A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress.

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871 · see citing works

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81079-x · Cited by 1,585 · see citing works

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580 · see citing works

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566 · see citing works

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452 · see citing works

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339 · see citing works

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

Molofsky, A. V., Pardal, R., Iwashita, T., Park, I.-K., Clarke, M. F., & Morrison, S. J. (2003) · Nature · doi:10.1038/nature02060 · Cited by 1,301 · see citing works

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development · doi:10.1101/gad.12.15.2424 · Cited by 1,245 · see citing works

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

Sharpless, N. E., Bardeesy, N., Lee, K.-H., Carrasco, D., Castrillon, D. H., Aguirre, A. J., Wu, E. A., Horner, J. W., & DePinho, R. A. (2001) · Nature · doi:10.1038/35092592 · Cited by 848 · see citing works

Cellular Senescence

Sherr, C. J., & DePinho, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00046-5 · Cited by 745 · see citing works

HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo

Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00697-9 · Cited by 700 · see citing works

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

Krimpenfort, P., Quon, K. C., Mooi, W. J., Loonstra, A., & Berns, A. (2001) · Nature · doi:10.1038/35092584 · Cited by 568 · see citing works

Stem cell repopulation efficiency but not pool size is governed by p27kip1

Cheng, T., Rodrigues, N. P., Dombkowski, D., Stier, S., & Scadden, D. T. (2000) · Nature Medicine · doi:10.1038/81335 · Cited by 347 · see citing works

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

Allsopp, R. C., Morin, G. B., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Blood · doi:10.1182/blood-2002-07-2334 · Cited by 324 · see citing works

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C

Yuan, Y., Shen, H., Franklin, D. S., Scadden, D. T., & Cheng, T. (2004) · Nature Cell Biology · doi:10.1038/ncb1126 · Cited by 269 · see citing works

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(01)00681-6 · Cited by 221 · see citing works

Transduction of Murine Bone Marrow Cells With an MDR1 Vector Enables Ex Vivo Stem Cell Expansion, but These Expanded Grafts Cause a Myeloproliferative Syndrome in Transplanted Mice

Bunting, K. D., Galipeau, J., Topham, D. J., Benaim, E., & Sorrentino, B. P. (1998) · Blood · doi:10.1182/blood.v92.7.2269 · Cited by 191 · see citing works

Clinical strategies for expansion of haematopoietic stem cells

Sorrentino, B. (2004) · Nature reviews. Immunology · doi:10.1038/nri1487 · Cited by 173 · see citing works

Hematopoietic Stem Cell Expansion and Distinct Myeloid Developmental Abnormalities in a Murine Model of the AML1 - ETO Translocation

de Guzman, C. G., Warren, A. J., Zhang, Z., Gartland, L., Erickson, P., Drabkin, H. A., Hiebert, S. W., & Klug, C. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5506-5517.2002 · Cited by 171 · see citing works

Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo

Bunting, K. D., Zhou, S., Lu, T., & Sorrentino, B. P. (2000) · Blood · doi:10.1182/blood.v96.3.902 · Cited by 168 · see citing works

Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells

Allsopp, R. C., Morin, G. B., Horner, J. W., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Nature Medicine · doi:10.1038/nm0403-369 · Cited by 155 · see citing works

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

Zindy, F., Williams, R. T., Baudino, T. A., Rehg, J. E., Skapek, S. X., Cleveland, J. L., Roussel, M. F., & Sherr, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536808100 · Cited by 150 · see citing works

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element

Mulloy, J. C., Cammenga, J., Berguido, F. J., Wu, K., Zhou, P. H., Comenzo, R. L., Jhanwar, S. C., Moore, M. A. S., & Nimer, S. D. (2003) · Blood · doi:10.1182/blood-2003-05-1762 · Cited by 111 · see citing works

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works

The Regulation of INK4/ARF in Cancer and Aging

Kim, W. Y., & Sharpless, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.10.003 · Cited by 1,009 · see citing works

How stem cells age and why this makes us grow old

Sharpless, N. E., & DePinho, R. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2241 · Cited by 843 · see citing works

Mechanisms of Stem Cell Self-Renewal

He, S., Nakada, D., & Morrison, S. J. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113248 · Cited by 607 · see citing works

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Carlson, M. E., Hsu, M., & Conboy, I. M. (2008) · Nature · doi:10.1038/nature07034 · Cited by 483 · see citing works

Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E., & Orkin, S. H. (2007) · Cell · doi:10.1016/j.cell.2007.03.055 · Cited by 424 · see citing works

Reactive Oxygen Species in Normal and Tumor Stem Cells

Zhou, D., Shao, L., & Spitz, D. R. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-420117-0.00001-3 · Cited by 400 · see citing works

DNA damage checkpoints in stem cells, ageing and cancer

Sperka, T., Wang, J., & Rudolph, K. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3420 · Cited by 393 · see citing works

Total body irradiation selectively induces murine hematopoietic stem cell senescence.

