S100A8/A9 in Inflammation

Wang, Siwen; Song, Rui; Wang, Ziyi; Jing, Zhaocheng; Wang, Shaoxiong; Ma, Jian

doi:10.3389/fimmu.2018.01298

Cited by 1,450S100 Proteins and AnnexinsBiomarkers in Disease MechanismsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

S100A8/A9 in Inflammation

Open access

Wang, Siwen, Song, Rui, Wang, Ziyi, Jing, Zhaocheng, Wang, Shaoxiong, Ma, Jian·2018·Frontiers in Immunology

DOI 10.3389/fimmu.2018.01298PMC PMC6004386

Open this paper in CoChat — free account Open PDF

Abstract

S100A8 and S100A9 (also known as MRP8 ang MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fimmu.2018.01298

Cites

165 of 165 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

S100A8/A9 is recognized as both a biomarker of colitis and a promoter of inflammation-associated tumorigenesis.
“Importantly, S100A8/A9 has been recognized as both a biomarker of colitis and a promoter of inflammation-associated tumorigenesis [16–18].”
From Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis (2026) · cites this paper as [16]
S100A8/A9 potentiates NF-κB signaling activation.
“Moreover, S100A8/A9 has been shown to potentiate NF-κB signaling activation [16].”
From Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis (2026) · cites this paper as [16]
S100A8/A9 is predominantly secreted by monocytes, macrophages, and neutrophils, serving as a key amplifier of inflammatory responses.
“It is predominantly secreted by monocytes, macrophages, and neutrophils, serving as a key amplifier of inflammatory responses [16].”
From Inhibition of SPI1 by ADAP Regulates S100A8/A9 Signaling in Macrophages to Control the Development of Colitis (2026) · cites this paper as [16]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418 · cited 2× · see citing works
“S100A9−/− mice are less sensitive to LPS stimulation and more resistant to LPS-induced septic shock (69).”
Background
Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion
Ryckman, C., Vandal, K., Rouleau, P., Talbot, M., & Tessier, P. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3233 · Cited by 861 · see citing works
Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Corbin, B. D., Seeley, E. H., Raab, A., Feldmann, J., Miller, M. R., Torres, V. J., Anderson, K. L., Dattilo, B. M., Dunman, P. M., Gerads, R., et al. (2008) · Science · doi:10.1126/science.1152449 · Cited by 857 · see citing works
Nutritional immunity beyond iron: a role for manganese and zinc
Kehl-Fie, T. E., & Skaar, E. P. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.008 · Cited by 634 · see citing works
Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin
Steinbakk, M., Naess-Andresen, C. F., Fagerhol, M. K., Lingaas, E., Dale, I., & Brandtzaeg, P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93237-j · Cited by 512 · see citing works
Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity
Nagareddy, P. R., Kraakman, M. J., Masters, S. L., Stirzaker, R. A., Gorman, D. J., Grant, R. W., Dragoljevic, D., Hong, E. S., Abdel‐Latif, A., Smyth, S. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.029 · Cited by 510 · see citing works
Inflammation – Cause or Consequence of Heart Failure or Both?
Linthout, S. V., & Tschöpe, C. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0337-9 · Cited by 475 · see citing works
S100A8/A9: From basic science to clinical application
Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 451 · see citing works
Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., et al. (2008) · Diabetes · doi:10.2337/db07-1808 · Cited by 407 · see citing works
Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens
Damo, S. M., Kehl-Fie, T. E., Sugitani, N., Holt, M. E., Rathi, S., Murphy, W. J., Zhang, Y., Betz, C., Hench, L., Fritz, G., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220341110 · Cited by 388 · see citing works
β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares
Goldberg, E. L., Asher, J. L., Molony, R. D., Shaw, A. C., Zeiss, C. J., Wang, C., Morozova-Roche, L. A., Herzog, R. I., Iwasaki, A., & Dixit, V. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.004 · Cited by 370 · see citing works
Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides
Björk, P., Björk, A., Vogl, T., Stenström, M., Liberg, D., OLSSON, A. G., Roth, J., Ivars, F., & Leanderson, T. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000097 · Cited by 357 · see citing works
MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes
Vogl, T., Ludwig, S., Goebeler, M., Strey, A., Thorey, I. S., Reichelt, R., Foell, D., Gerke, V., Manitz, M. P., Nacken, W. K. F., et al. (2004) · Blood · doi:10.1182/blood-2004-02-0446 · Cited by 354 · see citing works
Inflammation-associated S100 proteins: new mechanisms that regulate function
Goyette, J., & Geczy, C. L. (2010) · Amino Acids · doi:10.1007/s00726-010-0528-0 · Cited by 346 · see citing works
Platelet Expression Profiling and Clinical Validation of Myeloid-Related Protein-14 as a Novel Determinant of Cardiovascular Events
Healy, A. M., Pickard, M. D., Pradhan, A. D., Wang, Y., Chen, Z., Croce, K., Sakuma, M., Shi, C., Zago, A. C., Garasic, J. M., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.607333 · Cited by 333 · see citing works
Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells
Viemann, D., Strey, A., Janning, A., Jurk, K., Klimmek, K., Vogl, T., Hirono, K., Ichida, F., Foell, D., Kehrel, B. E., et al. (2004) · Blood · doi:10.1182/blood-2004-07-2520 · Cited by 316 · see citing works
S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway
Ghavami, S., Rashedi, I., Dattilo, B. M., Eshraghi, M., Chazin, W., Hashemi, M. M., Wesselborg, S., Kerkhoff, C., & Łoś, M. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607397 · Cited by 312 · see citing works
S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease
Șchiopu, A., & Cotoi, O. S. (2013) · Mediators of Inflammation · doi:10.1155/2013/828354 · Cited by 269 · see citing works
S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis
Gopal, R., Monin, L., Torres‐García, D., Slight-Webb, S. R., Mehra, S., McKenna, K. C., Junecko, B. A. F., Reinhart, T. A., Kolls, J. K., Báez-Saldaña, R., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201304-0803oc · Cited by 259 · see citing works
Myeloid-Related Protein-8/14 Is Critical for the Biological Response to Vascular Injury
Croce, K., Gao, H., Wang, Y., Mooroka, T., Sakuma, M., Shi, C., Sukhova, G. K., Packard, R. R. S., Hogg, N., Libby, P., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.814582 · Cited by 254 · see citing works
S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3
Schönthaler, H. B., Guinea‐Viniegra, J., Wculek, S. K., Ruppen, I., Ximénez‐Embún, P., Guío-Carrión, A., Navarro, R., Hogg, N., Ashman, K., & Wagner, E. F. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.011 · Cited by 248 · see citing works
Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa
Lima, Á. L. M., Karl, I., Giner, T., Poppe, H., Schmidt, M., Presser, D., Goebeler, M., & Bauer, B. (2015) · British Journal of Dermatology · doi:10.1111/bjd.14214 · Cited by 233 · see citing works
The Ca2+-binding Proteins S100A8 and S100A9 Are Encoded by Novel Injury-regulated Genes
Thorey, I. S., Roth, J., Regenbogen, J., Halle, J.-P., Bittner, M., Vogl, T., Kaesler, S., Bugnon, P., Reitmaier, B., Durka, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104871200 · Cited by 233 · see citing works
MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner
Roth, J., BURWINKEL, F., van den Bos, C., Goebeler, M., Vollmer, E., & Sorg, C. (1993) · Blood · doi:10.1182/blood.v82.6.1875.1875 · Cited by 233 · see citing works
Treatment with laquinimod reduces development of active MRI lesions in relapsing MS
Polman, C. H., Barkhof, F., Sandberg‐Wollheim, M., Linde, A., Nordle, Ö., & Nederman, T. (2005) · Neurology · doi:10.1212/01.wnl.0000154520.48391.69 · Cited by 227 · see citing works
Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes
Kraakman, M. J., Lee, M. K. S., Al‐Sharea, A., Dragoljevic, D., Barrett, T. J., Montenont, E., Basu, D., Heywood, S. E., Kammoun, H. L., Flynn, M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92450 · Cited by 221 · see citing works
Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer’s disease
Kamphuis, W., Kooijman, L., Schetters, S., Orre, M., & Hol, E. M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.007 · Cited by 209 · see citing works
Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes
Altwegg, L. A., Neidhart, M., Hersberger, M., Muller, S., Eberli, F. R., Corti, R., Roffi, M., Sütsch, G., Gay, S., von Eckardstein, A., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm078 · Cited by 200 · see citing works
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells
Ma, L., Sun, P., Zhang, J.-C., Zhang, Q., & Yao, S.-L. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2987 · Cited by 196 · see citing works
Calcium-dependent Tetramer Formation of S100A8 and S100A9 is Essential for Biological Activity
Leukert, N., Vogl, T., Strupat, K., Reichelt, R., Sorg, C., & Roth, J. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.04.009 · Cited by 195 · see citing works
DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway
Tsai, S.-Y., Segovia, J. A., Chang, T.-H., Morris, I. R., Berton, M. T., Tessier, P. A., Tardif, M. R., Césaro, A., & Bose, S. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003848 · Cited by 193 · see citing works
