The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease
Open accessAbstract
Graft-versus-host disease (GVHD) remains the major complication after allogeneic bone marrow transplantation (BMT). The process whereby acute GVHD mediated by alloreactive donor T cells transitions into chronic GVHD, which is characterized by prominent features of auto-immunity, has long been unresolved. In this study, we demonstrate that GVHD-associated autoimmunity and, by extension, chronic GVHD is attributable to the progressive loss of CD4+CD25+Foxp3+ regulatory T cells during the course of acute GVHD. This leads to the expansion of donor-derived CD4+ T cells with TH1 and TH17 cytokine phenotypes that release proinflammatory cytokines and cause autoimmune-mediated pathological damage. These T cells are present early after transplantation, indicating that the pathophysiological events that lead to chronic GVHD are set in motion during the acute phase of GVHD. We conclude that the absence of CD4+CD25+ regulatory T cells coupled with unregulated TH1 and TH17 cells leads to the development of autoimmunity and that donor-derived TH1 and TH17 cells serve as the nexus between acute and chronic GVHD.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526
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Cited by
Tumor-specific Th17-polarized cells eradicate large established melanoma
Muranski, P., Boni, A., Antony, P. A., Cassard, L., Irvine, K. R., Kaiser, A., Paulos, C. M., Palmer, D. C., Touloukian, C. E., Ptak, K., et al. (2008) · Blood · doi:10.1182/blood-2007-11-120998 · Cited by 845
Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., et al. (2017) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2016.09.023 · Cited by 472
Favre, D., Lederer, S., Kanwar, B., Ma, Z.-M., Proll, S., Kasakow, Z., Mold, J., Swainson, L., Barbour, J. D., Baskin, C. R., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000295 · Cited by 405
Bone marrow and the control of immunity
Zhao, E., Xu, H., Wang, L., Kryczek, I., Wu, K., Hu, Y., Wang, G., & Zou, W. (2012) · Cellular & Molecular Immunology · doi:10.1038/cmi.2011.47 · Cited by 356
Chronic graft-versus-host disease: biological insights from preclinical and clinical studies
MacDonald, K. P. A., Hill, G. R., & Blazar, B. R. (2017) · Blood · doi:10.1182/blood-2016-06-686618 · Cited by 300
Metadata
- Authors
- Chen, X., Vodanovic-Jankovic, S., Johnson, B., Keller, M., Komorowski, R., & Drobyski, W. R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2007-11-15
- Volume
- 110
- Issue
- 10
- Pages
- 3804-3813
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1988361537
- Cited by
- 228
- References
- 6
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Chen, X., Vodanovic-Jankovic, S., Johnson, B., Keller, M., Komorowski, R., & Drobyski, W. R. (2007). Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. Blood. https://doi.org/10.1182/blood-2007-05-091074
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