The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes
Open accessAbstract
MRP14 (S100A9) is the major calcium-binding protein of neutrophils and monocytes. Targeted gene disruption reveals an essential role of this S100 protein for transendothelial migration of phagocytes. The underlying molecular mechanism comprises major alterations of cytoskeletal metabolism. MRP14, in complex with its binding partner MRP8 (S100A8), promotes polymerization of microtubules. MRP14 is specifically phosphorylated by p38 mitogen-activated protein kinase (MAPK). This phosphorylation inhibits MRP8/MRP14-induced tubulin polymerization. Phosphorylation of MRP14 is antagonistically regulated by binding of MRP8 and calcium. The biologic relevance of these findings is confirmed by the fact that MAPK p38 fails to stimulate migration of MRP14-/- granulocytes in vitro and MRP14-/- mice show a diminished recruitment of granulocytes into the granulation tissue during wound healing in vivo. MRP14-/- granulocytes contain significantly less polymerized tubulin, which subsequently results in minor activation of Rac1 and Cdc42 after stimulation of p38 MAPK. Thus, the complex of MRP8/MRP14 is the first characterized molecular target integrating MAPK- and calcium-dependent signals during migration of phagocytes.
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Cites
Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism
Sampson, B., Fagerhol, M. K., Sunderkötter, C., Golden, B. E., Richmond, P., Klein, N., Kovar, I. Z., Beattie, J. H., Wolska-Kusnierz, B., Saito, Y., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11683-7 · Cited by 122
Self-citation
Cited by
Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01298 · Cited by 1,450
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418
Self-citationDonato, R., R. Cannon, B., Sorci, G., Riuzzi, F., Hsu, K., J. Weber, D., & L. Geczy, C. (2013) · Current Molecular Medicine · doi:10.2174/156652413804486214 · Cited by 1,316
Ehrchen, J. M., Sunderkötter, C., Foell, D., Vogl, T., & Roth, J. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008647 · Cited by 846
Self-citationS100A8 and S100A9 in inflammation and cancer
Gebhardt, C., Németh, J., Angel, P., & Hess, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.05.017 · Cited by 696
Metadata
- Authors
- Vogl, T., Ludwig, S., Goebeler, M., Strey, A., Thorey, I. S., Reichelt, R., Foell, D., Gerke, V., Manitz, M. P., Nacken, W., Werner, S., Sorg, C., & Roth, J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-12-15
- Volume
- 104
- Issue
- 13
- Pages
- 4260-4268
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2124020845
- Cited by
- 359
- References
- 1
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. https://app.cochat.ai/papers/10.1182/blood-2004-02-0446
- The paper
- Vogl, T., Ludwig, S., Goebeler, M., Strey, A., Thorey, I. S., Reichelt, R., Foell, D., Gerke, V., Manitz, M. P., Nacken, W., Werner, S., Sorg, C., & Roth, J. (2004). MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood. https://doi.org/10.1182/blood-2004-02-0446
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