Calprotectin in rheumatic diseases
Ometto, F., Friso, L., Astorri, D., Botsios, C., Raffeiner, B., Punzi, L., & Doria, A. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216681551 · Cited by 179 · see citing works
The arachidonic acid‐binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67 phox and Rac‐2
Kerkhoff, C., Nacken, W. K. F., Benedyk‐Machaczka, M., Dagher, M., Sopalla, C., & Doussière, J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2377fje · Cited by 178 · see citing works
The Two Calcium-binding Proteins, S100A8 and S100A9, Are Involved in the Metabolism of Arachidonic acid in Human Neutrophils
Kerkhoff, C., Klempt, M., Kaever, V., & Sorg, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32672 · Cited by 165 · see citing works
Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion
Pruenster, M., Kurz, A. R. M., Chung, K., Cao-Ehlker, X., Bieber, S., Nußbaum, C., Bierschenk, S., Eggersmann, T. K., Rohwedder, I., Heinig, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms7915 · Cited by 164 · see citing works
Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions
Ghavami, S., Kerkhoff, C., Łoś, M., Hashemi, M. M., Sorg, C., & Karami‐Tehrani, F. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0903435 · Cited by 160 · see citing works
Oxidative modifications of S100 proteins: functional regulation by redox
Lim, S. Y., Raftery, M. J., Goyette, J., Hsu, K., & Geczy, C. L. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008608 · Cited by 156 · see citing works
The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade
Wang, C., Klechikov, A. G., Gharibyan, A. L., Wärmländer, S. K. T. S., Jarvet, J., Zhao, L., Jia, X., Shankar, S. K., Olofsson, A., Brännström, T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1208-4 · Cited by 151 · see citing works
In vitro candidastatic properties of the human neutrophil calprotectin complex.
Murthy, A. R., Lehrer, R. I., Harwig, S. S. L., & Miyasaki, K. T. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.11.6291 · Cited by 150 · see citing works
Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular <i>Aspergillus fumigatus</i> Hyphal Growth and Corneal Infection
Clark, H. L., Jhingran, A., Sun, Y., Vareechon, C., de Jesus Carrion, S., Skaar, E. P., Chazin, W. J., Calera, J. A., Hohl, T. M., & Pearlman, E. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502037 · Cited by 149 · see citing works
Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications
Boyapati, R. K., Rossi, A. G., Satsangi, J., & Ho, G. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.14 · Cited by 148 · see citing works
Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10
Lackmann, M., Rajasekariah, P., Iismaa, S. E., Jones, G. L., Cornish, C. J., Hu, S., Simpson, R. J., Moritz, R. L., & Geczy, C. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.7.2981 · Cited by 147 · see citing works
Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis
Wang, Y., Fang, C., Gao, H., Bilodeau, M. L., Zhang, Z., Croce, K., Liu, S., Morooka, T., Sakuma, M., Nakajima, K., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70966 · Cited by 146 · see citing works
S100A9 induces differentiation of acute myeloid leukemia cells through TLR4
Laouedj, M., Tardif, M. R., Gil, L., Raquil, M.-A., Lachhab, A., Pelletier, M., Tessier, P. A., & Barabé, F. (2017) · Blood · doi:10.1182/blood-2016-09-738005 · Cited by 142 · see citing works
Blockade of Antimicrobial Proteins S100A8 and S100A9 Inhibits Phagocyte Migration to the Alveoli in Streptococcal Pneumonia
Raquil, M.-A., Anceriz, N., Rouleau, P., & Tessier, P. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3366 · Cited by 138 · see citing works
The Zinc-Reversible Antimicrobial Activity of Neutrophil Lysates and Abscess Fluid Supernatants
Sohnle, P. G., Collins-Lech, C., & Wiessner, J. H. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/164.1.137 · Cited by 135 · see citing works
Myeloid-Related Protein-14 Contributes to Protective Immunity in Gram-Negative Pneumonia Derived Sepsis
Achouiti, A., Vogl, T., Urban, C. F., Röhm, M., Hommes, T. J., van Zoelen, M. A. D., Florquin, S., Roth, J., van 't Veer, C., de Vos, A. F., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002987 · Cited by 135 · see citing works
Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR‐215757), a new quinoline‐3‐carboxamide derivative: Studies in lupus‐prone mice and a multicenter, randomized, double‐blind, placebo‐controlled, repeat‐dose, dose‐ranging study in patients with systemic lupus erythematosus
Bengtsson, A. A., Sturfelt, G. K., Lood, C., Rönnblom, L., van Vollenhoven, R., Axelsson, B., Sparre, B., Tuvesson, H., Öhman, M. W., & Leanderson, T. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33493 · Cited by 130 · see citing works
Expression and Role of Myeloid-related Protein-14 in Clinical and Experimental Sepsis
van Zoelen, M. A. D., Vogl, T., Foell, D., van Veen, S. Q., van Till, J. W. O., Florquin, S., Tanck, M. W. T., Wittebole, X., Laterre, P., Boermeester, M. A., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1552oc · Cited by 130 · see citing works
Gene Expression Profiling Reveals Distinct Molecular Signatures Associated With the Rupture of Intracranial Aneurysm
Nakaoka, H., Tajima, A., Yoneyama, T., Hosomichi, K., Kasuya, H., Mizutani, T., & Inoue, I. (2014) · Stroke · doi:10.1161/strokeaha.114.005851 · Cited by 128 · see citing works
Increased perivascular synovial membrane expression of myeloid‐related proteins in psoriatic arthritis
Kane, D. J., Roth, J., Frosch, M., Vogl, T., Bresnihan, B., & FitzGerald, O. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10988 · Cited by 126 · see citing works
Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation
Swindell, W. R., Johnston, A., Xing, X., Little, A., Robichaud, P., Voorhees, J. J., Fisher, G., & Gudjonsson, J. E. (2013) · Scientific Reports · doi:10.1038/srep01215 · Cited by 124 · see citing works
S100A9 Induced Inflammatory Responses Are Mediated by Distinct Damage Associated Molecular Patterns (DAMP) Receptors In Vitro and In Vivo
Chen, B., Miller, A. L., Rebelatto, M. C., Brewah, Y. A., Rowe, D. C., Clarke, L., Czapiga, M., Rosenthal, K., Imamichi, T., Chen, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115828 · Cited by 124 · see citing works
Phagocyte-specific S100A8/A9 Protein Levels During Disease Exacerbations and Infections in Systemic Lupus Erythematosus
Soyfoo, M. S., Roth, J., Vogl, T. J., Pochet, R., & Decaux, G. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.081302 · Cited by 123 · see citing works
Differential expression and response to anti‐TNFα treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis
Rycke, L. D., Baeten, D., Foell, D., Kruithof, E., VEYS, E. M., Roth, J., & Keyser, F. D. (2005) · The Journal of Pathology · doi:10.1002/path.1758 · Cited by 123 · see citing works
Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions
Austermann, J., Friesenhagen, J., Fassl, S. K., Ortkras, T., Burgmann, J., Barczyk‐Kahlert, K., Faist, E., Zedler, S., Pirr, S. M., Rohde, C., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.020 · Cited by 118 · see citing works
Calprotectin — A Novel Marker of Obesity
Mortensen, O. H., Nielsen, A. R., Erikstrup, C., Plomgaard, P., Fischer, C. P., Krogh‐Madsen, R., Lindegaard, B., Petersen, A. M. W., Taudorf, S., & Pedersen, B. K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007419 · Cited by 118 · see citing works
An Inflammation Loop Orchestrated by S100A9 and Calprotectin Is Critical for Development of Arthritis
Césaro, A., Anceriz, N., Plante, A., Pagé, N., Tardif, M. R., & Tessier, P. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045478 · Cited by 116 · see citing works
Increased Serum Levels of MRP-8/14 in Type 1 Diabetes Induce an Increased Expression of CD11b and an Enhanced Adhesion of Circulating Monocytes to Fibronectin
Bouma, G., Lam‐Tse, W., Wierenga‐Wolf, A. F., Drexhage, H. A., & Versnel, M. A. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1979 · Cited by 113 · see citing works
S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4/MyD88 pathway
Lu, S., Yu, C., Liu, Y.-H., Dong, H., Zhang, X., Zhang, S., Hu, L., Zhang, F., Qian, Y., & Gui, B. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.10.011 · Cited by 106 · see citing works
The Acute Neutrophil Response Mediated by S100 Alarmins during Vaginal Candida Infections Is Independent of the Th17-Pathway
Yano, J., Kolls, J., Happel, K., Wormley, F., Wozniak, K., & Fidel, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046311 · Cited by 106 · see citing works
Phosphorylation of MRP14, an S100 protein expressed during monocytic differentiation, modulates Ca(2+)-dependent translocation from cytoplasm to membranes and cytoskeleton
van den Bos, C., Roth, J., Koch, H., Hartmann, M., & Sorg, C. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1247 · Cited by 105 · see citing works
Damage-Associated Molecular Pattern S100A9 Increases Bactericidal Activity of Human Neutrophils by Enhancing Phagocytosis
Simard, J.-C., Simon, M.-M., Tessier, P. A., & Girard, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002956 · Cited by 104 · see citing works
