Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes
Abstract
Early erythroblasts from patients with refractory anemia (RA) and RA with ringed sideroblasts (RARS) show constitutive mitochondrial release of cytochrome c. Moreover, mature erythroblasts in RARS, but not in RA, display aberrant accumulation of mitochondrial ferritin (MtF). We analyzed cytochrome c release, MtF expression, and gene expression during erythroid differentiation in bone marrow cells from myelodysplastic syndrome (MDS) patients and healthy controls. Whereas none or few cultured erythroid cells from healthy individuals and RA patients expressed MtF, those from RARS patients showed MtF expression at an early stage, when cells were CD34+ and without morphologic signs of erythroid differentiation. The proportion of RARS erythroblasts that were MtF+ increased further upon in vitro maturation. Moreover, a significant overexpression of mRNA encoding cytochrome c, and proapoptotic Bid and Bax, was seen in freshly isolated cells from MDS patients. Genes involved in erythroid differentiation were also dysregulated in MDS cells. Importantly, GATA-1 expression increased during normal erythroid maturation, but remained low in MDS cultures, indicating a block of erythroid maturation at the transcriptional level. In conclusion, aberrant MtF expression in RARS erythroblasts occurs at a very early stage of erythroid differentiation and is paralleled by an up-regulation of genes involved in this process.
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Tf is involved in transport of iron from reticuloendocytic cells and the liver to proliferative cells throughout the body, thereby controlling levels of labile iron.
“Tf is also involved in the transport of iron from reticuloendocytic cells [red blood cell (RBC) recycling] and the liver to proliferative cells throughout the body, thereby controlling the levels of “labile iron” (293).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [293]
Cites
International scoring system for evaluating prognosis in myelodysplastic syndromes
Greenberg, P., Cox, C., LeBeau, M. M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., et al. (1997) · Blood · doi:10.1182/blood.v89.6.2079 · Cited by 4,427 · see citing works
Regulation of ferritin genes and protein
Torti, F. M., & Torti, S. V. (2002) · Blood · doi:10.1182/blood.v99.10.3505 · Cited by 1,173 · see citing works
Cytochrome c release from mitochondria proceeds by a two-step process
Ott, M., Robertson, J. D., Gogvadze, V. G., Zhivotovsky, B., & Orrenius, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241655498 · Cited by 955 · see citing works
The genetics and pathology of oxidative phosphorylation
Smeitink, J. A. M., van den Heuvel, L., & DiMauro, S. (2001) · Nature Reviews Genetics · doi:10.1038/35072063 · Cited by 718 · see citing works
Transcriptional regulation of erythropoiesis: an affair involving multiple partners
Cantor, A. B., & Orkin, S. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205326 · Cited by 584 · see citing works
Arosio, P., & Levi, S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00842-0 · Cited by 543 · see citing works
Global regulation of erythroid gene expression by transcription factor GATA-1
Welch, J. J. (2004) · Blood · doi:10.1182/blood-2004-04-1603 · Cited by 408 · see citing works
The Mitochondrion in Cell Death Control: Certainties and Incognita
Loeffler, M. W., & Kroemer, G. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4833 · Cited by 394 · see citing works
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1
Maria, R. D., Zeuner, A., Eramo, A., Domenichelli, C., Bonci, D., Grignani, F., Srinivasula, S. M., Alnemri, E. S., Testa, U., & Peschle, C. (1999) · Nature · doi:10.1038/46809 · Cited by 390 · see citing works
Injected cytochrome c induces apoptosis
Zhivotovsky, B., Orrenius, S., Brustugun, O. T., & Døskeland, S. O. (1998) · Nature · doi:10.1038/35060 · Cited by 351 · see citing works
Hellström-Lindberg, E., Ahlgren, T., Beguin, Y. P., Carlsson, M., Carneskog, J., Dahl, I. M. S., Dybedal, I., Grimfors, G., Kanter‐Lewensohn, L. R., Linder, O., et al. (1998) · Blood · doi:10.1182/blood.v92.1.68.413k23_68_75 · Cited by 303 · see citing works
Dibbert, B., Weber, M., Nikolaizik, W. H., Vogt, P., Schöni, M. H., Blaser, K., & Simon, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13330 · Cited by 278 · see citing works
Apoptotic mechanisms in the control of erythropoiesis
Testa, U. (2004) · Leukemia · doi:10.1038/sj.leu.2403383 · Cited by 226 · see citing works
Early Mitochondrial Activation and Cytochrome c Up-regulation during Apoptosis
Chandra, D., Liu, J.-W., & Tang, D. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207622200 · Cited by 217 · see citing works
GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages.
