Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

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Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

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FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

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Current concepts in the pathophysiology and treatment of aplastic anemia

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Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

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Toll-like receptor 2 controls expansion and function of regulatory T cells

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Regulatory T cells in cancer

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Multiple immuno-regulatory defects in type-1 diabetes

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The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells

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Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

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Multiple immuno-regulatory defects in type-1 diabetes

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Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus

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Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

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High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT

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Functional Study of CD4+CD25+ Regulatory T Cells in Health and Autoimmune Hepatitis

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Regulatory T Cells

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T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia

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Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus

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FOXP3 and NFAT: Partners in Tolerance

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Perforin gene mutations in patients with acquired aplastic anemia

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Protein Kinase C-θ Participates in the Activation of Cyclic AMP-Responsive Element-Binding Protein and Its Subsequent Binding to the −180 Site of the IL-2 Promoter in Normal Human T Lymphocytes

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Direct Transfer of p65 into T Lymphocytes from Systemic Lupus Erythematosus Patients Leads to Increased Levels of Interleukin-2 Promoter Activity

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Autoimmunity and Its Treatment in Aplastic Anemia

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The Medical Scientist and Medical Care

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Aplastic Anemia

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How I treat acquired aplastic anemia

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Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug

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Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro

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Aplastic anemia

Young, N. S., Scheinberg, P., & Calado, R. T. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282fa7470 · Cited by 224 · see citing works

Current concepts in the pathophysiology and treatment of aplastic anemia

Young, N. S. (2013) · Hematology · doi:10.1182/asheducation-2013.1.76 · Cited by 199 · see citing works

IL‐17‐producing CD4+T cells, pro‐inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome

Kordasti, S. Y., Afzali, B., Lim, Z., Ingram, W. A., Hayden, J., Barber, L. D., Matthews, K., Chelliah, R., Guinn, B., Lombardi, G., et al. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07593.x · Cited by 194 · see citing works

Th17 immune responses contribute to the pathophysiology of aplastic anemia

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Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

Tran, D. Q., Andersson, J., Hardwick, D., Bebris, L., Illei, G. G., & Shevach, E. M. (2009) · Blood · doi:10.1182/blood-2009-01-199950 · Cited by 187 · see citing works

Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party

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Functional characterization of CD4+ T cells in aplastic anemia

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Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)

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Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

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Intrinsic impairment of CD4+CD25+ regulatory T cells in acquired aplastic anemia

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Advances in understanding the pathogenesis of acquired aplastic anaemia

Luzzatto, L., & Risitano, A. M. (2018) · British Journal of Haematology · doi:10.1111/bjh.15443 · Cited by 122 · see citing works

Aplastic anemia: Etiology, molecular pathogenesis, and emerging concepts

Shallis, R. M., Ahmad, R., & Zeidan, A. M. (2018) · European Journal Of Haematology · doi:10.1111/ejh.13153 · Cited by 108 · see citing works

Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia

Hosokawa, K. T., Muranski, P. J., Feng, X., Townsley, D. M., Liu, B., Knickelbein, J. E., Keyvanfar, K., Dumitriu, B., Ito, S., Kajigaya, S., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501739 · Cited by 102 · see citing works

The Th17/Treg imbalance exists in patients with heart failure with normal ejection fraction and heart failure with reduced ejection fraction

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The Pathophysiology of Acquired Aplastic Anemia

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Regulatory T Cells Are Reduced During Anti-CD25 Antibody Treatment of Multiple Sclerosis

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Regulatory T cells for tolerance

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Aplastic anemia: Pathophysiology

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Abnormal erythropoiesis and the pathophysiology of chronic anemia

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Comparison between horse and rabbit antithymocyte globulin as first-line treatment for patients with severe aplastic anemia: a single-center retrospective study

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Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

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GATA Transcription Factors: Basic Principles and Related Human Disorders

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Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries

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Long-term outcome after immunosuppressive therapy with horse or rabbit antithymocyte globulin and cyclosporine for severe aplastic anemia in children

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Abnormal immunity and stem/progenitor cells in acquired aplastic anemia

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Activity of eltrombopag in severe aplastic anemia

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Double‐negative regulatory T cells induce allotolerance when expanded after allogeneic haematopoietic stem cell transplantation

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Isolation strategies of regulatory T cells for clinical trials: Phenotype, function, stability, and expansion capacity

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Alterations in Hematopoietic Microenvironment in Patients with Aplastic Anemia

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Retrovirus-Specificity of Regulatory T Cells Is Neither Present nor Required in Preventing Retrovirus-Induced Bone Marrow Immune Pathology

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Aplastic Anemia: What Have We Learned From Animal Models and From the Clinic

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Aplastic Anemia: Pathogenesis and Treatment

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Severe Aplastic Anemia Associated With Eosinophilic Fasciitis

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The efficacy of rabbit antithymocyte globulin with cyclosporine in comparison to horse antithymocyte globulin as a first-line treatment in adult patients with severe aplastic anemia: a single-center retrospective study

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Indoleamine 2,3-dioxygenase and regulatory T cells in acute myeloid leukemia

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Rapamycin is highly effective in murine models of immune-mediated bone marrow failure

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Abnormalities of quantities and functions of natural killer cells in severe aplastic anemia

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Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia

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Therapeutic potential of FOXP3+ regulatory T cells and their interactions with dendritic cells

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Efficacy and safety of mesenchymal stromal cell treatment from related donors for patients with refractory aplastic anemia

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CD4 CD25 Foxp3 regulatory T cells and hematologic malignancies

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CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia

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Regulatory T cells: a review.

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Aberrant T cell responses in the bone marrow microenvironment of patients with poor graft function after allogeneic hematopoietic stem cell transplantation

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Erratum: Human gingiva tissue-derived MSC ameliorates immune-mediated bone marrow failure of aplastic anemia via suppression of Th1 and Th17 cells and enhancement of CD4+Foxp3+ regulatory T cells differentiation.

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Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells

Wassenhove, L. D. V., Mochly‐Rosen, D., & Weinberg, K. I. (2016) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2016.07.004 · Cited by 39 · see citing works

Meta-analysis of treatment with rabbit and horse antithymocyte globulin for aplastic anemia

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Hematologic recovery induced by eltrombopag in Japanese patients with aplastic anemia refractory or intolerant to immunosuppressive therapy

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Hypoplastic myelodysplastic syndrome and acquired aplastic anemia: Immune‑mediated bone marrow failure syndromes (Review)

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Activity of eltrombopag in severe aplastic anemia

Scheinberg, P. (2018) · Hematology · doi:10.1182/asheducation-2018.1.450 · Cited by 36 · see citing works

Abnormal quantity and function of regulatory T cells in peripheral blood of patients with severe aplastic anemia

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Optimization of Therapy for Severe Aplastic Anemia Based on Clinical, Biologic, and Treatment Response Parameters: Conclusions of an International Working Group on Severe Aplastic Anemia Convened by the Blood and Marrow Transplant Clinical Trials Network, March 2010

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Deficit of circulating CD19+CD24hiCD38hi regulatory B cells in severe aplastic anaemia

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Th1/17 cells, a subset of Th17 cells, are expanded in patients with active systemic lupus erythematosus

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Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes

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