The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells
Abstract
The molecular alterations underlying the pathogenesis of angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, unspecified (PTCL-u) are largely unknown. In order to characterize the ontogeny and molecular differences between both entities, a series of AITLs (n = 18) and PTCLs-u (n = 16) was analyzed using gene expression profiling. Unsupervised clustering correlated with the pathological classification and with CD30 expression in PTCL-u. The molecular profile of AITLs was characterized by a strong microenvironment imprint (overexpression of B-cell– and follicular dendritic cell–related genes, chemokines, and genes related to extracellular matrix and vascular biology), and overexpression of several genes characteristic of normal follicular helper T (TFH) cells (CXCL13, BCL6, PDCD1, CD40L, NFATC1). By gene set enrichment analysis, the AITL molecular signature was significantly enriched in published TFH-specific genes. The enrichment was higher for sorted AITL cells than for tissue samples. Overexpression of several TFH genes was validated by immunohistochemistry in AITLs. A few cases with molecular TFH-like features were identified among CD30− PTCLs-u. Our findings strongly support that TFH cells represent the normal counterpart of AITL, and suggest that the AITL spectrum may be wider than suspected, as a subset of CD30− PTCLs-u may derive from or be related to AITL.
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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
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Cited by
Campo, E., Jaffe, E. S., Cook, J. R., Quintanilla-Martinez, L., Swerdlow, S. H., Anderson, K. C., Brousset, P., Cerroni, L., de Leval, L., Dirnhofer, S., et al. (2022) · Blood · doi:10.1182/blood.2022015851 · Cited by 1,608
Self-citationT Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses
King, C., Tangye, S. G., & Mackay, C. R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090344 · Cited by 632
Jaffe, E. S. (2009) · Hematology · doi:10.1182/asheducation-2009.1.523 · Cited by 632
Iqbal, J., Wright, G., Wang, C., Rosenwald, A., Gascoyne, R. D., Weisenburger, D. D., Greiner, T. C., Smith, L., Guo, S., Wilcox, R. A., et al. (2014) · Blood · doi:10.1182/blood-2013-11-536359 · Cited by 552
Self-citationInterleukin-21: a double-edged sword with therapeutic potential
Spolski, R., & Leonard, W. J. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4296 · Cited by 548
Metadata
- Authors
- de Leval, L., Rickman, D. S., Thielen, C., Reynies, A. D., Huang, Y.-L., Delsol, G., Lamant, L., Leroy, K., Brière, J., Molina, T., Berger, F., Gisselbrecht, C., Xerri, L., & Gaulard, P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2007-06-01
- Volume
- 109
- Issue
- 11
- Pages
- 4952-4963
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2088636620
- Cited by
- 631
- References
- 42
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- de Leval, L., Rickman, D. S., Thielen, C., Reynies, A. D., Huang, Y.-L., Delsol, G., Lamant, L., Leroy, K., Brière, J., Molina, T., Berger, F., Gisselbrecht, C., Xerri, L., & Gaulard, P. (2007). The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood. https://doi.org/10.1182/blood-2006-10-055145
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