Iwasaki, H., Mizuno, S., Wells, R., Cantor, A., Watanabe, S., & Akashi, K. (2003) · Immunity · doi:10.1016/s1074-7613(03)00242-5 · Cited by 214 · see citing works
Barrett, J., Saunthararajah, Y., & Molldrem, J. (2000) · Seminars in Hematology · doi:10.1016/s0037-1963(00)90027-1 · Cited by 207 · see citing works
Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia
Cazzola, M., Invernizzi, R., Bergamaschi, G., Levi, S., Corsi, B., Travaglino, E., Rolandi, V., Biasiotto, G., Drysdale, J., & Arosio, P. (2003) · Blood · doi:10.1182/blood-2002-07-2006 · Cited by 205 · see citing works
Hematopoietic development: a balancing act
Cantor, A. B., & Orkin, S. H. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00226-4 · Cited by 191 · see citing works
Mitochondrial Ferritin: A New Player in Iron Metabolism
Drysdale, J., Arosio, P., Invernizzi, R., Cazzola, M., Volz, A., Corsi, B., Biasiotto, G., & Levi, S. (2002) · Blood Cells, Molecules, and Diseases · doi:10.1006/bcmd.2002.0577 · Cited by 180 · see citing works
Nie, G., Sheftel, A. D., Kim, S. F., & Ponka, P. (2004) · Blood · doi:10.1182/blood-2004-07-2722 · Cited by 179 · see citing works
Miyazato, A., Ueno, S., Ohmine, K., Ueda, M., Yoshida, K., Yamashita, Y., Kaneko, T., Mori, M., Kirito, K., Toshima, M., et al. (2001) · Blood · doi:10.1182/blood.v98.2.422 · Cited by 170 · see citing works
Pathogenesis, etiology and epidemiology of myelodysplastic syndromes.
Aul, C., Bowen, D. T., & Yoshida, Y. (1998) · PubMed · Cited by 167 · see citing works
Mayanskiy, N. A., Mul, E. P. J., van Buul, J. D., Roos, D., & Kuijpers, T. W. (2002) · Blood · doi:10.1182/blood.v99.2.672 · Cited by 165 · see citing works
Molldrem, J. J., Jiang, Y. Z., Stetler‐Stevenson, M., Mavroudis, D., Hensel, N. F., & Barrett, A. J. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00920.x · Cited by 160 · see citing works
Wibom, R., Hagenfeldt, L., & von Döbeln, U. (2002) · Analytical Biochemistry · doi:10.1016/s0003-2697(02)00424-4 · Cited by 148 · see citing works
Hypocellular myelodysplastic syndromes (MDS): new proposals
Tüzüner, N., Cox, C., Rowe, J. M., Watrous, D., & Bennett, J. M. (1995) · British Journal of Haematology · doi:10.1111/j.1365-2141.1995.tb05356.x · Cited by 143 · see citing works
Chiba, T., Ikawa, Y., & Todokoro, K. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.14.3843 · Cited by 143 · see citing works
Tehranchi, R., Fadeel, B., Forsblom, A., Christensson, B., Samuelsson, J., Zhivotovsky, B., & Hellström‐Lindberg, E. (2003) · Blood · doi:10.1182/blood-2002-06-1774 · Cited by 130 · see citing works
Self-citationParker, Fishlock, Mijovic, Czepulkowski, Pagliuca, A., & Mufti (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.01114.x · Cited by 118 · see citing works
Mayanskiy, N. A., Roos, D., & Kuijpers, T. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.7024 · Cited by 81 · see citing works
Erythropoietin receptor signals both proliferation and erythroid-specific differentiation.
Liboi, E., Carroll, M. P., D’Andrea, A. D., & Mathey-Prévôt, B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11351 · Cited by 77 · see citing works
Role of iron and ferritin in TNFα‐induced apoptosis in HeLa cells
Cozzi, A., Levi, S., Corsi, B., Santambrogio, P., Campanella, A., Gerardi, G., & Arosio, P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00114-5 · Cited by 76 · see citing works
Fontenay, M., Bouscary, D., Guesnu, M., Picard, F., Melle, J., Lacombe, C., Gisselbrecht, S., Mayeux, P., & Dreyfus, F. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01539.x · Cited by 74 · see citing works
Lindberg, E. H., Schmidt‐Mende, J., Forsblom, A., Christensson, B., Fadeel, B., & Zhivotovsky, B. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.02581.x · Cited by 62 · see citing works
Refractory myelodysplastic anaemias with hypocellular bone marrow.
