The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses
Abstract
T cell help for antibody production is a fundamental aspect of immune responses. Only recently has a better understanding of the cellular and molecular mechanisms for T cell help emerged. A subset of T cells, termed T follicular helper cells (T FH cells), provides a helper function to B cells and represents one of the most numerous and important subsets of effector T cells in lymphoid tissues. T FH cells are distinguishable from Th1 and Th2 cells by several criteria, including chemokine receptor expression (CXCR5), location/migration (B cell follicles), and function (B cell help). Central to the function of CD4+T cells is IL-21, a “helper” cytokine produced by T FH cells that potently stimulates the differentiation of B cells into Ab-forming cells through IL-21R. Consequently, dysregulation of T FH cell function, and over- or under-expression of T FH cell–associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies.
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Phenotypic and functional features of human Th17 cells
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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
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IL-17 family cytokines and the expanding diversity of effector T cell lineages
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Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
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Cited by
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Johnston, R. J., Poholek, A. C., DiToro, D., Yusuf, I., Eto, D., Barnett, B., Dent, A. L., Craft, J., & Crotty, S. (2009) · Science · doi:10.1126/science.1175870 · Cited by 1,626
Metadata
- Authors
- King, C., Tangye, S. G., & Mackay, C. R.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2008-04-01
- Volume
- 26
- Issue
- 1
- Pages
- 741-766
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2099739487
- Cited by
- 632
- References
- 150
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- King, C., Tangye, S. G., & Mackay, C. R. (2008). T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.26.021607.090344
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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