The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels
Open accessAbstract
Tissue engineering requires formation of a de novo stable vascular network. Because of their ability to proliferate, differentiate into endothelial cells, and form new vessels, blood-derived endothelial progenitor cells (EPCs) are attractive source of cells for use in engineering blood vessels. However, the durability and function of EPC-derived vessels implanted in vivo are unclear. To this end, we directly compared formation and functions of tissue-engineered blood vessels generated by peripheral blood– and umbilical cord blood–derived EPCs in a model of in vivo vasculogenesis. We found that adult peripheral blood EPCs form blood vessels that are unstable and regress within 3 weeks. In contrast, umbilical cord blood EPCs form normal-functioning blood vessels that last for more than 4 months. These vessels exhibit normal blood flow, perm-selectivity to macromolecules, and induction of leukocyte-endothelial interactions in response to cytokine activation similar to normal vessels. Thus, umbilical cord blood EPCs hold great therapeutic potential, and their use should be pursued for vascular engineering.
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Cites
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Self-citationEndothelial Progenitor Cells: Characterization and Role in Vascular Biology
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Cited by
Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells
Hirschi, K. K., Ingram, D. A., & Yoder, M. C. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.155960 · Cited by 746
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Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
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Bone and the hematopoietic niche: a tale of two stem cells
Bianco, P. (2011) · Blood · doi:10.1182/blood-2011-01-315069 · Cited by 254
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Metadata
- Authors
- Au, P., Daheron, L. M., Duda, D. G., Cohen, K. S., Tyrrell, J. A., Lanning, R. M., Fukumura, D., Scadden, D. T., & Jain, R. K.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-02-01
- Volume
- 111
- Issue
- 3
- Pages
- 1302-1305
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2031462636
- Cited by
- 342
- References
- 15
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Au, P., Daheron, L. M., Duda, D. G., Cohen, K. S., Tyrrell, J. A., Lanning, R. M., Fukumura, D., Scadden, D. T., & Jain, R. K. (2008). Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood. https://doi.org/10.1182/blood-2007-06-094318
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