Yoshida, Y., Oguma, S., Uchino, H., & MAEKAWA, T. (1988) · Journal of Clinical Pathology · doi:10.1136/jcp.41.7.763 · Cited by 61 · see citing works
Increased apoptosis in acquired sideroblastic anaemia
Matthes, T., Meyer, G., Samii, K., & Beris, P. (2000) · British Journal of Haematology · doi:10.1111/j.1365-2141.2000.02425.x · Cited by 41 · see citing works
Scicchitano, M. S., McFarland, D. C., Tierney, L. A., Narayanan, P. K., & Schwartz, L. W. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00185-1 · Cited by 38 · see citing works
Schmidt-Mende, J., Tehranchi, R., Forsblom, A., Joseph, B., Christensson, B., Fadeel, B., Zhivotovsky, B., & Hellström‐Lindberg, E. (2001) · Leukemia · doi:10.1038/sj.leu.2402110 · Cited by 37 · see citing works
Self-citationBackx, B., Broeders, L., Lh, H., Wognum, B., & Löwenberg, B. (1996) · PubMed · Cited by 35 · see citing works
Toyama, K., Ohyashiki, K., Yoshida, Y., Abe, T., Asano, S., Hirai, H., Hirashima, K., Hotta, T., Kuramoto, A., & Kuriya, S. (1993) · PubMed · Cited by 33 · see citing works
Ljung, T., Bäck, R., & Hellström‐Lindberg, E. (2004) · PubMed · Cited by 18 · see citing works
Umemura, T., Constantoulakis, P., Papayannopoulou, T., & Stamatoyannopoulos, G. (1990) · PubMed · Cited by 7 · see citing works
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Somatic<i>SF3B1</i>Mutation in Myelodysplasia with Ring Sideroblasts
Papaemmanuil, E., Cazzola, M., Boultwood, J., Malcovati, L., Vyas, P., Bowen, D., Pellagatti, A., Wainscoat, J. S., Hellstrom-Lindberg, E., Gambacorti-Passerini, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103283 · Cited by 1,222 · see citing works
Ferritins: A family of molecules for iron storage, antioxidation and more
Arosio, P., Ingrassia, R., & Cavadini, P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.004 · Cited by 886 · see citing works
Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
Fenaux, P., Platzbecker, U., Mufti, G. J., Garcia‐Manero, G., Buckstein, R. J., Santini, V., Díez‐Campelo, M., Finelli, C., Cazzola, M., İlhan, O., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1908892 · Cited by 551 · see citing works
Intracellular iron transport and storage: from molecular mechanisms to health implications
Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526 · see citing works
Malcovati, L., Papaemmanuil, E., Bowen, D., Boultwood, J., Porta, M. G. D., Pascutto, C., Travaglino, E., Groves, M. J., Godfrey, A. L., Ambaglio, I., et al. (2011) · Blood · doi:10.1182/blood-2011-09-377275 · Cited by 496 · see citing works
Adès, L., Itzykson, R., & Fenaux, P. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61901-7 · Cited by 396 · see citing works
Myelodysplastic syndromes: the complexity of stem-cell diseases
Corey, S. J., Minden, M. D., Barber, D. L., Kantarjian, H. M., Wang, J. C. Y., & Schimmer, A. D. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2047 · Cited by 341 · see citing works
Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells
Pellagatti, A., Cazzola, M., Giagounidis, A. A. N., Perry, J., Malcovati, L., Porta, M. G. D., Jädersten, M., Killick, S. B., Verma, A. K., Norbury, C. J., et al. (2010) · Leukemia · doi:10.1038/leu.2010.31 · Cited by 288 · see citing works
Hexner, E. O., Serdikoff, C., Jan, M., Swider, C. R., Robinson, C., Yang, S., Angeles, T. S., Emerson, S. G., Carroll, M. P., Ruggeri, B., et al. (2007) · Blood · doi:10.1182/blood-2007-04-083402 · Cited by 253 · see citing works
The Myelodysplastic Syndromes: Diagnosis and Treatment
Steensma, D. P., & Bennett, J. M. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.1.104 · Cited by 242 · see citing works