Total-body bone mineral content in non–corticosteroid-treated postpubertal females with juvenile rheumatoid arthritis: Frequency of osteopenia and contributing factors
Henderson, C. J., SPECKER, B. L., Sierra, R. I., Campaigne, B. N., & Lovell, D. J. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200003)43:3 · Cited by 103 · see citing works
Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets
Rosenberg, J. H., Rai, V., Dilisio, M. F., & Agrawal, D. K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3047-4 · Cited by 103 · see citing works
HaCaT Keratinocytes Overexpressing the S100 Proteins S100A8 and S100A9 Show Increased NADPH Oxidase and NF-κB Activities
Benedyk‐Machaczka, M., Sopalla, C., Nacken, W. K. F., Bode, G., Melkonyan, H., Bánfi, B., & Kerkhoff, C. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700820 · Cited by 100 · see citing works
Modulation of Gene Expression Induced in Human Epidermis by Environmental Stress In Vivo
Bernerd, F., Compan, D., Bernard, B. A., Leclaire, J., Medaisko, C., Méhul, B., Seité, S., Marionnet, C., Dumas, A., Verrecchia, F., et al. (2003) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2003.12629.x · Cited by 94 · see citing works
Induction of apoptotic cell death in mouse lymphoma and human leukemia cell lines by a calcium-binding protein complex, calprotectin, derived from inflammatory peritoneal exudate cells
Yui, S., Mikami, M., & Yamazaki, M. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.58.6.650 · Cited by 92 · see citing works
Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice
Zhang, X., Wei, L., Wang, J., Qin, Z., Wang, J., Lu, Y., Zheng, X., Qiu, P., Ye, Q., Ai, F., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01774 · Cited by 92 · see citing works
Self-citation
Increase of calcium levels in epithelial cells induces translocation of calcium-binding proteins migration inhibitory factor-related protein 8 (MRP8) and MRP14 to keratin intermediate filaments
Goebeler, M., Roth, J., van den Bos, C., Ader, G., & Sorg, C. (1995) · Biochemical Journal · doi:10.1042/bj3090419 · Cited by 91 · see citing works
Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9
Low, D., Subramaniam, R., Li, L., Aomatsu, T., Mizoguchi, A., Ng, A., DeGruttola, A. K., Lee, C. G., Elias, J. A., Andoh, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5440 · Cited by 90 · see citing works
Gene profiling in human blood leucocytes during recovery from septic shock
Payen, D. M., Lukaszewicz, A., Bélikova, I., Faivre, V., Gélin, C., Rußwurm, S., Launay, J., & Sévenet, N. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1048-1 · Cited by 89 · see citing works
S100A8/A9 as a biomarker for synovial inflammation and joint damage in patients with rheumatoid arthritis
Kang, K. Y., Woo, J., & Park, S. (2014) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2014.29.1.12 · Cited by 86 · see citing works
Low dose linomide in Type I juvenile diabetes of recent onset: a randomised placebo-controlled double blind trial
Coutant, R., Landais, P., Rosilio, M., Johnsen, C., Lahlou, N., Chatelain, P., Carel, J., Ludvigsson, J., Boîtard, C., & Bougneres, P. F. (1998) · Diabetologia · doi:10.1007/s001250051028 · Cited by 83 · see citing works
Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium
van den Bosch, M. H., Blom, A. B., Schelbergen, R. F. P., Koenders, M. I., van de Loo, F. A. J., van den Berg, W. B., Vogl, T., Roth, J., van der Kraan, P. M., & van Lent, P. L. (2016) · The Journal of Rheumatology · doi:10.3899/jrheum.160270 · Cited by 81 · see citing works
Acute inflammatory activity of the S100 protein CP-10. Activation of neutrophils in vivo and in vitro.
Devery, J. M., King, N. J. C., & Geczy, C. L. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1888 · Cited by 79 · see citing works
Bariatric Surgery Induces Disruption in Inflammatory Signaling Pathways Mediated by Immune Cells in Adipose Tissue: A RNA-Seq Study
Poitou, C., Perret, C., Mathieu, F., Trương, V., Blum, Y., Durand, H., Alili, R., Chelghoum, N., Pelloux, V., Aron‐Wisnewsky, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125718 · Cited by 77 · see citing works
S-Calprotectin (S100A8/S100A9): A Potential Marker of Inflammation in Patients with Psoriatic Arthritis
Hansson, C., Eriksson, C., & Alenius, G.-M. (2014) · Journal of Immunology Research · doi:10.1155/2014/696415 · Cited by 76 · see citing works
Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation
Lorey, M. B., Rossi, K., Eklund, K. K., Nyman, T. A., & Matikainen, S. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m116.064840 · Cited by 76 · see citing works
Proteomics Analysis of Blood Serums from Alzheimer’s Disease Patients Using iTRAQ Labeling Technology
Shen, L., Liao, L., Chen, C., Guo, Y. C., Song, D., Wang, Y., Chen, Y., Zhang, K., Ying, M., Li, S., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160913 · Cited by 74 · see citing works
Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model
Tang, A., Li, N., Li, X., Yang, H., Wang, W., Zhang, L., Li, G., Xiong, W., Ma, J., & Shen, S. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs183 · Cited by 73 · see citing works
Self-citation
Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus
Tydén, H., Lood, C., Gullstrand, B., Jönsen, A., Ivars, F., Leanderson, T., & Bengtsson, A. A. (2016) · Lupus · doi:10.1177/0961203316655208 · Cited by 73 · see citing works
Calprotectin Induces IL‐6 and MCP‐1 Production via Toll‐Like Receptor 4 Signaling in Human Gingival Fibroblasts
Nishikawa, Y., Kajiura, Y., Lew, J. H., Kido, J., Nagata, T., & Naruishi, K. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25724 · Cited by 73 · see citing works
Myeloid‐Related Proteins 8 and 14 Contribute to Monosodium Urate Monohydrate Crystal–Induced Inflammation in Gout
Holzinger, D., Nippe, N., Vogl, T., Marketon, K., Mysore, V., Weinhage, T., Dalbeth, N., Pool, B., Merriman, T. R., Baeten, D., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38369 · Cited by 72 · see citing works
Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis
Nordal, H. H., Brokstad, K. A., Solheim, M. H., Halse, A., Kvien, T. K., & Hammer, H. B. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1201-0 · Cited by 72 · see citing works
Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis
Martel, B. C., Litman, T., Hald, A., Norsgaard, H., Lovato, P., Dyring‐Andersen, B., Skov, L., Thestrup‐Pedersen, K., Skov, S., Skak, K., et al. (2016) · Experimental Dermatology · doi:10.1111/exd.12967 · Cited by 71 · see citing works
Growth-inhibitory and apoptosis-inducing activities of calprotectin derived from inflammatory exudate cells on normal fibroblasts: regulation by metal ions
Yui, S., Mikami, M., Tsurumaki, K., & Yamazaki, M. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.61.1.50 · Cited by 71 · see citing works
Calprotectin S100A9 Calcium-binding Loops I and II Are Essential for Keratinocyte Resistance to Bacterial Invasion
Champaiboon, C., Sappington, K. J., Guenther, B. D., Ross, K. F., & Herzberg, M. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806605200 · Cited by 70 · see citing works
S100A8 Modulates Mast Cell Function and Suppresses Eosinophil Migration in Acute Asthma
Zhao, J., Endoh, I., Hsu, K., Tedla, N. T., Endoh, Y., & Geczy, C. L. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3583 · Cited by 70 · see citing works
Zinc binding reverses the calcium‐induced arachidonic acid‐binding capacity of the S100A8/A9 protein complex
Kerkhoff, C., Vogl, T., Nacken, W. K. F., Sopalla, C., & Sorg, C. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01322-8 · Cited by 70 · see citing works
Mrp14 Deficiency Ameliorates Amyloid β Burden by Increasing Microglial Phagocytosis and Modulation of Amyloid Precursor Protein Processing
Kummer, M. P., Vogl, T., Axt, D., Griep, A., Vieira-Saecker, A. M. M., Jessen, F., Gelpí, E., Roth, J., & Heneka, M. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1504-12.2012 · Cited by 70 · see citing works
Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients
Pouwels, S. D., Nawijn, M. C., Bathoorn, E., Riezebos‐Brilman, A., van Oosterhout, A. J. M., Kerstjens, H. A. M., & Heijink, I. H. (2015) · European Respiratory Journal · doi:10.1183/09031936.00158414 · Cited by 70 · see citing works
Pro-inflammatory S100A9 Protein as a Robust Biomarker Differentiating Early Stages of Cognitive Impairment in Alzheimer’s Disease
Horváth, I., Jia, X., Johansson, P., Wang, C., Moskalenko, R., Steinau, A., Forsgren, L., Wågberg, T., Svensson, J., Zetterberg, H., et al. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00265 · Cited by 69 · see citing works
Purification and characterization of the cytotoxic factor in rat peritoneal exudate cells: its identification as the calcium binding protein complex, calprotectin
Yui, S., Mikami, M., & Yamazaki, M. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.58.3.307 · Cited by 65 · see citing works
Role of S100A9 in the development of neutrophilic inflammation in asthmatics and in a murine model
Lee, T.-H., Chang, H. S., Bae, D.-J., Song, H. J., Kim, M.-S., Park, J., Jun, J. A., Lee, S. Y., Uh, S. T., Kim, S. H., et al. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.08.013 · Cited by 65 · see citing works
Regulation of S100A8/A9 (Calprotectin) Binding to Tumor Cells byZinc Ion and Its Implication for Apoptosis‐Inducing Activity
