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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

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A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

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A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

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Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

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Potential biomarkers of tissue hypoxia during acute hemodilutional anemia in cardiac surgery: A prospective study to assess tissue hypoxia as a mechanism of organ injury

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Anemia in -thalassemia patients targets hepatic hepcidin transcript levels independently of iron metabolism genes controlling hepcidin expression

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Coordination of iron homeostasis by bone morphogenetic proteins: Current understanding and unanswered questions

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Iron as a therapeutic target in chronic liver disease

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Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice

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Hepcidin in Trauma: Linking Injury, Inflammation, and Anemia

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The transcription factor ATOH 8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD 1,5,8 levels

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Mouse Models of Anemia of Cancer

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Inverse relationship of serum hepcidin levels with CD4 cell counts in HIV-infected patients selected from an Indonesian prospective cohort study

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Normal and dysregulated crosstalk between iron metabolism and erythropoiesis

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Polysaccharide Isolated from Angelica sinensis Inhibits Hepcidin Expression in Rats with Iron Deficiency Anemia

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Testosterone Administration During Energy Deficit Suppresses Hepcidin and Increases Iron Availability for Erythropoiesis

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Iron overload, hematopoietic cell transplantation, and graft-versus-host disease

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Study of Circulating Prohepcidin in Association with Insulin Sensitivity and Changing Iron Stores

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Erythropoietic drive is the strongest predictor of hepcidin level in adults with sickle cell disease

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Influence of post-exercise hypoxic exposure on hepcidin response in athletes

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Regulation of Iron Absorption in Hemoglobinopathies

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Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice

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Exogenous iron increases hemoglobin in β–thalassemic mice

Ginzburg, Y. Z., Rybicki, A. C., Suzuka, S. M., Hall, C. B., Breuer, W. V., Cabantchik, Z. I., Bouhassira, E. E., Fabry, M. E., & Nagel, R. L. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.10.004 · Cited by 33

Iron and oxygen sensing: a tale of 2 interacting elements?

Simpson, R. J., & McKie, A. T. (2014) · Metallomics · doi:10.1039/c4mt00225c · Cited by 32

Increased ferroportin-1 expression and rapid splenic iron loss occur with anemia caused by Salmonella enterica serovar Typhimurium infection in mice

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Greater potency of darbepoetin‐α than erythropoietin in suppression of serum hepcidin‐25 and utilization of iron for erythropoiesis in hemodialysis patients

Shoji, S., Inaba, M., Tomosugi, N., Okuno, S., Ichii, M., Yamakawa, T., & Kurihara, S. (2013) · European Journal Of Haematology · doi:10.1111/ejh.12067 · Cited by 31

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

Gutschow, P., Schmidt, P. J., Han, H., Ostland, V., Bartnikas, T. B., Pettiglio, M. A., Herrera, C., Butler, J. S., Nemeth, E., Ganz, T., et al. (2014) · Haematologica · doi:10.3324/haematol.2014.116723 · Cited by 31

The relationship between systemic iron homeostasis and erythropoiesis

Rishi, G., & Subramaniam, V. N. (2017) · Bioscience Reports · doi:10.1042/bsr20170195 · Cited by 35

RAP‐011, an activin receptor ligand trap, increases hemoglobin concentration in hepcidin transgenic mice

Langdon, J. M., Barkataki, S., Berger, A. E., Cheadle, C., Xue, Q., Sung, V., & Roy, C. N. (2014) · American Journal of Hematology · doi:10.1002/ajh.23856 · Cited by 30

An intensified training schedule in recreational male runners is associated with increases in erythropoiesis and inflammation and a net reduction in plasma hepcidin

Moretti, D., Mettler, S., Zeder, C., Lundby, C., Geurts-Moespot, A. J., Monnard, A., Swinkels, D. W., Brittenham, G. M., & Zimmermann, M. B. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy247 · Cited by 30

Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver

Keel, S., Doty, R. T., Liu, L., Nemeth, E., Cherian, S., Ganz, T., & Abkowitz, J. L. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.03.001 · Cited by 29

Iron status in patients with pyruvate kinase deficiency: neonatal hyperferritinaemia associated with a novel frameshift deletion in thePKLRgene (p.Arg518fs), and low hepcidin to ferritin ratios