Pellagatti, A., Armstrong, R. N., Steeples, V., Sharma, E., Repapi, E., Singh, S., Sanchi, A., Radujkovic, A., Horn, P., Dolatshad, H., et al. (2018) · Blood · doi:10.1182/blood-2018-04-843771 · Cited by 240 · see citing works
Pellagatti, A., Jädersten, M., Forsblom, A., Cattan, H., Christensson, B., Emanuelsson, E. K., Merup, M., Nilsson, L., Samuelsson, J., Sander, B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610477104 · Cited by 232 · see citing works
SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts
Visconte, V., Makishima, H., Jankowska, A. M., Szpurka, H., Traina, F., Jerez, A., O'Keefe, C., Rogers, H. J., Sekeres, M. A., Maciejewski, J. P., et al. (2011) · Leukemia · doi:10.1038/leu.2011.232 · Cited by 212 · see citing works
Shiozawa, Y., Malcovati, L., Gallì, A., Sato‐Otsubo, A., Kataoka, K., Sato, Y., Watatani, Y., Suzuki, H., Yoshizato, T., Yoshida, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06063-x · Cited by 172 · see citing works
Mitochondrial Ferritin Expression in Adult Mouse Tissues
Santambrogio, P., Biasiotto, G., Sanvito, F., Olivieri, S., Arosio, P., & Levi, S. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.7a7273.2007 · Cited by 169 · see citing works
Cavadini, P., Biasiotto, G., Poli, M., Levi, S., Verardi, R., Zanella, I., Derosas, M., Ingrassia, R., Corrado, M., & Arosio, P. (2006) · Blood · doi:10.1182/blood-2006-08-041632 · Cited by 155 · see citing works
Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms
Cazzola, M., Rossi, M., & Malcovati, L. (2012) · Blood · doi:10.1182/blood-2012-09-399725 · Cited by 151 · see citing works
Flow cytometry evaluation of erythroid dysplasia in patients with myelodysplastic syndrome
Porta, M. G. D., Malcovati, L., Invernizzi, R., Travaglino, E., Pascutto, C., Maffioli, M., Gallì, A., Boggi, S., Pietra, D., Vanelli, L., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404142 · Cited by 137 · see citing works
Ghoti, H., Amer, J., Winder, A., Rachmilewitz, E. A., & Fibach, E. (2007) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2007.00972.x · Cited by 110 · see citing works
Clinical Relevance of Anemia and Transfusion Iron Overload in Myelodysplastic Syndromes
Cazzola, M., Porta, M. G. D., & Malcovati, L. (2008) · Hematology · doi:10.1182/asheducation-2008.1.166 · Cited by 101 · see citing works
Nikpour, M., Scharenberg, C., Liu, A., Conte, S., Karimi, M., Blanco, T. M., Giai, V., Fernández‐Mercado, M., Papaemmanuil, E., Högstrand, K., et al. (2012) · Leukemia · doi:10.1038/leu.2012.298 · Cited by 99 · see citing works
Abnormal erythropoiesis and the pathophysiology of chronic anemia
Koury, M. J. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.01.002 · Cited by 96 · see citing works
Pellagatti, A., Hellström‐Lindberg, E., Giagounidis, A. A. N., Perry, J., Malcovati, L., Porta, M. G. D., Jädersten, M., Killick, S. B., Fidler, C., Cazzola, M., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07178.x · Cited by 92 · see citing works
A variant erythroferrone disrupts iron homeostasis in <i>SF3B1</i> -mutated myelodysplastic syndrome
Bondu, S., Alary, A.-S., Lefèvre, C., Houy, A., Jung, G., Lefebvre, T., Rombaut, D., Boussaid, I., Bousta, A., Guillonneau, F., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav5467 · Cited by 85 · see citing works
Recent advances in the understanding of inherited sideroblastic anaemia
Camaschella, C. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07290.x · Cited by 77 · see citing works
The bone marrow hematopoietic microenvironment is impaired in iron‐overloaded mice
Okabe, H., Suzuki, T., Uehara, E., Ueda, M., Nagai, T., & Ozawa, K. (2014) · European Journal Of Haematology · doi:10.1111/ejh.12309 · Cited by 75 · see citing works
Targeting autophagy to fight hematopoietic malignancies