Nakatani, Y., Yamazaki, M., Chazin, W., & Yui, S. (2005) · Mediators of Inflammation · doi:10.1155/mi.2005.280 · Cited by 64 · see citing works
S100A8 Induces IL-10 and Protects against Acute Lung Injury
Hiroshima, Y., Hsu, K., Tedla, N. T., Chung, Y. M., Chow, S., Herbert, C. A., & Geczy, C. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302556 · Cited by 63 · see citing works
MRP14 (S100A9) Protein Interacts with Alzheimer Beta-Amyloid Peptide and Induces Its Fibrillization
Zhang, C., Liu, Y., Gilthorpe, J. D., & van der Maarel, J. R. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032953 · Cited by 61 · see citing works
Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns
Buhimschi, C. S., Bhandari, V., Dulay, A. T., Nayeri, U. A., Abdel‐Razeq, S. S., Pettker, C. M., Thung, S., Zhao, G., Han, Y. W., Bizzarro, M. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026111 · Cited by 60 · see citing works
Beneficial effects of quinoline-3-carboxamide (ABR-215757) on atherosclerotic plaque morphology in S100A12 transgenic ApoE null mice
Yan, L., Björk, P., Butuc, R., Gawdzik, J. C., Earley, J. U., Kim, G. H., & Bowman, M. A. H. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.02.023 · Cited by 60 · see citing works
MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis
Lee, D., Woo, J., Kwok, S., Cho, M., & Park, S. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.39 · Cited by 58 · see citing works
Inflammation‐induced S100A8 activates I d3 and promotes colorectal tumorigenesis
Zhang, X., Ai, F., Li, X., She, X., Li, N., Tang, A., Qin, Z., Ye, Q., Tian, L., Li, G., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29671 · Cited by 57 · see citing works
Self-citation
Subversion of antimicrobial calprotectin (S100A8/S100A9 complex) in the cytoplasm of TR146 epithelial cells after invasion by Listeria monocytogenes
Zaia, A. A., Sappington, K. J., Nisapakultorn, K., Chazin, W., Dietrich, E. A., Ross, K. F., & Herzberg, M. C. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.63 · Cited by 57 · see citing works
Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions
Lodeiro, M., Puerta, E., Ismail, M.-A.-M., Rodriguez‐Rodriguez, P., Rönnbäck, A., Codita, A., Parrado‐Fernández, C., Maioli, S., Gil-Bea, F. J., Merino‐Serrais, P., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw073 · Cited by 57 · see citing works
Suppression of Inflammation in Rat Autoimmune Myocarditis by S100A8/A9 Through Modulation of the Proinflammatory Cytokine Network
Otsuka, K., Terasaki, F., Ikemoto, M., Fujita, S., Tsukada, B., Katashima, T., Kanzaki, Y., Sohmiya, K., Kono, T., Toko, H., et al. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfn049 · Cited by 56 · see citing works
Injury‐induced MRP8/MRP14 stimulates IP‐10/CXCL10 in monocytes/macrophages
Wang, J., Yoram Vodovotz, B., Fan, L., Li, Y., Liu, Z., Namas, R. A., Barclay, D. A., Zamora, R., Billiar, T. R., Wilson, M. A., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-255992 · Cited by 56 · see citing works
HIV-1 Transcription and Virus Production Are Both Accentuated by the Proinflammatory Myeloid-Related Proteins in Human CD4+ T Lymphocytes
Ryckman, C., Robichaud, G. A., Roy, J., Cantin, R., Tremblay, M. J., & Tessier, P. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3307 · Cited by 56 · see citing works
Diagnostic and prognostic value of myeloid-related protein complex 8/14 for sepsis
Gao, S., Yang, Y., Fu, Y., Guo, W., & Liu, G. (2015) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2015.06.025 · Cited by 55 · see citing works
The Expression of Inflammatory Genes Is Upregulated in Peripheral Blood of Patients With Type 1 Diabetes
Jin, Y., Sharma, A. K., Carey, C., Hopkins, D., Wang, X., Robertson, D. G., Bode, B. W., Anderson, S. W., Reed, J. H. C., Steed, R. D., et al. (2013) · Diabetes Care · doi:10.2337/dc12-1986 · Cited by 55 · see citing works
Calprotectin in rheumatic diseases: a review
Kopeć-Mędrek, M., Widuchowska, M., & Kucharz, E. J. (2016) · Reumatologia/Rheumatology · doi:10.5114/reum.2016.64907 · Cited by 55 · see citing works
2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue
Oliva, K., Barker, G., Rice, G. E., Bailey, M. J., & Lappas, M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0010 · Cited by 54 · see citing works
The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout
Chang, K., Kim, H. J., & Suh, Y. (2012) · Neurodegenerative Diseases · doi:10.1159/000333781 · Cited by 53 · see citing works
Visualized macrophage dynamics and significance of S100A8 in obese fat
Sekimoto, R., Fukuda, S., Maeda, N., Tsushima, Y., Matsuda, K., Mori, T., Nakatsuji, H., Nishizawa, H., Kishida, K., Kikuta, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409480112 · Cited by 52 · see citing works
A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia
Filippo, K. D., Neill, D. R., Mathies, M., Bangert, M., McNeill, E., Kadioglu, A., & Hogg, N. (2014) · The FASEB Journal · doi:10.1096/fj.13-247460 · Cited by 51 · see citing works
Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis
Nistala, K., Varsani, H., Wittkowski, H., Vogl, T., Król, P., Shah, V., Mamchaoui, K., Brogan, P. A., Roth, J., & Wedderburn, L. R. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4311 · Cited by 48 · see citing works
Role of inflammasome activation in development and exacerbation of asthma
Lee, T.-H., Song, H. J., & Park, C. (2014) · Asia Pacific Allergy · doi:10.5415/apallergy.2014.4.4.187 · Cited by 48 · see citing works
Macrophage suppression following phagocytosis of apoptotic neutrophils is mediated by the S100A9 calcium-binding protein
Lorenzo, B. H. P. D., Godoy, L. C., Brito, R. R. N. E., Pagano, R. L., Amorim-Dias, M. A., Grosso, D. M., Lopes, J. D., & Mariano, M. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.05.013 · Cited by 46 · see citing works
Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes
Yonekawa, K., Neidhart, M., Altwegg, L. A., Wyss, C. A., Corti, R., Vogl, T., Grigorian, M., Gay, S., Lüscher, T. F., & Maier, W. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.020 · Cited by 46 · see citing works
Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways
Coveney, A., Wang, W., Kelly, J., Liu, J. H., Blankson, S., Wu, Q. D., Redmond, H. P., & Wang, J. H. (2015) · Scientific Reports · doi:10.1038/srep13694 · Cited by 45 · see citing works
DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes
Sakaguchi, M., Murata, H., Aoyama, Y., Hibino, T., Putranto, E. W., Ruma, I. M. W., Inoue, Y., Sakaguchi, Y. M., Yamamoto, K.-I., Kinoshita, R., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573071 · Cited by 45 · see citing works
S100-alarmins: potential therapeutic targets for arthritis
Austermann, J., Zenker, S., & Roth, J. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1330411 · Cited by 45 · see citing works
Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint
Rosenberg, J. H., Rai, V., Dilisio, M. F., Sekundiak, T. D., & Agrawal, D. K. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3078-x · Cited by 45 · see citing works
Neutrophil-derived MRP-14 is up-regulated in infectious osteomyelitis and stimulates osteoclast generation
Dapunt, U., Giese, T., Maurer, S., Stegmaier, S., Prior, B., Hänsch, G. M., & Gaida, M. M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3vma1014-482r · Cited by 43 · see citing works
The anti-oxidative, anti-inflammatory, and protective effect of S100A8 in endotoxemic mice
Sun, Y., Lu, Y., Engeland, C. G., Gordon, S. C., & Sroussi, H. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.10.002 · Cited by 43 · see citing works
IL-1 receptor regulates S100A8/A9-dependent keratinocyte resistance to bacterial invasion
Sorenson, B. S., Khammanivong, A., Guenther, B. D., Ross, K. F., & Herzberg, M. C. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.48 · Cited by 42 · see citing works
The Role of Proteomics in the Diagnosis of Chorioamnionitis and Early-Onset Neonatal Sepsis
Buhimschi, I. A., & Buhimschi, C. S. (2010) · Clinics in Perinatology · doi:10.1016/j.clp.2010.03.002 · Cited by 42 · see citing works
Myeloid-related protein 8/14 complex describes microcirculatory alterations in patients with type 2 diabetes and nephropathy
Burkhardt, K., Schwarz, S., Pan, C., Stelter, F., Kotliar, K. E., Eynatten, M. V., Sollinger, D., Lanzl, I. M., Heemann, U. W., & Baumann, M. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-10 · Cited by 40 · see citing works
New ELISA System for Myeloid-related Protein Complex (MRP8/14) and Its Clinical Significance as a Sensitive Marker for Inflammatory Responses Associated with Transplant Rejection
Ikemoto, M., Tanaka, T., Takai, Y., Murayama, H., Tanaka, K., & Fujita, M. (2003) · Clinical Chemistry · doi:10.1373/49.4.594 · Cited by 40 · see citing works
Synovial macrophages promote TGF-β signaling and protect against influx of S100A8/S100A9-producing cells after intra-articular injections of oxidized low-density lipoproteins
de Munter, W., Geven, E. J., Blom, A. B., Walgreen, B., Helsen, M. M., Joosten, L. A. B., Roth, J., Vogl, T., van de Loo, F. A. J., Koenders, M. I., et al. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.07.020 · Cited by 39 · see citing works
Human S100A9 potentiates IL‐8 production in response to GM‐CSF or fMLP via activation of a different set of transcription factors in neutrophils