Mojzíková, R., Kořalková, P., Holub, D., Zidova, Z., Pospíšilová, D., Čermák, J., Striezencova, Z. L., Indrák, K., Suková, M., Partschova, M., et al. (2014) · British Journal of Haematology · doi:10.1111/bjh.12779 · Cited by 29

Systemic inflammation up-regulates serum hepcidin in exacerbations and stabile chronic obstructive pulmonary disease

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Serum hepcidin: a novel diagnostic tool in disorders of iron metabolism

Bergamaschi, G., & Villani, L. (2009) · Haematologica · doi:10.3324/haematol.2009.013615 · Cited by 28

20 years of Hepcidin: How far we have come

Colucci, S., Marques, O., & Altamura, S. (2021) · Seminars in Hematology · doi:10.1053/j.seminhematol.2021.05.001 · Cited by 28

Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling

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Effects of GlyT1 inhibition on erythropoiesis and iron homeostasis in rats

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Hepcidin and Hfe in iron overload in β‐thalassemia

Gardenghi, S., Ramos, P., Follenzi, A., Rao, N., Rachmilewitz, E. A., Giardina, P. J., Grady, R. W., & Rivella, S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05595.x · Cited by 27

Iron in Multiple Myeloma

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Liver-gut axis in the regulation of iron homeostasis

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New strategies to target iron metabolism for the treatment of beta thalassemia

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Serum Hepcidin as a Diagnostic Marker of Severe Iron Overload in Beta-thalassemia Major

Kaddah, A. M., Abdel-Salam, A., Farhan, M. S., & Ragab, R. (2017) · The Indian Journal of Pediatrics · doi:10.1007/s12098-017-2375-4 · Cited by 29

Anemia in the Elderly Population

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Serum hepcidin measured by immunochemical and mass-spectrometric methods and their correlation with iron status indicators in healthy children aged 0.5–3 y

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Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing glucose-6-phosphate isomerase deficiency are associated with erythroid dysplasia and inappropriately suppressed hepcidin

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Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels

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A High Serum Iron Level Causes Mouse Retinal Iron Accumulation Despite an Intact Blood-Retinal Barrier

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Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients

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Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy

Mast, A. E., Schlumpf, K. S., Wright, D. J., Johnson, B. R., Glynn, S. A., Busch, M. P., Olbina, G., Westerman, M., Nemeth, E., Ganz, T., et al. (2013) · Haematologica · doi:10.3324/haematol.2012.070979 · Cited by 25

Circulating factors are involved in hypoxia-induced hepcidin suppression

Ravasi, G., Pelucchi, S., Greni, F., Mariani, R., Giuliano, A., Parati, G., Silvestri, L., & Piperno, A. (2014) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2014.06.006 · Cited by 25

Iron homeostasis and its disruption in mouse lung in iron deficiency and overload

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Anemic Copper-Deficient Rats, but Not Mice, Display Low Hepcidin Expression and High Ferroportin Levels

Jenkitkasemwong, S., Broderius, M. A., Nam, H., Prohaska, J. R., & Knutson, M. D. (2010) · Journal of Nutrition · doi:10.3945/jn.109.117077 · Cited by 24

Ferroportin and Erythroid Cells: An Update

Cianetti, L., Gabbianelli, M., & Sposi, N. M. (2010) · Advances in Hematology · doi:10.1155/2010/404173 · Cited by 28

Serum hepcidin levels and muscle iron proteins in humans injected with low‐ or high‐dose erythropoietin

Robach, P., Recalcati, S., Girelli, D., Campostrini, N., Kempf, T., Wollert, K. C., Corbella, M., Santambrogio, P., Perbellini, L., Brasse‐Lagnel, C., et al. (2013) · European Journal Of Haematology · doi:10.1111/ejh.12122 · Cited by 25

Hepcidin Expression in Adipose Tissue Increases during Cardiac Surgery

Vokurka, M., Lacinová, Z., Křemen, J., Kopecky, P., Bláha, J., Pelinková, K., Haluzı́k, M., & Nečas, E. (2010) · Physiological Research · doi:10.33549/physiolres.931759 · Cited by 25

Characterization of erythropoietin and hepcidin in the regulation of persistent injury-associated anemia

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Reciprocal regulation between hepcidin and erythropoiesis and its therapeutic application in erythroid disorders

Wang, C., Fang, Z., Zhu, Z., Liu, J., & Chen, H. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.05.002 · Cited by 25

