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Cited by 273

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants

Open access
Rosenberg, Philip S., Socié, Gerard, Alter, Blanche P., Gluckman, Eliane·2005·Blood
DOI 10.1182/blood-2004-04-1652
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Abstract

Hematopoietic stem cell transplant (SCT) is currently the only therapy that can restore normal hematopoiesis in patients with Fanconi anemia (FA). Patients with FA have a high baseline risk of squamous cell cancers (SCCs) of the head, neck, and esophagus, and SCT conditioning may increase SCC incidence. We evaluated the risks of SCC and death in 145 patients with FA in the North American Survey (NAS) cohort who did not receive transplants, and 117 patients with FA in the Hôpital Saint Louis (SLH) cohort who did receive transplants. The age-specific hazard of SCC was 4.4-fold higher in patients who received transplants than in those who did not (P = .003), and SCCs occurred at significantly younger ages in the former (respective medians, 18 and 33 years, P = .004). Survival after SCC was similarly poor in both cohorts (P = .135, median, 13 months). The hazard of SCC increased at a greater than linear rate, to 4.4% per year by age 40 in NAS and 4.7% per year by 10 years after transplant in SLH. In SLH, the hazard of non-SCC death was biphasic, declining significantly (P = .004) from 7.1% per month during the first 6 months after transplant to 0.13% per month (1.6% per year) after the first year. Acute and chronic graft-versus-host diseases were significant SCC risk factors. Adverse event rates in these cohorts provide historical control rates to assess emerging therapies for FA.

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Metadata

Authors
Rosenberg, P. S., Socié, G., Alter, B. P., & Gluckman, E.
Venue
Blood
Publisher
American Society of Hematology
Published
2005-01-01
Volume
105
Issue
1
Pages
67-73
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2004-04-1652
OpenAlex
W2062073391
Cited by
273
References
40
FWCI
5.66
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants. https://app.cochat.ai/papers/10.1182/blood-2004-04-1652
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Rosenberg, P. S., Socié, G., Alter, B. P., & Gluckman, E. (2005). Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants. Blood. https://doi.org/10.1182/blood-2004-04-1652

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