Simard, J.-C., Noël, C., Tessier, P. A., & Girard, D. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.027 · Cited by 38 · see citing works
Loss of Myeloid Related Protein-8/14 Exacerbates Cardiac Allograft Rejection
Shimizu, K., Libby, P., Rocha, V. Z., Folco, E. J. E., Shubiki, R., Grabie, N., Jang, S., Lichtman, A. H., Shimizu, A., Hogg, N., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.009910 · Cited by 38 · see citing works
Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes
Nyalwidhe, J. O., Grzesik, W. J., Burch, T. C., Semeraro, M. L., Waseem, T. C., Gerling, I., Mirmira, R. G., Morris, M. A., & Nadler, J. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183908 · Cited by 37 · see citing works
Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae
Swathi Raju, M., Jahnavi, V. S., Kamaraju, S. R., Sritharan, V., Rajkumar, K., Natarajan, S., Kumar, A., & Burgula, S. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5112 · Cited by 36 · see citing works
Expression and Function of S100A8/A9 (Calprotectin) in Human Typhoid Fever and the Murine Salmonella Model
de Jong, H. K., Achouiti, A., Koh, G. C. K. W., Parry, C. M., Baker, S. G., Faiz, M. A., van Dissel, J. T., Vollaard, A. M., van Leeuwen, E. M. M., Roelofs, J. J. T. H., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003663 · Cited by 35 · see citing works
Proinflammatory effects and mechanisms of calprotectin on human gingival fibroblasts
Gao, H., Hou, J., Meng, H., Zhang, X., Zheng, Y., & Peng, L. (2017) · Journal of Periodontal Research · doi:10.1111/jre.12465 · Cited by 35 · see citing works
Inflammatory peritoneal reaction after perforated appendicitis: continuous peritoneal lavage versus non lavage.
Schwarz, A., Bölke, E., Peiper, M., Esch, J. S. A., Steinbach, G., van Griensven, M., & Orth, K. (2007) · PubMed · Cited by 32 · see citing works
Pathophysiologic consequences following inhibition of a CFTR-dependent developmental cascade in the lung
Cohen, J., & Larson, J. E. (2005) · BMC Developmental Biology · doi:10.1186/1471-213x-5-2 · Cited by 31 · see citing works
Calgranulins May Contribute Vascular Protection In Atherogenesis
Geczy, C. L., Chung, Y. M., & Hiroshima, Y. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-1505 · Cited by 31 · see citing works
Elevated levels of serum MRP8/14 in ankylosing spondylitis: associated with peripheral arthritis and active disease
Gupta, L., Bhattacharya, S., Agarwal, V., & Aggarwal, A. (2016) · Clinical Rheumatology · doi:10.1007/s10067-016-3448-x · Cited by 31 · see citing works
Myeloid-related protein-14 deficiency promotes inflammation in staphylococcal pneumonia
Achouiti, A., Vogl, T., van der Meer, A. J., Stroo, I., Florquin, S., de Boer, O. J., Roth, J., Zeerleder, S. S., Veer, C. V. ′., de Vos, A. F., et al. (2015) · European Respiratory Journal · doi:10.1183/09031936.00183814 · Cited by 29 · see citing works
High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density
Hirata, A., Kishida, K., Nakatsuji, H., Hiuge-Shimizu, A., Funahashi, T., & Shimomura, I. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.01.026 · Cited by 29 · see citing works
S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
Chimenti, M. S., Triggianese, P., Botti, E., Narcisi, A., Conigliaro, P., Giunta, A., Teoli, M., Perricone, R., & Costanzo, A. (2016) · Journal of International Medical Research · doi:10.1177/0300060515598900 · Cited by 29 · see citing works
Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils
McNeill, E., Conway, S. J., Roderick, H. L., Bootman, M. D., & Hogg, N. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.05.004 · Cited by 28 · see citing works
Advanced glycation end products increase expression of S100A8 and A9 via RAGE – MAPK in rat dental pulp cells
Nakajima, Y., Inagaki, Y., Kido, J., & Nagata, T. (2014) · Oral Diseases · doi:10.1111/odi.12280 · Cited by 28 · see citing works
Chronic Pseudomonas aeruginosa Biofilm Infection Impairs Murine S100A8/A9 and Neutrophil Effector Cytokines – Implications for Delayed Wound Closure?
Trøstrup, H., Lerche, C. J., Christophersen, L., Thomsen, K., Jensen, P. Ø., Hougen, H. P., Høiby, N., & Moser, C. E. (2017) · Pathogens and Disease · doi:10.1093/femspd/ftx068 · Cited by 27 · see citing works
Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing
Reichman, H., Moshkovits, I., Itan, M., Pasmanik-Chor, M., Vogl, T., Roth, J., & Munitz, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-07738-z · Cited by 27 · see citing works
S100A8 protein attenuates airway hyperresponsiveness by suppressing the contraction of airway smooth muscle
Xu, Y., Wang, Y., Yin, L.-M., Park, G., Ulloa, L., & Yang, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.033 · Cited by 26 · see citing works
Differential Association of S100A9, an Inflammatory Marker, and p53, a Cell Cycle Marker, Expression with Epicardial Adipocyte Size in Patients with Cardiovascular Disease
Agra, R. M., Fernández‐Trasancos, Á., Sierra, J. C., González‐Juanatey, J. R., & Eiras-Penas, S. (2014) · Inflammation · doi:10.1007/s10753-014-9876-3 · Cited by 23 · see citing works
Augmentation of Epithelial Resistance to Invading Bacteria by Using mRNA Transfections
Zou, X., Sorenson, B. S., Ross, K. F., & Herzberg, M. C. (2013) · Infection and Immunity · doi:10.1128/iai.00539-13 · Cited by 23 · see citing works
Possible roles of barrier-to-autointegration factor 1 in regulation of keratinocyte differentiation and proliferation
Takama, H., Sugiura, K., Ogawa, Y., Muro, Y., & Akiyama, M. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.04.007 · Cited by 21 · see citing works
Myeloid-Related Protein-14/MRP-14/S100A9/Calgranulin B is Associated with Inflammation in Proliferative Diabetic Retinopathy
El‐Asrar, A. M. A., Alam, K., Siddiquei, M. M., den Eynde, K. V., Mohammad, G., Hertogh, G. D., & Opdenakker, G. (2016) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2016.1245759 · Cited by 20 · see citing works
Upregulation of calprotectin in mild IgE-mediated ovalbumin hypersensitivity
Zhu, Q., Li, F., Wang, J., Ma, J., & Sheng, X. (2017) · Oncotarget · doi:10.18632/oncotarget.16954 · Cited by 19 · see citing works
Self-citation
Obesity Corrupts Myelopoiesis
Murray, P. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.010 · Cited by 15 · see citing works
Characterization of Cell Growth‐Inhibitory Factor in Inflammatory Peritoneal Exudate Cells of Rats
Yui, S., Yang, D., Mikami, M., & Yamazaki, M. (1993) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1993.tb01730.x · Cited by 14 · see citing works
The accumulation of macrophages expressing myeloid-related protein 8 (MRP8) and MRP14 in the spleen of BALB/cA mice during infection with Plasmodium berghei
Mizobuchi, H., Yamakoshi, S., Omachi, S., Osada, Y., Sanjoba, C., Goto, Y., & Matsumoto, Y. (2014) · Experimental Parasitology · doi:10.1016/j.exppara.2014.01.003 · Cited by 14 · see citing works
Myeloid-related protein-8/14 is associated with proinflammatory cytokines in cervical mucus
Kunimi, K., Maegawa, M., Kamada, M., Yamamoto, S., Yasui, T., Matsuzaki, T., Kuwahara, A., Furumoto, H., Ohmoto, Y., Kido, H., et al. (2006) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2005.12.010 · Cited by 14 · see citing works
Immunodetection of the murine chemotactic protein CP-10 in bleomycin-induced pulmonary injury
Kumar, R. K., Harrison, C. A., Cornish, C. J., Kocijer, M., & Geczy, C. R. (1998) · Pathology · doi:10.1080/00313029800169665 · Cited by 13 · see citing works
S100A8 and S100A9 Positive Cells in Colorectal Carcinoma: Clinicopathological Analysis
Başsorgun, C. İ., Ünal, B., Erin, N., Özlük, A. A., Uzun, Ö. C., & Elpek, G. Ö. (2014) · Gastroenterology Research and Practice · doi:10.1155/2014/943175 · Cited by 12 · see citing works
Upregulation of ANGPTL6 in mouse keratinocytes enhances susceptibility to psoriasis
Tanigawa, H., Miyata, K., Tian, Z., Aoi, J., Kadomatsu, T., Fukushima, S., Ogata, A., Takeda, N., Zhao, J., Zhu, S., et al. (2016) · Scientific Reports · doi:10.1038/srep34690 · Cited by 12 · see citing works
Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice
Алексеевна, Г. М., Davydova, T. V., Fomina, V. G., Vetrilé, L. A., Morozova‐Roche, L. A., & Sewell, R. D. E. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3632-2 · Cited by 11 · see citing works
Differential proteomics of monosodium urate crystals‐induced inflammatory response in dissected murine air pouch membranes by iTRAQ technology
Chiu, C., Chen, H., Wu, T., Shih, Y., Huang, K., Tsai, Y., Hsu, Y., & Chen, S. (2015) · PROTEOMICS · doi:10.1002/pmic.201400626 · Cited by 10 · see citing works
Time-dependent expression of leukotriene B4 receptors in rat collagen-induced arthritis
Han, C., Huang, H., Hu, M., Wang, Q., Gao, Y., & Liu, Y. (2007) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2007.01.011 · Cited by 10 · see citing works
The S100A8-serum amyloid A3-LOX-1 cascade in atherosclerotic plaque rupture
Wang, Y., & Xu, D. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.11.082 · Cited by 2 · see citing works
好中球からの広範囲アポトーシス誘導活性を有する炎症性蛋白質複合体calprotectin(S100A8/S100A9)(Calprotectin (S100A8/S100A9),an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity)
Satoru, Y., Yuichi, N., & Masaaki, M. (2003) · Institutional Repositories DataBase (IRDB) · doi:10.1248/bpb.26.753

