Cited by 335Neutrophil, Myeloperoxidase and Oxidative MechanismsAmino Acid Enzymes and MetabolismImmune cells in cancer

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Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity

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Munder, M.·2005·Blood

DOI 10.1182/blood-2004-07-2521

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Abstract

The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an important determinant of the inflammatory response of murine macrophages and dendritic cells. Here we analyzed the expression of the isoform arginase I in human myeloid cells. Using healthy donors and patients with arginase I deficiency, we found that in human leukocytes arginase I is constitutively expressed only in granulocytes and is not modulated by a variety of proinflammatory and anti-inflammatory stimuli in vitro. We demonstrate that arginase I is localized in azurophil granules of neutrophils and constitutes a novel antimicrobial effector pathway, likely through arginine depletion in the phagolysosome. Our findings demonstrate important differences between murine and human leukocytes with respect to regulation and function of arginine metabolism via arginase.

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Authors: Munder, M.
Affiliations: University Hospital Heidelberg (DE)
Corresponding author: Munder, M.
ORCID: Munder, M.
Venue: Blood
Publisher: American Society of Hematology
Published: 2005-03-15
Volume: 105
Issue: 6
Pages: 2549-2556
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2004-07-2521
OpenAlex: W2108273635
Cited by: 335
References: 42
Citations by year: 2026: 7 · 2025: 12 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 19 · 2020: 15 · 2019: 18 · 2018: 12 · 2017: 15 · 2016: 17 · 2015: 20 · 2014: 28 · 2013: 25 · 2012: 17
FWCI: 3.33
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: arginase-1, granulocytes, neutrophils, arginine metabolism, nitric oxide synthase, fungicidal activity, azurophilic granules, arginine deprivation, phagolysosomes, myeloid cells, inflammation
MeSH terms: Animals, Antifungal Agents, Arginase, Arginine, Humans, Isoenzymes, Macrophages, Neutrophils, Phagosomes, Species Specificity, Gene Expression Regulation, Enzymologic, Nitric Oxide Synthase, Hyperargininemia, Secretory Vesicles, Microscopy, Electron, Transmission, Mice

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Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity

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