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Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity
Open accessAbstract
The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an important determinant of the inflammatory response of murine macrophages and dendritic cells. Here we analyzed the expression of the isoform arginase I in human myeloid cells. Using healthy donors and patients with arginase I deficiency, we found that in human leukocytes arginase I is constitutively expressed only in granulocytes and is not modulated by a variety of proinflammatory and anti-inflammatory stimuli in vitro. We demonstrate that arginase I is localized in azurophil granules of neutrophils and constitutes a novel antimicrobial effector pathway, likely through arginine depletion in the phagolysosome. Our findings demonstrate important differences between murine and human leukocytes with respect to regulation and function of arginine metabolism via arginase.
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“Importantly, in contrast to rodent Mp, human M2a Mp or monocytes do not express arginase [36,37].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [36]
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Cites
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
Granules of the Human Neutrophilic Polymorphonuclear Leukocyte
Borregaard, N., & Cowland, J. B. (1997) · Blood · doi:10.1182/blood.v89.10.3503 · Cited by 1,554
Killing activity of neutrophils is mediated through activation of proteases by K+ flux
Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153
Sørensen, O. E., Follin, P., Johnsen, A. H., Calafat, J., Tjabringa, G. S., Hiemstra, P. S., & Borregaard, N. (2001) · Blood · doi:10.1182/blood.v97.12.3951 · Cited by 894
Kusmartsev, S. A., Nefedova, Y., Yoder, D., & Gabrilovich, D. I. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.989 · Cited by 876
Hesse, M., Modolell, M., Flamme, A. C. L., Schito, M. L., Fuentes, J. M., Cheever, A. W., Pearce, E. J., & Wynn, T. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6533 · Cited by 723
Munder, M., Eichmann, K., & Modolell, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5347 · Cited by 647
Self-citationTh1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells.
Munder, M., Eichmann, K., Morán, J., Centeno, F., Soler, G., & Modolell, M. (1999) · Journal of Immunology · doi:10.4049/jimmunol.163.7.3771 · Cited by 619
Self-citationComparative properties of arginases
Jenkinson, C. P., Grody, W. W., & Cederbaum, S. D. (1996) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)02138-8 · Cited by 610
Modolell, M., Corraliza, I. M., Link, F., Soler, G., & Eichmann, K. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250436 · Cited by 554
Research works printed but not linked: 4
- Jenkinson CP, Grody WW, Cederbaum SD. Com- parative properties of arginases. Comp Biochem Physiol B Biochem Mol Biol. 1996;114:107-132.
- Modolell M, Corraliza IM, Link F, Soler G, Eich- mann K. Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone mar- row-derived macrophages by TH1 and TH2 cyto- kines. Eur J Immunol. 1995;25:1101-1104.
- Rutschman R, Lang R, Hesse M, Ihle JN, Wynn TA, Murray PJ. Stat6-dependent substrate deple- tion regulates nitric oxide production. J Immunol. 2001;166:2173-2177.
- Diez A, Fuentes JM, Prada F, Campo ML, Soler G. Immunological identity of the two different mo- lecular mass constitutive subunits of liver argi- nase. Biol Chem Hoppe Seyler. 1994;375:537- 541.
Cited by
Sorted by citations
Items 201–300 of 335
(1980) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-8914-9 · Cited by 19
Myeloid-Derived Suppressor Cells in Trypanosoma cruzi Infection
Fresno, M., & Gironès, N. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.737364 · Cited by 19
Rodríguez-López, J. M., Iglesias-González, J. L., Lozano-Sanchez, F. S., Palomero-Rodríguez, M. Á., & Sánchez-Conde, P. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144187 · Cited by 17
Fitzpatrick, J. M., Fuentes, J. M., Chalmers, I. W., Wynn, T. A., Modolell, M., Hoffmann, K. F., & Hesse, M. (2008) · International Journal for Parasitology · doi:10.1016/j.ijpara.2008.06.015 · Cited by 17
Kinetic Analysis of Ex Vivo Human Blood Infection by Leishmania
Moreno, I., Domínguez, M., Rodríguez, D. C., Aizpurúa, C., & Toraño, A. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000743 · Cited by 17
Jørgensen, M. A., Holmström, M. O., Martinenaite, E., Riley, C. H., Hasselbalch, H. C., & Andersen, M. H. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1468957 · Cited by 16
Detection and functional evaluation of arginase-1 isolated from human PMNs and murine MDSC
Canè, S., & Bronte, V. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.07.022 · Cited by 16
Hsieh, L. L., Thompson, E. A., Jairam, N. P., Roznik, K., Figueroa, A., Aytenfisu, T. Y., Zhou, W., Gour, N., Chao, K.-H., Milstone, A. M., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adn7527 · Cited by 15
Myeloid‐Derived Suppressor Cells in Cancers and Inflammatory Diseases: Angel or Demon?