Wang, Y., Schulte, B. A., LaRue, A. C., Ogawa, M., & Zhou, D. (2006) · Blood · doi:10.1182/blood-2005-04-1418 · Cited by 351 · see citing works

Hematopoietic Stem Cell Injury Induced by Ionizing Radiation

Shao, L., Luo, Y., & Zhou, D. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5635 · Cited by 337 · see citing works

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

Oguro, H., Iwama, A., Morita, Y., Kamijo, T., van Lohuizen, M., & Nakauchi, H. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052477 · Cited by 227 · see citing works

Cancer Therapy-Induced Residual Bone Marrow Injury: Mechanisms of Induction and Implication for Therapy

Wang, Y., Probin, V., & Zhou, D. (2006) · Current Cancer Therapy Reviews · doi:10.2174/157339406777934717 · Cited by 214 · see citing works

A matter of life and death: self‐renewal in stem cells

Fuchs, E. V., & Chen, T. (2012) · EMBO Reports · doi:10.1038/embor.2012.197 · Cited by 210 · see citing works

Reactive oxygen species and hematopoietic stem cell senescence

Shao, L., Li, H., Pazhanisamy, S. K., Meng, A., Wang, Y., & Zhou, D. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0872-1 · Cited by 198 · see citing works

Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice

Rossi, L., Lin, K. K., Boles, N. C., Yang, L., King, K. Y., Jeong, M., Mayle, A., & Goodell, M. A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.08.006 · Cited by 192 · see citing works

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

Akala, O. O., Park, I.-K., Qian, D., Pihalja, M., Becker, M. W., & Clarke, M. F. (2008) · Nature · doi:10.1038/nature06869 · Cited by 168 · see citing works

Defective Notch activation in microenvironment leads to myeloproliferative disease

Kim, Y.-W., Koo, B., Jeong, H., Yoon, M.-J., Song, R., Shin, J., Jeong, D.-C., Kim, S., & Kong, Y. (2008) · Blood · doi:10.1182/blood-2008-03-148999 · Cited by 164 · see citing works

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

Shao, L., Feng, W., Li, H., Gardner, D., Luo, Y., Wang, Y., Liu, L., Meng, A., Sharpless, N. E., & Zhou, D. (2014) · Blood · doi:10.1182/blood-2013-07-515619 · Cited by 165 · see citing works

A Limited Role for p21Cip1/Waf1 in Maintaining Normal Hematopoietic Stem Cell Functioning

van Os, R. P., Kamminga, L. M., Ausema, A., Bystrykh, L. V., Draijer, D. P., van Pelt, K., Dontje, B., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0631 · Cited by 118 · see citing works

Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells

Jin, H. J., Lee, H. J., Heo, J., Lim, J., Kim, M., Kim, M. K., Nam, H. Y., Hong, G. H., Cho, Y. S., Choi, S. J., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6359 · Cited by 115 · see citing works

The PKB/FOXO switch in aging and cancer

Kloet, D. E. A., & Burgering, B. M. T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.04.003 · Cited by 104 · see citing works

Reversal of Hepatocyte Senescence After Continuous In Vivo Cell Proliferation

Wang, M., Chen, F., Li, J., Liu, C.-C., Zhang, H., Xia, Y., Yu, B., You, P., Xiang, D., Lu, L., et al. (2014) · Hepatology · doi:10.1002/hep.27094 · Cited by 103 · see citing works

The 9p21 Myocardial Infarction Risk Allele Increases Risk of Peripheral Artery Disease in Older People

Cluett, C., McDermott, M. M., Guralnik, J. M., Ferrucci, L., Bandinelli, S., Miljkovic, I., Zmuda, J. M., Li, R., Tranah, G. J., Harris, T. B., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.825935 · Cited by 92 · see citing works

Adipogenic Differentiation Is Impaired in Replicative Senescent Human Subcutaneous Adipose-Derived Stromal/Progenitor Cells

Mitterberger, M. C., Lechner, S., Mattesich, M., & Zwerschke, W. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt043 · Cited by 82 · see citing works

MOZ-Mediated Repression of p16INK4a Is Critical for the Self-Renewal of Neural and Hematopoietic Stem Cells

Pérez-Campo, F. M., Costa, G., Lie‐A‐Ling, M., Stifani, S., Kouskoff, V., & Lacaud, G. (2013) · Stem Cells · doi:10.1002/stem.1606 · Cited by 81 · see citing works

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.

Shao, L., Wang, Y., Chang, J., Luo, Y., Meng, A., & Zhou, D. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.07.03 · Cited by 79 · see citing works

Bone Marrow-Derived Cells: The Influence of Aging and Cellular Senescence

Beausejour, C. M. (2007) · Springer eBooks · doi:10.1007/978-3-540-68976-8_4 · Cited by 79 · see citing works

Ageing as developmental decay: insights from p16INK4a.

