The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Epac: Defining a New Mechanism for cAMP Action
Abstract
cAMP is a second messenger that is essential for relaying hormonal responses in many biological processes. The discovery of the cAMP target Epac explained various effects of cAMP that could not be attributed to the established targets PKA and cyclic nucleotide–gated ion channels. Epac1 and Epac2 function as guanine nucleotide exchange factors for the small G protein Rap. cAMP analogs that selectively activate Epac have helped to reveal a role for Epac in processes ranging from insulin secretion to cardiac contraction and vascular permeability. Advances in the understanding of the activation mechanism of Epac and its regulation by diverse anchoring mechanisms have helped to elucidate the means by which cAMP fulfills these functions via Epac.
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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
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Self-citationGEFs and GAPs: Critical Elements in the Control of Small G Proteins
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Self-citationSignaling Mechanisms Regulating Endothelial Permeability
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A Family of cAMP-Binding Proteins That Directly Activate Rap1
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The role of adherens junctions and VE-cadherin in the control of vascular permeability
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Cytoskeletal regulation of pulmonary vascular permeability
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A ras-related gene with transformation suppressor activity
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Metadata
- Authors
- Gloerich, M., & Bos, J. L.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2010-02-01
- Volume
- 50
- Issue
- 1
- Pages
- 355-375
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2126312769
- Cited by
- 473
- References
- 140
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gloerich, M., & Bos, J. L. (2010). Epac: Defining a New Mechanism for cAMP Action. Annual Review of Pharmacology and Toxicology. https://doi.org/10.1146/annurev.pharmtox.010909.105714
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
