Regulators of iron balance in humans [see comments]
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Duodenal iron absorption increases several-fold after blood loss or exposure to hypoxia, or in response to iron deficiency.
“Moreover, duodenal iron absorption increases several-fold after blood loss or exposure to hypoxia, or in response to iron deficiency.”
From Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis (2021) · cites this paper as [3]
The Store Regulator (p. 2) says absorption is high when iron stores are depleted, and The Erythroid-Regulator (p. 3) reports increased absorption after phlebotomy and in iron-deficiency anemia. The latter section links hypoxia to erythropoietin release, but does not report a several-fold rise in duodenal absorption after hypoxia exposure; it also does not establish a several-fold increase for each condition in the claim. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThese observations provided early evidence that the absorption and tissue distribution of iron must be subject to endocrine regulation.
“These observations provided early evidence that the absorption and tissue distribution of iron must be subject to endocrine regulation [3].”
From Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis (2021) · cites this paper as [3]
The opening section (p. 1) describes evidence that iron stores and erythropoiesis regulate absorption, and Clinical Implications and Speculations (p. 4) describes changes in both absorption and iron flow from tissues during inflammation. But Interaction of the Two Regulators (p. 4) says the regulators cannot yet be characterized beyond physiological terms; the paper does not establish that this regulation is endocrine. (LLM, conf=0.86)
Experimental — accuracy not yet measuredDespite changes in dietary iron content and tissue demand for iron, the concentration of iron in the blood plasma in healthy humans is remarkably stable, as is the total body iron content.
“Despite changes in dietary iron content and tissue demand for iron, the concentration of iron in the blood plasma in healthy humans is remarkably stable, as is the total body iron content.”
From Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis (2021) · cites this paper as [3]
The opening section (p. 1) reports that increased dietary iron did not raise plasma ferritin, a measure of iron stores, in men with adequate stores. But THE STORE REGULATOR (p. 2) reports that changing iron requirements alter stores, and the paper does not establish that plasma iron concentration remains stable. The claim extends the dietary finding to tissue demand and conflates plasma ferritin with plasma iron. (LLM, conf=0.84)
Experimental — accuracy not yet measuredLoss of iron in a typical adult male is very small and can be met by absorbing 1-2 mg of iron per day.
“However, the loss of iron in a typical adult male is very small [208,209] and can be met by absorbing just 1 – 2 mg of iron per day [210,211].”
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Research works printed but not linked: 4
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- [60]60. Bothwell TH, Charlton RW, Motulsky AG: Idiopathic hemochromatosis, in Stanbury JB, Wyngarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds): The Metabolic Basis of Inherited Disease. New York, NY, McGraw-Hill, 1983, p 1269
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- Authors
- Finch, C.
- Affiliations
- University of Washington (US)
- Corresponding author
- Finch, C
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1994-09-15
- Volume
- 84
- Issue
- 6
- Pages
- 1697-1702
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1677338
- Cited by
- 455
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 16 · 2017: 14 · 2016: 17 · 2015: 27 · 2014: 23 · 2013: 21 · 2012: 22
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- iron homeostasis, iron regulation, iron metabolism, iron balance
- MeSH terms
- Erythrocytes, Erythropoiesis, Ferritins, Homeostasis, Humans, Iron, Male
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