Martin, N., Beach, D., & Gil, J. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.09.008 · Cited by 76 · see citing works

Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells

Walkley, C. R., & Orkin, S. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603389103 · Cited by 71 · see citing works

The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans

Carrasco, D. R., Fenton, T. R., Sukhdeo, K., Protopopova, M., Enos, M., You, M. J., Divicio, D., Nogueira, C., Stommel, J. M., Pinkus, G. S., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.028 · Cited by 69 · see citing works

Breaking the Cell Cycle of HSCs by p57 and Friends

Tesio, M., & Trumpp, A. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.08.005 · Cited by 57 · see citing works

Age-Specific Functional Epigenetic Changes in p21 and p16 in Injury-Activated Satellite Cells

Li, J., Han, S., Cousin, W., & Conboy, I. M. (2014) · Stem Cells · doi:10.1002/stem.1908 · Cited by 56 · see citing works

The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress

Daria, D., Filippi, M.-D., Knudsen, E. S., Faccio, R., Li, Z., Kalfa, T., & Geiger, H. (2008) · Blood · doi:10.1182/blood-2007-02-071746 · Cited by 46 · see citing works

Life and death in hematopoietic stem cells

Oguro, H., & Iwama, A. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.05.001 · Cited by 44 · see citing works

Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells

Konuma, T., Nakamura, S., Miyagi, S., Negishi, M., Chiba, T., Oguro, H., Yuan, J., Mochizuki‐Kashio, M., Ichikawa, H., Miyoshi, H., et al. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2011.03.008 · Cited by 40 · see citing works

Inhibition of p16INK4A to Rejuvenate Aging Human Cardiac Progenitor Cells via the Upregulation of Anti-oxidant and NFκB Signal Pathways

Khatiwala, R. V., Zhang, S., Li, X., Devejian, N. S., Bennett, E. V., & Cai, C. (2018) · Stem Cell Reviews and Reports · doi:10.1007/s12015-018-9815-z · Cited by 34 · see citing works

Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status

Song, Z., Ju, Z., & Rudolph, K. L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.009 · Cited by 33 · see citing works

Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update

Bi, S., Wang, H., & Kuang, W. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.005 · Cited by 27 · see citing works

Regulation of murine hematopoietic stem cell quiescence by Dmtf1

Kobayashi, M., & Srour, E. F. (2011) · Blood · doi:10.1182/blood-2011-05-349084 · Cited by 27 · see citing works

Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B

Carnevalli, L. S., Scognamiglio, R., Cabezas‐Wallscheid, N., Rahmig, S., Laurenti, E., Masuda, K., Joeckel, L. T., Kuck, A., Sujer, S., Polykratis, A., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131072 · Cited by 25 · see citing works

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Jackson, J. T., Shields, B. J., Shi, W., Rago, L. D., Metcalf, D., Nicola, N. A., & McCormack, M. P. (2017) · Stem Cells · doi:10.1002/stem.2648 · Cited by 24 · see citing works

Hematopoietic Stem Cells Are Not the Direct Target of Spontaneous Leukemic Transformation in p18INK4C-Null Reconstituted Mice

Yuan, Y., Yu, H. M., Boyer, M. J., Song, X., Cao, S., Shen, H., & Cheng, T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2945 · Cited by 22 · see citing works

Cytokine signaling to the cell cycle

Quelle, F. W. (2007) · Immunologic Research · doi:10.1007/s12026-007-0080-5 · Cited by 21 · see citing works

Roles of p53 in Various Biological Aspects of Hematopoietic Stem Cells

Nii, T., Marumoto, T., & Tani, K. (2012) · BioMed Research International · doi:10.1155/2012/903435 · Cited by 20 · see citing works

Stem cell ageing: does it happen and can we intervene?

Bellantuono, I., & Keith, W. N. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239940700049x · Cited by 20 · see citing works

Role of Polycomb-group genes in sustaining activities of normal and malignant stem cells

Takihara, Y. (2007) · International Journal of Hematology · doi:10.1007/s12185-007-0006-y · Cited by 18 · see citing works

Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting

Farina, A. R., Cappabianca, L. A., Zelli, V., Sebastiano, M., & Mackay, A. R. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i7.685 · Cited by 17 · see citing works

Traditional herbs: mechanisms to combat cellular senescence

Wang, L., Wang, J., Yang, Z., Wang, Y., Zhao, T., Luo, W., Liang, T., & Zheng, Y. (2023) · Aging · doi:10.18632/aging.205269 · Cited by 17 · see citing works