Flagged first, then by citations

Sorted by citations

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19
Silvin, A., Chapuis, N., Dunsmore, G., Goubet, A.-G., Dubuisson, A., Derosa, L., Almire, C., Hénon, C., Kosmider, O., Droin, N., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.002 · Cited by 834 · see citing works
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0939-8 · Cited by 740 · see citing works
Sexual-dimorphism in human immune system aging
Márquez, E. J., Chung, C.-H., Marches, R., Rossi, R. J., Nehar-Belaid, D., Eroglu, A., Mellert, D. J., Kuchel, G. A., Banchereau, J., & Ucar, D. (2020) · Nature Communications · doi:10.1038/s41467-020-14396-9 · Cited by 584 · see citing works
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Cervia, C., Brüningk, S. C., Hoch, T., Fan, B., Muzio, G., Thompson, R. C., Ceglarek, L., Meledin, R., Westermann, P., Emmenegger, M., et al. (2024) · Science · doi:10.1126/science.adg7942 · Cited by 421 · see citing works
Microbe-host interplay in atopic dermatitis and psoriasis
Fyhrquist, N., Muirhead, G., Prast‐Nielsen, S., Jeanmougin, M., Oláh, P., Skoog, T., Jules-Clément, G., Feld, M., Barrientos‐Somarribas, M., Sinkko, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12253-y · Cited by 416 · see citing works
Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing
Hu, J., Zhang, L., Xia, H., Yan, Y., Zhu, X., Sun, F., Sun, L., Li, S., Li, D., Wang, J., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01164-9 · Cited by 393 · see citing works
Role of S100 proteins in health and disease
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118677 · Cited by 363 · see citing works
An immune-based biomarker signature is associated with mortality in COVID-19 patients
Abers, M. S., Delmonte, O. M., Ricotta, E., Fintzi, J., Fink, D. L., de Jesus, A. A., Zarember, K. A., Alehashemi, S., Oikonomou, V., Desai, J. V., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.144455 · Cited by 335 · see citing works
Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19
Shu, T., Ning, W., Wu, D., Xu, J., Han, Q., Huang, M., Zou, X., Yang, Q., Yuan, Y., Bie, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.008 · Cited by 337 · see citing works
Acute inflammatory response via neutrophil activation protects against the development of chronic pain
Parisien, M., Lima, L. B. Q., Dagostino, C., El-Hachem, N., Drury, G. L., Grant, A. V., Huising, J., Verma, V., Meloto, C. B., Silva, J. R., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abj9954 · Cited by 327 · see citing works
S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic/Reperfusion Injury
Li, Y., Chen, B., Yang, X., Zhang, C., Yao, J., Li, P., Liu, Y., Li, Z., Qiao, B., Lau, W. B., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.039262 · Cited by 317 · see citing works
Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design
Bahr, G., González, L. J., & Vila, A. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00138 · Cited by 284 · see citing works
Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19
Guo, Q., Zhao, Y., Li, J., Liu, J., Yang, X., Guo, X., Kuang, M., Xia, H., Zhang, Z., Cao, L., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.12.016 · Cited by 242 · see citing works
Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis
Rojahn, T. B., Vorstandlechner, V., Krausgruber, T., Bauer, W. M., Alkon, N., Bangert, C., Thaler, F. M., Sadeghyar, F., Fortelny, N., Fife, V. E. R., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.041 · Cited by 229 · see citing works
Neutrophils: from IBD to the gut microbiota
Danne, C., Skerniškytė, J., Marteyn, B., & Sokol, H. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00871-3 · Cited by 238 · see citing works
Neutrophils as potential therapeutic targets in hepatocellular carcinoma
Geh, D., Leslie, J., Rumney, R., Reeves, H. L., Bird, T. G., & Mann, D. A. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00568-5 · Cited by 222 · see citing works
Transcriptional and epigenetic decoding of the microglial aging process
Li, X., Li, Y., Jin, Y., Zhang, Y., Wu, J., Xu, Z., Huang, Y., Cai, L., Gao, S., Liu, T., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00479-x · Cited by 225 · see citing works
COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects
Smadja, D. M., Mentzer, S. J., Fontenay, M., Laffan, M., Ackermann, M., Helms, J., Jonigk, D. D., Chocron, R., Pier, G. B., Gendron, N., et al. (2021) · Angiogenesis · doi:10.1007/s10456-021-09805-6 · Cited by 200 · see citing works
COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis
Sohn, K. M., Lee, S., Kim, H. J., Cheon, S., Jeong, H., Lee, J.-Y., Kim, I. S., Silwal, P., Kim, Y. J., Paik, S., et al. (2020) · Journal of Korean Medical Science · doi:10.3346/jkms.2020.35.e343 · Cited by 198 · see citing works
The local microenvironment drives activation of neutrophils in human brain tumors
Maas, R. R., Soukup, K., Fournier, N., Massara, M., Galland, S., Kornete, M., Wischnewski, V., Lourenço, J., Croci, D., Álvarez-Prado, Á. F., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.043 · Cited by 197 · see citing works
Multifunctional Role of S100 Protein Family in the Immune System: An Update
Singh, P., & Ali, S. A. (2022) · Cells · doi:10.3390/cells11152274 · Cited by 196 · see citing works
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases
Wu, M., Chen, Y., Xia, H., Wang, C., Tan, C. Y., Cai, X., Liu, Y., Ji, F., Peng, X., Liu, R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018030117 · Cited by 192 · see citing works
Innate immunological pathways in COVID-19 pathogenesis
Paludan, S. R., & Mogensen, T. H. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm5505 · Cited by 186 · see citing works
STING agonist promotes CAR T cell trafficking and persistence in breast cancer
Xu, N., Palmer, D. C., Robeson, A. C., Shou, P., Bommiasamy, H., Laurie, S. J., Willis, C., Dotti, G., Vincent, B. G., Restifo, N. P., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200844 · Cited by 183 · see citing works
Hexokinase 1 cellular localization regulates the metabolic fate of glucose
Jesus, A. D., Keyhani‐Nejad, F., Pusec, C. M., Goodman, L., Geier, J., Stoolman, J. S., Stanczyk, P. J., Nguyen, T., Xu, K., Suresh, K. V., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.02.028 · Cited by 183 · see citing works
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
Unterman, A., Sumida, T. S., Nouri, N., Yan, X., Zhao, A., Gasque, V., Schupp, J. C., Asashima, H., Liu, Y., Cosme, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27716-4 · Cited by 174 · see citing works
Self-citation
S100A8 and S100A9 in Cancer
Chen, Y., Ouyang, Y., Li, Z., Wang, X., & Ma, J. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188891 · Cited by 165 · see citing works
Self-citation
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19
Theobald, S. J., Simonis, A., Georgomanolis, T., Kreer, C., Zehner, M., Eisfeld, H. S., Albert, M., Chhen, J., Motameny, S., Erger, F., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114150 · Cited by 161 · see citing works
Roles of S100A8 , S100A9 and S100A12 in infection, inflammation and immunity
Xia, P., Ji, X., Li, Y., Lian, S., Chen, Z., & Luo, Y. (2023) · Immunology · doi:10.1111/imm.13722 · Cited by 165 · see citing works
Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia
Mikacenic, C. R., Moore, R., Dmyterko, V., West, T. E., Altemeier, W. A., Liles, W. C., & Lood, C. (2018) · Critical Care · doi:10.1186/s13054-018-2290-8 · Cited by 153 · see citing works
Neutrophil calprotectin identifies severe pulmonary disease in COVID-19
Shi, H., Zuo, Y., Yalavarthi, S., Gockman, K., Zuo, M., Madison, J. A., Blair, C., Woodard, W., Lezak, S. P., Lugogo, N. L., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3covcra0720-359r · Cited by 151 · see citing works
Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death
Teng, Y., Mu, J., Xu, F., Zhang, X., Sriwastva, M. K., Liu, Q. M., Li, X., Lei, C., Sundaram, K., Hu, X., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.05.005 · Cited by 135 · see citing works
Neutrophils in Tuberculosis-Associated Inflammation and Lung Pathology
Muefong, C. N., & Sutherland, J. S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00962 · Cited by 132 · see citing works
Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing
Franz, S., Ertel, A., Engel, K. M., Simon, J. C., & Saalbach, A. (2022) · Theranostics · doi:10.7150/thno.67174 · Cited by 129 · see citing works
Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine–dependent manner in atopic dermatitis and psoriasis
Yang, L., Fu, J., Han, X., Zhang, C., Xia, L., Zhu, R., Huang, S., Xiao, W., Yu, H., Gao, Y., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.11.024 · Cited by 125 · see citing works
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124 · see citing works
Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness
Jiang, K., Chen, H., Fang, Y., Chen, L., Zhong, C., Bu, T., Dai, S., Pan, X., Fu, D., Qian, Y., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01816-3 · Cited by 124 · see citing works
Comparative analysis of the tumor immune-microenvironment of primary and brain metastases of non-small-cell lung cancer reveals organ-specific and EGFR mutation-dependent unique immune landscape
Song, S. G., Kim, S., Koh, J., Yim, J., Han, B., Kim, Y. A., Jeon, Y. K., & Chung, D. H. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02840-0 · Cited by 123 · see citing works
Regulation of zinc-dependent enzymes by metal carrier proteins
Thompson, M. W. (2022) · BioMetals · doi:10.1007/s10534-022-00373-w · Cited by 121 · see citing works
Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation
Mihaila, A. C., Ciortan, L., Macarie, R. D., Vadana, M., Cecoltan, S., Preda, M. B., Hudiță, A., Gan, A., Jakobsson, G., Tucureanu, M. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708770 · Cited by 118 · see citing works
Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution
Zheng, Y., Li, S., Li, S., Yu, S., Wang, Q., Zhang, K., Qu, L., Sun, Y., Bi, Y., Tang, F., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201288119 · Cited by 117 · see citing works
S100‐A9 protein in exosomes derived from follicular fluid promotes inflammation via activation of NF‐κB pathway in polycystic ovary syndrome
Li, H., Huang, X. Y., Chang, X., Yao, J., He, Q., Shen, Z., Ji, Y., & Wang, K. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14642 · Cited by 115 · see citing works
Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2
Zhang, S., Huang, W., Ren, L., Ju, X., Gong, M., Rao, J. Y., Sun, L., Li, P., Ding, Q., Wang, J., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00581-y · Cited by 115 · see citing works
S100A9 Regulates MDSCs-Mediated Immune Suppression via the RAGE and TLR4 Signaling Pathways in Colorectal Carcinoma
Huang, M., Wu, R., Chen, L., Peng, Q., Li, S., Zhang, Y., Zhou, L., & Duan, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02243 · Cited by 113 · see citing works
Targeting and exploitation of tumor-associated neutrophils to enhance immunotherapy and drug delivery for cancer treatment
Zhang, Y., Liu, G., Sun, M., & Lü, X. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0372 · Cited by 111 · see citing works
S100A8/A9 drives the formation of procoagulant platelets through GPIbα
Colicchia, M., Schrottmaier, W. C., Perrella, G., Reyat, J. S., Begum, J., Slater, A., Price, J. M. J., Clark, J. C., Zhi, Z., Simpson, M., et al. (2022) · Blood · doi:10.1182/blood.2021014966 · Cited by 110 · see citing works
Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations
Krasniewski, L. K., Chakraborty, P., Cui, C., Mazan-Mamczarz, K., Dunn, C., Piao, Y., Fan, J., Shi, C., Wallace, T., Nguyen, C., et al. (2022) · eLife · doi:10.7554/elife.77974 · Cited by 107 · see citing works
S100 family proteins in inflammation and beyond
Sreejit, G., Flynn, M., Patil, M., Krishnamurthy, P., Murphy, A. J., & Nagareddy, P. R. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.02.006 · Cited by 107 · see citing works
Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss
Hall, B. E., Macdonald, E., Cassidy, M. M., Yun, S., Sapio, M. R., Ray, P. R., Doty, M. E., Nara, P., Burton, M. D., Shiers, S. I., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08100-8 · Cited by 105 · see citing works
Neutrophil signaling during myocardial infarction wound repair
Daseke, M. J., Chalise, U., Becirovic‐Agic, M., Salomon, J., Cook, L. M., Case, A. J., & Lindsey, M. L. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109816 · Cited by 105 · see citing works
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes
Mellett, L., & Khader, S. A. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.10.004 · Cited by 101 · see citing works
A shift in lung macrophage composition is associated with COVID-19 severity and recovery
Chen, S. T., Park, M. D., Valle, D. M. D., Buckup, M., Tabachnikova, A., Thompson, R. C., Simons, N. W., Mouskas, K., Lee, B. H., Geanon, D., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn5168 · Cited by 104 · see citing works
Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function
Yao, R.-Q., Zhao, P., Li, Z., Liu, Y., Zheng, L., Duan, Y., Wang, L., Yang, R., Kang, H., Hao, J.-W., et al. (2023) · Military Medical Research · doi:10.1186/s40779-023-00462-y · Cited by 108 · see citing works
Multifunctional Microgel-Based Cream Hydrogels for Postoperative Abdominal Adhesion Prevention
Liu, B., Kong, Y., Alimi, O. A., Kuss, M. A., Tu, H., Hu, W., Rafay, A., Vikas, K., Shi, W., Lerner, M. L., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c12104 · Cited by 103 · see citing works
DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod
Talley, S., Valiauga, R., Anderson, L., Cannon, A. R., Choudhry, M. A., & Campbell, E. M. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02317-6 · Cited by 99 · see citing works
Transdermal psoriasis treatment inspired by tumor microenvironment-mediated immunomodulation and advanced by exosomal engineering
Yang, J., Zhu, J., Lu, S., Qin, H., & Zhou, W. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113664 · Cited by 97 · see citing works
IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system
Seyedsadr, M., Wang, Y., Elzoheiry, M., Gopal, S. S., Jang, S., Duran, G., Chervoneva, I., Kasimoglu, E., Wrobel, J. A., Hwang, D., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221007120 · Cited by 91 · see citing works
VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation
Kosmider, O., Posseme, C., Templé, M., Corneau, A., Carbone, F., Duroyon, E., Breillat, P., Chirayath, T.-W., Oulès, B., Sohier, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44811-4 · Cited by 92 · see citing works
Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade
Zhao, L., Pang, Y., Zhou, Y., Chen, J., Fu, H., Guo, W., Xu, W., Xue, X., Su, G., Sun, L., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01853-w · Cited by 91 · see citing works
Self-citation
Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc Degeneration
Ling, Z., Liu, Y., Wang, Z., Zhang, Z., Chen, B., Yang, J., Zeng, B., Gao, Y., Jiang, C., Huang, Y., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.833420 · Cited by 87 · see citing works
Self-citation
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization
Mahon, O. R., Kelly, D. J., McCarthy, G., & Dunne, A. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.10.010 · Cited by 86 · see citing works
Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma
Tumino, N., Weber, G., Besi, F., Bufalo, F. D., Bertaina, V., Paci, P., Quatrini, L., Antonucci, L., Sinibaldi, M., Quintarelli, C., et al. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01193-0 · Cited by 91 · see citing works
Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction
Jakobsson, G., Papareddy, P., Andersson, H., Mulholland, M., Bhongir, R. K. V., Ljungcrantz, I., Engelbertsen, D., Björkbacka, H., Nilsson, J. Å., Manea, A., et al. (2023) · Critical Care · doi:10.1186/s13054-023-04652-x · Cited by 89 · see citing works
Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host
Lloréns‐Rico, V., Gregory, A., Weyenbergh, J. V., Jansen, S., Buyten, T. V., Qian, J., Braz, M., Menezes, S. M., Mol, P. V., Vanderbeke, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26500-8 · Cited by 84 · see citing works
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy
Li, J., Shu, X., Xu, J., Su, S. M., Chan, U. I., Mo, L., Liu, J., Zhang, X., Adhav, R., Chen, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29151-5 · Cited by 86 · see citing works
Multimodule characterization of immune subgroups in intrahepatic cholangiocarcinoma reveals distinct therapeutic vulnerabilities
Lin, J., Dai, Y., Sang, C., Song, G., Xiang, B., Zhang, M., Dong, L., Xia, X., Ma, J., Shen, X., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004892 · Cited by 86 · see citing works
Self-citation
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis
Kai, H., Wang, C., Vagts, C. L., Raguveer, V., Finn, P. W., & Perkins, D. L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0261242 · Cited by 84 · see citing works
Premise and peril of Wnt signaling activation through GSK-3β inhibition
Law, S. M., & Zheng, J. (2022) · iScience · doi:10.1016/j.isci.2022.104159 · Cited by 85 · see citing works
Role of Neutrophils in the Pathogenesis of Nonalcoholic Steatohepatitis
Hwang, S., Yun, H., Moon, S., Cho, Y. E., & Gao, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.751802 · Cited by 84 · see citing works
Zinc Homeostasis in Platelet-Related Diseases
Mammadova‐Bach, E., & Braun, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215258 · Cited by 85 · see citing works
Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions
Mossel, D. M., Moganti, K., Riabov, V., Weiß, C., Kopf, S., Cordero, J., Dobreva, G. D., Rots, M. G., Klüter, H., Harmsen, M. C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01071 · Cited by 82 · see citing works
Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
Palma, C., Rocca, C. L., Gigantino, V., Aquino, G., Piccaro, G., Silvestre, D. D., Brambilla, F., Rossi, R., Bonacina, F., Lepore, M. T., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.016 · Cited by 81 · see citing works
Targeting conserved TIM3 + VISTA + tumor-associated macrophages overcomes resistance to cancer immunotherapy
Vanmeerbeek, I., Naulaerts, S., Sprooten, J., Laureano, R. S., Govaerts, J., Trotta, R., Pretto, S., Zhao, S., Cafarello, S. T., Verelst, J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adm8660 · Cited by 78 · see citing works
Interleukin 17 Promotes Expression of Alarmins S100A8 and S100A9 During the Inflammatory Response of Keratinocytes
Christmann, C., Zenker, S., Martens, L., Hübner, J., Loser, K., Vogl, T., & Roth, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599947 · Cited by 81 · see citing works
Deficiency of S100A9 Alleviates Sepsis-Induced Acute Liver Injury through Regulating AKT-AMPK-Dependent Mitochondrial Energy Metabolism
Zhang, Y.-T. Y., Wu, F., Teng, F., Guo, S., & Li, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032112 · Cited by 78 · see citing works
Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation
Tousif, S., Singh, A. P., Umbarkar, P., Galindo, C. L., Wheeler, N. D., Cora, A. T., Zhang, Q., Prabhu, S. D., & Lal, H. (2023) · Circulation Research · doi:10.1161/circresaha.122.321504 · Cited by 76 · see citing works
Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions
Lv, Y., Cai, F., Zhao, X., Zhu, X., Wei, F., Zheng, Y., Shi, X., & Yang, J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202314402 · Cited by 76 · see citing works
Re-establishment of macrophage homeostasis by titanium surface modification in type II diabetes promotes osseous healing
Lee, R. S. B., Hamlet, S. M., Moon, H., & Ivanovski, S. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120464 · Cited by 75 · see citing works
Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone
Kumar, A., Kim, S., Su, Y., Sharma, M., Kumar, P., Singh, S., Lee, J., Furdui, C. M., Singh, R. N., Hsu, F., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2020.103192 · Cited by 75 · see citing works
Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery
Li, Y., Hou, G., Zhou, H., Wang, Y., Tun, H. M., Zhu, A., Zhao, J., Xiao, F., Liu, D., Liu, D., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00508-4 · Cited by 75 · see citing works
Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance
Genovese, I., Carinci, M., Modesti, L., Aguiari, G., Pinton, P., & Giorgi, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094770 · Cited by 76 · see citing works
S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fission and respiratory dysfunction
Wu, F., Zhang, Y.-T. Y., Teng, F., Li, H., & Guo, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109716 · Cited by 75 · see citing works
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging
Xu, F., Wang, L., Zhou, R., Zhou, R., Chen, L., Peng, H., Huang, Y., Guo, Q., Luo, X., & Zhou, H. (2023) · Nature Communications · doi:10.1038/s41467-023-38842-6 · Cited by 76 · see citing works
Proteomic landscape of the extracellular matrix in the fibrotic kidney
Li, L., He, M., Tang, X., Huang, J., Li, J., Hong, X., Fu, H., & Liu, Y. (2023) · Kidney International · doi:10.1016/j.kint.2023.01.021 · Cited by 74 · see citing works
Single-Cell RNA Sequencing Identifies New Inflammation-Promoting Cell Subsets in Asian Patients With Chronic Periodontitis
Qian, S., Huang, Q., Chen, R., Mo, J., Zhou, L., Zhao, Y., Li, B., & Lai, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.711337 · Cited by 73 · see citing works
Characterization of Cellular Heterogeneity and an Immune Subpopulation of Human Megakaryocytes
Liu, C., Wu, D., Xia, M., Li, M., Sun, Z., Shen, B., Liu, Y., Jiang, E., Wang, H., Su, P., et al. (2021) · Advanced Science · doi:10.1002/advs.202100921 · Cited by 72 · see citing works
Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Lim, W., Ng, B., Widjaja, A. A., Xie, C., Su, L., Ko, N. S. J., Lim, S.-Y., Kwek, X.-Y., Lim, S., Cook, S. A., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227505 · Cited by 77 · see citing works
Tumor-Mediated Neutrophil Polarization and Therapeutic Implications
Raftopoulou, S., Valadez-Cosmes, P., Mihalič, Z. N., Schicho, R., & Kargl, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063218 · Cited by 68 · see citing works
Biological Roles of Fibroblasts in Periodontal Diseases
Naruishi, K. (2022) · Cells · doi:10.3390/cells11213345 · Cited by 71 · see citing works
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A
Zhang, L., Ma, X., Shi, R., Zhang, L., Zhao, R., Duan, R., Qin, Y., Gao, S., Li, X., Duan, J., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15983 · Cited by 71 · see citing works
Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans
Yoo, R., Kim, J.-H., Moon, H. Y., Park, J. Y., Cheon, S., Shin, H.-S., Han, D., Kim, Y., Park, S., & Choi, S. H. (2025) · Nature Communications · doi:10.1038/s41467-025-58726-1 · Cited by 75 · see citing works
S100 proteins in obesity: liaisons dangereuses
Riuzzi, F., Chiappalupi, S., Arcuri, C., Giambanco, I., Sorci, G., & Donato, R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03257-4 · Cited by 68 · see citing works
Myeloperoxidase and Related Biomarkers are Suggestive Footprints of Endothelial Microvascular Inflammation in HFpEF Patients
Hage, C., Michaëlsson, E., Kull, B., Miliotis, T., Svedlund, S., Linde, C. M., Donal, E., Daubert, J., Gan, L., & Lund, L. H. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12700 · Cited by 69 · see citing works
Types of necroinflammation, the effect of cell death modalities on sterile inflammation
Mázló, A., Jenei, V., Sára, B., Molnár, T., Bácsi, A., & Koncz, G. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04883-w · Cited by 68 · see citing works
Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy
Hunt, L. C., Graça, F. A., Pagala, V., Wang, Y., Li, Y., Yuan, Z., Fan, Y., Labelle, M., Peng, J., & Demontis, F. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109971 · Cited by 69 · see citing works
Integrative transcriptomics analysis of lung epithelial cells and identification of repurposable drug candidates for COVID-19
Islam, T., Rahman, M. R., Aydın, B., Beklen, H., Arğa, K. Y., & Shahjaman, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173594 · Cited by 66 · see citing works
Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass
Inoue, K., Qin, Y., Xia, Y., Han, J., Yuan, R., Sun, J., Xu, R., Jiang, J. X., Greenblatt, M. B., & Zhao, B. (2023) · eLife · doi:10.7554/elife.82118 · Cited by 65 · see citing works
Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis
Wu, Y., Cao, Y., Xu, K., Zhu, Y., Qiao, Y., Wu, Y., Chen, J., Li, C., Zeng, R., & Ge, G. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03443-y · Cited by 65 · see citing works
Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants
Fischer, N. G., & Aparicio, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.019 · Cited by 65 · see citing works
Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status–Dependent Manner
Singh, K., Sinha, M., Pal, D., Tabasum, S., Gnyawali, S. C., Khona, D. K., Sarkar, S., Mohanty, S. K., Gonzalez, F. S., Khanna, S., et al. (2019) · Diabetes · doi:10.2337/db19-0202 · Cited by 65 · see citing works