Puissant, A., Robert, G., & Auberger, P. (2010) · Cell Cycle · doi:10.4161/cc.9.17.13048 · Cited by 71 · see citing works
Frisan, E., Vandekerckhove, J., de Thonel, A., Pierre‐Eugène, C., Sternberg, A. J., Arlet, J., Floquet, C., Gyan, E., Kosmider, O., Dreyfus, F., et al. (2011) · Blood · doi:10.1182/blood-2011-03-343475 · Cited by 71 · see citing works
Ring sideroblasts and sideroblastic anemias
Cazzola, M., & Invernizzi, R. (2011) · Haematologica · doi:10.3324/haematol.2011.044628 · Cited by 71 · see citing works
Myelodysplastic syndromes: biology and treatment
Jädersten, M., & Hellström‐Lindberg, E. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.02052.x · Cited by 65 · see citing works
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
Lieu, Y. K., Liu, Z., Ali, A. M., Wei, X., Penson, A., Zhang, J., An, X., Rabadán, R., Raza, A., Manley, J. L., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111703119 · Cited by 59 · see citing works
Mitochondrial Ferritin: Its Role in Physiological and Pathological Conditions
Levi, S., Ripamonti, M., Dardi, M., Cozzi, A., & Santambrogio, P. (2021) · Cells · doi:10.3390/cells10081969 · Cited by 59 · see citing works
Choi, Y., Uhm, S. J., Song, S.-J., Song, H., Park, J.-K., Kim, T., Park, C., & Kim, J. (2008) · Journal of Reproduction and Development · doi:10.1262/jrd.19116 · Cited by 59 · see citing works
Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes
Wulfert, M., Küpper, A. C., Tapprich, C., Bottomley, S. S., Bowen, D., Germing, U., Haas, R. R., & Gattermann, N. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.01.004 · Cited by 58 · see citing works
Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity
Maccarinelli, F., Gammella, E., Asperti, M., Regoni, M., Biasiotto, G., Turco, E., Altruda, F., Lonardi, S., Cornaghi, L., Donetti, E., et al. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1147-0 · Cited by 56 · see citing works
Nie, G., Chen, G., Sheftel, A. D., Pantopoulos, K., & Ponka, P. (2006) · Blood · doi:10.1182/blood-2006-04-018341 · Cited by 56 · see citing works
The RNA Binding Protein RBM38 (RNPC1) Regulates Splicing during Late Erythroid Differentiation
Heinicke, L. A., Nabet, B., Shen, S., Jiang, P., van Zalen, S., Cieply, B. W., Russell, J., Xing, Y., & Carstens, R. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078031 · Cited by 51 · see citing works
Houwerzijl, E. J., Pol, H.-W., Blom, N. R., van der Want, J. J. L., de Wolf, J., & Vellenga, E. (2009) · Leukemia · doi:10.1038/leu.2008.389 · Cited by 50 · see citing works
Supportive Care and Use of Hematopoietic Growth Factors in Myelodysplastic Syndromes
Hellström‐Lindberg, E., & Malcovati, L. (2008) · Seminars in Hematology · doi:10.1053/j.seminhematol.2007.10.004 · Cited by 49 · see citing works
Martinez, P. A., Li, R., Ramanathan, H. N., Bhasin, M., Pearsall, R. S., Kumar, R., & Suragani, R. N. V. S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15243 · Cited by 49 · see citing works
The Role of JAK2 Mutations in RARS and Other MDS
Hellström‐Lindberg, E., & Cazzola, M. (2008) · Hematology · doi:10.1182/asheducation-2008.1.52 · Cited by 42 · see citing works
Conte, S., Katayama, S., Vesterlund, L., Karimi, M., Dimitriou, M., Jansson, M., Blanco, T. M., Unneberg, P., Papaemmanuil, E., Sander, B., et al. (2015) · British Journal of Haematology · doi:10.1111/bjh.13610 · Cited by 37 · see citing works
Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?
Zhou, T., Hasty, P., Walter, C. A., Bishop, A. J. R., Scott, L. M., & Rebel, V. I. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.04.008 · Cited by 39 · see citing works
“In a later study, the same group also found increased levels of mRNA encoding cytochrome-C, as well as the pro-apoptotic proteins BID and BAX [66].”