Rb and hematopoiesis: stem cells to anemia

Walkley, C. R., Sankaran, V., & Orkin, S. (2008) · Cell Division · doi:10.1186/1747-1028-3-13 · Cited by 23 · see citing works

RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion

Tapia, P. C. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.09.008 · Cited by 15 · see citing works

Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging

Ju, Z., Zhang, J., Gao, Y., & Cheng, T. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0882-z · Cited by 14 · see citing works

Establishment of an aging model of Sca-1+ hematopoietic stem cell and studies on its relative biological mechanisms

Zhou, Y., Yang, B., Yao, X., & Wang, Y. (2010) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-010-9372-5 · Cited by 11 · see citing works

Quiescence regulation by normal haematopoietic stem cells and leukaemia stem cells

Gudmundsson, K. O., & Du, Y. (2022) · FEBS Journal · doi:10.1111/febs.16472 · Cited by 9 · see citing works

Emerging Evidence of the Significance of Thioredoxin-1 in Hematopoietic Stem Cell Aging

Jabbar, S., Mathews, P., & Kang, Y. (2022) · Antioxidants · doi:10.3390/antiox11071291 · Cited by 6 · see citing works

Dissecting dormancy and quiescence in hematopoietic stem cells

Ibneeva, L., & Grinenko, T. (2024) · Frontiers in Hematology · doi:10.3389/frhem.2024.1401713 · Cited by 6 · see citing works

Histone-deacetylase inhibitors may accelerate the aging process in stem cell-dependent mammals: Stem cells, Ku70, and Drosophila at the crossroads

Tapia, P. C. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.08.032 · Cited by 5 · see citing works

Guilu erxian glue alleviates chemotherapy-induced myelosuppression by regulating histone methylation level of p16 gene in hematopoietic stem cells

Wang, M., Wang, J. W., Lai, W., Lou, Z., Lin, S., Shao, K., Su, J., Zeng, T., Lu, J., & Jiang, J. (2025) · Clinical Traditional Medicine and Pharmacology · doi:10.1016/j.ctmp.2025.200213 · Cited by 3 · see citing works

Principles of Hematopoietic Stem Cell Biology

Ema, H., Kobayashi, T., & Nakauchi, H. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-347-3_1 · Cited by 3 · see citing works

Therapeutics of Stem Cell Treatment in Anti-Aging and Rejuvenation

Yeh, D.-C., & Chan, T.-M. (2018) · Stem Cell Discovery · doi:10.4236/scd.2018.82002 · Cited by 3 · see citing works

Hematopoietic Stem Cell Stress and Regeneration

Termini, C. M., & Chute, J. P. (2020) · Current Stem Cell Reports · doi:10.1007/s40778-020-00181-3 · Cited by 3 · see citing works

Networks Establishing Hematopoietic Stem Cell Multipotency and Self-Renewal

Abdelhay, E. S. F. W., Pizzatti, L., & Binato, R. (2012) · InTech eBooks · doi:10.5772/32211 · Cited by 1 · see citing works

CDK Inhibitors in Normal and Malignant Cells

Besser, A., & Slingerland, J. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.30059-1 · Cited by 1 · see citing works

p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?

Sharpless, N. E. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_9

The Stem Cell Niche and Its Role in Self-Renewal, Aging, and Malignancy

Breslin, S. J. P., Volk, A. G., & Zhang, J. (2013) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.201200010

Leukemia Stem Cells, A Pioneering Paradigmatic Model

Pearce, D. J., & Bonnet, D. A. (2007) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812775870_0009

A Telomere-Independent Process?

Sharpless, N. E. (2008)

A Limited Role for p21 in Maintaining Normal Hematopoietic Stem Cell Functioning

Kamminga, L. M., Ausema, A., Bystrykh, L. V., & Draijer, D. P. (2007)

CDK Inhibitors in Normal and Malignant Cells

Besser, A. H., & Slingerland, J. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00221-2

634. The Role of Ink4a-Arf Locus in Control of Hematopoietic Stem Cell Proliferation

(2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.06.567

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

Oguro, H., Iwama, A., Morita, Y., Kamijo, T., van Lohuizen, M., & Nakauchi, H. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052477 · Cited by 227 · see citing works

Hematopoietic stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners

Yu, H., Yuan, Y., Shen, H., & Cheng, T. (2006) · Blood · doi:10.1182/blood-2005-02-0685 · Cited by 127 · see citing works

Research Status for INK4a/ARF Gene Regulating the Senescence of Hematopoietic Stem Cells and Leukemia Stem Cells

汪洁 (2011) · Guoji shuxue ji xueyexue zazhi · doi:10.3760/cma.j.issn.1673-419x.2011.03.009

Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence

Attema, J. L., Pronk, C. J. H., Norddahl, G. L., Nygren, J. M., & Bryder, D. (2009) · Oncogene · doi:10.1038/onc.2009.94 · Cited by 72 · see citing works