Cited by 225T-cell and B-cell ImmunologyBlood disorders and treatmentsHematopoietic Stem Cell Transplantation

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Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia

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Solomou, Elena E., Rezvani, Katayoun, Mielke, Stephan, Malide, Daniela, Keyvanfar, Keyvan, Visconte, Valeria, Kajigaya, Sachiko, Barrett, A. John, Young, Neal S.·2007·Blood

DOI 10.1182/blood-2007-01-066258PMC PMC1975843

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Abstract

Regulatory T cells are believed to control the development and progression of autoimmunity by suppressing autoreactive T cells. Decreased numbers of CD4(+)CD25(+) FOXP3(+) T cells (Tregs) are associated with impaired immune homeostasis and development of autoimmune diseases. The transcription factors FOXP3 and NFAT1 have key roles in regulatory T-cell development and function. We show that Tregs are decreased at presentation in almost all patients with aplastic anemia; FOXP3 protein and mRNA levels also are significantly lower in patients with aplastic anemia and NFAT1 protein levels are decreased or absent. Transfection of FOXP3-deficient CD4(+)CD25(+) T cells from patients with a plasmid encoding wild-type NFAT1 resulted in increased FOXP3 expression in these cells. By NFAT1 knockdown in CD4(+)CD25(+) T cells, FOXP3 expression was decreased when NFAT1 expression was decreased. Our findings indicate that decreased NFAT1 could explain low FOXP3 expression and diminished Treg frequency in aplastic anemia. Treg defects are now implicated in autoimmune marrow failure.

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Authors: Solomou, E. E., Rezvani, K., Mielke, S., Malide, D., Keyvanfar, K., Visconte, V., Kajigaya, S., Barrett, A. J., & Young, N. S.
Affiliations: Hematology Branch and
National Institutes of Health (US)
ORCID: Solomou, Elena E.
Rezvani, Katayoun
Mielke, Stephan
Visconte, Valeria
Kajigaya, Sachiko
Young, Neal S.
Venue: Blood
Publisher: American Society of Hematology
Published: 2007-09-01
Volume: 110
Issue: 5
Pages: 1603-1606
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2007-01-066258
PMC: PMC1975843
OpenAlex: W2066935327
Cited by: 225
References: 24
Citations by year: 2026: 11 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 7 · 2021: 11 · 2020: 21 · 2019: 10 · 2018: 18 · 2017: 19 · 2016: 9 · 2015: 11 · 2014: 11 · 2013: 10 · 2012: 11
FWCI: 4.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords: regulatory T cells, CD4+CD25+ T cells, Foxp3, NFAT1, acquired aplastic anemia, Treg deficiency, immune homeostasis, transcription factors, Treg reprogramming
MeSH terms: Adolescent, Adult, Anemia, Aplastic, Autoimmune Diseases, Cells, Cultured, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Transfection, Autoimmunity, T-Lymphocytes, Regulatory, NFATC Transcription Factors, Forkhead Transcription Factors

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Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia

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