A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia
Abstract
Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism. (Blood. 2004;103:4672-4673)
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Cytoplasmic ferritin consists of 24 subunits of heavy and light chains in various ratios and can sequester 4,500 iron atoms.
“This ubiquitous protein consists of 24 subunits of heavy (H) and light (L) chains in various ratios and can sequester 4,500 iron atoms (125).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [125]
H expression is abundant in the heart, whereas the L subunit is predominant in the liver and spleen.
“H expression is abundant in the heart, whereas the L subunit is predominant in the liver and spleen (125).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [125]
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- Authors
- Harris, Z. L., Davis-Kaplan, S. R., Gitlin, J. D., & Kaplan, J.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Harris, Z. Leah
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-06-15
- Volume
- 103
- Issue
- 12
- Pages
- 4672-4673
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2118387359
- Cited by
- 33
- References
- 11
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 2 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 1 · 2013: 3 · 2012: 4
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058086, R01DK061763, DK58086, DK61763, DK30534)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- aceruloplasminemia, ceruloplasmin, multicopper oxidase, iron homeostasis, copper proteins, iron mobilization, phlebotomy, iron metabolism
- MeSH terms
- Animals, Ceruloplasmin, Fungal Proteins, Homeostasis, Iron, Transferrin, Gene Deletion, Saccharomyces cerevisiae Proteins, Mice
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