Cited by 117Connective Tissue Growth Factor ResearchAngiogenesis and VEGF in CancerCell Adhesion Molecules Research

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The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration

Grote, Karsten, Salguero, Gustavo, Ballmaier, Matthias, Dangers, Marc, Drexler, Helmut, Schieffer, Bernhard·2007·Blood

DOI 10.1182/blood-2006-07-036202

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Abstract

Tissue regeneration involves the formation of new blood vessels regulated by angiogenic factors. We reported recently that the expression of the angiogenic factor CCN1 is up-regulated under various pathophysiologic conditions within the cardiovascular system. Because CD34+ progenitor cells participate in cardiovascular tissue regeneration, we investigated whether CCN1—detected for the first time in human plasma—promotes the recruitment of CD34+ progenitor cells to endothelial cells, thereby enhancing endothelial proliferation and neovascularization. In this study, we demonstrated that CCN1 and supernatants from CCN1-stimulated human CD34+ progenitor cells promoted proliferation of endothelial cells and angiogenesis in vitro and in vivo. In addition, CCN1 induced migration and transendothelial migration of CD34+ cells and the release of multiple growth factors, chemokines, and matrix metalloproteinase-9 (MMP-9) from these cells. Moreover, the CCN1-specific integrins αMβ2 and αVβ3 are expressed on CD34+ cells and CCN1 stimulated integrin-dependent signaling. Furthermore, integrin antagonists (RGD-peptides) suppressed both binding of CCN1 to CD34+ cells and CCN1-induced adhesion of CD34+ cells to endothelial cells. These data suggest that CCN1 promotes integrin-dependent recruitment of CD34+ progenitor cells to endothelial cells, which may contribute to paracrine effects on angiogenesis and tissue regeneration.

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Authors: Grote, K., Salguero, G., Ballmaier, M., Dangers, M., Drexler, H., & Schieffer, B.
Affiliations: Departments ofCardiology and Angiology,
Pediatric Hematology, and
Medizinische Hochschule Hannover (DE)
ORCID: Grote, Karsten
Salguero, Gustavo
Ballmaier, Matthias
Schieffer, Bernhard
Venue: Blood
Publisher: American Society of Hematology
Published: 2007-08-01
Volume: 110
Issue: 3
Pages: 877-885
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2006-07-036202
OpenAlex: W1984831138
Cited by: 117
References: 43
Citations by year: 2026: 1 · 2025: 3 · 2024: 8 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 2 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 5
FWCI: 2.65
Type: journal article
Language: en
Open access: closed
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: CYR61, angiogenesis, CD34+ cells, re-endothelialization, cell adhesion, cell migration, integrins, integrin αvβ3, RGD peptide, MMP-9, endothelial cell proliferation, neovascularization, paracrine signaling, tissue regeneration, circulating progenitor cells
MeSH terms: Animals, Antineoplastic Agents, Cardiovascular System, Cell Adhesion, Cells, Cultured, Humans, Oligopeptides, Regeneration, Stem Cells, Signal Transduction, Up-Regulation, Macrophage-1 Antigen, Immediate-Early Proteins, Neovascularization, Physiologic, Antigens, CD34, Paracrine Communication, Matrix Metalloproteinase 9, Intercellular Signaling Peptides and Proteins, Integrin alphaVbeta3, Endothelial Cells, Cell Proliferation, Mice, Cysteine-Rich Protein 61

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The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration

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