S100A8 and S100A9 in inflammation and cancer

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NF-κB regulation in the immune system

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Signaling to NF-κB

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NF-κB: linking inflammation and immunity to cancer development and progression

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High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

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Paradoxical roles of the immune system during cancer development

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AP-1: a double-edged sword in tumorigenesis

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RAGE Mediates a Novel Proinflammatory Axis

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Friends or foes — bipolar effects of the tumour stroma in cancer

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Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

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AP-1 subunits: quarrel and harmony among siblings

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Understanding RAGE, the receptor for advanced glycation end products

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The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

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Shaping the nuclear action of NF-κB

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Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases

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The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

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Intracellular and extracellular roles of S100 proteins

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Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion

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S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)

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S100 proteins structure functions and pathology

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Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis

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Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins

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The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins

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Myeloid-related Protein (MRP) 8 and MRP14, Calcium-binding Proteins of the S100 Family, Are Secreted by Activated Monocytes via a Novel, Tubulin-dependent Pathway

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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

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Tumor necrosis factor or tumor promoting factor?

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Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin

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Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells.

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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

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S100 Proteins in the Epidermis

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Tumor–stroma interactions

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S100 proteins: structure, functions and pathology

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Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules

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Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

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Tumour necrosis factor-α as a tumour promoter

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MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes

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S100A4, a Mediator of Metastasis

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S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity

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c-fos is required for malignant progression of skin tumors

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Loss of S100A9 (MRP14) Results in Reduced Interleukin-8-Induced CD11b Surface Expression, a Polarized Microfilament System, and Diminished Responsiveness to Chemoattractants In Vitro

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Protein Expression Profiles in Pancreatic Adenocarcinoma Compared with Normal Pancreatic Tissue and Tissue Affected by Pancreatitis as Detected by Two-Dimensional Gel Electrophoresis and Mass Spectrometry

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THE ROLE OF THE COMPLEMENT SYSTEM IN ISCHEMIA-REPERFUSION INJURY

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Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells

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Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation

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RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

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The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis

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The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils.

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Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings

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Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: Results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis

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Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues.

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Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes

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Activator protein 1 (AP-1)– and nuclear factor κB (NF-κB)–dependent transcriptional events in carcinogenesis

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JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

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Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers

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The Human S100 Protein MRP-14 Is a Novel Activator of the β2 Integrin Mac-1 on Neutrophils

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Calcium-Binding Proteins S100A8 and S100A9 as Novel Diagnostic Markers in Human Prostate Cancer

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Gastric cancers overexpress S100A calcium-binding proteins.

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S100P Promotes Pancreatic Cancer Growth, Survival, and Invasion

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The Ca2+-binding Proteins S100A8 and S100A9 Are Encoded by Novel Injury-regulated Genes

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MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner

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Purification and Partial Characterization of a Highly Immunogenic Human Leukocyte Protein, the L1 Antigen

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Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment

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Calcium-dependent complex assembly of the myeloic differentiation proteins MRP-8 and MRP-14

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Myeloid Cell Function in MRP-14 (S100A9) Null Mice

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High Level Expression and Dimer Characterization of the S100 EF-hand Proteins, Migration Inhibitory Factor-related Proteins 8 and 14

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The S100 Family Heterodimer, MRP-8/14, Binds with High Affinity to Heparin and Heparan Sulfate Glycosaminoglycans on Endothelial Cells

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Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.

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Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray

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Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues

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Tumors are unique organs defined by abnormal signaling and context

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Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

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Cytogenetic findings in 73 osteosarcoma specimens and a review of the literature

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Promising molecular targets for cancer prevention: AP-1, NF-κB and Pdcd4

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The Two Calcium-binding Proteins, S100A8 and S100A9, Are Involved in the Metabolism of Arachidonic acid in Human Neutrophils

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Interaction of S100A8/S100A9−Arachidonic Acid Complexes with the Scavenger Receptor CD36 May Facilitate Fatty Acid Uptake by Endothelial Cells

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Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade – results of an explorative CGH meta-analysis

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Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays

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Frequent amplification and rearrangement of chromosomal bands 6p12‐p21 and 17p11.2 in osteosarcoma

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Chromosomal alterations in the clonal evolution to the metastatic stage of squamous cell carcinomas of the lung

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The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones.

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Two Proteins Modulating Transendothelial Migration of Leukocytes Recognize Novel Carboxylated Glycans on Endothelial Cells

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S100 proteins and their influence on pro-survival pathways in cancer

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Transendothelial migration of 27E10+ human monocytes

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IFN-γ and TNF Regulate Macrophage Expression of the Chemotactic S100 Protein S100A8

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Calcium‐dependent secretion in human neutrophils: A proteomic approach

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Calgranulins S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner and overexpressed throughout skin carcinogenesis

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The endothelial cell binding site for advanced glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptide

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Hyperzincaemia and hypercalprotectinaemia: a new disorder of zinc metabolism

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Immunohistochemical Distribution and Serum Levels of the Ca 2 + -Binding Proteins MRP8, MRP14 and Their Heterodimeric Form MRP8/14 in Crohn’s Disease

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Soluble Mediators of Inflammation During Tumor Development

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NF-κB inhibition: A double-edged sword in cancer?

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Untitled work

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MntABC and MntH Contribute to Systemic Staphylococcus aureus Infection by Competing with Calprotectin for Nutrient Manganese

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A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

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Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

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Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation

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The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration

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Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation

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Cancer‐associated fibroblasts induce an aggressive phenotypic shift in non‐malignant breast epithelial cells via interleukin‐8 and S100A8

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Chronic alcohol administration causes expression of calprotectin and RAGE altering the distribution of zinc ions in mouse testis

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