Therapeutic Opportunities for Hepcidin in Acute Care Medicine

Chawla, L. S., Beers-Mulroy, B., & Tidmarsh, G. F. (2019) · Critical Care Clinics · doi:10.1016/j.ccc.2018.11.014 · Cited by 28

Mechanism and regulation of iron absorption throughout the life cycle

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Iron Mining for Erythropoiesis

Correnti, M., Gammella, E., Cairo, G., & Recalcati, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105341 · Cited by 30

Hepcidin mimetics in polycythemia vera: resolving the irony of iron deficiency and erythrocytosis

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Perinatal role of hepcidin and iron homeostasis in full‐term intrauterine growth–restricted infants

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Urinary hepcidin level as an early predictor of iron deficiency in children: A case control study

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Is hepcidin the star player in iron metabolism in chronic kidney disease?

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Body weight and its influence on hepcidin levels in patients with type 2 diabetes: A systematic review and meta-analysis of clinical studies

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Erythroferrone exacerbates iron overload and ineffective extramedullary erythropoiesis in a mouse model of β-thalassemia

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Future alternative therapies for β-thalassemia

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Hepcidin in Iron Homeostasis: Diagnostic and Therapeutic Implications in Type 2 Diabetes Mellitus Patients

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Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice

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Iron Deficiency Anemia: A Public Health Problem of Global Proportions

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Hepcidin regulation in a mouse model of acute hypoxia

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New diagnostic tools for delineating iron status

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The Effect of Vitamin D3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon

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Molecular regulation of hepatic expression of iron regulatory hormone hepcidin

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Hepcidin and GDF-15 are potential biomarkers of iron deficiency anaemia in chronic kidney disease patients in South Africa

Nalado, A. M., Olorunfemi, G., Dix‐Peek, T., Dickens, C., Khambule, L., Snyman, T., Paget, G., Mahlangu, J. N., Duarte, R. A. B., George, J. A., et al. (2020) · BMC Nephrology · doi:10.1186/s12882-020-02046-7 · Cited by 21

Critical Issues in Diamond-Blackfan Anemia and Prospects for Novel Treatment

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Effect of Iron Overload and Iron Deficiency on Liver Hemojuvelin Protein

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Iron metabolism and ineffective erythropoiesis in β‐thalassemia mouse models

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Deficiency of heme-regulated eIF2 kinase decreases hepcidin expression and splenic iron in HFE-/- mice

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PCB-77 disturbs iron homeostasis through regulating hepcidin gene expression

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Activation of STAT and SMAD Signaling Induces Hepcidin Re-Expression as a Therapeutic Target for β-Thalassemia Patients

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Iron age: novel targets for iron overload

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In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Erythropoietin Treatment

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IRON HOMEOSTASIS AND ITS DISORDERS IN MICE AND MEN: POTENTIAL LESSONS FOR RHINOS

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A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum

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Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice

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Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice

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Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome

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Evaluation of a competitive hepcidin ELISA assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients

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Serum maternal hepcidin levels 3 days after delivery are higher compared to those measured at parturition

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Is iron overload in alcohol-related cirrhosis mediated byhepcidin?

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Novel therapies in β‐thalassaemia

Grech, L., Borg, K., & Borg, J. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14918 · Cited by 18

Bmp6 Expression Can Be Regulated Independently of Liver Iron in Mice

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Role of Hepcidin in Iron Metabolism and Potential Clinical Applications

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Is Hepcidin-25 a Clinically Relevant Parameter for the Iron Status in Hemodialysis Patients?

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New perspectives on the molecular basis of the interaction between oxygen homeostasis and iron metabolism

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Mutual Cross Talk Between Iron Homeostasis and Erythropoiesis

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Hepcidin–Minireview

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Hepcidin expression in patients with acute leukaemia

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Hepcidin downregulation by repeated bleeding is not mediated by soluble hemojuvelin.

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Systemic Iron Metabolism

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Hepcidin Suppression Following Phlebotomy Is Regulated by an Erythropoietic Regulator Found in Serum.

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The suppression of hepcidin by anemia and erythropoietin (EPO) is mediated by a fall in serum iron

Rivera, S., Lopez, M. A., Pak, M., & Ganz, T. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.5.lb84-d

Summary

Erythropoiesis, O., Vokurka, M., Krijt, J., Šulc, K., & Nečas, E. (2005)

Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

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Molecular liaisons between erythropoiesis and iron metabolism

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