Su, Z., Ni, P., Zhou, C., & Wang, J. (2016) · Scandinavian Journal of Immunology · doi:10.1111/sji.12473 · Cited by 15
Arginase 1 is upregulated at admission in patients with ST‐elevation myocardial infarction
Tengbom, J., Cederström, S., Verouhis, D., Böhm, F., Eriksson, P. O., Folkersen, L., Gabrielsen, A., Jernberg, T., Lundman, P., Persson, J., et al. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13358 · Cited by 15
Pietsch, C., Neumann, N., Preuer, T., & Kloas, W. (2011) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2011.02981.x · Cited by 15
Alibardi, L. (2020) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2020.151549 · Cited by 15
Ogino, K., Murakami, I., Wang, D.-H., Tsukiyama, Y., Takahashi, H., Kubo, M., Sakano, N., Setiawan, H., Bando, M., & Ohmoto, Y. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.08.012 · Cited by 15
Human eosinophil granulocytes do not express the enzyme arginase
Luckner‐Minden, C., Fischer, I., Langhans, C., Schiller, M. R., Kropf, P., Müller, I., Hohlfeld, J. M., Ho, A. D., & Munder, M. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1109741 · Cited by 15
Self-citationArginase I levels are decreased in the plasma of pediatric patients with atopic dermatitis
Dimitriades, V. R., Rodrı́guez, P. C., Zabaleta, J., & Ochoa, A. C. (2014) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2014.06.010 · Cited by 15
Takeda, Y., Kato, T., Ito, H., Kurota, Y., Yamagishi, A., Sakurai, T., Araki, A., Nara, H., Tsuchiya, N., & Asao, H. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12859 · Cited by 15
North, M. L., Meurs, H., Zaagsma, J., Scott, J. A., & Maarsingh, H. (2010) · The Open Nitric Oxide Journal · doi:10.2174/1875042701002020020 · Cited by 15
Palomero-Rodríguez, M. Á., Báez, Y. L., Sánchez-Conde, P., & Mollinedo, F. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu024 · Cited by 15
An arginase 2 promoter transgenic line illuminates immune cell polarisation in zebrafish
Hammond, F. R., Lewis, A., Speirs, Z. C., Anderson, H. E., Sipka, T., Williams, L. G., Chi, M. N., Meijer, A. H., Wiegertjes, G. F., & Elks, P. M. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049966 · Cited by 14
Poole, J. A., Cole, K., Thiele, G. M., Talmadge, J. E., England, B. R., Nelson, A. J., Gleason, A., Schwab, A. D., Gaurav, R., Duryee, M. J., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111330 · Cited by 15
Nitric Oxide: Regulation and Function in Neutrophil Immune Responses
Kumar, S., & Dikshit, M. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0220 · Cited by 17
Lung arginase expression and activity is increased in cystic fibrosis mouse models
Jaecklin, T., Duerr, J., Huang, H., Rafii, M., Bear, C. E., Ratjen, F. A., Pencharz, P. B., Kavanagh, B. P., Mall, M. A., & Grasemann, H. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2014 · Cited by 14
Elevated levels of arginase activity are related to inflammation in patients with COPD exacerbation
Guzmàn, M. J. R., Romero, G. P.-B., Pérez-Rial, S., del Castillo, C. S., Rodríguez, M. Á. P., Mahíllo, I., & Álvarez, F. V. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01629-w · Cited by 14
Warnken, M., Haag, S., Matthiesen, S., Juergens, U. R., & Racké, K. (2010) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0489-6 · Cited by 14
Hyperargininemia: A Family with a Novel Mutation in an Unexpected Site
Cohen, Y. H., Bargal, R., Zeigler, M., Markus-Eidlitz, T., Zuri, V., & Zeharia, A. (2011) · JIMD Reports · doi:10.1007/8904_2011_101 · Cited by 13
Saligan, L. N., Lukkahatai, N., Zhang, Z. J., Cheung, C. W., & Wang, X. M. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000454 · Cited by 13
Inhibition of Matrix Metalloproteinase-8 Protects Against Sepsis Serum Mediated Leukocyte Adhesion
Fang, X., Duan, S., Hu, Z., Wang, J., Qiu, L., Wang, F., & Chen, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.814890 · Cited by 13
Influence of human immune cells on cancer: studies at the University of Colorado
Bruno, T. C., French, J. D., Jordan, K. R., Ramirez, O., Sippel, T. R., Borges, V. F., Haugen, B. R., McCarter, M. D., Waziri, A. E., & Slansky, J. E. (2012) · Immunologic Research · doi:10.1007/s12026-012-8346-y · Cited by 13
Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation
Chioda, M., Marigo, I., Mandruzzato, S., D, S. M. M., & Bronte, V. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394296-8.00034-8 · Cited by 14
Poljakovic, M., Porter, D. W., Millecchia, L., Kepka‐Lenhart, D., Beighley, C. M., Wolfarth, M. G., Castranova, V., & Morris, S. M. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390600755075 · Cited by 13
Mühling, J., Nickolaus, K. A., Halabi, M., Fuchs, M., Krüll, M., Engel, J., Wolff, M., Matejec, R., Langefeld, T. W., Welters, I. D., et al. (2005) · Amino Acids · doi:10.1007/s00726-005-0223-8 · Cited by 13
Ravi, S., Duraisamy, P., Krishnan, M., Martin, L. C., Manikandan, B., & Ramar, M. (2023) · 3 Biotech · doi:10.1007/s13205-023-03741-6 · Cited by 13
Gene expression analyses reveal differences in children’s response to malaria according to their age
Tebben, K., Yirampo, S., Coulibaly, D. M., Kone, A. K., Laurens, M. B., Stucke, E. M., Dembélé, A., Tolo, Y., Traoré, K., Niangaly, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46416-3 · Cited by 10
Chen, Y., & Guo, T. L. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800885 · Cited by 11
Zhang, J., Thakuri, B. K. C., Zhao, J., Nguyen, L. N., Nguyen, L. N., Khanal, S., Cao, D., Dang, X., Schank, M., Lu, Z., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001008 · Cited by 11
Role of arginase in asthma: potential clinical applications
Munder, M. (2009) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.09.53 · Cited by 11
Self-citationSrivastava, S. C., & Ghosh, S. K. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.16.7031 · Cited by 11
Wu, J., Luo, J., Cai, H., Li, C., Lei, Z., Lu, Y., Ni, L., Cao, J., Cheng, B., & Hu, X. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10020079 · Cited by 12
Mühling, J., Engel, J., Halabi, M., Müller, M., Fuchs, M., Krüll, M., Harbach, H., Langefeld, T. W., Wolff, M., Matejec, R., et al. (2006) · Amino Acids · doi:10.1007/s00726-006-0273-6 · Cited by 11
Measuring exhaled nitric oxide in COPD: from theoretical consideration to practical views
Högman, M., Pham-Ngoc, H., Nguyen-Duy, B., Ellingsen, J., Hua-Huy, T., Nguyen, D. V., & Dinh‐Xuan, A. T. (2024) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2024.2433537 · Cited by 11
The Interaction Between Filarial Parasites and Human Monocyte/Macrophage Populations
Semnani, R. T. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6217-0_6 · Cited by 10
Self-harm to preferentially harm the pathogens within: non-specific stressors in innate immunity
LeGrand, E. K., & Day, J. (2016) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2016.0266 · Cited by 9
Zaki, M. E. A., Al‐Hussain, S. A., Al‐Mutairi, A. A., Samad, A., Ghosh, A., Chaudhari, S., Khatale, P. N., Ajmire, P. V., & Jawarkar, R. D. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1129997 · Cited by 9
The Dark Side of an Essential Amino Acid: L-Arginine in Spinal Cord Injury
Erens, C., Broeckhoven, J. V., Bronckaers, A., Lemmens, S., & Hendrix, S. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0271 · Cited by 9
Phagosomal and Lysosomal NO Synthesis
Rőszer, T. (2012) · Springer eBooks · doi:10.1007/978-94-007-2819-6_8 · Cited by 8
Hong, Y., Wen, R., Wu, G.-C., Shi, L., Liu, W., Chen, Z., & Yang, Z. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108821 · Cited by 8
[Macrophages and arginase induction as a mechanism for parasite escape].
Stempin, C. C., & Cerbán, F. M. (2007) · PubMed · Cited by 8
Lipid Metabolism in Tumor-Associated Myeloid-Derived Suppressor Cells
Liu, W., Song, H., Li, X., Ren, D., Ding, S., & Li, Y. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6785-2_7 · Cited by 7
Schroeder, J., McGachy, H. A., Woods, S., Plevin, R. J., & Alexander, J. K. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002064 · Cited by 7
Natural suppressor cells; past, present and future
Forghani, P. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/454 · Cited by 7
de Souza, W. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80373 · Cited by 8
Sakhno, L. V., Shevela, Е. Y., Tikhonova, M. A., Maksimova, А. А., Викторовна, Т. Т., Ostanin, A. A., & Chernykh, E. R. (2021) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-021-05153-z · Cited by 7
Induction of arginase-1 in MDSC requires exposure to CD3/CD28 activated T cells
Abdelaal, A. M., Bian, Z., Culpepper, C. D., & Liu, Y. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.198.supp.154.13 · Cited by 7
Rőszer, T. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-50480-9_1 · Cited by 6
Velásquez, S. Y., Coulibaly, A., Sticht, C., Schulte, J., Hahn, B., Sturm, T., Schefzik, R., Thiel, M., & Lindner, H. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.864835 · Cited by 7
Relationship between serum arginase I and l -arginine or exhaled nitric oxide in asthma
Ogino, K., Obase, Y., Ito, T., Fujimura, M., Eguchi, E., Kubo, M., Nagaoka, K., & Nakamura, H. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1202407 · Cited by 6
Chantharakhit, C., & Sujaritvanichpong, N. (2021) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2021.22.4.1149 · Cited by 6
Potential Role of CXCL10 in Monitoring Response to Treatment in Leprosy Patients
Ferreira, H., Mendes, M. A., Barbosa, M. G. D. M., de Oliveira, E. B., Sales, A. M., Moraes, M. O., Sarno, E. N., & Pinheiro, R. O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662307 · Cited by 6
Koklin, I. S., & Даниленко, Л. М. (2019) · Research Results in Pharmacology · doi:10.3897/rrpharmacology.5.39522 · Cited by 6
Heuser, S. K., Li, J., Li, Z., LoBue, A., Heard, K., Hocks, J., Suvorava, T., Cadeddu, R., Strupp, C., Dunaway, L. S., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103768 · Cited by 5
Tanito, K., Nii, T., Wakuya, K., Hamabe, Y., Yoshimi, T., Hosokawa, T., Kishimura, A., Mori, T., & Katayama, Y. (2024) · Cancers · doi:10.3390/cancers16223787 · Cited by 5
Characterization of arginase expression by equine neutrophils
Lavoie‐Lamoureux, A., Martin, J. G., & Lavoie, J. (2014) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.12.007 · Cited by 5
Correction: Arginase Activity in the Blood of Patients with Visceral Leishmaniasis and HIV Infection
Takele, Y., Abebe, T., Weldegebreal, T., Hailu, A., Hailu, W., Hurissa, Z., Ali, J., Diro, E., Yifru, S., Cloke, T., et al. (2013) · PLoS neglected tropical diseases · doi:10.1371/annotation/9e89dee8-e2b7-4559-bd4e-933692403410 · Cited by 5
Self-citationHuang, X., He, Y., Yi, G., Zheng, S., Deng, W., Chen, S., Zhu, R., Wang, Y., Chen, J., Zheng, C. F., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1530077 · Cited by 4
Low-density granulocytes in the pathogenesis of inflammatory disease
Nutley, A. S., Pisacano, N., & Prendecki, M. F. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf133 · Cited by 5
Han, Y., Li, N., Zhao, Y. F., Jin, Z., Lv, B., Shen, D., Chen, X., Weng, Q., Zhang, M., Chen, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65400-z · Cited by 5
Jin, K., Chu, X., & Qian, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114146 · Cited by 4
LeGrand, E. K. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1508767 · Cited by 4
Hansakon, A., & Angkasekwinai, P. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111995 · Cited by 4
Arginase as a new concern in blood transfusion.
Mollinedo, F., Palomero-Rodríguez, M. Á., Sánchez-Conde, P., García‐Navas, R., Báez, Y. L., de Vicente-Sánchez, J., & Suárez-Gonzalo, L. (2014) · Europe PMC (PubMed Central) · doi:10.2450/2013.0237-12 · Cited by 4
Voelz, B. E., Kalubowilage, M., Bossmann, S. H., Troyer, D. L., Chebel, R. C., & Mendonça, L. G. D. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.04.025 · Cited by 4
Shevela, Е. Y., Sakhno, L. V., Maksimova, A. A., Tikhonova, M. A., Ostanin, A. A., & Chernykh, E. R. (2022) · Immunologiya · doi:10.33029/0206-4952-2022-43-5-515-524 · Cited by 4
Models of inflammatory processes in cancer
Benelli, R., Frumento, G., Albini, A., & Noonan, D. M. (2006) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7520-1_4 · Cited by 3
Astigiano, S., Morini, M., Damonte, P., Orcioni, G. F., Cassanello, M., Puglisi, A., Noonan, D. M., Bronte, V., & Barbieri, O. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv129 · Cited by 3
Regulation and Antimicrobial Function of Inducible Nitric Oxide Synthase in Phagocytes
Bogdan, C. (2014) · ASM Press eBooks · doi:10.1128/9781555816650.ch22 · Cited by 3
Tanito, K., Nii, T., Kishimura, A., Mori, T., & Katayama, Y. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b25-00112 · Cited by 2
Ravi, S., Martin, L. C., Kumaresan, M., Mani, J. S., Manikandan, B., & Ramar, M. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106951 · Cited by 2
Lavryk, G., Kornіychuk, O., Besedina, A. S., & Vorobets, Z. D. (2017) · Regulatory Mechanisms in Biosystems · doi:10.15421/021791 · Cited by 2
L-arginine Metabolism in the Infection withTrypanosoma cruzi
Gutiérrez‐Kobeh, L., & Wilkins‐Rodríguez, A. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85010 · Cited by 2
Koliada, O. M., Vdovichenko, N., Kolyada, T. I., & Bilozorov, O. (2020) · Regulatory Mechanisms in Biosystems · doi:10.15421/022075 · Cited by 2
Rodrı́guez, P. C., & Ochoa, A. C. (2014) · Springer eBooks · doi:10.1007/978-1-4899-8056-4_13 · Cited by 2
Transcriptomic identification of HBx-associated hub genes in hepatocellular carcinoma
Ni, Z., Lü, J., Huang, W., Khan, H., Wu, X., Huang, D., Shi, G., Niu, Y., & Huang, H. (2021) · PeerJ · doi:10.7717/peerj.12697 · Cited by 2
Effect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages.
Adua, E., Danso, F. O., Boa‐Amponsem, O., & Mensah, F. A. (2015) · PubMed · doi:10.22034/iji.2015.16739 · Cited by 2
IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
Старикова, Э. А., Av, S., Burova, L. A., & Is, F. (2015) · Medical Immunology (Russia) · doi:10.15789/1563-0625-2015-4-303-318 · Cited by 2
Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis
Li, N., & He, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-07962-y · Cited by 1
Human immunosuppressive neutrophils: recent answers to old and new questions
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Metadata
- Authors
- Munder, M.
- Affiliations
- University Hospital Heidelberg (DE)
- Corresponding author
- Munder, M.
- ORCID
- Munder, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-03-15
- Volume
- 105
- Issue
- 6
- Pages
- 2549-2556
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2108273635
- Cited by
- 335
- References
- 42
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 19 · 2020: 15 · 2019: 18 · 2018: 12 · 2017: 15 · 2016: 17 · 2015: 20 · 2014: 28 · 2013: 25 · 2012: 17
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- arginase-1, granulocytes, neutrophils, arginine metabolism, nitric oxide synthase, fungicidal activity, azurophilic granules, arginine deprivation, phagolysosomes, myeloid cells, inflammation
- MeSH terms
- Animals, Antifungal Agents, Arginase, Arginine, Humans, Isoenzymes, Macrophages, Neutrophils, Phagosomes, Species Specificity, Gene Expression Regulation, Enzymologic, Nitric Oxide Synthase, Hyperargininemia, Secretory Vesicles, Microscopy, Electron, Transmission, Mice
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