The DOI matches its Crossref record; 72 of the 75 references it cites were found in a registry or an index.
Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets
Open accessAbstract
Early in life, thymic export establishes the size and the diversity of the human naive T-cell pool. Yet, on puberty thymic activity drastically decreases. Because the overall size of the naive T-cell pool decreases only marginally during ageing, peripheral postthymic expansion of naive T cells has been postulated to account partly for the maintenance of T-cell immunity in adults. So far, the analysis of these processes had been hampered by the inability to distinguish recent thymic emigrants from proliferated, peripheral, naive T cells. However, recently, CD31 has been introduced as a marker to distinguish 2 subsets of naive CD4+ T cells with distinct T-cell receptor excision circle (TREC) content in the peripheral blood of healthy humans. Here, we review studies that have characterized TREChi CD31+ thymicnaive CD4+ T cells and have accordingly used the assessment of this distinct subset of naive CD4+ T cells as a correlate of thymic activity. We will discuss further potential clinical applications and how more research on CD31+ thymicnaive and CD31− centralnaive CD4+ T cells may foster our knowledge of the impact of thymic involution on immune competence.
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“Lymphopenia leads to an increase in the homeostatic proliferation of naive T cells, which is usually not sufficient to keep their number constant [332, 333].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [332]
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“This setting of partial lymphopenia results in increasing naive T-cell homeostatic proliferation, although this is not sufficient to maintain a constant number of these cells [77, 78].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [77]
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Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
(2002) · PsycEXTRA Dataset · doi:10.1037/e548512006-001 · Cited by 1,713
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
Newman, P., Berndt, M., Gorski, J., White, G. C., Lyman, S., Paddock, C., & Muller, W. (1990) · Science · doi:10.1126/science.1690453 · Cited by 1,011
The Influence of Age on T Cell Generation and TCR Diversity
Naylor, K., Li, G., Vallejo, A. N., Lee, W.-W., Koetz, K., Bryl, E., Witkowski, J., Fulbright, J., Weyand, C. M., & Goronzy, J. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7446 · Cited by 802
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.
King, C., Ilic, A., Koelsch, K., & Sarvetnick, N. (2004) · Cell · doi:10.1016/s0092-8674(04)00335-6 · Cited by 747
Ernst, B., Dong-Sup, L., Chang, J. M., Sprent, J., & Surh, C. D. (1999) · Immunity · doi:10.1016/s1074-7613(00)80092-8 · Cited by 717
Newman, P. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119129 · Cited by 671
Muraro, P. A., Douek, D. C., Packer, A., Chung, K., Guenaga, J., Cassiani‐Ingoni, R., Campbell, C., Memon, S. A., Nagle, J. W., Hakim, F. T., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041679 · Cited by 505
(2004) · PsycEXTRA Dataset · doi:10.1037/e548622006-001 · Cited by 472
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Allers, K., Hütter, G., Hofmann, J., Loddenkemper, C., Rieger, K., Thiel, E., & Schneider, T. (2011) · Blood · doi:10.1182/blood-2010-09-309591 · Cited by 681
Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
Li, F.-Y., Chaigne-Delalande, B., Kanellopoulou, C., Davis, J. C., Matthews, H. F., Douek, D. C., Cohen, J. I., Uzel, G., Su, H. C., & Lenardo, M. J. (2011) · Nature · doi:10.1038/nature10246 · Cited by 579
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Matsuoka, K., Koreth, J., Kim, H. T., Bascug, G., McDonough, S. M., Kawano, Y., Murase, K., Cutler, C. S., Ho, V. T., Alyea, E. P., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005265 · Cited by 467
Regulatory T cells in embryo implantation and the immune response to pregnancy
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Metadata
- Authors
- Kohler, S., & Thiel, A.
- Affiliations
- Clinical Immunology Group, Deutsches Rheuma-Forschungszentrum Berlin, Berlin; and
- German Rheumatism Research Centre (DE)
- ORCID
- Thiel, Andreas
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-01-22
- Volume
- 113
- Issue
- 4
- Pages
- 769-774
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1999924197
- Cited by
- 307
- References
- 75
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 6 · 2022: 11 · 2021: 25 · 2020: 18 · 2019: 23 · 2018: 21 · 2017: 18 · 2016: 24 · 2015: 21 · 2014: 25 · 2013: 23 · 2012: 18
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- CD31, naive CD4+ T cells, thymic emigrants, thymic involution, TREC, T cell receptor diversity, immunosenescence, T cell subsets
- MeSH terms
- Animals, Homeostasis, Humans, Immunity, Innate, Thymus Gland, CD4-Positive T-Lymphocytes, Platelet Endothelial Cell Adhesion Molecule-1, Cell Proliferation
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