The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase
Open accessAbstract
Endothelial cell-cell junctional proteins and cortical actin are of central importance for regulating vascular permeability. Rap1, a member of the Ras family of GTPases, is enriched at endothelial cell-cell contacts and activated by cyclic AMP (cAMP) through a PKA-independent pathway. Activation of a cAMP-inducible guanine-exchange factor for Rap, Epac, results in markedly enhanced basal endothelial barrier function by increasing cortical actin and subsequent redistribution of adherens and tight junctional molecules to cell-cell contacts. Activation of Epac also counteracts thrombin-induced hyperpermeability through down-regulation of Rho GTPase activation, suggesting cross-talk between Rap and Rho GT-Pases. Thus, Epac/Rap activation represents a new pathway for regulating endothelial cell barrier function.
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Cites
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Rap1 signalling: adhering to new models
Bos, J. L., de Rooij, J., & Reedquist, K. A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073073 · Cited by 626
Epac: a new cAMP target and new avenues in cAMP research
Bos, J. L. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1197 · Cited by 489
Rho GTPases and the regulation of endothelial permeability
Wojciak-Stothard, B., & Ridley, A. J. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(03)00008-9 · Cited by 470
Shaw, S. K., Bamba, P. S., Perkins, B. N., & Luscinskas, F. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2323 · Cited by 300
Self-citationRole of cyclic adenosine monophosphate in the induction of endothelial barrier properties
Stelzner, T. J., Weil, J. V., & O'Brien, R. F. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041390122 · Cited by 251
Protein kinase signaling in the modulation of microvascular permeability
Yuan, S. Y. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(03)00010-7 · Cited by 242
Rap1 GTPase Regulation of Adherens Junction Positioning and Cell Adhesion
Knox, A. L., & Brown, N. H. (2002) · Science · doi:10.1126/science.1067549 · Cited by 238
Mechanisms of increased endothelial permeability
Lum, H., & Malik, A. B. (1996) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-74-7-787 · Cited by 231
The role of Rap1 in integrin-mediated cell adhesion
Bos, J. L., de Bruyn, K., Enserink, J., Kuiperij, B., Rangarajan, S., Rehmann, H., Riedl, J., de Rooij, J., van Mansfeld, F., & Zwartkruis, F. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310083 · Cited by 216
Cited by
The role of adherens junctions and VE-cadherin in the control of vascular permeability
Dejana, E., Orsenigo, F., & Lampugnani, M. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.017897 · Cited by 986
Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions
Persidsky, Y., Ramirez, S. H., Haorah, J., & Kanmogne, G. D. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9025-3 · Cited by 922
VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity
Giannotta, M., Trani, M., & Dejana, E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.020 · Cited by 854
Epac proteins: multi-purpose cAMP targets
Bos, J. L. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.10.002 · Cited by 532
Epac: Defining a New Mechanism for cAMP Action
Gloerich, M., & Bos, J. L. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105714 · Cited by 473
Metadata
- Authors
- Cullere, X., Shaw, S. K., Andersson, L., Hirahashi, J., Luscinskas, F. W., & Mayadas, T. N.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-03-01
- Volume
- 105
- Issue
- 5
- Pages
- 1950-1955
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1964171635
- Cited by
- 360
- References
- 23
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cullere, X., Shaw, S. K., Andersson, L., Hirahashi, J., Luscinskas, F. W., & Mayadas, T. N. (2005). Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. https://doi.org/10.1182/blood-2004-05-1987
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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