed to Established Prothrombotic Genotypes
Evensen, L. H., Arnesen, C. A. L., Rosendaal, F. R., Gabrielsen, M. E., Brumpton, B. M., Hveem, K., Hansen, J., & Brækkan, S. K. (2021) · Thrombosis and Haemostasis · doi:10.1055/a-1698-6717 · Cited by 12 · see citing works
Self-citationBocher, O., Ludwig, T. E., Ogloblinsky, M. C., Marenne, G., Deleuze, J., Suryakant, S., Odeberg, J., Morange, P., Trégouët, D., Perdry, H., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1009923 · Cited by 11 · see citing works
Self-citationMunsch, G., Goumidi, L., Vlieg, A. V. H., Ibrahim‐Kosta, M., Bruzelius, M., Deleuze, J., Rosendaal, F. R., Jacqmin‐Gadda, H., Morange, P., & Trégouët, D. (2023) · BMC Medical Research Methodology · doi:10.1186/s12874-023-01915-7 · Cited by 11 · see citing works
Self-citationYuan, S., Li, X., Morange, P., Bruzelius, M., & Larsson, S. C. (2022) · Nutrients · doi:10.3390/nu14163354 · Cited by 11 · see citing works
Self-citationVerdier, H., Thomas, P., Batista, J., Kempster, C., McKinney, H., Gleadall, N., Danesh, J., Mumford, A. D., Heemskerk, J. W. M., Ouwehand, W. H., et al. (2023) · Blood · doi:10.1182/blood.2023021100 · Cited by 10 · see citing works
Zhu, Q. M., Hsu, Y.-H. H., Lassen, F. H., MacDonald, B. T., Stead, S. M., Małolepsza, E., Kim, A., Li, T., Mizoguchi, T., Schenone, M., et al. (2024) · Communications Biology · doi:10.1038/s42003-023-05705-1 · Cited by 10 · see citing works
Multi-ancestry polygenic risk scores for venous thromboembolism
Jee, Y. H., Thibord, F., Dominguez, A., Sept, C. E., Boulier, K. M., Venkateswaran, V., Ding, Y., Cherlin, T., Verma, S. S., Faro, V. L., et al. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae097 · Cited by 10 · see citing works
Self-citationSerum albumin, genetic susceptibility, and risk of venous thromboembolism
Sun, Y.-Y., Deng, J., Ding, Y.-J., Luo, S., Li, S., Guan, Y., Cao, X., Hao, X.-J., & Hu, Y. (2024) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2024.102509 · Cited by 11 · see citing works
Manderstedt, E., Lind‐Halldén, C., Halldén, C., Elf, J. L., Svensson, P. J., Engström, G., Melander, O., Baras, A., Lotta, L. A., Zöller, B., et al. (2022) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12842 · Cited by 10 · see citing works
Srivastava, S., Kumari, B., Garg, I., Rai, C., Kumar, V., Yanamandra, U., Singh, J., Panjawani, U., Bansal, A., & Kumar, B. (2020) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2020.102421 · Cited by 10 · see citing works
Zhang, Y., Li, Z., Shen, D., Zhang, P., Fu, S., Yao, Y., Wang, J., Chen, P., Zhang, P., Zhang, X., et al. (2022) · Thrombosis and Haemostasis · doi:10.1055/s-0042-1744377 · Cited by 10 · see citing works
Liu, C., Hou, J., Li, W., Chen, J., Li, Y., Zhang, J., Zhou, W., Zhang, W., Deng, F., Wang, Y., et al. (2023) · Journal of Vascular Surgery Venous and Lymphatic Disorders · doi:10.1016/j.jvsv.2023.08.007 · Cited by 9 · see citing works
Hasbani, N. R., Westerman, K. E., Kwak, S. H., Chen, H., Li, X., DICORPO, D. A., Wessel, J., Bis, J. C., Sarnowski, C., Wu, P., et al. (2023) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.123.004176 · Cited by 9 · see citing works
Self-citationUpdate on pregnancy-associated venous thromboembolism
Langer, A. L., & Connell, N. T. (2022) · Thrombosis Update · doi:10.1016/j.tru.2022.100107 · Cited by 9 · see citing works
Folsom, A. R., Tang, W., Hong, C.-P., Rosamond, W. D., Lane, J., Cushman, M., & Pankratz, N. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280657 · Cited by 9 · see citing works
Self-citationPolygenic risk scores and risk stratification in deep vein thrombosis.