BackgroundThe molecular pathogenesis of myelodysplastic syndromes
Davids, M. S., & Steensma, D. P. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.4.12612 · Cited by 40 · see citing works
Supportive care, growth factors, and new therapies in myelodysplastic syndromes
Hellström‐Lindberg, E., & Malcovati, L. (2008) · Blood Reviews · doi:10.1016/j.blre.2007.10.003 · Cited by 38 · see citing works
Nikpour, M., Pellagatti, A., Liu, A., Karimi, M., Malcovati, L., Gogvadze, V. G., Forsblom, A., Wainscoat, J. S., Cazzola, M., Zhivotovsky, B., et al. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08174.x · Cited by 36 · see citing works
Wang, J., Wang, F., Yuan, L., Ruan, H., Zhu, Z., Fan, X., Zhu, L., & Peng, X. X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.813676 · Cited by 34 · see citing works
Myelodysplasia paranoia: Iron as the new radon
Steensma, D. P. (2008) · Leukemia Research · doi:10.1016/j.leukres.2008.10.017 · Cited by 34 · see citing works
Santambrogio, P., Erba, B. G., Campanella, A., Cozzi, A., Causarano, V., Cremonesi, L., Gallì, A., Porta, M. G. D., Invernizzi, R., & Levi, S. (2011) · Haematologica · doi:10.3324/haematol.2011.042952 · Cited by 33 · see citing works
Recent advances in the understanding of iron overload in sideroblastic myelodysplastic syndrome
Cuijpers, M. L. H., Raymakers, R. A. P., MacKenzie, M. A., de Witte, T. J. M., & Swinkels, D. W. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.08051.x · Cited by 32 · see citing works
Hellström‐Lindberg, E. (2005) · Hematology · doi:10.1182/asheducation-2005.1.161 · Cited by 31 · see citing works
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1 -mutated myelodysplasia
Mian, S. A., Philippe, C., Maniati, E., Protopapa, P., Bergot, T., Piganeau, M., Nemkov, T. G., Bella, D. D., Morales, V., Finch, A. J., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abn5135 · Cited by 28 · see citing works
Lu, Z., Nie, G., Li, Y., Soe-Lin, S., Tao, Y., Cao, Y., Zhang, Z., Liu, N., Ponka, P., & Zhao, B. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2306 · Cited by 28 · see citing works
Zhou, T., Chen, P., Gu, J. H., Bishop, A. J. R., Scott, L., Hasty, P., & Rebel, V. I. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16010966 · Cited by 26 · see citing works
Dyserythropoiesis of myelodysplastic syndromes
Lefèvre, C., Bondu, S., Goff, S. L., Kosmider, O., & Fontenay, M. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000325 · Cited by 25 · see citing works
Garcia‐Manero, G., Gartenberg, G. J., Steensma, D. P., Schipperus, M. R., Breems, D. A., de Paz, R., Valcárcel, D., Kranenburg, B., Reddy, M. P., & Komrokji, R. S. (2014) · American Journal of Hematology · doi:10.1002/ajh.23780 · Cited by 24 · see citing works
Park, S., Sapena, R., Kelaïdi, C., Vassilieff, D., Bordessoule, D., Stamatoullas, A., Chèze, S., Beyne‐Rauzy, O., Vey, N., Rose, C., et al. (2011) · Leukemia Research · doi:10.1016/j.leukres.2011.07.007 · Cited by 24 · see citing works
Steensma, D. P., Hecksel, K. A., Porcher, J. C., & Lasho, T. L. (2006) · Leukemia Research · doi:10.1016/j.leukres.2006.06.005 · Cited by 24 · see citing works
Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy
Zahid, M. F., Patnaik, M. M., Gangat, N., Hashmi, S. K., & Rizzieri, D. A. (2016) · European Journal Of Haematology · doi:10.1111/ejh.12771 · Cited by 23 · see citing works
Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis
Hopfer, O., Nolte, F., Mossner, M., Komor, M., Kmetsch, A., Benslasfer, O., Reißmann, M., Nowak, D., Hoelzer, D. F., Thiel, E., et al. (2011) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2011.01715.x · Cited by 23 · see citing works
Elvarsdóttir, E. M., Blanco, T. M., Dimitriou, M., Bouderlique, T., Jansson, M., Hofman, I. J., Conte, S., Karimi, M., Sander, B., Douagi, I., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0532-7 · Cited by 22 · see citing works
Dong, X., Zhao, K., Zheng, W., Xu, C., Zhang, M., Yin, R., Gao, R., Tang, L., Liu, J., Chen, H., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902946r · Cited by 16 · see citing works
