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Identification and characterization of undifferentiated mast cells in mouse bone marrow

Jamur, Maria Célia, Grodzki, Ana Cristina G., Berenstein, Elsa H., Hamawy, Majed M., Siraganian, Reuben P., Oliver, Constance·2005·Blood
DOI 10.1182/blood-2004-02-0756
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Abstract

Sequential immunomagnetic isolation with 2 monoclonal antibodies was used to purify and characterize an undifferentiated mast cell in adult mouse bone marrow that had not been previously recognized. This cell represents 0.02% of the cells in the bone marrow, is CD34+, CD13+, and c-kit+, and does not express FcϵRI. However, by polymerase chain reaction (PCR) the cell contains message for the α and β subunits of FcϵRI, mast cell–specific proteases, and carboxypeptidase A. Morphologically, this cell has a large nucleus, little cytoplasm, few cytoplasmic organelles, and no cytoplasmic granules. In vitro, in the presence of interleukin-3 (IL-3) and stem cell factor (SCF) these cells differentiate only into a granulated mast cell that now expresses CD13, c-kit, mast cell–specific gangliosides, FcϵRI, and binds immunoglobulin E (IgE). When injected into lethally irradiated mice, these cells are able to reconstitute the mast cell population in the spleen.

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Metadata

Authors
Jamur, M. C., Grodzki, A. C. G., Berenstein, E. H., Hamawy, M. M., Siraganian, R. P., & Oliver, C.
Affiliations
From the Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto-Universidade de São Paulo, Ribeirão Preto, Brasil; and the Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD.
Venue
Blood
Publisher
American Society of Hematology
Published
2005-06-01
Volume
105
Issue
11
Pages
4282-4289
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2004-02-0756
Cited by
70
References
0
Language
en

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