Faro, V. L., Johansson, T., Hoglund, J., Hadizadeh, F., & Johansson, Å. (2023) · Thrombosis Research · doi:10.1016/j.thromres.2023.06.011 · Cited by 5 · see citing works
Zöller, B., Sundquist, J., Sundquist, K., & Ohlsson, H. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.11.024 · Cited by 9 · see citing works
Björkman, L. S., Pirouzifard, M., Grover, S. P., Egesten, A., Sundquist, J., Sundquist, K., & Zöller, B. (2024) · Blood · doi:10.1182/blood.2023022996 · Cited by 9 · see citing works
Genetic landscape of thrombophilia in recurrent miscarriages
Athar, A., Kashyap, P., Khan, S., Sattar, R. S. A., Khan, S. A., Prasad, S., Husain, S. A., & Parveen, F. (2024) · Obstetrics & Gynecology Science · doi:10.5468/ogs.22084 · Cited by 9 · see citing works
The Roles of GRKs in Hemostasis and Thrombosis
Chen, X., Zhao, X., Cooper, M., & Ma, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155345 · Cited by 9 · see citing works
- Authors
- Lindström, S., Wang, L., Smith, E. N., Gordon, W., van Hylckama Vlieg, A., de Andrade, M., Brody, J. A., Pattee, J. W., Haessler, J., Brumpton, B. M., Chasman, D. I., Suchon, P., Chen, M.-H., Turman, C., Germain, M., Wiggins, K. L., MacDonald, J., Braekkan, S. K., Armasu, S. M., Pankratz, N., Jackson, R. D., Nielsen, J. B., Giulianini, F., Puurunen, M. K., Ibrahim, M., Heckbert, S. R., Damrauer, S. M., Natarajan, P., Klarin, D., Program, T. M. V., de Vries, P. S., Sabater-Lleal, M., Huffman, J. E., The CHARGE Hemostasis Working Group, Bammler, T. K., Frazer, K. A., McCauley, B. M., Taylor, K., Pankow, J. S., Reiner, A. P., Gabrielsen, M. E., Deleuze, J.-F., O'Donnell, C. J., Kim, J., McKnight, B., Kraft, P., Hansen, J.-B., Rosendaal, F. R., Heit, J. A., Psaty, B. M., Tang, W., Kooperberg, C., Hveem, K., Ridker, P. M., Morange, P.-E., Johnson, A. D., Kabrhel, C., Trégouët, D.-A., & Smith, N. L.
- Affiliations
- University of Washington (US)
- University of California San Diego (US)
- Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands;
- Department of Health Sciences Research, Mayo Clinic, Rochester, MN;
- University of Minnesota (US)
- Fred Hutch Cancer Center (US)
- Norwegian University of Science and Technology (NO)
- Brigham and Women's Hospital (US)
- Inserm (FR)
- National Institutes of Health (US)
- Harvard University (US)
- Université de Bordeaux (FR)
- K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT–The Arctic University of Norway, Tromsø, Norway;
- Mayo Clinic (US)
- The Ohio State University (US)
- University of Michigan (US)
- Framingham Heart Study (US)
- Hôpital de la Timone (FR)
- Kaiser Permanente Washington Health Research Institute (US)
- Philadelphia VA Medical Center (US)
- Broad Institute (US)
- The University of Texas Health Science Center at Houston (US)
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX;
- Unit of Genomics of Complex Diseases, Institut de Recerca de l’Hospital de Sant Pau, IIB-Sant Pau, Barcelona, Spain;
- University of California, Los Angeles (US)
- Department of Epidemiology, University of Washington, Seattle, WA;
- University Hospital of North Norway (NO)
- United States Department of Veterans Affairs (US)
- ORCID
- Lindström, Sara
- Wang, Lu
- Smith, Erin N.
- de Andrade, Mariza
- Brody, Jennifer A.
- Pattee, Jack W.
- Brumpton, Ben M.
- Chasman, Daniel I.
- Suchon, Pierre
- Chen, Ming-Huei
- Turman, Constance
- Germain, Marine
- Wiggins, Kerri L.
- MacDonald, James
- Armasu, Sebastian M.
- Pankratz, Nathan
- Nielsen, Jonas B.
- Puurunen, Marja K.
- Heckbert, Susan R.
- Damrauer, Scott M.
- Natarajan, Pradeep
- Klarin, Derek
- Sabater-Lleal, Maria
- Huffman, Jennifer E.
- Bammler, Theo K.
- Frazer, Kelly A.
- McCauley, Bryan M.
- Taylor, Kent
- Pankow, James S.
- Gabrielsen, Maiken E.
- Deleuze, Jean-François
- Kim, Jihye
- Kraft, Peter
- Rosendaal, Frits R.
- Heit, John A.
- Psaty, Bruce M.
- Tang, Weihong
- Kooperberg, Charles
- Hveem, Kristian
- Ridker, Paul M.
- Morange, Pierre-Emmanuel
- Johnson, Andrew D.
- Kabrhel, Christopher
- Trégouët, David-Alexandre
- Smith, Nicholas L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2019-08-16
- Volume
- 134
- Issue
- 19
- Pages
- 1645-1657
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC6871304
- OpenAlex
- W2968081931
- Cited by
- 223
- References
- 98
- Citations by year
- 2026: 15 · 2025: 31 · 2024: 34 · 2023: 45 · 2022: 38 · 2021: 38 · 2020: 18 · 2019: 4
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- Stiftelsen Kristian Gerhard Jebsen
- Agence Nationale de la Recherche (ANR-10-LABX-0013)
- National Institutes of Health (1r01hl120393-01a1, HL141791)
- National Heart, Lung, and Blood Institute (HL134894, R61HL141791, HL116854, R01-HL120393, R01HL134894, U01HL130114, HL141791, U01HL120393, HL139553, R01HL116854, R01HL059367, R01HL105756, R33HL141791, R01HL139553)
- National Cancer Institute (U01CA182913)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- venous thromboembolism, genetic susceptibility loci, transcriptome-wide association study, whole blood gene expression, hepatic gene expression, expression quantitative trait loci, Mendelian randomization, blood characteristics, pleckstrin, GRK5, PLCγ2, SMG6, eIF5A, SH2B3, ERAP1, thrombosis risk
- MeSH terms
- Humans, Genetic Predisposition to Disease, Venous Thromboembolism, Genome-Wide Association Study
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