Saito, K., Fujiwara, T., Hatta, S., Morita, M., Ono, K., Suzuki, C., Fukuhara, N., Onishi, Y., Nakamura, Y., Kawamata, S., et al. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00387-18 · Cited by 15 · see citing works
Nishiuchi, T., Okutani, Y., Fujita, T., Yoshida, K., Ohnishi, H., & Haba, R. (2010) · International Journal of Hematology · doi:10.1007/s12185-010-0500-5 · Cited by 15 · see citing works
AUF-1 and YB-1 are critical determinants of β-globin mRNA expression in erythroid cells
van Zalen, S., Jeschke, G. R., Hexner, E. O., & Russell, J. (2011) · Blood · doi:10.1182/blood-2011-10-387316 · Cited by 15 · see citing works
Significance of JAK2 and TET2 mutations in myelodysplastic syndromes
Hellström‐Lindberg, E. (2010) · Blood Reviews · doi:10.1016/j.blre.2010.01.002 · Cited by 14 · see citing works
Garderet, L., Kobari, L., Mazurier, C., Witte, C. D., Giarratana, M., Pérot, C., Gorin, N. C., Lapillonne, H., & Douay, L. (2009) · Haematologica · doi:10.3324/haematol.2009.012773 · Cited by 12 · see citing works
Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors
Invernizzi, R., Travaglino, E., Porta, M. G. D., Gallì, A., Malcovati, L., Rosti, V., Bergamaschi, G., Erba, B. G., Bellistri, F., Bastia, R., et al. (2013) · British Journal of Haematology · doi:10.1111/bjh.12316 · Cited by 12 · see citing works
Zou, J., Shi, Q., Chen, H., Juskevicius, R., & Zinkel, S. S. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.09.004 · Cited by 10 · see citing works
Castiglioni, E., Finazzi, D., Goldwurm, S., Levi, S., Pezzoli, G., Garavaglia, B., Nardocci, N., Malcovati, L., della Porta, M. D., Gallì, A., et al. (2010) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2010.0076 · Cited by 16 · see citing works
Apoptotic pathways to death in myelodysplastic syndromes
Fontenay, M., & Gyan, E. (2008) · Haematologica · doi:10.3324/haematol.13563 · Cited by 10 · see citing works
Ringed sideroblasts in β‐thalassemia
Cattivelli, K., Campagna, D. R., Schmitz‐Abe, K., Heeney, M. M., Yaish, H. M., Brown, A. E. C., Kearney, S. L., Walkovich, K. J., Markianos, K., Fleming, M. D., et al. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26324 · Cited by 9 · see citing works
Impact of Growth Factors in the Regulation of Apoptosis in Low-Risk Myelodysplastic Syndromes
Tehranchi, R. (2006) · Medical Oncology · doi:10.1385/mo:23:1:37 · Cited by 8 · see citing works
Self-citationDonaires, F. S., Martelli, F., Alves-Paiva, R. D. M., Magalhães, S. M. M., Pinheiro, R. F., & Calado, R. T. (2016) · Revista Brasileira de Hematologia e Hemoterapia · doi:10.1016/j.bjhh.2016.06.002 · Cited by 7 · see citing works
Murphy, P. T., Quinn, J., O’Donghaile, D., Swords, R. T., & O’Donnell, J. R. (2006) · Annals of Hematology · doi:10.1007/s00277-006-0107-3 · Cited by 7 · see citing works
Pathophysiology of Myelodysplastic Syndromes
Fontenay, M., Farhat, B., & Boussaid, I. (2021) · Hemato · doi:10.3390/hemato2030030 · Cited by 6 · see citing works
Increased Apoptosis as a Mechanism of Ineffective Erythropoiesis in Myelodysplastic Syndromes
Invernizzi, R., & Travaglino, E. (2008) · Clinical Leukemia · doi:10.3816/clk.2008.n.014 · Cited by 6 · see citing works
Thier, J., Hofmann, S., Kirchhof, K. M., Todisco, G., Blanco, T. M., Lilienthal, I., Kanellis, D. C., Barbosa, I., Björklund, A.-C., Deslauriers, A. G., et al. (2025) · Leukemia · doi:10.1038/s41375-025-02740-1 · Cited by 4 · see citing works
Treatment of myelodysplastic syndromes with exogenous erythropoietin: a new therapeutic paradigm
Mundle, S. D., & Raza, A. (2006) · Leukemia · doi:10.1038/sj.leu.2404291 · Cited by 4 · see citing works
Flow Cytometry in Myelodysplastic Syndromes
Alhan, C., Westers, T. M., Ossenkoppele, G. J., & van de Loosdrecht, A. A. (2011) · Springer eBooks · doi:10.1007/978-94-007-0440-4_8 · Cited by 3 · see citing works