S100A8/A9: From basic science to clinical application
Pruenster, M., Vogl, T., Roth, J., & Sperandio, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.015 · Cited by 451 · see citing works
Inflammatory role of S100A8/A9 in the central nervous system non-neoplastic diseases
Tian, Q., Li, Z., Yan, Z., Jiang, S., Zhao, X., Wang, L., & Li, M. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111100 · Cited by 19 · see citing works
S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity
Nacken, W. K. F., Roth, J., Sorg, C., & Kerkhoff, C. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10299 · Cited by 346 · see citing works
S100A8 and S100A9–Critical Mediators of Inflammation in Arthritis
Paramasivam, S., Selvan, P. S., & Ekambaram, S. P. (2025) · Current Proteomics · doi:10.2174/0115701646347924241111071800 · Cited by 2 · see citing works
S100A8 and S100A9 in Cancer
Chen, Y., Ouyang, Y., Li, Z., Wang, X., & Ma, J. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188891 · Cited by 165 · see citing works
Self-citation

Authors: Wang, S., Song, R., Wang, Z., Jing, Z., Wang, S., & Ma, J.
Affiliations: Central South University (CN)
Corresponding author: Ma, Jian
ORCID: Wang, Siwen
Song, Rui
Wang, Ziyi
Jing, Zhaocheng
Wang, Shaoxiong
Ma, Jian
Venue: Frontiers in Immunology
Publisher: Frontiers Media SA
Published: 2018-06-11
Volume: 9
Pages: 1298-1298
ISSN: 1664-3224 (ISSN-L)
DOI: 10.3389/fimmu.2018.01298
PMC: PMC6004386
OpenAlex: W2808305854
Cited by: 1,450
References: 165
Citations by year: 2026: 176 · 2025: 217 · 2024: 248 · 2023: 225 · 2022: 236 · 2021: 184 · 2020: 119 · 2019: 40 · 2018: 4 · 2017: 1
FWCI: 8.53
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Immunology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81672889, 81472694)
Hunan Provincial Science and Technology Department (2016JC2035)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: S100A8/A9, S-100 protein, heterodimer, calcium-binding proteins, inflammation, neutrophils, monocytes, leukocyte recruitment, cytokine production, arachidonic acid metabolism, biomarkers, therapeutic target, small molecule inhibitors
MeSH terms: Animals, Disease Susceptibility, Gene Expression Regulation, Humans, Immunity, Inflammation, Biomarkers, Autoimmunity, Protein Transport, Calgranulin A, Calgranulin B, Host-Pathogen Interactions, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

S100A8/A9 in Inflammation

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks