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Cited by 61Immune Cell Function and InteractionT-cell and B-cell ImmunologyReproductive System and Pregnancy

Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors

Open access
Henel, Gabriella, Singh, Karnail, Cui, Dapeng, Pryshchep, Sergey, Lee, Won-Woo, Weyand, Cornelia M., Goronzy, Jörg J.·2006·Blood
DOI 10.1182/blood-2005-06-2519PMC PMC1895796
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Abstract

Killer immunoglobulin–like receptors (KIRs) are a family of regulatory cell-surface molecules expressed on natural killer (NK) cells and memory T-cell subsets. Their ability to prevent the formation of an activation platform and to inhibit NK cell activation is the basis of the missing self model of NK cell function. The benefits of KIR expression for T-cell biology are unclear. We studied how KIR2DL2 regulates T-cell function. Engagement of KIR2DL2 by the ligand human leukocyte antigen (HLA)–Cw3 did not affect conjugate formation between CD4+KIR2DL2+ T cells and superantigen-pulsed target cells or the development of mature immune synapses with lipid rafts. KIR2DL2 and the corresponding HLA-C ligand were initially recruited to the peripheral supramolecular activation cluster (pSMAC). Consequently, KIR2DL2 engagement did not inhibit the phosphorylation of early signaling proteins and T-cell–receptor (TCR)–mediated cytotoxicity or granule exocytosis. After 15-30 minutes, KIR2DL2 moved to the central supramolecular activation cluster (cSMAC), colocalizing with CD3. TCR synapses dissociated, and phosphorylated phospholipase C (PLC)–γ1, Vav1, and extracellular signal–regulated kinase 1/2 (ERK1/2) were reduced 90 minutes after stimulation. Gene array studies documented that the inhibition of late signaling events by KIR2DL2 affected transcriptional gene activation. We propose that KIRs on memory T cells operate to uncouple effector functions by modifying the transcriptional profile while leaving granule exocytosis unabated.

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Crossref · 10.1182/blood-2005-06-2519

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  • TEMRAs express negative regulatory receptors such as killer immunoglobulin-like receptors and CD85j that interfere with their ability to proliferate but not with cytokine production.

    “TEMRAs express a host of negative regulatory receptors such as killer immunoglobulin-like receptors and CD85j that interfere with their ability to proliferate but not with cytokine production”

    From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Henel et al., 2006

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Authors
Henel, G., Singh, K., Cui, D., Pryshchep, S., Lee, W.-W., Weyand, C. M., & Goronzy, J. J.
Affiliations
  • Mayo Clinic (US)
  • From the Kathleen B. and Mason I. Lowance Center for Human Immunology, Emory University, Atlanta, GA; and the Department of Immunology, Mayo Graduate School, Rochester, MN.
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2006-06-01
Volume
107
Issue
11
Pages
4449-4457
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2005-06-2519
PMC
PMC1895796
OpenAlex
W2007920860
Cited by
61
References
46
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 1 · 2013: 3 · 2012: 6
FWCI
3.28
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01AG015043, R01AG15043)
  • National Institute of Allergy and Infectious Diseases (R01AI044142, U19-AI 44142)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR041974, R01 AR 41974, R01 AR 42567)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
killer cell immunoglobulin-like receptors, KIR2DL2, HLA-Cw3, memory T cells, T cell signaling, immunological synapse, supramolecular activation cluster, T cell receptor signaling, phospholipase C-gamma1, Vav1, ERK1/2, transcriptional regulation, granule exocytosis, NK cell inhibitory receptors
MeSH terms
Cytotoxicity, Immunologic, Gene Expression Regulation, Humans, Immunologic Memory, Receptors, Immunologic, Signal Transduction, CD4-Positive T-Lymphocytes, Transcriptional Activation, Cell Degranulation, T-Lymphocyte Subsets, Superantigens, Gene Expression Profiling, Protein Transport, Membrane Microdomains, Receptors, KIR, Receptors, KIR2DL2

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