Folkerts, H., Hazenberg, C. L. E., Houwerzijl, E. J., van den Heuvel, F. A. J., Mulder, A. B., van der Want, J. J. L., & Vellenga, E. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.11.005 · Cited by 3 · see citing works
The Hematopoietic Growth Factors in the Myelodysplastic Syndromes
Ortega, J., Komrokji, R. S., & List, A. F. (2010) · Cancer treatment and research · doi:10.1007/978-1-4419-7073-2_20 · Cited by 3 · see citing works
Zhang, H., Zhang, L., Liang, X., Zhang, L., Ma, B., Li, Y., Wang, J., Shen, Y., Pang, Y., & Xiong, J. (2024) · Hereditas · doi:10.1186/s41065-024-00335-x · Cited by 2 · see citing works
Physiopathologie des syndromes myélodysplasiques
Fontenay, M., Kosmider, O., Frisan, E., Ettou, S. S., & Lacombe, C. (2009) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(09)74245-5 · Cited by 1 · see citing works
Atypical ringed sideroblasts in association with trisomy 19 and myelodysplasia
Muhyieddeen, K., & Natelson, E. A. (2011) · Comparative Clinical Pathology · doi:10.1007/s00580-011-1298-0 · Cited by 1 · see citing works
Cytokines in MDS: Abnormalities and Treatment
Oster, H. S., Neumann, D., & Mittelman, M. (2011) · Springer eBooks · doi:10.1007/978-94-007-0440-4_13 · Cited by 1 · see citing works
Relationship between the Induced Iron Overload Model and Hepatic Erythropoiesis in Xenopus laevis
Sato, K., 正光, 谷., Kato, K., & Kato, T. (2020) · ZOOLOGICAL SCIENCE · doi:10.2108/zs190102 · Cited by 1 · see citing works
Recombinant human erythropoietin (rhEPO) therapy in myelodysplasia
Hellström‐Lindberg, E. (2008) · Springer eBooks · doi:10.1007/978-3-211-69459-6_20
de Matos, S. S. M. C. (2011)
Yoshida, Y. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.04.004
Activated lymphocytes and monocytes in myelodysplastic syndromes
Meers, S. (2008)
5. Iron Overload and Bone Marrow Failure.
Yamashita, T., & Nakao, S. (2010) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.99.1261
輸血後鉄過剰症に対するICL670 (deferasirox)投与により造血能の回復が得られた骨髄異形成症候群
寛, 岡., 隆浩, 鈴., 司, 大., 政樹, 森., Uehara, E., Hatano, K., 上田, 真., 松山, 智., 外島, 正., 尾崎勝俊, et al. (2009) · 臨床血液 · doi:10.11406/rinketsu.50.1626
Wilkins, B., & Porwit‐MacDonald, A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3147-2.00020-1
Syndromes myélodysplasiques et leucémies secondaires. Généralités, diagnostic et classification
Park, S., Cluzeau, T., Fenaux, P., & Dreyfus, F. (2014)
Erythropoiesis-Stimulating Agents in Low-Risk MDS
Park, S., & Götze, K. S. S. (2018) · Hematologic malignancies · doi:10.1007/978-3-319-76879-3_6
Modelling Ineffective Erythropoiesis in Myelodysplastic Syndromes with Ring Sideroblasts
Elvarsdóttir, E. M. (2019) · Figshare · doi:10.13140/rg.2.2.13726.28485
Thier, J., Hofmann, S., Kirchhof, K. M., Todisco, G., Blanco, T. M., Barbosa, I., Björklund, A.-C., Deslauriers, A. G., Papaemmanuil, E., Papapetrou, E. P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.28.610114
- Authors
- Tehranchi, R.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Tehranchi, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-03-15
- Volume
- 106
- Issue
- 1
- Pages
- 247-253
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2127054377
- Cited by
- 104
- References
- 42
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 3 · 2012: 3
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- myelodysplastic syndrome, ring sideroblasts, refractory anemia, erythroid precursors, mitochondrial ferritin, cytochrome c release, erythroid differentiation, GATA-1, Bid, Bax, apoptosis, low-risk MDS
- MeSH terms
- Adenosine Triphosphate, Anemia, Sideroblastic, Carrier Proteins, DNA-Binding Proteins, Erythroblasts, Ferritins, Glycoproteins, Hematopoietic Stem Cells, Hemoglobins, Humans, Iron, Mitochondria, Myelodysplastic Syndromes, Risk Factors, RNA, Messenger, Transcription Factors, Gene Expression, Granulocyte Colony-Stimulating Factor, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Cytochromes c, Erythroid-Specific DNA-Binding Factors, GATA1 Transcription Factor, BH3 Interacting Domain Death Agonist Protein, bcl-2-Associated X Protein
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