The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Transfer of allogeneic CD62L– memory T cells without graft-versus-host disease
Abstract
The major challenge in allogeneic hematopoietic cell transplantation is how to transfer allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we report a novel strategy to selectively prevent GVHD by depleting CD62L+ T cells (naive and a subset of memory T cells). In unprimed mice, CD62L– T cells (a subset of memory T cells) failed to proliferate in response to alloantigens (which the mice have never previously encountered) and were unable to induce GVHD in allogeneic hosts. CD62L– T cells contributed to T-cell reconstitution by peripheral expansion as well as by promoting T-cell regeneration from bone marrow stem/progenitor cells. CD62L– T cells from the animals previously primed with a tumor cell line (BCL1) were able to inhibit the tumor growth in vivo but were unable to induce GVHD in the third-party recipients. This novel technology may allow transfer of allogeneic recall antitumor and antimicrobial immunity without causing GVHD.
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Cites
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Cited by
Host-reactive CD8+ memory stem cells in graft-versus-host disease
Zhang, Y., Joe, G., Hexner, E., Zhu, J., & Emerson, S. G. (2005) · Nature Medicine · doi:10.1038/nm1326 · Cited by 369
Outcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts
Bleakley, M., Heimfeld, S., Loeb, K. R., Jones, L. A., Chaney, C., Seropian, S., Gooley, T. A., Sommermeyer, F., Riddell, S. R., & Shlomchik, W. D. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81229 · Cited by 268
Minor Histocompatibility Antigen-Specific T Cells
Summers, C., Sheth, V. S., & Bleakley, M. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00284 · Cited by 37
Metadata
- Authors
- Chen, B. J., Cui, X., Sempowski, G. D., Liu, C., & Chao, N. J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-02-15
- Volume
- 103
- Issue
- 4
- Pages
- 1534-1541
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2068699102
- Cited by
- 262
- References
- 47
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, B. J., Cui, X., Sempowski, G. D., Liu, C., & Chao, N. J. (2004). Transfer of allogeneic CD62L– memory T cells without graft-versus-host disease. Blood. https://doi.org/10.1182/blood-2003-08-2987
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