T CELL MEMORY

Dutton, R. W.; Bradley, L. M.; Swain, S. L.

doi:10.1146/annurev.immunol.16.1.201

Cited by 832T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

T CELL MEMORY

Dutton, R. W., Bradley, L. M., Swain, S. L.·1998·Annual Review of Immunology

DOI 10.1146/annurev.immunol.16.1.201

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Abstract

▪ Abstract Immunological memory can be defined as the faster and stronger response of an animal that follows reexposure to the same antigen. By this definition, it is an operational property of the whole animal or the immune system. Memory cells express a different pattern of cell surface markers, and they respond in several ways that are functionally different from those of naive cells. Murine memory cells are CD44 high and low in the expression of activation markers such as CD25 (IL-2R), whereas human memory cells are CD45RA−, CD45RO+. In contrast to naive cells, memory cells secrete a full range of T cell cytokines and can be polarized to secrete particular restricted patterns of secretion for both CD4 and CD8 T cells. The requirements for the activation of memory cells for proliferation and cytokine production are not quite as strict as those of naive cells, but costimulation in the broad sense is required for optimum responses and for responses to suboptimum antigen concentrations. It would appear that memory cells can persist in the absence of antigenic stimulation and persist as nondividing cells. Reencounter with the same antigen can expand the population to a new, stable, higher level and generate a separate population of CD44 high effectors that may be required for protection, while competition from other antigens can drive it down to a lower stable level. It is unclear how or where memory cells arise, but once generated they have different pathways of recirculation and homing.

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Once the pathogen has been cleared, most effector T cells die by apoptosis, but some persist as long-lived memory T cells that provide enhanced responses upon re-exposure to the cognate Ag.
“Once the pathogen has been cleared most of the effector T cells die by apoptosis, but some of them persist as long-lived memory T cells that can provide enhanced responses upon re-exposure to the cognate Ag [132, 133].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [133]

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Untitled work
Tsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6
CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10
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Authors: Dutton, R. W., Bradley, L. M., & Swain, S. L.
Affiliations: Scripps Research Institute (US)
ORCID: Dutton, R. W.
Bradley, L. M.
Swain, S. L.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 1998-04
Volume: 16
Issue: 1
Pages: 201-223
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.16.1.201
OpenAlex: W2149764521
Cited by: 832
References: 119
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 13 · 2020: 6 · 2019: 8 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 24 · 2014: 15 · 2013: 15 · 2012: 28
FWCI: 6.26
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01ai037935-04)
National Institute of Allergy and Infectious Diseases (AI 37935)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: T cell memory, immunological memory, memory T cells, naive T cells, CD44, CD25, CD45RA, CD45RO, T cell cytokine secretion, T cell polarization, costimulation, secondary immune response
MeSH terms: Animals, Humans, Immunologic Memory, Phenotype, T-Lymphocyte Subsets

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