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Cited by 542

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Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

Open access
Garín, Marina I., Chu, Chung-Ching, Golshayan, Dela, Cernuda-Morollón, Eva, Wait, Robin, Lechler, Robert I.·2007·Blood
DOI 10.1182/blood-2006-04-016451
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Abstract

The naturally occurring population of dedicated regulatory T cells that coexpress CD4 and CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of β-galactoside–binding proteins, galectin-1, is overexpressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibitory effects of human and mouse CD4+CD25+ T cells. Reduced regulatory activity was observed in CD4+CD25+ T cells obtained from galectin-1–homozygous null mutant mice. These results suggest that galectin-1 is a key effector of the regulation mediated by these cells.

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Metadata

Authors
Garín, M. I., Chu, C.-C., Golshayan, D., Cernuda-Morollón, E., Wait, R., & Lechler, R. I.
Venue
Blood
Publisher
American Society of Hematology
Published
2006-11-16
Volume
109
Issue
5
Pages
2058-2065
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2006-04-016451
OpenAlex
W2046361773
Cited by
542
References
2
FWCI
9.71
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. https://app.cochat.ai/papers/10.1182/blood-2006-04-016451
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Garín, M. I., Chu, C.-C., Golshayan, D., Cernuda-Morollón, E., Wait, R., & Lechler, R. I. (2007). Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood. https://doi.org/10.1182/blood-2006-04-016451

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