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Cited by 207Acute Myeloid Leukemia ResearchBlood disorders and treatmentsHematological disorders and diagnostics

Myelodysplastic syndrome and aplastic anemia: distinct entities or diseases linked by a common pathophysiology?

Barrett, John, Saunthararajah, Yogen, Molldrem, Jeffrey·2000·Seminars in Hematology
DOI 10.1016/s0037-1963(00)90027-1
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Abstract

It is often difficult to distinguish myelodysplastic syndrome (MDS) from severe aplastic anemia (SAA) because both can present with profoundly hypocellular bone marrows. The distinction matters because although both conditions are complicated by pancytopenia, the risk of progression to acute leukemia is much greater in MDS. This chapter reexamines the relationship between SAA and MDS. The clinical and morphological features and pathophysiology of AA (including moderate and severe forms of acquired AA) are compared with MDS and hypoplastic MDS, with particular reference to new observations implicating autoimmune processes in both conditions. SAA and hypoplastic MDS (HMDS) are discussed in the light of these findings and attempts to separate nonevolving bone marrow failure syndromes from marrow failure progressing to acute leukemia are reviewed. The weight of evidence supports a common pathophysiology and, more speculatively, a common etiology for at least some forms of AA and MDS.

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  • Hypocellular MDS can be understood as an exhausted form of AA in which selective clones have been established.

    “Thus, hypocellular MDS can be understood as an exhausted form of AA in which selective clones have been established.65”

    From Inflammatory bone marrow microenvironment (2019) · cites this paper as [65]

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Authors
Barrett, J., Saunthararajah, Y., & Molldrem, J.
Affiliations
National Institutes of Health (US)
Corresponding author
Barrett, John
ORCID
Venue
Seminars in Hematology
Publisher
Elsevier BV
Published
2000-01
Volume
37
Issue
1
Pages
15-29
ISSN
0037-1963 (ISSN-L)
DOI
10.1016/s0037-1963(00)90027-1
OpenAlex
W2053333573
Cited by
207
References
95
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 9 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 11
FWCI
2.92
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Seminars in Hematology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
  • Health Sciences › Medicine › Emergency Medicine › Hematological disorders and diagnostics
Keywords
myelodysplastic syndrome, severe aplastic anemia, hypoplastic myelodysplastic syndrome, bone marrow failure, pancytopenia, autoimmune processes, pathophysiology, disease classification, acquired aplastic anemia
MeSH terms
Anemia, Aplastic, Bone Marrow, Diagnosis, Differential, Humans, Immunosuppressive Agents, Myelodysplastic Syndromes, Pancytopenia, T-Lymphocytes

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