The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis
Open accessAbstract
Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via their ability to self-renew and to differentiate into all blood lineages. Although a central role for the canonical wnt signaling pathway has been suggested in HSC self-renewal as well as in the development of B and T cells, conditional deletion of β-catenin (which is considered to be essential for Wnt signaling) has no effect on hematopoiesis or lymphopoiesis. Here, we address whether this discrepancy can be explained by a redundant and compensatory function of γ-catenin, a close homolog of β-catenin. Unexpectedly, we find that combined deficiency of β- and γ-catenin in hematopoietic progenitors does not impair their ability to self-renew and to reconstitute all myeloid, erythroid, and lymphoid lineages, even in competitive mixed chimeras and serial transplantations. These results exclude an essential role for canonical Wnt signaling (as mediated by β- and/or γ-catenin) during hematopoiesis and lymphopoiesis.
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Cites
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Cited by
Hematopoietic stem cell: self‐renewal versus differentiation
Seita, J., & Weissman, I. L. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.86 · Cited by 932
Hematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
Adult haematopoietic stem cell niches
Crane, G. M., Jeffery, E., & Morrison, S. J. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.53 · Cited by 712
Goessling, W., North, T. E., Loewer, S., Lord, A. M., Lee, S., Stoick-Cooper, C. L., Weidinger, G., Puder, M., Daley, G. Q., Moon, R. T., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.015 · Cited by 699
Cabezas-Wallscheid, N., Klimmeck, D., Hansson, J., Lipka, D. B., Reyes, A., Wang, Q., Weichenhan, D., Lier, A., von Paleske, L., Renders, S., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.005 · Cited by 589
Metadata
- Authors
- Koch, U., Wilson, A., Cobas, M., Kemler, R., MacDonald, H. R., & Radtke, F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-01-01
- Volume
- 111
- Issue
- 1
- Pages
- 160-164
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2012796523
- Cited by
- 201
- References
- 2
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Koch, U., Wilson, A., Cobas, M., Kemler, R., MacDonald, H. R., & Radtke, F. (2008). Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis. Blood. https://doi.org/10.1182/blood-2007-07-099754
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