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Cited by 100Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchBlood disorders and treatments

Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance

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Perry, S. Scott, Zhao, Ying, Nie, Lei, Cochrane, Shawn W., Huang, Zhong, Sun, Xiao-Hong·2007·Blood
DOI 10.1182/blood-2007-01-069914PMC PMC1988946
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Abstract

E-proteins are widely expressed basic helix-loop-helix (HLH) transcription factors that regulate differentiation in many cell lineages, including lymphoid, muscle, and neuronal cells. E-protein function is controlled by HLH inhibitors such as Id and SCL/TAL1 proteins, which recently have been suggested to play a role in hematopoietic stem cell (HSC) differentiation. However, the precise stages when these proteins are expressed and their specific functions are not entirely clear. Using a knock-in mouse model where the sequence for the enhanced green fluorescent protein (GFP) was inserted downstream of the Id1 promoter, we were able to track Id1 expression on an individual cell basis and detected Id1 expression in long-term repopulating HSCs (LT-HSCs). Functional assays showed that the Id1/GFP+Lin−Sca1+c-kitHi population was highly enriched for LT-HSCs. Consistent with this expression pattern, Id1 deficiency led to a 2-fold reduction in the number of LT-HSCs defined as Lin−Sca1+c-kitHiCD48−CD150+. Primary bone marrow transplantation studies revealed that Id1 is dispensable for short-term engraftment. In contrast, both Id1−/− whole bone marrow and Lin−Sca1+c-kitHiThy1.1Lo-enriched HSCs, but not Id3−/− marrow, displayed impaired engraftment relative to wild-type controls in secondary transplantation assays. These findings suggest a unique role for Id1 in LT-HSC maintenance and hematopoietic development.

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  • Clusters RBC1-4 and 8 exhibited high expression of myb and id1, indicating HSC-like characteristics.

    “Clusters RBC1–4 and 8 exhibited high expression of myb and id1, indicating HSC-like characteristics (Perry et al., 2007; Singh et al., 2018; Zhang et al., 2021).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Perry et al., 2007

    The Results (page unavailable) report that Id1 expression increases with enrichment for long-term HSCs, supporting the use of id1 expression as an HSC-like characteristic. The paper does not report myb expression or identify clusters RBC1–4 and 8, so it cannot support those parts of the sentence. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Perry, S. S., Zhao, Y., Nie, L., Cochrane, S. W., Huang, Z., & Sun, X.-H.
Affiliations
Oklahoma Medical Research Foundation (US)
ORCID
Venue
Blood
Publisher
American Society of Hematology
Published
2007-10-01
Volume
110
Issue
7
Pages
2351-2360
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2007-01-069914
PMC
PMC1988946
OpenAlex
W1966790428
Cited by
100
References
4
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 10 · 2012: 5
FWCI
5.35
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01AI056129, AI33597, R01AI033597, R21AI033597, T32AI007633, T32AI07633, AI56129)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
Keywords
Id1, ID3, hematopoietic stem cells, E protein, bHLH transcription factors, SCL/TAL1, HSC maintenance, bone marrow transplantation, engraftment, knock-in mice, GFP reporter, hematopoietic development
MeSH terms
Animals, Bone Marrow, Gene Expression Regulation, Hematopoietic Stem Cells, Mice, Transgenic, Phenotype, Thymus Gland, Time Factors, Genes, Reporter, Hematopoietic Stem Cell Transplantation, Cell Lineage, Models, Animal, Cell Proliferation, Mice, Inhibitor of Differentiation Proteins, Inhibitor of Differentiation Protein 1

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